Search Results - "AKAO, Yukihiro"

PTBP1‐targeting microRNAs regulate cancer‐specific energy metabolism through the modulation of PKM1/M2 splicing by Taniguchi, Kohei, Uchiyama, Kazuhisa, Akao, Yukihiro

“…Understanding of the microRNAs (miRNAs) regulatory system has become indispensable for physiological/oncological research. Tissue and organ specificities are…”
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Regulated Polarization of Tumor-Associated Macrophages by miR-145 via Colorectal Cancer-Derived Extracellular Vesicles by Shinohara, Haruka, Kuranaga, Yuki, Kumazaki, Minami, Sugito, Nobuhiko, Yoshikawa, Yuki, Takai, Tomoaki, Taniguchi, Kohei, Ito, Yuko, Akao, Yukihiro

“…Macrophages are polarized into functional classically activated and alternatively activated (M2) phenotypes depending on their microenvironment, and these…”
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let-7 MicroRNA Functions as a Potential Growth Suppressor in Human Colon Cancer Cells by Akao, Yukihiro, Nakagawa, Yoshihito, Naoe, Tomoki

“…MicroRNAs (miRNAs) are endogenously expressed RNAs, 18—25 nucleotides in length, that repress protein translation through binding to target mRNAs. miRNAs have…”
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Downregulation of microRNAs‐143 and ‐145 in B‐cell malignancies by Akao, Yukihiro, Nakagawa, Yoshihito, Kitade, Yukio, Kinoshita, Tomohiro, Naoe, Tomoki

“…Recently, it has been found that inappropriate expression of microRNAs (miRNAs) is strongly associated with carcinogenesis. In this study, we demonstrated that…”
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Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains by Nomura, Teiko Komori, Heishima, Kazuki, Sugito, Nobuhiko, Sugawara, Ryota, Ueda, Hiroshi, Yukihiro, Akao, Honda, Ryo

“…Oncogenic RAS proteins, common oncogenic drivers in many human cancers, have been refractory to conventional small-molecule and macromolecule inhibitors due to…”
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MicroRNA-141 and -200a Are Involved in Bone Morphogenetic Protein-2-induced Mouse Pre-osteoblast Differentiation by Targeting Distal-less Homeobox 5 by Itoh, Tomohiro, Nozawa, Yoshinori, Akao, Yukihiro

“…MicroRNAs (miRs) are endogenously expressed 18–25-nucleotide RNAs that regulate gene expression through translational repression by binding to a target mRNA…”
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MiR‐133b inhibits growth of human gastric cancer cells by silencing pyruvate kinase muscle‐splicer polypyrimidine tract‐binding protein 1 by Sugiyama, Taro, Taniguchi, Kohei, Matsuhashi, Nobuhisa, Tajirika, Toshihiro, Futamura, Manabu, Takai, Tomoaki, Akao, Yukihiro, Yoshida, Kazuhiro

“…The metabolism in tumor cells shifts from oxidative phosphorylation to glycolysis even in an aerobic environment. This phenomenon is known as the Warburg…”
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Effects of MIR143 on rat sarcoma signaling networks in solid tumors: A brief overview by Tokumaru, Yoshihisa, Takabe, Kazuaki, Yoshida, Kazuhiro, Akao, Yukihiro

“…Rat sarcoma (RAS) is a well‐known oncogene that plays important roles in cancer proliferation, cell survival and cell invasion. RAS exists as three major…”
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Extracellular Vesicles Containing MicroRNA-92a-3p Facilitate Partial Endothelial-Mesenchymal Transition and Angiogenesis in Endothelial Cells by Yamada, Nami O, Heishima, Kazuki, Akao, Yukihiro, Senda, Takao

“…Extracellular vesicles (EVs) are nanometer-sized membranous vesicles used for primitive cell-to-cell communication. We previously reported that colon…”
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SRSF3, a Splicer of the PKM Gene, Regulates Cell Growth and Maintenance of Cancer-Specific Energy Metabolism in Colon Cancer Cells by Kuranaga, Yuki, Sugito, Nobuhiko, Shinohara, Haruka, Tsujino, Takuya, Taniguchi, Kohei, Komura, Kazumasa, Ito, Yuko, Soga, Tomoyoshi, Akao, Yukihiro

“…Serine and arginine rich splicing factor 3 (SRSF3), an SR-rich family protein, has an oncogenic function in various kinds of cancer. However, the detailed…”
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Anti-cancer effects of xanthones from pericarps of mangosteen by Akao, Yukihiro, Nakagawa, Yoshihito, Iinuma, Munekazu, Nozawa, Yoshinori

