Search Results - "ALAM, S. Munir"

Cold sensitivity of the SARS-CoV-2 spike ectodomain by Edwards, Robert J., Mansouri, Katayoun, Stalls, Victoria, Manne, Kartik, Watts, Brian, Parks, Rob, Janowska, Katarzyna, Gobeil, Sophie M. C., Kopp, Megan, Li, Dapeng, Lu, Xiaozhi, Mu, Zekun, Deyton, Margaret, Oguin, Thomas H., Sprenz, Jordan, Williams, Wilton, Saunders, Kevin O., Montefiori, David, Sempowski, Gregory D., Henderson, Rory, Munir Alam, S., Haynes, Barton F., Acharya, Priyamvada

“…The SARS-CoV-2 spike (S) protein, a primary target for COVID-19 vaccine development, presents its receptor binding domain in two conformations, the…”
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Broad and potent neutralization of HIV-1 by a gp41-specific human antibody by Huang, Jinghe, Ofek, Gilad, Laub, Leo, Louder, Mark K., Doria-Rose, Nicole A., Longo, Nancy S., Imamichi, Hiromi, Bailer, Robert T., Chakrabarti, Bimal, Sharma, Shailendra K., Alam, S. Munir, Wang, Tao, Yang, Yongping, Zhang, Baoshan, Migueles, Stephen A., Wyatt, Richard, Haynes, Barton F., Kwong, Peter D., Mascola, John R., Connors, Mark

“…Characterization of human monoclonal antibodies is providing considerable insight into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41…”
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Polyreactivity and autoreactivity among HIV-1 antibodies by Liu, Mengfei, Yang, Guang, Wiehe, Kevin, Nicely, Nathan I, Vandergrift, Nathan A, Rountree, Wes, Bonsignori, Mattia, Alam, S Munir, Gao, Jingyun, Haynes, Barton F, Kelsoe, Garnett

“…It is generally acknowledged that human broadly neutralizing antibodies (bNAbs) capable of neutralizing multiple HIV-1 clades are often polyreactive or…”
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Antibody‐virus co‐evolution in HIV infection: paths for HIV vaccine development by Bonsignori, Mattia, Liao, Hua‐Xin, Gao, Feng, Williams, Wilton B., Alam, S. Munir, Montefiori, David C., Haynes, Barton F.

“…Summary Induction of HIV‐1 broadly neutralizing antibodies (bnAbs) to date has only been observed in the setting of HIV‐1 infection, and then only years after…”
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Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements by Henderson, Rory, Lu, Maolin, Zhou, Ye, Mu, Zekun, Parks, Robert, Han, Qifeng, Hsu, Allen L., Carter, Elizabeth, Blanchard, Scott C., Edwards, R J, Wiehe, Kevin, Saunders, Kevin O., Borgnia, Mario J., Bartesaghi, Alberto, Mothes, Walther, Haynes, Barton F., Acharya, Priyamvada, Munir Alam, S.

“…The trimeric HIV-1 Envelope protein (Env) mediates viral-host cell fusion via a network of conformational transitions, with allosteric elements in each…”
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Vi-specific serological correlates of protection for typhoid fever by Jin, Celina, Hill, Jennifer, Gunn, Bronwyn M, Yu, Wen-Han, Dahora, Lindsay C, Jones, Elizabeth, Johnson, Mari, Gibani, Malick M, Spreng, Rachel L, Alam, S Munir, Nebykova, Anna, Juel, Helene B, Dennison, S Moses, Seaton, Kelly E, Fallon, Jonathan K, Tomaras, Georgia D, Alter, Galit, Pollard, Andrew J

“…Typhoid Vi vaccines have been shown to be efficacious in children living in endemic regions; however, a widely accepted correlate of protection remains to be…”
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Glycosylation Benchmark Profile for HIV-1 Envelope Glycoprotein Production Based on Eleven Env Trimers by Go, Eden P, Ding, Haitao, Zhang, Shijian, Ringe, Rajesh P, Nicely, Nathan, Hua, David, Steinbock, Robert T, Golabek, Michael, Alin, James, Alam, S Munir, Cupo, Albert, Haynes, Barton F, Kappes, John C, Moore, John P, Sodroski, Joseph G, Desaire, Heather

“…HIV-1 envelope glycoprotein (Env) glycosylation is important because individual glycans are components of multiple broadly neutralizing antibody epitopes,…”
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Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth by Huang, Jinghe, Kang, Byong H., Ishida, Elise, Zhou, Tongqing, Griesman, Trevor, Sheng, Zizhang, Wu, Fan, Doria-Rose, Nicole A., Zhang, Baoshan, McKee, Krisha, O’Dell, Sijy, Chuang, Gwo-Yu, Druz, Aliaksandr, Georgiev, Ivelin S., Schramm, Chaim A., Zheng, Anqi, Joyce, M. Gordon, Asokan, Mangaiarkarasi, Ransier, Amy, Darko, Sam, Migueles, Stephen A., Bailer, Robert T., Louder, Mark K., Alam, S. Munir, Parks, Robert, Kelsoe, Garnett, Von Holle, Tarra, Haynes, Barton F., Douek, Daniel C., Hirsch, Vanessa, Seaman, Michael S., Shapiro, Lawrence, Mascola, John R., Kwong, Peter D., Connors, Mark

