Search Results - "ALAIMO, Lisa"

Images of Marie Curie: How Reputational Entrepreneurs Shape Iconic Identities by Alaimo, Lisa, Chambers, Lori, Puddephatt, Antony

“…Marie Curie holds iconic status both within the scientific community and in the wider cultural imagination and collective memory. The first woman to be awarded…”
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Inhibitory effects of glycoprotein IIb/IIIa antagonists and aspirin on the release of soluble CD40 ligand during platelet stimulation by NANNIZZI-ALAIMO, Lisa, ALVES, Veronica L, PHILLIPS, David R

“…Glycoprotein (GP) IIb/IIIa antagonists inhibit platelet aggregation, an activity attributed to the clinical benefits of these drugs in settings that involve…”
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GP IIb/IIIa inhibition with eptifibatide lowers levels of soluble CD40L and RANTES after percutaneous coronary intervention by Welt, Frederick G.P., Rogers, Sarah D., Zhang, Xiaobin, Ehlers, Raila, Chen, Zhiping, Nannizzi-Alaimo, Lisa, Phillips, David R., Simon, Daniel I.

“…Platelets are the most abundant blood source of CD40L, a proinflammatory and prothrombotic costimulatory molecule implicated in atherosclerosis. Agonist…”
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Cardiopulmonary bypass induces release of soluble CD40 ligand by NANNIZZI-ALAIMO, Lisa, RUBENSTEIN, Mark H, ALVES, Veronica L, LEONG, Gil Y, PHILLIPS, David R, GOLD, Herman K

“…Cardiopulmonary bypass (CPB) is known to induce platelet activation, thrombosis, thrombocytopenia, and a systemic inflammatory response. It is known that CD40…”
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Tyrosine Phosphorylation of the β3 Cytoplasmic Domain Mediates Integrin-Cytoskeletal Interactions by Jenkins, Alison L., Nannizzi-Alaimo, Lisa, Silver, Debra, Sellers, James R., Ginsberg, Mark H., Law, Debbie A., Phillips, David R.

“…Tyrosine phosphorylation of the β3 subunit of the major platelet integrin αIIbβ3 has been shown to occur during thrombin-induced platelet aggregation (1). We…”
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Platelet-derived CD40L: the switch-hitting player of cardiovascular disease by André, Patrick, Nannizzi-Alaimo, Lisa, Prasad, Srinivasa K, Phillips, David R

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Signal transduction pathways for mouse platelet membrane adhesion receptors by Law, D A, Nannizzi-Alaimo, L, Cowan, K J, Prasad, K S, Ramakrishnan, V, Phillips, D R

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Outside-in Integrin Signal Transduction by Law, Debbie A., Nannizzi-Alaimo, Lisa, Phillips, David R.

“…α β -(GPIIb-IIIa) is the most abundant integrin expressed on platelets and plays a critical role in platelet aggregation and normal hemostasis. In response…”
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Integrin tyrosine phosphorylation in platelet signaling by Phillips, David R, Prasad, KS Srinivasa, Manganello, Jeanne, Bao, Ming, Nannizzi-Alaimo, Lisa

“…The β3 integrin cytoplasmic tyrosine (ICY) motif of αIIbβ3 becomes tyrosine phosphorylated during platelet aggregation, causing Shc and myosin to interact with…”
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Effect of Ca2+ on GP IIb-IIIa interactions with integrilin : Enhanced GP IIb-IIIa binding and inhibition of platelet aggregation by reductions in the concentration of ionized calcium in plasma anticoagulated with citrate by PHILLIPS, D. R, TENG, W, SCARBOROUGH, R. M, ARFSTEN, A, NANNIZZI-ALAIMO, L, WHITE, M. M, LONGHURST, C, SHATTIL, S. J, RANDOLPH, A, JAKUBOWSKI, J. A, JENNINGS, L. K

“…Integrilin (eptifibatide), a potent inhibitor of the fibrinogen binding function of GP IIb-llla, has been shown to reduce the thrombotic complications of…”
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Discovery of Novel 2,8-Diazaspiro[4.5]decanes as Orally Active Glycoprotein IIb-IIIa Antagonists by Mehrotra, Mukund M., Heath, Julie A., Smyth, Mark S., Pandey, Anjali, Rose, Jack W., Seroogy, Joseph M., Volkots, Deborah L., Nannizzi-Alaimo, Lisa, Park, Gary L., Lambing, Joseph L., Hollenbach, Stanley J., Scarborough, Robert M.

