Search Results - "AIKAWA, NAOKI"

Neutrophil-Derived Matrix Metalloproteinase 9 Triggers Acute Aortic Dissection by KURIHARA, Tomohiro, SHIMIZU-HIROTA, Ryoko, SHIMODA, Masayuki, ADACHI, Takeshi, SHIMIZU, Hideyuki, WEISS, Stephen J, ITOH, Hiroshi, HORI, Shingo, AIKAWA, Naoki, OKADA, Yasunori

“…Acute aortic dissection (AAD) is a life-threatening vascular disease without effective pharmaceutical therapy. Matrix metalloproteinases (MMPs) are implicated…”
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A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis by Rice, Todd W, Wheeler, Arthur P, Bernard, Gordon R, Vincent, Jean-Louis, Angus, Derek C, Aikawa, Naoki, Demeyer, Ignace, Sainati, Stephen, Amlot, Nicholas, Cao, Charlie, Ii, Masayuki, Matsuda, Hideyasu, Mouri, Kouji, Cohen, Jon

“…OBJECTIVE:To evaluate whether TAK-242, a small-molecule inhibitor of Toll-like receptor-4–mediated signaling, suppresses cytokine levels and improves 28-day…”
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Modified abbreviated burn severity index as a predictor of in-hospital mortality in patients with inhalation injury: development and validation using independent cohorts by Yamamoto, Ryo, Shibusawa, Takayuki, Aikawa, Naoki, Sasaki, Junichi

“…Purpose The ability to accurately evaluate the severity of inhalation injury can help to optimize patient care. However, there is no accepted severity grading…”
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Epidemiology of severe sepsis in Japanese intensive care units: A prospective multicenter study by Ogura, Hiroshi, MD, Gando, Satoshi, MD, FCCM, Saitoh, Daizoh, MD, Takeyama, Naoshi, MD, Kushimoto, Shigeki, MD, Fujishima, Seitaro, MD, Mayumi, Toshihiko, MD, Araki, Tsunetoshi, MD, Ikeda, Hiroto, MD, Kotani, Joji, MD, Miki, Yasuo, MD, Shiraishi, Shin-ichiro, MD, Suzuki, Koichiro, MD, Suzuki, Yasushi, MD, Takuma, Kiyotsugu, MD, Tsuruta, Ryosuke, MD, Yamaguchi, Yoshihiro, MD, Yamashita, Norio, MD, Aikawa, Naoki, MD, FACS

“…Abstract Severe sepsis is a leading cause of morbidity and mortality in the intensive care unit (ICU). We conducted a prospective multicenter study to evaluate…”
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Efficacy and safety of intravenous daptomycin in Japanese patients with skin and soft tissue infections by Aikawa, Naoki, Kusachi, Shinya, Mikamo, Hiroshige, Takesue, Yoshio, Watanabe, Shinichi, Tanaka, Yoshiyuki, Morita, Akiko, Tsumori, Keiko, Kato, Yoshiaki, Yoshinari, Tomoko

“…Abstract Daptomycin is a lipopeptide antibiotic active against gram-positive organisms and recently approved for marketing in Japan. This study investigates…”
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Cardiopulmonary Resuscitation Training in Schools: A Comparison of Trainee Satisfaction among Different Age Groups by Hori, Shingo, Suzuki, Masaru, Yamazaki, Motoyasu, Aikawa, Naoki, Yamazaki, Hajime

“…Cardiopulmonary resuscitation (CPR) has recently been added to the school curriculum worldwide and is currently taught to students between the ages of 10 and…”
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Brown adipose tissue and its modulation by a mitochondria-targeted peptide in rat burn injury-induced hypermetabolism by Yo, Kikuo, Yu, Yong-Ming, Zhao, Gaofeng, Bonab, Ali A, Aikawa, Naoki, Tompkins, Ronald G, Fischman, Alan J

“…Hypermetabolism is a prominent feature of burn injury, and altered mitochondria function is presumed to contribute to this state. Recently, brown adipose…”
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Evaluation of pathogen detection from clinical samples by real-time polymerase chain reaction using a sepsis pathogen DNA detection kit by Yanagihara, Katsunori, Kitagawa, Yuko, Tomonaga, Masao, Tsukasaki, Kunihiro, Kohno, Shigeru, Seki, Masafumi, Sugimoto, Hisashi, Shimazu, Takeshi, Tasaki, Osamu, Matsushima, Asako, Ikeda, Yasuo, Okamoto, Shinichiro, Aikawa, Naoki, Hori, Shingo, Obara, Hideaki, Ishizaka, Akitoshi, Hasegawa, Naoki, Takeda, Junzo, Kamihira, Shimeru, Sugahara, Kazuyuki, Asari, Seishi, Murata, Mitsuru, Kobayashi, Yoshio, Ginba, Hiroyuki, Sumiyama, Yoshinobu, Kitajima, Masaki

“…Sepsis is a serious medical condition that requires rapidly administered, appropriate antibiotic treatment. Conventional methods take three or more days for…”
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Assessment of mortality by qSOFA in patients with sepsis outside ICU: A post hoc subgroup analysis by the Japanese Association for Acute Medicine Sepsis Registry Study Group by Umemura, Yutaka, Ogura, Hiroshi, Gando, Satoshi, Kushimoto, Shigeki, Saitoh, Daizoh, Mayumi, Toshihiko, Fujishima, Seitaro, Abe, Toshikazu, Ikeda, Hiroto, Kotani, Joji, Miki, Yasuo, Shiraishi, Shin-ichiro, Shiraishi, Atsushi, Suzuki, Koichiro, Suzuki, Yasushi, Takeyama, Naoshi, Takuma, Kiyotsugu, Tsuruta, Ryosuke, Yamaguchi, Yoshihiro, Yamashita, Norio, Aikawa, Naoki

