Search Results - "AKUZAWA, Shinobu"

Effect of ASP8062 on morphine self-administration and morphine-induced respiratory suppression in monkeys by Akuzawa, Shinobu, Irie, Megumi, Kanki, Masayuki, Shirakawa, Takafumi, Sato, Yuichiro

“…ASP8062 is an orally available GABAB receptor positive allosteric modulator (PAM). This study assessed the potential of ASP8062 for treating opioid use…”
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Synthesis and structure–activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists by Moritomo, Ayako, Yamada, Hiroyoshi, Watanabe, Toshihiro, Itahana, Hirotsune, Akuzawa, Shinobu, Okada, Minoru, Ohta, Mitsuaki

“…A series of carbonyl guanidine derivatives have been discovered as potent dual 5-HT2B and 5-HT7 receptor antagonists…”
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Synthesis and structure–activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists. Part 2 by Moritomo, Ayako, Yamada, Hiroyoshi, Watanabe, Toshihiro, Itahana, Hirotsune, Koga, Yuji, Akuzawa, Shinobu, Okada, Minoru

“…[Display omitted] We previously reported that the novel dual 5-HT2B and 5-HT7 receptor antagonist N-(9-hydroxy-9H-fluorene-2-carbonyl)guanidine (4) exerted a…”
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Synthesis and pharmacological evaluation of optically pure, novel carbonyl guanidine derivatives as dual 5-HT2B and 5-HT7 receptor antagonists by Moritomo, Ayako, Yamada, Hiroyoshi, Matsuzawa-Nomura, Takaho, Watanabe, Toshihiro, Itahana, Hirotsune, Oku, Makoto, Akuzawa, Shinobu, Okada, Minoru

“…[Display omitted] A series of 9-disubstituted N-(9H-fluorene-2-carbonyl)guanidine derivatives have been discovered as potent and orally active dual 5-HT2B and…”
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Evaluation of the Pharmacological Profile of Ramosetron, a Novel Therapeutic Agent for Irritable Bowel Syndrome by Hirata, Takuya, Keto, Yoshihiro, Funatsu, Toshiyuki, Akuzawa, Shinobu, Sasamata, Masao

“…We examined the pharmacological profile of ramosetron, a 5-HT3-receptor antagonist for irritable bowel syndrome with diarrhea, comparing it with those of other…”
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Effect of ramosetron on conditioned emotional stress-induced colonic dysfunction as a model of irritable bowel syndrome in rats by Funatsu, Toshiyuki, Takeuchi, Asako, Hirata, Takuya, Keto, Yoshihiro, Akuzawa, Shinobu, Sasamata, Masao

“…The aim of this study was to establish a pathophysiologic model of irritable bowel syndrome, and then to evaluate the pharmaceutical efficacy of ramosetron, a…”
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Inhibitory Effects of Ramosetron, a Potent and Selective 5-HT3–Receptor Antagonist, on Conditioned Fear Stress–Induced Abnormal Defecation and Normal Defecation in Rats: Comparative Studies With Antidiarrheal and Spasmolytic Agents by Hirata, Takuya, Funatsu, Toshiyuki, Keto, Yoshihiro, Akuzawa, Shinobu, Sasamata, Masao, Miyata, Keiji

“…We examined the effect of ramosetron, a potent serotonin (5-HT)3-receptor antagonist for irritable bowel syndrome with diarrhea, on conditioned fear stress…”
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Effects of serotonin 5-HT3 receptor antagonists on CRF-induced abnormal colonic water transport and defecation in rats by HIRATA, Takuya, KETO, Yoshihiro, NAKATA, Mari, TAKEUCHI, Asako, FUNATSU, Toshiyuki, AKUZAWA, Shinobu, SASAMATA, Masao, MIYATA, Keiji

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A novel GABAB receptor positive allosteric modulator, ASP8062, exerts analgesic effects in a rat model of fibromyalgia by Murai, Nobuhito, Kondo, Yuji, Akuzawa, Shinobu, Mihara, Takuma, Shiraishi, Nobuyuki, Kakimoto, Shuichiro, Matsumoto, Mitsuyuki

“…The gamma-aminobutyric acid type B (GABAB) receptor agonist, the sodium salt of gamma-hydroxybutyrate (GHB), significantly improved pain, sleep disturbance and…”
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Effect of antiemetics on zolbetuximab-induced gastric injury and emesis in ferrets by Kinugasa, Fumitaka, Kajikawa, Satoru, Weng, Jane, Ugawa, Tohru, Fushiki, Hiroshi, Yamanaka, Yosuke, Nagata, Masanori, Haggerty, Gillian, Akuzawa, Shinobu, Nakazawa, Taisuke, Suzuki, Hiroshi, Sawamoto, Taiji

