Search Results - "AINSLIE, N"

Global and country-level estimates of human population at high altitude by Tremblay, Joshua C., Ainslie, Philip N.

“…Estimates of the global population of humans living at high altitude vary widely, and such data at the country level are unavailable. Herein, we use a…”
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Clinical pathophysiology of hypoxic ischemic brain injury after cardiac arrest: a "two-hit" model by Sekhon, Mypinder S, Ainslie, Philip N, Griesdale, Donald E

“…Hypoxic ischemic brain injury (HIBI) after cardiac arrest (CA) is a leading cause of mortality and long-term neurologic disability in survivors. The…”
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Regulation of cerebral blood flow and metabolism during exercise by Smith, Kurt J., Ainslie, Philip N.

“…New Findings What is the topic of this review? The manuscript collectively combines the experimental observations from >100 publications focusing on the…”
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Cerebral blood flow during exercise: mechanisms of regulation by Ogoh, Shigehiko, Ainslie, Philip N

“…1 Department of Biomedical Engineering, Toyo University, Kawagoe-shi, Saitama, Japan; ; 2 Department of Human Kinetics, Faculty of Health and Social…”
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Integrative regulation of human brain blood flow by Willie, Christopher K., Tzeng, Yu‐Chieh, Fisher, Joseph A., Ainslie, Philip N.

“…Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on humans. We revisit important concepts from the older literature and…”
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Transcranial Doppler ultrasound: valid, invalid, or both? by Ainslie, Philip N, Hoiland, Ryan L

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Neurovascular coupling in humans: Physiology, methodological advances and clinical implications by Phillips, Aaron A, Chan, Franco HN, Zheng, Mei Mu Zi, Krassioukov, Andrei V, Ainslie, Philip N

“…Neurovascular coupling reflects the close temporal and regional linkage between neural activity and cerebral blood flow. Although providing mechanistic…”
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Methodological comparison of active- and passive-driven oscillations in blood pressure; implications for the assessment of cerebral pressure-flow relationships by Smirl, Jonathan D, Hoffman, Keegan, Tzeng, Yu-Chieh, Hansen, Alex, Ainslie, Philip N

“…We examined the between-day reproducibility of active (squat-stand maneuvers)- and passive [oscillatory lower-body negative pressure (OLBNP) maneuvers]-driven…”
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Sympathetic control of the brain circulation: Appreciating the complexities to better understand the controversy by Brassard, Patrice, Tymko, Michael M, Ainslie, Philip N

“…Abstract Although the human cerebral circulation is richly innervated with sympathetic nerve fibers, the role of sympathetic nerve activity (SNA) on the…”
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Highs and lows of hyperoxia: physiological, performance, and clinical aspects by Brugniaux, Julien Vincent, Coombs, Geoff B, Barak, Otto F, Dujic, Zeljko, Sekhon, Mypinder S, Ainslie, Philip N

“…Molecular oxygen (O ) is a vital element in human survival and plays a major role in a diverse range of biological and physiological processes. Although…”
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Hypoxemia, oxygen content, and the regulation of cerebral blood flow by Hoiland, Ryan L, Bain, Anthony R, Rieger, Mathew G, Bailey, Damian M, Ainslie, Philip N

“…This review highlights the influence of oxygen (O2) availability on cerebral blood flow (CBF). Evidence for reductions in O2 content (CaO2 ) rather than…”
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The overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean natives by Stembridge, Mike, Williams, Alexandra M., Gasho, Christopher, Dawkins, Tony G., Drane, Aimee, Villafuerte, Francisco C., Levine, Benjamin D., Shave, Rob, Ainslie, Philip N.

“…In contrast to Andean natives, high-altitude Tibetans present with a lower hemoglobin concentration that correlates with reproductive success and exercise…”
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Nitric oxide is fundamental to neurovascular coupling in humans by Hoiland, Ryan L., Caldwell, Hannah G., Howe, Connor A., Nowak‐Flück, Daniela, Stacey, Benjamin S., Bailey, Damian M., Paton, Julian F. R., Green, Daniel J., Sekhon, Mypinder S., Macleod, David B., Ainslie, Philip N.

“…Key points Preclinical models have demonstrated that nitric oxide is a key component of neurovascular coupling; this has yet to be translated to humans. We…”
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Technical recommendations for the use of carotid duplex ultrasound for the assessment of extracranial blood flow by Thomas, Kate N, Lewis, Nia C S, Hill, Brigid G, Ainslie, Philip N

“…Duplex ultrasound is an evolving technology that allows the assessment of volumetric blood flow in the carotid and vertebral arteries during a range of…”
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Evaluating the methods used for measuring cerebral blood flow at rest and during exercise in humans by Tymko, Michael M., Ainslie, Philip N., Smith, Kurt J.

“…The first accounts of measuring cerebral blood flow (CBF) in humans were made by Angelo Mosso in ~1880, who recorded brain pulsations in patients with skull…”
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Evidence for hysteresis in the cerebral pressure-flow relationship in healthy men by Brassard, Patrice, Ferland-Dutil, Hélène, Smirl, Jonathan D, Paquette, Myriam, Le Blanc, Olivier, Malenfant, Simon, Ainslie, Philip N

“…The cerebrovasculature is more efficient at compensating for pharmacologically induced transient hypertension versus transient hypotension. Whether this…”
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Regulation of cerebral blood flow in mammals during chronic hypoxia: a matter of balance by Ainslie, Philip N., Ogoh, Shigehiko

“…Respiratory-induced changes in the partial pressures of arterial carbon dioxide and oxygen play a major role in cerebral blood flow (CBF) regulation…”
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Internal carotid and brachial artery shear‐dependent vasodilator function in young healthy humans by Carr, Jay M. J. R., Hoiland, Ryan L., Caldwell, Hannah G., Coombs, Geoff B., Howe, Connor A., Tremblay, Joshua C., Green, Daniel J., Ainslie, Philip N.

“…Key points Brachial artery (BA) shear‐mediated dilatation is a widely used assessment of vascular function with links to coronary artery health and…”
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Pulmonary vascular reactivity to supplemental oxygen in Sherpa and lowlanders during gradual ascent to high altitude by Subedi, Prajan, Gasho, Christopher, Stembridge, Michael, Williams, Alexandra M., Patrician, Alexander, Ainslie, Philip N., Anholm, James D.

“…New Findings What is the central question of this study? How does hypoxic pulmonary vasoconstriction and the response to supplemental oxygen change over time…”
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Influence of the mode of heating on cerebral blood flow, non‐invasive intracranial pressure and thermal tolerance in humans by Gibbons, Travis D., Ainslie, Philip N., Thomas, Kate N., Wilson, Luke C., Akerman, Ashley P., Donnelly, Joseph, Campbell, Holly A., Cotter, Jim D.

“…Key points The human brain is particularly vulnerable to heat stress; this manifests as impaired cognition, orthostatic tolerance, work capacity and…”
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