Search Results - "AIRLEY, Rachel"

Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeutics by Airley, Rachel E, Mobasheri, Ali

“…Cancer cells require a steady source of metabolic energy in order to continue their uncontrolled growth and proliferation. Accelerated glycolysis is one of the…”
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Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas by Golinska, Monika, Troy, Helen, Chung, Yuen-Li, McSheehy, Paul M, Mayr, Manuel, Yin, Xiaoke, Ly, Lucy, Williams, Kaye J, Airley, Rachel E, Harris, Adrian L, Latigo, John, Perumal, Meg, Aboagye, Eric O, Perrett, David, Stubbs, Marion, Griffiths, John R

“…HIF-1 deficiency has marked effects on tumour glycolysis and growth. We therefore investigated the consequences of HIF-1 deficiency in mice, using the well…”
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GLUT‐1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: Relationship to pimonidazole binding by Airley, Rachel E., Loncaster, Juliette, Raleigh, James A., Harris, Adrian L., Davidson, Susan E., Hunter, Robert D., West, Catharine M.L., Stratford, Ian J.

“…The presence of hypoxia in tumours results in the overexpression of certain genes, which are controlled via the transcription factor HIF‐1. Hypoxic cells are…”
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Glucose Transporter Glut-1 Expression Correlates with Tumor Hypoxia and Predicts Metastasis-free Survival in Advanced Carcinoma of the Cervix by AIRLEY, Rachel, LONCASTER, Juliette, DAVIDSON, Susan, BROMLEY, Mike, ROBERTS, Stephen, PATTERSON, Adam, HUNTER, Robin, STRATFORD, Ian, WEST, Catharine

“…Hypoxic tumors are known to be more malignant, to be more likely to metastasize, and to have a poor prognosis. They are also radio- and chemoresistant. For…”
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A protective role for HIF-1 in response to redox manipulation and glucose deprivation: implications for tumorigenesis by WILLIAMS, Kaye J, TELFER, Brian A, AIRLEY, Rachel E, PETERS, Hans P. W, SHERIDAN, Mary R, VAN DER KOGEL, Albert J, HARRIS, Adrian L, STRATFORD, Ian J

“…We have investigated the role of HIF-1 in the cellular response to redox modulation via the inhibition of oxidative phosphorylation. We demonstrate that…”
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Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts by Cowen, Rachel L, Patterson, Adam V, Telfer, Brian A, Airley, Rachel E, Hobbs, Steve, Phillips, Roger M, Jaffar, Mohammed, Stratford, Ian J, Williams, Kaye J

“…Indolequinones such as mitomycin C (MMC) require enzymatic bioreduction to yield cytotoxic moieties. An attractive approach to overcome the potential…”
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Lab reports and cat scans: can veterinary oncology guide our way to new treatments for human cancers? by Airley, Rachel

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How the science of personalized medicines will change the clinical management of patients in the pharmacy by Airley, Rachel, Evans, Andy

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Cancer Chemotherapy: Basic Science to the Clinic by Airley, Rachel

“…This textbook is a clear and accessible introduction to the scientific and clinical aspects of the creation, development and administration of drugs or drug…”
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The 'sick day rules' project

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Azide based routes to tetrazolo and oxadiazolo derivatives of pyrrolobenzodiazepines and pyrrolobenzothiadiazepines by Hemming, Karl, Chambers, Christopher S., Hamasharif, Muslih S., João, Heidi, Khan, Musharraf N., Patel, Nilesh, Airley, Rachel, Day, Sharn

“…Tetrazolo- and 1,2,4-oxadiazolo-fused derivatives of the antitumour, antibiotic, DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines and their…”
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Pharmacist-led lung cancer biomarker detection by Sheridan, Emer Ann, Stephenson, John, McHugh, Patrick, Chrystyn, Henry, Philip, Brown, Airley, Rachel

“…Abstract only…”
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Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies by Evans, Andrew, Bates, Victoria, Troy, Helen, Hewitt, Stephen, Holbeck, Susan, Chung, Yuen-Li, Phillips, Roger, Stubbs, Marion, Griffiths, John, Airley, Rachel

“…The facilitative glucose transporter Glut-1 is overexpressed and confers poor prognosis in a wide range of solid tumours. The peri-necrotic pattern of…”
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Glucose transporter Glut-1 is detectable in peri-necrotic regions in many human tumor types but not normal tissues: Study using tissue microarrays by Airley, Rachel, Evans, Andrew, Mobasheri, Ali, Hewitt, Stephen M.

“…The hypoxic tumor microenvironment is associated with malignant progression and poor treatment response. The glucose transporter Glut-1 is a prognostic factor…”
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Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report by Pujol-Gimenez, Jonai, de Heredia, Fátima Pérez, Idoate, Miguel Angel, Airley, Rachel, Lostao, María Pilar, Evans, Andrew Robert

“…Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells. GLUT12 expression was determined by…”
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Heterogeneous expression of the aquaporin 1 (AQP1) water channel in tumors of the prostate, breast, ovary, colon and lung: a study using high density multiple human tumor tissue microarrays by Mobasheri, Ali, Airley, Rachel, Hewitt, Stephen M, Marples, David

“…Aquaporin 1 (AQP1) water channels are membrane proteins that control the permeability of endothelial and epithelial barriers by facilitating water movement…”
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Hypoxia-regulated glucose transport in tumours: Individualisation of bioreductive chemotherapy using facilitative glucose transporters as surrogate markers of hypoxia by Airley, Rachel

“…Hypoxic tumours are known to be more malignant, more likely to metastasise, and to have a poor prognosis. They are also radio-and chemoresistant. It is…”
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