Search Results - "AIZAWA, KAZUMASA"
-
1
Optimization of dose and dose regimen of biapenem based on pharmacokinetic and pharmacodynamic analysis
Published in Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (2004)“…Pharmacokinetic and pharmacodynamic (PK/PD) parameters, which are important indices of the therapeutic efficacy of antimicrobials, and the minimum inhibitory…”
Get full text
Journal Article -
2
Effect of diet on the pharmacokinetics of tebipenem pivoxil fine granules in healthy male volunteers
Published in Japanese journal of antibiotics (01-04-2009)“…Tebipenem pivoxil (TBPM-PI), a novel oral carbapenem antibiotic, is a prodrug of tebipenem (TBPM). We assessed the pharmacokinetics of TBPM-PI fine granules at…”
Get more information
Journal Article -
3
Tissue and aural discharge distribution of tebipenem pivoxil
Published in Japanese journal of antibiotics (01-04-2009)“…Tebipenem pivoxil (TBPM-PI) is a novel oral carbapenem antibiotic. It has been developed as a prodrug of tebipenem (TBPM), to increase absorption. We assessed…”
Get more information
Journal Article -
4
Elderly, conscious patients have an accentuated hypotensive response to nitroglycerin
Published in Anesthesiology (Philadelphia) (01-10-1992)“…There is no adequate explanation for the highly variable response of systemic blood pressure to nitroglycerin (glyceryl trinitrate [GTN]). Aging produces…”
Get full text
Journal Article -
5
Physiological models are good tools to predict rat bioavailability of EF5154 prodrugs from in vitro intestinal parameters
Published in Journal of pharmaceutical sciences (01-04-2009)“…There are only a few reports on the methods that predict in vivo bioavailability from in vitro intestinal parameters. In the present study, we constructed…”
Get more information
Journal Article -
6
PHARMACOKINETICS OF ME 1207, A NOVEL ORAL CEPHEM ANTIBIOTIC, IN EXPERIMENTAL ANIMALS
Published in CHEMOTHERAPY (1992)“…The pharmacokinetics of ME 1207, a new oral cephem antibiotic, was studied in mice, rats and dogs. 1. ME 1207 was mainly absorbed from the upper part of the…”
Get full text
Journal Article -
7
-
8
イヌ及びヒトにおけるEthyl Loflazepate (CM6912) 代謝物の生体内動態コンピューターによるシミュレーション
Published in YAKUGAKU ZASSHI (1986)Get full text
Journal Article -
9
Points to be considered for conducting toxicokinetic studies under GLP and for validating analytical methods
Published in Journal of toxicological sciences (01-12-1996)“…Issues discussed by TK Working Group of the JPMA for the implementation of ICH guideline for toxicokinetics (TK) are summarized. 1) A unique management system…”
Get full text
Journal Article -
10
Dose- and time-dependent kinetics of the renal excretion of nitrofurantoin in the rabbit
Published in Journal of pharmaceutical sciences (01-02-1985)“…A pharmacokinetic study on the renal excretion of nitrofurantoin was carried out in rabbits at doses ranging from 0.5 to 15 mg/kg. With increasing dose,…”
Get more information
Journal Article -
11
Nonlinear assessment of nitrofurantoin bioavailability in rabbits
Published in Journal of pharmacokinetics and biopharmaceutics (01-10-1983)“…The influence of route of administration on the absolute bioavailability and GI tract absorption of nitrofurantoin was investigated in rabbits. The disposition…”
Get more information
Journal Article -
12
Disposition of prednisone and prednisolone in the perfused rabbit liver: modeling hepatic metabolic processes
Published in Journal of pharmacokinetics and biopharmaceutics (01-10-1991)“…The livers of 15 rabbits were perfused in situ with prednisone (PO) or prednisolone (POH) over a wide range of steady state concentrations, resulting in…”
Get more information
Journal Article -
13
Pharmacokinetics of the Two Major Metabolites of Ethyl Loflazepate (CM6912) in Dogs and Humans. Simulation by a Digital Computer
Published in YAKUGAKU ZASSHI (01-08-1986)“…A linear pharmacokinetic model was developed in order to calculate separately the plasma (or blood) concentrations of CM6913 and CM7116, major metabolites of…”
Get full text
Journal Article