Search Results - "AKIMOTO, Toshio"

Cesarean section delivery is a risk factor of autism-related behaviors in mice by Nagano, Masatoshi, Saitow, Fumihito, Higo, Shinpei, Uzuki, Makoto, Mikahara, Yasunori, Akimoto, Toshio, Ozawa, Hitoshi, Nishimori, Katsuhiko, Suzuki, Hidenori

“…Cesarean section (C/S) is one way of delivering babies, and is chosen when mothers or babies are facing problems or life-threatening conditions during…”
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Class III Alcohol Dehydrogenase Plays a Key Role in the Onset of Alcohol-Related/-Associated Liver Disease as an S-Nitrosoglutathione Reductase in Mice by Haseba, Takeshi, Maruyama, Motoyo, Akimoto, Toshio, Yamamoto, Isao, Katsuyama, Midori, Okuda, Takahisa

“…Lipid accumulation in the liver due to chronic alcohol consumption (CAC) is crucial in the development of alcohol liver disease (ALD). It is promoted by the…”
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Development and validation of a novel overhead method for anteroposterior radiographs of fractured rat femurs by Sato, Yosuke, Tagami, Takashi, Akimoto, Toshio, Takiguchi, Toru, Endo, Yusuke, Tsukamoto, Takeshi, Hara, Yoshiaki, Yokobori, Shoji

“…We aimed to establish a new method of obtaining femur anteroposterior radiographs from live rats. We used five adult male Sprague–Dawley rats and created a…”
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Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria by Nagahara, Noriyuki, Nagano, Masatoshi, Ito, Takaaki, Shimamura, Kenji, Akimoto, Toshio, Suzuki, Hidenori

“…Human mercaptolactate-cysteine disulfiduria (MCDU) was first recognized and reported in 1968. Most cases of MCDU are associated with mental retardation, while…”
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Metabolic pharmacokinetics of early chronic alcohol consumption mediated by liver alcohol dehydrogenases 1 and 3 in mice by Okuda, Takahisa, Haseba, Takeshi, Katsuyama, Midori, Maruyama, Motoyo, Akimoto, Toshio, Igarashi, Tsutomu, Ohno, Youkichi

“…Background and Aim Alcohol dehydrogenases (ADHs) 1 and 3 are responsible for systemic alcohol metabolism. The current study investigated the contribution of…”
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Roles of Two Major Alcohol Dehydrogenases, ADH1 (Class I) and ADH3 (Class III), in the Adaptive Enhancement of Alcohol Metabolism Induced by Chronic Alcohol Consumption in Mice by Haseba, Takeshi, Okuda, Takahisa, Maruyama, Motoyo, Akimoto, Toshio, Duester, Gregg, Ohno, Youkichi

“…Abstract Aims It is still unclear which enzymes contribute to the adaptive enhancement of alcohol metabolism by chronic alcohol consumption (CAC). ADH1 (Class…”
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Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states by Medina, Anya, Nakagawa, Yuko, Ma, Jinhui, Li, Longfei, Hamano, Kunihisa, Akimoto, Toshio, Ninomiya, Yuzo, Kojima, Itaru

“…We reported recently that the taste type 1 receptor 3 (T1R3), a subunit of the sweet taste receptor, functions as a cell-surface glucose-sensing receptor in…”
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Involvement of matrix metalloproteinase-2 in the development of renal interstitial fibrosis in mouse obstructive nephropathy by Du, Xuanyi, Shimizu, Akira, Masuda, Yukinari, Kuwahara, Naomi, Arai, Takashi, Kataoka, Mitue, Uchiyama, Masaaki, Kaneko, Tomohiro, Akimoto, Toshio, Iino, Yasuhiko, Fukuda, Yuh

“…Renal fibrosis is a common finding in progressive renal diseases. Matrix metalloproteinases (MMPs) are involved in epithelial-to-mesenchymal transition (EMT)…”
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Effect of H2 treatment in a mouse model of rheumatoid arthritis‐associated interstitial lung disease by Terasaki, Yasuhiro, Terasaki, Mika, Kanazawa, Satoshi, Kokuho, Nariaki, Urushiyama, Hirokazu, Kajimoto, Yusuke, Kunugi, Shinobu, Maruyama, Motoyo, Akimoto, Toshio, Miura, Yoko, Igarashi, Tsutomu, Ohsawa, Ikuroh, Shimizu, Akira

“…Rheumatoid arthritis (RA)‐associated interstitial lung disease (ILD), a primary cause of mortality in patients with RA, has limited treatment options. A…”
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Development of blastocyst complementation technology without contributions to gametes and the brain by Hashimoto, Haruo, Eto, Tomoo, Yamamoto, Masafumi, Yagoto, Mika, Goto, Motohito, Kagawa, Takahiro, Kojima, Keisuke, Kawai, Kenji, Akimoto, Toshio, Takahashi, Ri-ichi

“…In Japan, it is possible to generate chimeric animals from specified embryos by combining animal blastocysts with human pluripotent stem (PS) cells…”
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The Contribution of Alcohol Dehydrogenase 3 to the Development of Alcoholic Osteoporosis in Mice by Okuda, Takahisa, Naruo, Munehiro, Iijima, Osamu, Igarashi, Tsutomu, Katsuyama, Midori, Maruyama, Motoyo, Akimoto, Toshio, Ohno, Youkichi, Haseba, Takeshi

