A mechanism of cadmium poisoning: the cross effect of calcium and cadmium in the calmodulin-dependent system

A mechanism of cadmium poisoning: the cross effect of calcium and cadmium in the calmodulin-dependent system

The effects of the intraventricular (IVT) administration of cadmium on the amount of dopamine (DA) in various regions of the mice brain were analyzed immunohistochemically using a microphotometry system. DA levels in the neostriatum and nucleus accumbens were increased by approximately 30% (p less t...

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Bibliographic Details
Published in:Archives of toxicology Vol. 64; no. 2; pp. 161 - 164
Main Authors: SUTOO, D, AIKYAMA, K, IMAMIYA, S
Format: Journal Article
Language:English
Published: Berlin Springer 01-01-1990
Subjects:
Animals
Biological and medical sciences
Brain - drug effects
Cadmium Poisoning - metabolism
Calcium - physiology
Calmodulin - antagonists & inhibitors
Calmodulin - physiology
Chemical and industrial products toxicology. Toxic occupational diseases
Dopamine - metabolism
Immunohistochemistry
Injections, Intraventricular
Male
Medical sciences
Metals and various inorganic compounds
Mice
Mice, Inbred Strains
Sulfonamides - pharmacology
Toxicology
Cadmium
Brain
Dopamine
Calcium
Toxicity
Rodentia
Heavy metal
Vertebrata
Mammalia
Mouse
Animal
Intracerebral administration
Poisoning
Mechanism of action
Calmodulin
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Summary:The effects of the intraventricular (IVT) administration of cadmium on the amount of dopamine (DA) in various regions of the mice brain were analyzed immunohistochemically using a microphotometry system. DA levels in the neostriatum and nucleus accumbens were increased by approximately 30% (p less than 0.01) by the IVT administration of CdCl2 (1 mumol/kg). This effect was abolished by the calmodulin antagonist, W-7 (4.2 micrograms/mouse, IVT). The effects of cadmium on DA levels in the brain were very similar to those seen with calcium. Combining these results with our previous finding that calmodulin does not have the ability to distinguish between calcium and cadmium, a mechanism of cadmium poisoning is suggested in which cadmium activates catecholamine synthesizing enzyme and numerous other enzymes through calmodulin-dependent systems, thereby disturbing many functions in the organism.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0340-5761
1432-0738
DOI:10.1007/bf01974404