Search Results - "AIK CHOON TAN"

Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers by Pozdeyev, Nikita, Gay, Laurie M, Sokol, Ethan S, Hartmaier, Ryan, Deaver, Kelsi E, Davis, Stephanie, French, Jena D, Borre, Pierre Vanden, LaBarbera, Daniel V, Tan, Aik-Choon, Schweppe, Rebecca E, Fishbein, Lauren, Ross, Jeffrey S, Haugen, Bryan R, Bowles, Daniel W

“…To define the genetic landscape of advanced differentiated and anaplastic thyroid cancer (ATC) and identify genetic alterations of potential diagnostic,…”
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Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen by Brechbuhl, Heather M, Finlay-Schultz, Jessica, Yamamoto, Tomomi M, Gillen, Austin E, Cittelly, Diana M, Tan, Aik-Choon, Sams, Sharon B, Pillai, Manoj M, Elias, Anthony D, Robinson, William A, Sartorius, Carol A, Kabos, Peter

“…Antiendocrine therapy remains the most effective treatment for estrogen receptor-positive (ER ) breast cancer, but development of resistance is a major…”
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Brusatol overcomes chemoresistance through inhibition of protein translation by Harder, Bryan, Tian, Wang, La Clair, James J., Tan, Aik‐Choon, Ooi, Aikseng, Chapman, Eli, Zhang, Donna D.

“…The NRF2 pathway activates a cell survival response when cells are exposed to xenobiotics or are under oxidative stress. Therapeutic activation of NRF2 can…”
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ReSimNet: drug response similarity prediction using Siamese neural networks by Jeon, Minji, Park, Donghyeon, Lee, Jinhyuk, Jeon, Hwisang, Ko, Miyoung, Kim, Sunkyu, Choi, Yonghwa, Tan, Aik-Choon, Kang, Jaewoo

“…Traditional drug discovery approaches identify a target for a disease and find a compound that binds to the target. In this approach, structures of compounds…”
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AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells by Pei, Shanshan, Minhajuddin, Mohammad, Adane, Biniam, Khan, Nabilah, Stevens, Brett M., Mack, Stephen C., Lai, Sisi, Rich, Jeremy N., Inguva, Anagha, Shannon, Kevin M., Kim, Hyunmin, Tan, Aik-Choon, Myers, Jason R., Ashton, John M., Neff, Tobias, Pollyea, Daniel A., Smith, Clayton A., Jordan, Craig T.

“…Leukemia stem cells (LSCs) are thought to drive the genesis of acute myeloid leukemia (AML) as well as relapse following chemotherapy. Because of their unique…”
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Resistance to RET-Inhibition in RET-Rearranged NSCLC Is Mediated By Reactivation of RAS/MAPK Signaling by Nelson-Taylor, Sarah K, Le, Anh T, Yoo, Minjae, Schubert, Laura, Mishall, Katie M, Doak, Andrea, Varella-Garcia, Marileila, Tan, Aik-Choon, Doebele, Robert C

“…Oncogenic rearrangements in are present in 1%-2% of lung adenocarcinoma patients. Ponatinib is a multi-kinase inhibitor with low-nanomolar potency against the…”
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Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy by Huang, Qian, Li, Fang, Liu, Xinjian, Li, Wenrong, Shi, Wei, Liu, Fei-Fei, O'Sullivan, Brian, He, Zhimin, Peng, Yuanlin, Tan, Aik-Choon, Zhou, Ling, Shen, Jingping, Han, Gangwen, Wang, Xiao-Jing, Thorburn, Jackie, Thorburn, Andrew, Jimeno, Antonio, Raben, David, Bedford, Joel S, Li, Chuan-Yuan

“…Cytotoxic cancer therapy can induce accelerated growth of surviving cancer cells, a phenomenon known as tumor repopulation. This report uncovers a mechanism by…”
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Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2 by Lyons, Traci R, O'Brien, Jenean, Borges, Virginia F, Conklin, Matthew W, Keely, Patricia J, Eliceiri, Kevin W, Marusyk, Andriy, Tan, Aik-Choon, Schedin, Pepper

“…Postpartum involution of the mammary gland is a recognized risk factor for breast cancer. This report identifies a mechanism that could be at least partially…”
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BEST: Next-Generation Biomedical Entity Search Tool for Knowledge Discovery from Biomedical Literature by Lee, Sunwon, Kim, Donghyeon, Lee, Kyubum, Choi, Jaehoon, Kim, Seongsoon, Jeon, Minji, Lim, Sangrak, Choi, Donghee, Kim, Sunkyu, Tan, Aik-Choon, Kang, Jaewoo

“…As the volume of publications rapidly increases, searching for relevant information from the literature becomes more challenging. To complement standard search…”
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Optimizing the Detection of Lung Cancer Patients Harboring Anaplastic Lymphoma Kinase (ALK) Gene Rearrangements Potentially Suitable for ALK Inhibitor Treatment by ROSS CAMIDGE, D, KONO, Scott A, FLACCO, Antonella, TAN, Aik-Choon, DOEBELE, Robert C, QING ZHOU, CRINO, Lucio, FRANKLIN, Wilbur A, VARELLA-GARCIA, Marileila