“…Detailed studies of the broadly neutralizing antibodies (bNAbs) that underlie the best available examples of the humoral immune response to HIV are providing…”
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Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies by Yang, Guang, Holl, T Matt, Liu, Yang, Li, Yi, Lu, Xiaozhi, Nicely, Nathan I, Kepler, Thomas B, Alam, S Munir, Liao, Hua-Xin, Cain, Derek W, Spicer, Leonard, VandeBerg, John L, Haynes, Barton F, Kelsoe, Garnett

“…Many human monoclonal antibodies that neutralize multiple clades of HIV-1 are polyreactive and bind avidly to mammalian autoantigens. Indeed, the generation of…”
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An HIV-1 gp120 Envelope Human Monoclonal Antibody That Recognizes a C1 Conformational Epitope Mediates Potent Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity and Defines a Common ADCC Epitope in Human HIV-1 Serum by FERRARI, Guido, POLLARA, Justin, KAPPES, John C, SHAW, George M, HOXIE, James A, ROBINSON, James E, HAYNES, Barton F, KOZINK, Daniel, HARMS, Tiara, DRINKER, Mark, FREEL, Stephanie, MOODY, M. Anthony, MUNIR ALAM, S, TOMARAS, Georgia D, OCHSENBAUER, Christina

“…OA  Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
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Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG by Tomaras, Georgia D., Ferrari, Guido, Shen, Xiaoying, Alam, S. Munir, Liao, Hua-Xin, Pollara, Justin, Bonsignori, Mattia, Moody, M. Anthony, Fong, Youyi, Chen, Xi, Poling, Brigid, Nicholson, Cindo O., Zhang, Ruijun, Lu, Xiaozhi, Parks, Robert, Kaewkungwal, Jaranit, Nitayaphan, Sorachai, Pitisuttithum, Punnee, Rerks-Ngarm, Supachai, Gilbert, Peter B., Kim, Jerome H., Michael, Nelson L., Montefiori, David C., Haynes, Barton F.

“…Analysis of correlates of risk of infection in the RV144 HIV-1 vaccine efficacy trial demonstrated that plasma IgG against the HIV-1 envelope (Env) variable…”
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Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages by Zhang, Ruijun, Verkoczy, Laurent, Wiehe, Kevin, Munir Alam, S, Nicely, Nathan I, Santra, Sampa, Bradley, Todd, Pemble, 4th, Charles W, Zhang, Jinsong, Gao, Feng, Montefiori, David C, Bouton-Verville, Hilary, Kelsoe, Garnett, Larimore, Kevin, Greenberg, Phillip D, Parks, Robert, Foulger, Andrew, Peel, Jessica N, Luo, Kan, Lu, Xiaozhi, Trama, Ashley M, Vandergrift, Nathan, Tomaras, Georgia D, Kepler, Thomas B, Moody, M Anthony, Liao, Hua-Xin, Haynes, Barton F

“…Development of an HIV vaccine is a global priority. A major roadblock to a vaccine is an inability to induce protective broadly neutralizing antibodies…”
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Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier by Bonsignori, Mattia, Scott, Eric, Wiehe, Kevin, Easterhoff, David, Alam, S. Munir, Hwang, Kwan-Ki, Cooper, Melissa, Xia, Shi-Mao, Zhang, Ruijun, Montefiori, David C., Henderson, Rory, Nie, Xiaoyan, Kelsoe, Garnett, Moody, M. Anthony, Chen, Xuejun, Joyce, M. Gordon, Kwong, Peter D., Connors, Mark, Mascola, John R., McGuire, Andrew T., Stamatatos, Leonidas, Medina-Ramírez, Max, Sanders, Rogier W., Saunders, Kevin O., Kepler, Thomas B., Haynes, Barton F.

“…Elicitation of VRC01-class broadly neutralizing antibodies (bnAbs) is an appealing approach for a preventative HIV-1 vaccine. Despite extensive investigations,…”
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Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies by Gao, Feng, Bonsignori, Mattia, Liao, Hua-Xin, Kumar, Amit, Xia, Shi-Mao, Lu, Xiaozhi, Cai, Fangping, Hwang, Kwan-Ki, Song, Hongshuo, Zhou, Tongqing, Lynch, Rebecca M., Alam, S. Munir, Moody, M. Anthony, Ferrari, Guido, Berrong, Mark, Kelsoe, Garnett, Shaw, George M., Hahn, Beatrice H., Montefiori, David C., Kamanga, Gift, Cohen, Myron S., Hraber, Peter, Kwong, Peter D., Korber, Bette T., Mascola, John R., Kepler, Thomas B., Haynes, Barton F.

