Search Results - "AHLGREN, Ulf"

Illuminating the complete ß-cell mass of the human pancreas- signifying a new view on the islets of Langerhans by Lehrstrand, Joakim, Davies, Wayne I. L., Hahn, Max, Korsgren, Olle, Alanentalo, Tomas, Ahlgren, Ulf

“…Pancreatic islets of Langerhans play a pivotal role in regulating blood glucose homeostasis, but critical information regarding their mass, distribution and…”
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Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice by Baeyens, Luc, Lemper, Marie, Leuckx, Gunter, De Groef, Sofie, Bonfanti, Paola, Stangé, Geert, Shemer, Ruth, Nord, Christoffer, Scheel, David W, Pan, Fong C, Ahlgren, Ulf, Gu, Guoqiang, Stoffers, Doris A, Dor, Yuval, Ferrer, Jorge, Gradwohl, Gerard, Wright, Christopher V E, Van de Casteele, Mark, German, Michael S, Bouwens, Luc, Heimberg, Harry

“…Short-term treatment with cytokines reprograms acinar cells into beta cells and restores durable normoglycemia in diabetic mice. Reprogramming of pancreatic…”
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Type I interferon shapes brain distribution and tropism of tick-borne flavivirus by Chotiwan, Nunya, Rosendal, Ebba, Willekens, Stefanie M. A., Schexnaydre, Erin, Nilsson, Emma, Lindqvist, Richard, Hahn, Max, Mihai, Ionut Sebastian, Morini, Federico, Zhang, Jianguo, Ebel, Gregory D., Carlson, Lars-Anders, Henriksson, Johan, Ahlgren, Ulf, Marcellino, Daniel, Överby, Anna K.

“…Viral tropism within the brain and the role(s) of vertebrate immune response to neurotropic flaviviruses infection is largely understudied. We combine…”
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3D imaging of human organs with micrometer resolution - applied to the endocrine pancreas by Hahn, Max, Nord, Christoffer, Eriksson, Maria, Morini, Federico, Alanentalo, Tomas, Korsgren, Olle, Ahlgren, Ulf

“…The possibility to quantitatively study specific molecular/cellular features of complete human organs with preserved spatial 3D context would have widespread…”
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Mesoscopic 3D imaging of pancreatic cancer and Langerhans islets based on tissue autofluorescence by Hahn, Max, Nord, Christoffer, Franklin, Oskar, Alanentalo, Tomas, Mettävainio, Martin Isaksson, Morini, Federico, Eriksson, Maria, Korsgren, Olle, Sund, Malin, Ahlgren, Ulf

“…The possibility to assess pancreatic anatomy with microscopic resolution in three dimensions (3D) would significantly add to pathological analyses of disease…”
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Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies by Sharpe, James, Ahlgren, Ulf, Perry, Paul, Hill, Bill, Ross, Allyson, Hecksher-Sørensen, Jacob, Baldock, Richard, Davidson, Duncan

“…Current techniques for three-dimensional (3D) optical microscopy (deconvolution, confocal microscopy, and optical coherence tomography) generate 3D data by…”
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Tomographic molecular imaging and 3D quantification within adult mouse organs by Sharpe, James, Ahlgren, Ulf, Alanentalo, Tomas, Asayesh, Amir, Morrison, Harris, Lorén, Christina E, Holmberg, Dan

“…A convenient technology to quantify three-dimensional (3D) morphological features would have widespread applications in biomedical research. Based on combined…”
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Mesoscopic Optical Imaging of the Pancreas-Revisiting Pancreatic Anatomy and Pathophysiology by Alanentalo, Tomas, Hahn, Max, Willekens, Stefanie M A, Ahlgren, Ulf

“…The exocrine-endocrine multipart organization of the pancreas makes it an exceedingly challenging organ to analyze, quantitatively and spatially. Both in…”
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An MR-based brain template and atlas for optical projection tomography and light sheet fluorescence microscopy in neuroscience by Willekens, Stefanie M A, Morini, Federico, Mediavilla, Tomas, Nilsson, Emma, Orädd, Greger, Hahn, Max, Chotiwan, Nunya, Visa, Montse, Berggren, Per-Olof, Ilegems, Erwin, Överby, Anna K, Ahlgren, Ulf, Marcellino, Daniel

“…Optical Projection Tomography (OPT) and light sheet fluorescence microscopy (LSFM) are high resolution optical imaging techniques, ideally suited for ex vivo…”
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SARS-CoV-2 infection induces hyaluronan production in vitro and hyaluronan levels in COVID-19 patients relate to morbidity and long-term lung impairment: a prospective cohort study by Hellman, Urban, Rosendal, Ebba, Lehrstrand, Joakim, Henriksson, Johan, Björsell, Tove, Wennemo, Alfred, Hahn, Max, Österberg, Björn, Dorofte, Luiza, Nilsson, Emma, Forsell, Mattias N E, Smed-Sörensen, Anna, Lange, Anna, Karlsson, Mats G, Ahlm, Clas, Blomberg, Anders, Cajander, Sara, Ahlgren, Ulf, Lind, Alicia, Normark, Johan, Överby, Anna K, Lenman, Annasara

