Search Results - "AIGNER, Achim"

Therapeutic siRNA: State-of-the-Art and Future Perspectives by Friedrich, Maik, Aigner, Achim

“…The highly specific induction of RNA interference-mediated gene knockdown, based on the direct application of small interfering RNAs (siRNAs), opens novel…”
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Applications of RNA interference: current state and prospects for siRNA-based strategies in vivo by Aigner, Achim

“…Within the recent years, RNA interference (RNAi) has become an almost-standard method for in vitro knockdown of any target gene of interest. Now, one major…”
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Drug Delivery by Ultrasound-Responsive Nanocarriers for Cancer Treatment by Entzian, Kristin, Aigner, Achim

“…Conventional cancer chemotherapies often exhibit insufficient therapeutic outcomes and dose-limiting toxicity. Therefore, there is a need for novel…”
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Gene silencing through RNA interference (RNAi) in vivo: Strategies based on the direct application of siRNAs by Aigner, Achim

“…RNA interference (RNAi) offers great potential not only for in vitro target validation, but also as a novel therapeutic strategy based on the highly specific…”
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Polyethylenimines for siRNA and miRNA delivery in vivo by Höbel, Sabrina, Aigner, Achim

“…The discovery of RNA interference (RNAi) as a naturally occurring mechanism for gene knockdown has attracted considerable attention toward the use of small…”
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MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma by AHMED FAWZY IBRAHIM, WEIRAUCH, Ulrike, THOMAS, Maren, GRÜNWELLER, Arnold, HARTMANN, Roland K, AIGNER, Achim

“…MicroRNAs (miRNA) aberrantly expressed in tumors may offer novel therapeutic approaches to treatment. miR-145 is downregulated in various cancers including…”
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Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells by Ertych, Norman, Stolz, Ailine, Stenzinger, Albrecht, Weichert, Wilko, Kaulfuß, Silke, Burfeind, Peter, Aigner, Achim, Wordeman, Linda, Bastians, Holger

“…Chromosomal instability (CIN) is defined as the perpetual missegregation of whole chromosomes during mitosis and represents a hallmark of human cancer…”
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MicroRNAs (miRNAs) in colorectal cancer: from aberrant expression towards therapy by Dassow, Hannelore, Aigner, Achim

“…MiRNAs are small noncoding RNA molecules that are often aberrantly over- or underexpressed in tumors, including colorectal cancer (CRC). Due to their capacity…”
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A novel tyrosine-modified low molecular weight polyethylenimine (P10Y) for efficient siRNA delivery in vitro and in vivo by Ewe, Alexander, Przybylski, Susanne, Burkhardt, Jana, Janke, Andreas, Appelhans, Dietmar, Aigner, Achim

“…The delivery of nucleic acids, particularly of small RNA molecules like siRNAs for the induction of RNA interference (RNAi), still represents a major hurdle…”
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From the exposome to mechanistic understanding of chemical-induced adverse effects by Escher, Beate I., Hackermüller, Jörg, Polte, Tobias, Scholz, Stefan, Aigner, Achim, Altenburger, Rolf, Böhme, Alexander, Bopp, Stephanie K., Brack, Werner, Busch, Wibke, Chadeau-Hyam, Marc, Covaci, Adrian, Eisenträger, Adolf, Galligan, James J., Garcia-Reyero, Natalia, Hartung, Thomas, Hein, Michaela, Herberth, Gunda, Jahnke, Annika, Kleinjans, Jos, Klüver, Nils, Krauss, Martin, Lamoree, Marja, Lehmann, Irina, Luckenbach, Till, Miller, Gary W., Müller, Andrea, Phillips, David H., Reemtsma, Thorsten, Rolle-Kampczyk, Ulrike, Schüürmann, Gerrit, Schwikowski, Benno, Tan, Yu-Mei, Trump, Saskia, Walter-Rohde, Susanne, Wambaugh, John F.