“…Quick sequential organ failure assessment (qSOFA) was proposed in the new sepsis definition (Sepsis-3). Although qSOFA was created to identify patients with…”
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Effects of thrombomodulin alfa on hemostatic parameters in disseminated intravascular coagulation: Post hoc analysis of a phase 3 randomized controlled trial by Ito, Takashi, Maruyama, Ikuro, Shimazaki, Shuji, Yamamoto, Yasuhiro, Aikawa, Naoki, Hirayama, Akio, Honda, Goichi, Saito, Hidehiko

“…The efficacy and safety of thrombomodulin alfa (TM‐α), a cofactor protein promoting thrombin‐mediated protein C activation, have been examined in a phase 3…”
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A multicenter, prospective evaluation of quality of care and mortality in Japan based on the Surviving Sepsis Campaign guidelines by Fujishima, Seitaro, MD, Gando, Satoshi, MD, FCCM, Saitoh, Daizoh, MD, Mayumi, Toshihiko, MD, Kushimoto, Shigeki, MD, Shiraishi, Shin-ichiro, MD, Ogura, Hiroshi, MD, Takuma, Kiyotsugu, MD, Kotani, Joji, MD, Ikeda, Hiroto, MD, Yamashita, Norio, MD, Suzuki, Koichiro, MD, Tsuruta, Ryosuke, MD, Takeyama, Naoshi, MD, Araki, Tsunetoshi, MD, Suzuki, Yasushi, MD, Miki, Yasuo, MD, Yamaguchi, Yoshihiro, MD, Aikawa, Naoki, MD, FACS

“…Abstract To elucidate the standard Surviving Sepsis Campaign (SSC) guidelines-based quality of care and mortality related to severe sepsis in Japan, we…”
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Pharmacokinetic-Pharmacodynamic Relationship of Arbekacin for Treatment of Patients Infected with Methicillin-Resistant Staphylococcus aureus by SATO, Reiko, TANIGAWARA, Yusuke, KAKU, Mitsuo, AIKAWA, Naoki, SHIMIZU, Kihachiro

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Revised Surviving Sepsis Campaign Guidelines and therapy for severe sepsis by Aikawa, Naoki

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Correlation of the Blood Test Results Obtained between Assays Using Microliter-scale Fingertip Blood Samples Collected with a Novel Blood Collection Device and Conventional Venous Blood Assays: a Secondary Publication in English by Iwasawa, Hajime, Nishimura, Tomoaki, Nemoto, Shota, Aikawa, Naoki, Watanabe, Kiyoaki

“…In this study, we investigated the correlations between biochemical and hematological test results obtained using microliter-scale fingertip blood samples…”
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Clinical efficacy and safety of intravenous itraconazole in the management of invasive candidiasis in patients of surgery and critical care by Takesue, Yoshio, Oda, Shigeto, Fujishima, Seitaro, Aikawa, Naoki, Mikamo, Hiroshige

“…Abstract Although itraconazole exhibits potent activity against Candida species, there have been few studies examining the use of intravenous itraconazole in…”
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Usefulness of procalcitonin serum level for the discrimination of severe sepsis from sepsis: a multicenter prospective study by Endo, Shigeatsu, Aikawa, Naoki, Fujishima, Seitaro, Sekine, Isao, Kogawa, Kazuhiro, Yamamoto, Yasuhiro, Kushimoto, Shigeki, Yukioka, Hidekazu, Kato, Noboru, Totsuka, Kyoichi, Kikuchi, Ken, Ikeda, Toshiaki, Ikeda, Kazumi, Yamada, Hiroyuki, Harada, Kazuaki, Satomura, Shinji

“…Abstract Procalcitonin serum level has been recommended as a new marker of bacterial infectious diseases. The aim of this prospective, multicenter study was to…”
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The estimation of tissue loss during tangential hydrosurgical debridement by Matsumura, Hajime, Nozaki, Motohiro, Watanabe, Katsueki, Sakurai, Hiroyuki, Kawakami, Shigehiko, Nakazawa, Hiroaki, Matsumura, Izumi, Katahira, Jiro, Inokuchi, Sadaki, Ichioka, Shigeru, Ikeda, Hiroto, Mole, Trevor, Smith, Jennifer, Martin, Robin, Aikawa, Naoki

“…The preservation of healthy tissue during surgical debridement is desirable as this may improve clinical outcomes. This study has estimated for the first time…”
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Micafungin Concentrations in the Plasma and Burn Eschar of Severely Burned Patients by SASAKI, Junichi, YAMANOUCHI, Satoshi, AIKAWA, Naoki, KUDO, Daisuke, ENDO, Tomoyuki, NOMURA, Ryosuke, TAKUMA, Kiyotsugu, KUSHIMOTO, Shigeki, SHINOZAWA, Yotaro, KISHINO, Satoshi, HORI, Shingo

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Population Pharmacokinetics of Arbekacin in Patients Infected with Methicillin-Resistant Staphylococcus aureus by TANIGAWARA, Yusuke, SATO, Reiko, MORITA, Kunihiko, KAKU, Mitsuo, AIKAWA, Naoki, SHIMIZU, Kihachiro

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A Phase II study of polyclonal anti-TNF-α (AZD9773) in Japanese patients with severe sepsis and/or septic shock by Aikawa, Naoki, Maruyama, Tatsuya, Takahashi, Takeshi, Fujimi, Satoshi, Yokoyama, Takeshi, Yoshihara, Katsunori, Ikeda, Toshiaki, Sadamitsu, Daikai, Momozawa, Michiru

“…Abstract Because tumor necrosis factor-alpha (TNF-α) induces many of the pathophysiological signs and symptoms observed in sepsis, it is a potential…”
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