“…Development of strategies for induction of HIV-1 broadly neutralizing antibodies (bnAbs) by vaccines is a priority. Determining the steps of bnAb induction in…”
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Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions by Pierre, Camille N, Adams, Lily E, Higgins, Jaclyn S, Anasti, Kara, Goodman, Derrick, Mielke, Dieter, Stanfield-Oakley, Sherry, Powers, John M, Li, Dapeng, Rountree, Wes, Wang, Yunfei, Edwards, Robert J, Alam, S Munir, Ferrari, Guido, Tomaras, Georgia D, Haynes, Barton F, Baric, Ralph S, Saunders, Kevin O

“…Antibodies perform both neutralizing and non-neutralizing effector functions that protect against certain pathogen-induced diseases. A human antibody directed…”
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Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations by Han, Qifeng, Jones, Julia A., Nicely, Nathan I., Reed, Rachel K., Shen, Xiaoying, Mansouri, Katayoun, Louder, Mark, Trama, Ashley M., Alam, S. Munir, Edwards, Robert J., Bonsignori, Mattia, Tomaras, Georgia D., Korber, Bette, Montefiori, David C., Mascola, John R., Seaman, Michael S., Haynes, Barton F., Saunders, Kevin O.

“…The HIV-1 envelope (Env) is the target for neutralizing antibodies and exists on the surface of virions in open or closed conformations…”
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Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies by Henderson, Rory, Watts, Brian E., Ergin, Hieu N., Anasti, Kara, Parks, Robert, Xia, Shi-Mao, Trama, Ashley, Liao, Hua-Xin, Saunders, Kevin O., Bonsignori, Mattia, Wiehe, Kevin, Haynes, Barton F., Alam, S. Munir

“…Somatic mutations within antibody variable and framework regions (FWR) can alter thermostability and structural flexibility, but their impact on functional…”
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HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities by Pollara, Justin, Bonsignori, Mattia, Moody, M Anthony, Liu, Pinghuang, Alam, S Munir, Hwang, Kwan-Ki, Gurley, Thaddeus C, Kozink, Daniel M, Armand, Lawrence C, Marshall, Dawn J, Whitesides, John F, Kaewkungwal, Jaranit, Nitayaphan, Sorachai, Pitisuttithum, Punnee, Rerks-Ngarm, Supachai, Robb, Merlin L, O'Connell, Robert J, Kim, Jerome H, Michael, Nelson L, Montefiori, David C, Tomaras, Georgia D, Liao, Hua-Xin, Haynes, Barton F, Ferrari, Guido

“…The RV144 ALVAC/AIDSVax HIV-1 vaccine clinical trial showed an estimated vaccine efficacy of 31.2%. Viral genetic analysis identified a vaccine-induced site of…”
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Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16 by Pancera, Marie, Shahzad-ul-Hussan, Syed, Doria-Rose, Nicole A, McLellan, Jason S, Bailer, Robert T, Dai, Kaifan, Loesgen, Sandra, Louder, Mark K, Staupe, Ryan P, Yang, Yongping, Zhang, Baoshan, Parks, Robert, Eudailey, Joshua, Lloyd, Krissey E, Blinn, Julie, Alam, S Munir, Haynes, Barton F, Amin, Mohammed N, Wang, Lai-Xi, Burton, Dennis R, Koff, Wayne C, Nabel, Gary J, Mascola, John R, Bewley, Carole A, Kwong, Peter D

“…Some broadly neutralizing antibodies against HIV-1 recognize glycopeptide epitopes in the gp120 V1–V2 region. Now X-ray crystallography and NMR approaches,…”
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Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors by BONSIGNORI, Mattia, HWANG, Kwan-Ki, SINANGIL, Faruk, PANCERA, Marie, YONGPING, Yang, ZHANG, Baoshan, JIANG ZHU, KWONG, Peter D, O'DELL, Sijy, MASCOLA, John R, LAN WU, NABEL, Gary J, XI CHEN, PHOGAT, Sanjay, SEAMAN, Michael S, WHITESIDES, John F, ANTHONY MOODY, M, KELSOE, Garnett, XINZHEN YANG, SODROSKI, Joseph, SHAW, George M, MONTEFIORI, David C, KEPLER, Thomas B, TSAO, Chun-Yen, TOMARAS, Georgia D, MUNIR ALAM, S, LIAO, Hua-Xin, HAYNES, Barton F, MORRIS, Lynn, GRAY, Elin, MARSHALL, Dawn J, CRUMP, John A, KAPIGA, Saidi H, SAM, Noel E

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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