“…Mangosteen, Garcinia mangostana Linn, is a tree found in South East Asia, and its pericarps have been used as traditional medicine. Phytochemical studies have…”
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Colorectal cancer cell-derived microvesicles containing microRNA-1246 promote angiogenesis by activating Smad 1/5/8 signaling elicited by PML down-regulation in endothelial cells by Yamada, Nami, Tsujimura, Nonoka, Kumazaki, Minami, Shinohara, Haruka, Taniguchi, Kohei, Nakagawa, Yoshihito, Naoe, Tomoki, Akao, Yukihiro

“…Emerging studies on circulating microRNAs (miRNAs) or microvesicles (MVs) have shown the potential of them to be novel biomarkers and therapeutic targets for…”
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Postoperative changes in plasma miR21‐5p as a novel biomarker for colorectal cancer recurrence: A prospective study by Fukada, Masahiro, Matsuhashi, Nobuhisa, Takahashi, Takao, Sugito, Nobuhiko, Heishima, Kazuki, Yoshida, Kazuhiro, Akao, Yukihiro

“…Cancer‐related microRNAs (miRNAs) are emerging as promising and noninvasive biomarkers for colorectal cancer (CRC). This study aimed to investigate the…”
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MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer by Taniguchi, Kohei, Sugito, Nobuhiko, Kumazaki, Minami, Shinohara, Haruka, Yamada, Nami, Nakagawa, Yoshihito, Ito, Yuko, Otsuki, Yoshinori, Uno, Bunji, Uchiyama, Kazuhisa, Akao, Yukihiro

“…Highlights • The expression levels of miR-124 were decreased in clinical colorectal cancer (CRC) and adenoma (CRA) patients' samples. • MiR-124 induced…”
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Low expression of miR-29a is associated with aggressive biology and worse survival in gastric cancer by Tokumaru, Yoshihisa, Oshi, Masanori, Huyser, Michelle R., Yan, Li, Fukada, Masahiro, Matsuhashi, Nobuhisa, Futamura, Manabu, Akao, Yukihiro, Yoshida, Kazuhiro, Takabe, Kazuaki

“…Advanced gastric cancer (GC) is one of the most lethal cancer types, thus a better understanding of its biology in patients is urgently needed. MicroRNA…”
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Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells by Akao, Yukihiro, Noguchi, Shunsuke, Iio, Akio, Kojima, Keitaro, Takagi, Takeshi, Naoe, Tomoki

“…Abstract MiR-34a was identified as one of the down-regulated micro-RNAs (miRs) in human colorectal cancer 5-fluorouracil (5-FU)-resistant DLD-1 cells compared…”
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MicroRNAs and Their Therapeutic Potential for Human Diseases: MicroRNAs, miR-143 and -145, Function as Anti-oncomirs and the Application of Chemically Modified miR-143 as an Anti-cancer Drug by Kitade, Yukio, Akao, Yukihiro

“…We examined the expression levels of microRNAs (miRNAs; miRs) in colorectal tumors (63 cancer specimens and 65 adenoma specimens) compared to adjacent…”
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Chemically modified MIR143-3p exhibited anti-cancer effects by impairing the KRAS network in colorectal cancer cells by Sugito, Nobuhiko, Heishima, Kazuki, Akao, Yukihiro

“…Kirsten rat sarcoma virus (KRAS) mutations are frequently detected in many cancers and are major driver genes. Therefore, KRAS inhibitors have been the subject…”
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Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells by Kumazaki, Minami, Noguchi, Shunsuke, Yasui, Yuki, Iwasaki, Junya, Shinohara, Haruka, Yamada, Nami, Akao, Yukihiro

“…Much evidence indicates that various naturally occurring compounds have an anti-cancer effect, but the detailed mechanisms are not well understood. In this…”
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Impairment of K‐Ras signaling networks and increased efficacy of epidermal growth factor receptor inhibitors by a novel synthetic miR‐143 by Akao, Yukihiro, Kumazaki, Minami, Shinohara, Haruka, Sugito, Nobuhiko, Kuranaga, Yuki, Tsujino, Takuya, Yoshikawa, Yuki, Kitade, Yukio

“…Despite considerable research on K‐Ras inhibitors, none had been established until now. We synthesized nuclease‐resistant synthetic miR‐143 (miR‐143#12), which…”
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