“…In our efforts to develop orally active GPIIb-IIIa antagonists with improved pharmaceutical properties, we have utilized a novel 2,8-diazaspiro[4.5]decane…”
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Glycoprotein IIb/IIIa receptor inhibition with eptifibatide reduces levels of soluble CD40 ligand and RANTES post stenting by Welt, Frederick G., Demtrak, Sarah, Zhang, Xiaobin, Ehlers, Raila, Chen, Zhiping, Nannizzi-Alaimo, Lisa, Phillips, David R., Simon, Daniel I.

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Effect of Ca(2positive) on GP IIb-IIIa interactions with integrilin by Phillips, David R, Teng, Willie, Arfsten, Ann, Nannizzi-Alaimo, Lisa

“…BACKGROUND: Integrilin (eptifibatide), a potent inhibitor of the fibrinogen binding function of GP IIb-llla, has been shown to reduce the thrombotic…”
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Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 3: Synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes by MEHROTRA, Mukund M, HEATH, Julie A, PANDEY, Anjali, SCARBOROUGH, Robert M, ROSE, Jack W, SMYTH, Mark S, SEROOGY, Joseph, VOLKOTS, Deborah L, RUHTER, Gerd, SCHOTTEN, Theo, ALAIMO, Lisa, PARK, Gary

“…The synthesis and biological activity of analogues containing spiro piperidinylpyridine and pyrrolidinylpyridine templates are described. The potent activity…”
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Differential effects of citrate versus PPACK anticoagulation on measured platelet inhibition by abciximab, eptifibatide and tirofiban by KEREIAKES, Dean J, LORENZ, Todd, YOUNG, John J, KUKIELKA, Gilbert, MUELLER, Michele N, NANNIAZZI-ALAIMO, Lisa, PHILLIPS, David R

“…High levels of glycoprotein (GP) IIb/IIIa receptor inhibition are required to prevent arterial thrombosis following percutaneous coronary intervention. Ex-vivo…”
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Genetic and Pharmacological Analyses of Syk Function in IIbβ3 Signaling in Platelets by Law, Debbie A., Nannizzi-Alaimo, Lisa, Ministri, Kathleen, Hughes, Paul E., Forsyth, Jane, Turner, Martin, Shattil, Sanford J., Ginsberg, Mark H., Tybulewicz, Victor L.J., Phillips, David R.

“…Abstract Agonists induce inside-out IIbβ3signaling resulting in fibrinogen binding and platelet aggregation. These in turn trigger outside-in signaling…”
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Genetic and Pharmacological Analyses of Syk Function in IIbβ3 Signaling in Platelets by Law, Debbie A., Nannizzi-Alaimo, Lisa, Ministri, Kathleen, Hughes, Paul E., Forsyth, Jane, Turner, Martin, Shattil, Sanford J., Ginsberg, Mark H., Tybulewicz, Victor L.J., Phillips, David R.

“…Agonists induce inside-out IIbβ3signaling resulting in fibrinogen binding and platelet aggregation. These in turn trigger outside-in signaling resulting in…”
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Genetic and Pharmacological Analyses of Syk Function in αIIbβ3 Signaling in Platelets by Law, Debbie A., Nannizzi-Alaimo, Lisa, Ministri, Kathleen, Hughes, Paul E., Forsyth, Jane, Turner, Martin, Shattil, Sanford J., Ginsberg, Mark H., Tybulewicz, Victor L.J., Phillips, David R.

“…Agonists induce inside-out αIIbβ3signaling resulting in fibrinogen binding and platelet aggregation. These in turn trigger outside-in signaling resulting in…”
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Effect of Ca 2+ on GP IIb-IIIa Interactions With Integrilin: Enhanced GP IIb-IIIa Binding and Inhibition of Platelet Aggregation by Reductions in the Concentration of Ionized Calcium in Plasma Anticoagulated With Citrate by Phillips, David R., Teng, Willie, Arfsten, Ann, Nannizzi-Alaimo, Lisa, White, Melanie M., Longhurst, Celia, Shattil, Sanford J., Randolph, Anne, Jakubowski, Joseph A., Jennings, Lisa K., Scarborough, Robert M.

“…Background Integrilin (eptifibatide), a potent inhibitor of the fibrinogen binding function of GP IIb-IIIa, has been shown to reduce the thrombotic…”
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Tyrosine Phosphorylation of the β3 Cytoplasmic Domain Mediates Integrin-Cytoskeletal Interactions by Alison L. Jenkins, Lisa Nannizzi-Alaimo, Debra Silver, James R. Sellers, Mark H. Ginsberg, Debbie A. Law, David R. Phillips

“…Tyrosine phosphorylation of the β 3 subunit of the major platelet integrin α IIb β 3 has been shown to occur during thrombin-induced platelet aggregation (…”
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