“…Anaplastic lymphoma kinase (ALK) rearrangements, associated with sensitivity to an experimental ALK/MET inhibitor, occur in 3% to 5% of non-small cell lung…”
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Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2 by Keysar, Stephen B, Le, Phuong N, Miller, Bettina, Jackson, Brian C, Eagles, Justin R, Nieto, Cera, Kim, Jihye, Tang, Binwu, Glogowska, Magdalena J, Morton, J Jason, Padilla-Just, Nuria, Gomez, Karina, Warnock, Emily, Reisinger, Julie, Arcaroli, John J, Messersmith, Wells A, Wakefield, Lalage M, Gao, Dexiang, Tan, Aik-Choon, Serracino, Hilary, Vasiliou, Vasilis, Roop, Dennis R, Wang, Xiao-Jing, Jimeno, Antonio

“…We have an incomplete understanding of the differences between cancer stem cells (CSCs) in human papillomavirus-positive (HPV-positive) and -negative…”
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Neoadjuvant endocrine therapy expands stromal populations that predict poor prognosis in estrogen receptor‐positive breast cancer by Brechbuhl, Heather M., Xie, Mengyu, Kopin, Etana G., Han, Amy L., Vinod‐Paul, Kiran, Hagen, Jaime, Edgerton, Susan, Owens, Philip, Sams, Sharon, Elias, Anthony, Sartorius, Carol A., Tan, Aik‐Choon, Kabos, Peter

“…The tumor microenvironment (TME) is an important modulator of response and resistance to endocrine therapy in estrogen receptor alpha (ER) positive breast…”
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Exploiting receptor tyrosine kinase co-activation for cancer therapy by Tan, Aik-Choon, Vyse, Simon, Huang, Paul H.

“…•Description of the key general principles of RTK co-activation in cancer.•Hierarchical RTK networks maintain robust signalling and drive drug…”
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CD44 Facilitates Epithelial-to-Mesenchymal Transition Phenotypic Change at Acquisition of Resistance to EGFR Kinase Inhibitors in Lung Cancer by Suda, Kenichi, Murakami, Isao, Yu, Hui, Kim, Jihye, Tan, Aik-Choon, Mizuuchi, Hiroshi, Rozeboom, Leslie, Ellison, Kim, Rivard, Christopher J, Mitsudomi, Tetsuya, Hirsch, Fred R

“…Epithelial-to-mesenchymal transition (EMT) is one of the acquired resistance mechanisms to EGFR tyrosine kinase inhibitors (TKI) in lung cancers. Because EMT…”
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AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non-Small Cell Lung Cancer Cells Following EGFR Inhibition by Scarborough, Hannah A, Helfrich, Barbara A, Casás-Selves, Matias, Schuller, Alwin G, Grosskurth, Shaun E, Kim, Jihye, Tan, Aik-Choon, Chan, Daniel C, Zhang, Zhiyong, Zaberezhnyy, Vadym, Bunn, Paul A, DeGregori, James

“…The emergence of EGFR inhibitors such as gefitinib, erlotinib, and osimertinib has provided novel treatment opportunities in EGFR-driven non-small cell lung…”
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An Epigenomic fingerprint of human cancers by landscape interrogation of super enhancers at the constituent level by Liu, Xiang, Gillis, Nancy, Jiang, Chang, McCofie, Anthony, Shaw, Timothy I, Tan, Aik-Choon, Zhao, Bo, Wan, Lixin, Duckett, Derek R, Teng, Mingxiang

“…Super enhancers (SE), large genomic elements that activate transcription and drive cell identity, have been found with cancer-specific gene regulation in human…”
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MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells by Mukherjee, Nabanita, Skees, Jenette, Todd, Kaleb J., West, Drake A., Lambert, Karoline A., Robinson, William A., Amato, Carol M., Couts, Kasey L., Van Gulick, Robert, MacBeth, Morgan, Nassar, Kelsey, Tan, Aik-Choon, Zhai, Zili, Fujita, Mayumi, Bagby, Stacey M., Dart, Chiara R., Lambert, James R., Norris, David A., Shellman, Yiqun G.

“…Current treatment for patients with metastatic melanoma include molecular-targeted therapies and immune checkpoint inhibitors. However, a subset of melanomas…”
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Loss of prdm1a accelerates melanoma onset and progression by Iwanaga, Ritsuko, Truong, Brittany T., Hsu, Jessica Y., Lambert, Karoline A., Vyas, Rajesh, Orlicky, David, Shellman, Yiqun G., Tan, Aik‐Choon, Ceol, Craig, Artinger, Kristin Bruk

“…Melanoma is an aggressive, deadly skin cancer derived from melanocytes, a neural crest cell derivative. Melanoma cells mirror the developmental program of…”
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Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells by Liu, Xinjian, Li, Fang, Stubblefield, Elizabeth A, Blanchard, Barbara, Richards, Toni L, Larson, Gaynor A, He, Yujun, Huang, Qian, Tan, Aik-Choon, Zhang, Dabing, Benke, Timothy A, Sladek, John R, Zahniser, Nancy R, Li, Chuan-Yuan

“…Transplantation of exogenous dopaminergic neuron （DA neurons） is a promising approach for treating Parkin- son＇s disease （PD）. However, a major stumbling block…”
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Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer by Davies, Kurtis D, Mahale, Sakshi, Astling, David P, Aisner, Dara L, Le, Anh T, Hinz, Trista K, Vaishnavi, Aria, Bunn, Jr, Paul A, Heasley, Lynn E, Tan, Aik-Choon, Camidge, D Ross, Varella-Garcia, Marileila, Doebele, Robert C

“…The targeting of oncogenic 'driver' kinases with small molecule inhibitors has proven to be a highly effective therapeutic strategy in selected non-small cell…”
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