“…Background: Alcohol dehydrogenase 3 (ADH3) plays major roles not only in alcohol metabolism but also in nitric oxide metabolism as S-nitrosoglutathione…”
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Adiponectin deficiency-induced diabetes increases TNFα and FFA via downregulation of PPARα by HASHIMOTO, Haruo, YAMAMOTO, Masafumi, SUGIURA, Emika, ABE, Hayato, KAGAWA, Takahiro, GOTO, Motohito, TAKAHASHI, Ri-ichi, AKIMOTO, Toshio, SUEMIZU, Hiroshi

“…Expression of peroxisome proliferator-activated receptor (PPAR) α was investigated in adiponectin knockout mice to elucidate the relationship between PPARα and…”
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Inhibition of matrix metalloproteinases reduces ischemia-reperfusion acute kidney injury by Kunugi, Shinobu, Shimizu, Akira, Kuwahara, Naomi, Du, Xuanyi, Takahashi, Mikiko, Terasaki, Yasuhiro, Fujita, Emiko, Mii, Akiko, Nagasaka, Shinya, Akimoto, Toshio, Masuda, Yukinari, Fukuda, Yuh

“…Matrix metalloproteinases (MMPs) are endopeptidases that degrade extracellular matrix and involved in ischemic organ injuries. The present study was designed…”
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Expression of MCP-1 in white adipose tissues induce the resistin-hypersecretion in type 2 diabetes by Hashimoto, Haruo, Eto, Tomoo, Kawai, Kenji, Akimoto, Toshio, Hioki, Kyoji

“…Inflammation induced by MCP-1 plays an important role in the development of type 2 diabetes. Obese mice with MCP-1 deficiency showed an improvement of insulin…”
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Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis by Goto, Maki, Kitamura, Hiroshi, Alam, Md. Morshedul, Ota, Nao, Haseba, Takeshi, Akimoto, Toshio, Shimizu, Akio, Takano‐Yamamoto, Teruko, Yamamoto, Masayuki, Motohashi, Hozumi

“…Nutritional steatohepatitis is closely associated with dysregulation of lipid metabolism and oxidative stress control. ADH3 is a highly conserved bifunctional…”
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Direct and specific effect of sevoflurane anesthesia on rat Per2 expression in the suprachiasmatic nucleus by Anzai, Megumi, Iijima, Norio, Higo, Shimpei, Takumi, Ken, Matsuo, Izumi, Mori, Keisuke, Ohe, Yumiko, Kadota, Kana, Akimoto, Toshio, Sakamoto, Atsuhiro, Ozawa, Hitoshi

“…Our previous studies revealed that application of the inhalation anesthetic, sevoflurane, reversibly repressed the expression of Per2 in the mouse…”
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Nrf2 Lowers the Risk of Lung Injury via Modulating the Airway Innate Immune Response Induced by Diesel Exhaust in Mice by Li, Ying-Ji, Shimizu, Takako, Shinkai, Yusuke, Ihara, Tomomi, Sugamata, Masao, Kato, Katsuhito, Kobayashi, Maiko, Hirata, Yukiyo, Inagaki, Hirofumi, Uzuki, Makoto, Akimoto, Toshio, Umezawa, Masakazu, Takeda, Ken, Azuma, Arata, Yamamoto, Masayuki, Kawada, Tomoyuki

“…In the present study, we investigated the role of Nrf2 in airway immune responses induced by diesel exhaust (DE) inhalation in mice. C57BL/6J Nrf2+/+ and…”
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A new in vivo analysis model to detect sexually dimorphic rat liver cytochrome P450 gene expression dependent on growth hormone secretory patterns by Maruyama, Motoyo, Fujisawa, Masahiko, Yokosuka, Makoto, Saito, Toru R., Hayama, Shin-ichi, Akimoto, Toshio, Hakamata, Yoji

“…Several drug-metabolizing cytochrome P450 (CYP) enzymes exhibit sexual dimorphism depending on the pituitary growth hormone (GH) secretory patterns. However,…”
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Role of matrix metalloproteinase-2 in recovery after tubular damage in acute kidney injury in mice by Kaneko, Tomohiro, Shimizu, Akira, Mii, Akiko, Fujita, Emiko, Fujino, Teppei, Kunugi, Shinobu, Du, Xuanyi, Akimoto, Toshio, Tsuruoka, Shuichi, Ohashi, Ryuji, Masuda, Yukinari, Iino, Yasuhiko, Katayama, Yasuo, Fukuda, Yuh

“…Matrix metalloproteinases (MMPs) are zinc endopeptidases that degrade extracellular matrix and are involved in the pathogenesis of ischemic damage in acute…”
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Progression of Pancreatitis Prior to Diabetes Onset in WBN/Kob-Leprfa Rats by AKIMOTO, Toshio, TERADA, Misao, SHIMIZU, Akira

“…We established the WBN/Kob-Leprfa rat as a new congenic strain for the fa allele of the leptin receptor gene (Lepr). Homozygous (fa/fa) WBN/Kob-Leprfa rats…”
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