“…Claudin-18 splice variant 2 (CLDN18.2), a tight junction protein, is a highly cell type–specific antigen that is expressed by differentiated gastric mucosa…”
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New thiazole derivatives as potent and selective 5-hydroxytriptamine 3 (5-HT3) receptor agonists for the treatment of constipation by IMANISHI, Naoki, IWAOKA, Kiyoshi, TSUKAMOTO, Shin-Ichi, MASE, Toshiyasu, KOSHIO, Hiroyuki, NAGASHIMA, Shin-Ya, KAZUTA, Ken-Ichi, OHTA, Mitsuaki, SAKAMOTO, Shuichi, ITO, Hiroyuki, AKUZAWA, Shinobu, KISO, Tetsuo

“…The syntheses and biological evaluation of a series of novel indeno[1,2-d]thiazole derivatives are described. Several groups reported 5-HT(3) receptor agonists…”
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Pharmacological and clinical profile of ramosetron hydrochloride (Irribow), a novel therapeutic agent for irritable bowel syndrome with diarrhea by Hirata, Takuya, Funatsu, Toshiyuki, Keto, Yoshihiro, Akuzawa, Shinobu, Akiho, Hiraku, Nishida, Akito, Sasamata, Masao, Miyata, Keiji

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116.1 GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Some Cognitive Deficits in a Fragile X Syndrome Mouse Model by Siegel, Steven, Sinclair, Dunan, Matsumoto, Mitsuyuki, Featherstone, Robert, Melnechenko, Olya, Nascheck, Melissa, Weger, Rachel, Akuzawa, Shinobu, Pance, Katarina, Wright, Saidha, Nam, Jehee, Du, Austin

“…Background: Fragile X syndrome (FXS) is a genetic condition which results from FMR1 gene mutation and leads to intellectual disability, autism-like symptoms…”
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Characterization of [3H]YM060, a potent and selective 5-HT3 receptor radioligand, in the cerebral cortex of rats by AKUZAWA, Z, MIYATA, K, FUKUTOMI, H

“…The binding properties of a new radioligand, [methyl-3H]-(-)-(R)-5-[(1-methyl-1H-indol-3-yl)carbonyl]-4,5,6,7- tetrahydro-1H-benzimidazole monohydrochloride…”
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Comparison of [3H]YM060 binding to native and cloned rat 5-HT3 receptors by AKUZAWA, S, MIYAKE, A, MIYATA, K, FUKUTOMI, H

“…We characterized [3H]YM060 ([methyl-3H]-(-)-(R)-5-[(methyl-1H- indol-3-yl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole monohydrochloride) binding in membrane…”
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A novel GABA B receptor positive allosteric modulator, ASP8062, exerts analgesic effects in a rat model of fibromyalgia by Murai, Nobuhito, Kondo, Yuji, Akuzawa, Shinobu, Mihara, Takuma, Shiraishi, Nobuyuki, Kakimoto, Shuichiro, Matsumoto, Mitsuyuki

“…The gamma-aminobutyric acid type B (GABA ) receptor agonist, the sodium salt of gamma-hydroxybutyrate (GHB), significantly improved pain, sleep disturbance and…”
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Synthesis and pharmacological evaluation of optically pure, novel carbonyl guanidine derivatives as dual 5-HT sub(2B) and 5-HT sub(7) receptor antagonists by Moritomo, Ayako, Yamada, Hiroyoshi, Matsuzawa-Nomura, Takaho, Watanabe, Toshihiro, Itahana, Hirotsune, Oku, Makoto, Akuzawa, Shinobu, Okada, Minoru

“…A series of 9-disubstituted N-(9H-fluorene-2-carbonyl)guanidine derivatives have been discovered as potent and orally active dual 5-HT sub(2B) and 5-HT sub(7)…”
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Biological Activity of Analogues of YM022. Novel (3-Amino Substituted Phenyl)urea Derivatives of 1, 4-Benzodiazepin-2-one as Gastrin : Cholecystokinin-B Receptor Antagonists by SATOH, Masato, OKAMOTO, Yoshinori, KOSHIO, Hiroyuki, OHTA, Mitsuaki, NISHIDA, Akito, AKUZAWA, Shinobu, MIYATA, Keiji, MASE, Toshiyasu, SEMPLE, Graeme

“…A series of (3-substituted phenyl)urea analogues of the potent gastrin/cholecystokinin (CCK)-B receptor antagonist YM022 has been prepared. Structure-activity…”
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Hepatic accumulation and hepatotoxicity of luteoskyrin in mice by Masuda, T, Ito, J, Akuzawa, S, Ishii, K, Takagi, H, Ueno, Y

“…HPLC analysis revealed that luteoskyrin administered orally to male mice accumulated selectively in the liver, with minor distribution to the serum and…”
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Effects of serotonin 5-HT(3) receptor antagonists on CRF-induced abnormal colonic water transport and defecation in rats by Hirata, Takuya, Keto, Yoshihiro, Nakata, Mari, Takeuchi, Asako, Funatsu, Toshiyuki, Akuzawa, Shinobu, Sasamata, Masao, Miyata, Keiji

“…The effects of corticotropin releasing factor (CRF) and serotonin (5-HT)(3) receptor antagonists on intestinal water transport are not well understood. Hence,…”
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