“…We previously demonstrated that the lungs of deceased COVID-19 patients were filled with a clear hydrogel consisting of hyaluronan (HA). In this translational…”
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Differential regulation of myosin heavy chains defines new muscle domains in zebrafish by Nord, Hanna, Burguiere, Anne-Cecile, Muck, Joscha, Nord, Christoffer, Ahlgren, Ulf, von Hofsten, Jonas

“…Numerous muscle lineages are formed during myogenesis within both slow- and fast-specific cell groups. In this study, we show that six fast muscle-specific…”
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Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism by Witek, Barbara, El Wakil, Abeer, Nord, Christoffer, Ahlgren, Ulf, Eriksson, Maria, Vernersson-Lindahl, Emma, Helland, Åslaug, Alexeyev, Oleg A, Hallberg, Bengt, Palmer, Ruth H

“…Mice lacking ALK activity have previously been reported to exhibit subtle behavioral phenotypes. In this study of ALK of loss of function mice we present data…”
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Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice by Baeyens, Luc, Lemper, Marie, Leuckx, Gunter, De Groef, Sofie, Bonfanti, Paola, Stangé, Geert, Shemer, Ruth, Nord, Christoffer, Scheel, David W., Pan, Fong C., Ahlgren, Ulf, Gu, Guoqiang, Stoffers, Doris A., Dor, Yuval, Ferrer, Jorge, Gradwohl, Gerard, Wright, Christopher V. E., Van de Casteele, Mark, German, Michael S., Bouwens, Luc, Heimberg, Harry

“…This article has been retracted; see accompanying Retraction Note, which can be accessed via a link at the top of the paper…”
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Gsα-dependent signaling is required for postnatal establishment of a functional β-cell mass by Serra-Navarro, Berta, Fernandez-Ruiz, Rebeca, García-Alamán, Ainhoa, Pradas-Juni, Marta, Fernandez-Rebollo, Eduardo, Esteban, Yaiza, Mir-Coll, Joan, Mathieu, Julia, Dalle, Stephane, Hahn, Max, Ahlgren, Ulf, Weinstein, Lee S., Vidal, Josep, Gomis, Ramon, Gasa, Rosa

“…Early postnatal life is a critical period for the establishment of the functional β-cell mass that will sustain whole-body glucose homeostasis during the…”
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Nuclear Factor-κB Activity in β-Cells Is Required for Glucose-Stimulated Insulin Secretion by NORLIN, Stefan, AHLGREN, Ulf, EDLUND, Helena

“…Nuclear Factor-κB Activity in β-Cells Is Required for Glucose-Stimulated Insulin Secretion Stefan Norlin , Ulf Ahlgren and Helena Edlund From the Umeå Center…”
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Topologically selective islet vulnerability and self-sustained downregulation of markers for β-cell maturity in streptozotocin-induced diabetes by Hahn, Max, van Krieken, Pim P., Nord, Christoffer, Alanentalo, Tomas, Morini, Federico, Xiong, Yan, Eriksson, Maria, Mayer, Jürgen, Kostromina, Elena, Ruas, Jorge L., Sharpe, James, Pereira, Teresa, Berggren, Per-Olof, Ilegems, Erwin, Ahlgren, Ulf

“…Mouse models of Streptozotocin (STZ) induced diabetes represent the most widely used preclinical diabetes research systems. We applied state of the art optical…”
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Quantitative 3D OPT and LSFM datasets of pancreata from mice with streptozotocin-induced diabetes by Hahn, Max, Nord, Christoffer, van Krieken, Pim P., Berggren, Per-Olof, Ilegems, Erwin, Cheddad, Abbas, Ahlgren, Ulf

“…Mouse models for streptozotocin (STZ) induced diabetes probably represent the most widely used systems for preclinical diabetes research, owing to the…”
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An improved protocol for optical projection tomography imaging reveals lobular heterogeneities in pancreatic islet and β-cell mass distribution by Hörnblad, Andreas, Cheddad, Abbas, Ahlgren, Ulf

“…Optical projection tomography (OPT) imaging is a powerful tool for three-dimensional imaging of gene and protein distribution patterns in biomedical specimens…”
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Biochemical profiling of diabetes disease progression by multivariate vibrational microspectroscopy of the pancreas by Nord, Christoffer, Eriksson, Maria, Dicker, Andrea, Eriksson, Anna, Grong, Eivind, Ilegems, Erwin, Mårvik, Ronald, Kulseng, Bård, Berggren, Per-Olof, Gorzsás, András, Ahlgren, Ulf

“…Despite the dramatic increase in the prevalence of diabetes, techniques for in situ studies of the underlying pancreatic biochemistry are lacking. Such methods…”
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Growth-limiting role of endothelial cells in endoderm development by Sand, Fredrik Wolfhagen, Hörnblad, Andreas, Johansson, Jenny K., Lorén, Christina, Edsbagge, Josefina, Ståhlberg, Anders, Magenheim, Judith, Ilovich, Ohad, Mishani, Eyal, Dor, Yuval, Ahlgren, Ulf, Semb, Henrik

“…Endoderm development is dependent on inductive signals from different structures in close vicinity, including the notochord, lateral plate mesoderm and…”
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