Search Results - "AKAHORI, Fumiaki"

Application in veterinary and human clinical toxicology by Akahori, Fumiaki

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NOVEL AND EXTENSIVE ASPECTS OF PARAQUAT-INDUCED PULMONARY FIBROGENESIS: COMPARATIVE AND TIME-COURSE MICROARRAY ANALYSES IN FIBROGENIC AND NON-FIBROGENIC RATS by SATOMI, Yoshihide, SAKAGUCHI, Kazuko, KASAHARA, Yoshinori, AKAHORI, Fumiaki

“…Although paraquat (PQ) is widely known to induce pulmonary fibrosis, the molecular mechanisms are poorly understood. Therefore, to bring a new dimension to the…”
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Effects of vertically transferred 3,3',4,4',5-pentachlorobiphenyl (PCB-126) on the reproductive development of female rats by Shirota, M.(Azabu Univ., Sagamihara, Kanagawa (Japan)), Mukai, M, Sakurada, Y, Doyama, A, Inoue, K, Haishima, A, Akahori, F, Shirota, K

“…In order to study the effects of vertically transferred coplanar polychlorinated biphenyls on female reproductive development, female rat offspring from dams…”
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Chymase is Activated in the Pulmonary Inflammation and Fibrosis Induced by Paraquat in Hamsters by Orito, Kensuke, Suzuki, Yuko, Matsuda, Hiroshi, Shirai, Mitsuyuki, Akahori, Fumiaki

“…The involvement of chymase has been implicated in fibrotic response to tissue injuries. Besides its direct action, chymase indirectly promotes fibrotic…”
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DNA MICROARRAY ANALYSIS OF PULMONARY FIBROSIS THREE MONTHS AFTER EXPOSURE TO PARAQUAT IN RATS by SATOMI, Yoshihide, TSUCHIYA, Wakana, MIURA, Daishiro, KASAHARA, Yoshinori, AKAHORI, Fumiaki

“…Although paraquat (PQ) is known to induce pulmonary fibrosis, how it does so is not entirely clear. To elucidate the mechanisms involved, the profile of gene…”
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The formation of g=2.49-species of cytochrome P450 in the rat liver by PCB126 oral administration: Identification of heme axial ligands EPR spectroscopy by Morita, H.(Azabu Univ., Sagamihara, Kanagawa (Japan). School of Veterinary Medicine), Yoshikawa, H, Takizawa, T, Shirai, M, Akahori, F, Yoshimura, T

“…Rat livers and microsomes were subjected to electron paramagnetic resonance (EPR) measurements at 77 K. The EPR spectra of the livers from the control group,…”
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An assessment of mutagenic effect of 3,3',4,4',5 pentachlorobiphenyl (PCB126) in Muta Mouse fetuses by Inomata, T.(Azabu Univ., Sagamihara, Kanagawa (Japan). Azabu Univ., Sagamihara, Kanagawa (Japan). School of Veterinary Medicine), Sekiguchi, M, Hirayama, S, Akahori, F, Shirai, M, Kashiwazaki, N, Ito, J, Hisamatsu, S, Sakita, K, Ninomiya, H

“…PCBs are persistent environmental agents that induce multiple impairments in living beings. In this study we used a transgenic mouse model (Mutasup(TM) Mouse),…”
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GENE EXPRESSION ANALYSIS OF THE LUNG FOLLOWING PARAQUAT ADMINISTRATION IN RATS USING DNA MICROARRAY by SATOMI, Yoshihide, TSUCHIYA, Wakana, MIHARA, Keiko, OTA, Mikio, KASAHARA, Yoshinori, AKAHORI, Fumiaki

“…Gene expression changes in the lungs induced by paraquat (PQ) administration were studied in rats using DNA microarrays that were detectable for 1,090 genes…”
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Effects of vertically transferred 3,3',4,4',5-pentachlorobiphenyl on gene expression in the ovaries of immature Sprague-Dawley rats by Sakurada, Y.(Azabu Univ., Sagamihara, Kanagawa (Japan)), Shirota, M, Mukai, M, Inoue, K, Akahori, F, Watanabe, G, Taya, K, Shirota, K

“…We have previously shown that 3,3',4,4',5-pentachlorobiphenyl (PCB-126) vertically transferred from dams potentially exerts a direct effect on the ovaries of…”
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Effect of oral administration of 3,3',4,4',5-pentachlorobiphyenl on the intestinal microbiota of Sprague-Dawley rats by Yamazaki, Kaoru, Suzuki, Takehito, Shirai, Mitsuyuki, Takizawa, Tatsuya, Shinoda, Tadashi, Masaoka, Toshio, Akahori, Fumiaki, Morita, Hidetoshi

“…The effect of the endocrine-disrupting chemical 3,3',4,4',5-pentachlorobiphyenl (PCB 126) on intestinal microbiota after oral administration, and the…”
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Current educational status of clinical toxicology in the school of veterinary medicine by Akahori, Fumiaki