“…The exposome encompasses an individual's exposure to exogenous chemicals, as well as endogenous chemicals that are produced or altered in response to external…”
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Nanoparticles for radiooncology: Mission, vision, challenges by Kunz-Schughart, Leoni A, Dubrovska, Anna, Peitzsch, Claudia, Ewe, Alexander, Aigner, Achim, Schellenburg, Samuel, Muders, Michael H, Hampel, Silke, Cirillo, Giuseppe, Iemma, Francesca, Tietze, Rainer, Alexiou, Christoph, Stephan, Holger, Zarschler, Kristof, Vittorio, Orazio, Kavallaris, Maria, Parak, Wolfgang J, Mädler, Lutz, Pokhrel, Suman

“…Abstract Cancer is one of the leading non-communicable diseases with highest mortality rates worldwide. About half of all cancer patients receive radiation…”
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Mesoporous Silica-Based Membranes in Transdermal Drug Delivery: The Role of Drug Loss in the Skin by Baumann, Frank, Paul, Theresa, Ossmann, Susann, Enke, Dirk, Aigner, Achim

“…Compared to other forms of drug administration, the use of Transdermal Drug Delivery Systems (TDDSs) offers significant advantages, including uniform drug…”
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Polyethylenimine Nanoparticle-Mediated siRNA Delivery to Reduce α-Synuclein Expression in a Model of Parkinson’s Disease by Helmschrodt, Christin, Höbel, Sabrina, Schöniger, Sandra, Bauer, Anne, Bonicelli, Jana, Gringmuth, Marieke, Fietz, Simone A., Aigner, Achim, Richter, Angelika, Richter, Franziska

“…RNA interference (RNAi)-based strategies that mediate the specific knockdown of target genes by administration of small interfering RNAs (siRNAs) could be…”
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Restoration of MARCK enhances chemosensitivity in cancer by Wenzel, Tim, Büch, Thomas, Urban, Nicole, Weirauch, Ulrike, Schierle, Katrin, Aigner, Achim, Schaefer, Michael, Kalwa, Hermann

“…Purpose Increased ATP-binding-cassette (ABC) transporter activity is a major cause of chemotherapy resistance in cancer. The ABC transporter family member…”
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Tyrosine-Modification of Polypropylenimine (PPI) and Polyethylenimine (PEI) Strongly Improves Efficacy of siRNA-Mediated Gene Knockdown by Noske, Sandra, Karimov, Michael, Aigner, Achim, Ewe, Alexander

“…The delivery of small interfering RNAs (siRNA) is an efficient method for gene silencing through the induction of RNA interference (RNAi). It critically…”
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Functional Role and Therapeutic Potential of the Pim-1 Kinase in Colon Carcinoma by Weirauch, Ulrike, Beckmann, Nadine, Thomas, Maren, Grünweller, Arnold, Huber, Kilian, Bracher, Franz, Hartmann, Roland K, Aigner, Achim

“…Abstract PURPOSE: The provirus integration site for Moloney murine leukemia virus 1 (Pim-1) kinase is overexpressed in various tumors and has been linked to…”
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In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(–PEG)/siRNA complexes by Malek, Anastasia, Merkel, Olivia, Fink, Ludger, Czubayko, Frank, Kissel, Thomas, Aigner, Achim

“…RNA interference (RNAi) represents a novel therapeutic strategy allowing the knockdown of any pathologically relevant target gene. Since it relies on the…”
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SATB1 as oncogenic driver and potential therapeutic target in head & neck squamous cell carcinoma (HNSCC) by Panchal, Omkar, Wichmann, Gunnar, Grenman, Reidar, Eckhardt, Lisa, Kunz-Schughart, Leoni A., Franke, Heike, Dietz, Andreas, Aigner, Achim

“…The Special AT-rich sequence binding protein 1 (SATB1) is a genome organizer protein that controls gene expression of numerous genes by regulating chromatin…”
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Impact of medication on blood transcriptome reveals off-target regulations of beta-blockers by Rode, Michael, Nenoff, Kolja, Wirkner, Kerstin, Horn, Katrin, Teren, Andrej, Regenthal, Ralf, Loeffler, Markus, Thiery, Joachim, Aigner, Achim, Pott, Janne, Kirsten, Holger, Scholz, Markus

“…For many drugs, mechanisms of action with regard to desired effects and/or unwanted side effects are only incompletely understood. To investigate possible…”
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Vorinostat Treatment of Gastric Cancer Cells Leads to ROS-Induced Cell Inhibition and a Complex Pattern of Molecular Alterations in Nrf2-Dependent Genes by Lorenz, Leoni, Zenz, Tamara, Oliinyk, Denys, Meier-Rosar, Florian, Jenke, Robert, Aigner, Achim, Büch, Thomas

“…Histone deacetylase inhibitors (HDACi) show high antineoplastic potential in preclinical studies in various solid tumors, including gastric carcinoma; however,…”
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