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Identification of novel cytochrome P450 1A genes from five marine mammal species by Teramitsu, Ikuko, Yamamoto, Yukio, Chiba, Issei, Iwata, Hisato, Tanabe, Shinsuke, Fujise, Yoshihiro, Kazusaka, Akio, Akahori, Fumiaki, Fujita, Shoichi

“…Marine mammals, being endangered by the chronic exposure of hydrophobic environmental contaminants as an assorting result of global pollution, are especially…”
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Hypervitaminosis A resulting in DNA aberration in fetal transgenic mice (Muta ™ Mouse) by Inomata, Tomo, Kiuchi, Akio, Yoshida, Tomoo, Hisamatsu, Shin, Takizawa, Akiko, Kashiwazaki, Naomi, Akahori, Fumiaki, Ninomiya, Hiroyoshi

“…Treatment with excessive amounts of Vitamin A during maternity induces fetal malformations. However, it is unclear whether these malformations are due to gene…”
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Negative correlation between plasma thyroid hormone levels and chlorinated hydrocarbon levels accumulated in seals from the coast of Hokkaido, Japan by Chiba, Issei, Sakakibara, Akihito, Goto, Yoko, Isono, Takeomi, Yamamoto, Yukie, Iwata, Hisato, Tanabe, Shinsuke, Shimazaki, Kenji, Akahori, Fumiaki, Kazusaka, Akio, Fujita, Shoichi

“…Chlorinated hydrocarbon (CHC) levels in the blubber of larga seals (Phoca largha) and ribbon seals (Phoca fasciata) collected from the coastal waters of…”
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Testicular Toxicology of Pubescent and Adult Rats Prenatally Exposure to 3,3',4,4',5-Pentachlorobiphenyl by Wakui, Shin, Akagi, Yousuke, Muto, Tomoko, Yokoo, Kiyofumi, Hirono, Shyou, Kobayashi, Yasuko, Kamei, Yousuke, Shirota, Kinji, Akahori, Fumiaki, Suzuki, Yoshihiko, Hano, Hiroshi, Endou, Hitoshi, Kanai, Yoshikatsu

“…The present study investigated the dose-response relationship in testicular toxicology of pubescent (7-) and adult (17-week-old) Sprague-Dawley rats whose dams…”
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Effects of Maternal Exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126) or 3,3',4,4',5,5'-Hexachlorobiphenyl (PCB169) on Testicular Steroidogenesis and Spermatogenesis in Male Offspring Rats by Yamamoto, Masako, Narita, Akiko, Kagohata, Mari, Shirai, Mitsuyuki, Akahori, Fumiaki, Arishima, Kazuyoshi

“…On days 7–21 of gestation, Sprague‐Dawley rats were orally administered 3 or 30 μg/kg/d of 3,3′,4,4′,5‐pentachlorobiphenyl (PCB126) or…”
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Hepatic microsomal cytochrome P450S and chlorinated hydrocarbons in largha and ribbon seals from Hokkaido, Japan: Differential response of seal species to ah receptor agonist exposure by Chiba, Issei, Sakakibara, Akihito, Iwata, Hisato, Ishizuka, Mayumi, Tanabe, Shinsuke, Akahori, Fumiaki, Kazusaka, Akio, Fujita, Shoichi

“…From 16 largha seals (Phoca larghá) and 15 ribbon seals (Phoca fasciata) in the coastal waters of Hokkaido, Japan, blubber chlorinated hydrocarbon (CHC) levels…”
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GENE EXPRESSION ANALYSIS OF THE LUNG FOLLOWING PARAQUAT ADMINISTRATION IN RATS USING DNA MICRO ARRAY by SATOMI, Yoshihide, TSUCHIYA, Wakana, MIHARA, Keiko, OTA, Mikio, KASAHARA, Yoshinori, AKAHORI, Fumiaki

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Accumulation patterns of polychlorinated biphenyl congeners and organochlorine pesticides in Steller's sea eagles and white-tailed sea eagles, threatened species, in Hokkaido, Japan by Sakamoto, Kentaro Q, Kunisue, Tatsuya, Watanabe, Mafumi, Masuda, Yasushi, Iwata, Hisato, Tanabe, Shinsuke, Akahori, Fumiaki, Ishizuka, Mayumi, Kazusaka, Akio, Fujita, Shoichi

“…Polychlorinated biphenyls (PCBs), including coplanar congeners, hexachlorocyclohexane isomers, chlordane‐related compounds, and hexachlorobenzene, were found…”
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New insecticides--focusing phenylpyrazol derivatives by Kobayashi, Haruo, Suzuki, Tadahiko, Sato, Itaru, Orito, Kensuke, Shirai, Akimune, Akahori, Fumiaki

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