Search Results - "AHERN, J. D"

Hydrocortisone and IL-4 induce IgE isotype switching in human B cells by Jabara, HH, Ahern, DJ, Vercelli, D, Geha, RS

“…Induction of IgE synthesis in human B cells requires two signals. The first signal is delivered by the cytokine IL-4. The second signal activates B cells and…”
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Deletional Switch Recombination Occurs in Interleukin-4-Induced Isotype Switching to IgE Expression by Human B Cells by SHAPIRA, S. K, JABARA, H. H, THIENES, C. P, AHERN, D. J, VERCELLI, D, GOULD, H. J, GEHA, R. S

“…There is controversy as to whether deletional rearrangement occurs between the IgM and IgE switch regions (Sμand Sε, respectively) during switching to the IgE…”
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Transforming Growth Factor α-Pseudomonas Exotoxin Fusion Protein Prolongs Survival of Nude Mice Bearing Tumor Xenografts by Heimbrook, David C., Stirdivant, Steven M., Ahern, Janet D., Balishin, Nancy L., Patrick, Denis R., Edwards, Gwynneth M., Defeo-Jones, Deborah, FitzGerald, David J., Pastan, Ira, Oliff, Allen

“…Transforming growth factor α (TGFα)-Pseudomonas exotoxin 40 (PE40) is a chimeric protein consisting of an N-terminal TGFα domain fused to a C-terminal 40-kDa…”
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IgE regulation and lymphokine patterns in aging humans by al-Rayes, H, Pachas, W, Mirza, N, Ahern, D J, Geha, R S, Vercelli, D

“…IgE production declines with age, and allergic symptoms tend to improve. Aging therefore represents an in vivo model to study IgE regulation. We compared IgE…”
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Global deficiency in the inflammatory chemokine receptors 1,2,3 and 5 prevents vascular dysfunction in angiotensin II-induced hypertension and selectively modulates aortic myeloid cell phenotype by Gu, S, Gurgone, D, Macritchie, N, Shoaran, M, Nosalski, R, Vidler, F, Crespo, E, Ahern, D J, Monaco, C, Graham, G J, Guzik, T J, Maffia, P

“…Abstract Background Leukocyte migration to the vasculature and the heart plays a critical role in hypertensive immune responses and is a carefully orchestrated…”
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A single-cell atlas of immune checkpoint molecules in atherosclerosis in ApoE-/- mice by Bazioti, V, Bosmans, L A, Van Tiel, C M, Joppich, M, Ahern, D J, Shami, A, Weber, C, De Winther, M M P J, Atzler, D, Monaco, C, Lutgens, E

“…Abstract Introduction Immune checkpoint (IC) targeting is an attractive way to combat atherosclerosis, since ICs regulate the immune response by activating or…”
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Retinoblastoma protein binding properties are dependent on 4 cysteine residues in the protein binding pocket by Stirdivant, S M, Ahern, J D, Oliff, A, Heimbrook, D C

“…The retinoblastoma gene product (pRB) participates in regulating mammalian cell replication. The mechanism responsible for pRB's growth regulatory activity is…”
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The ras oncogene protein as a G-protein by Sigal, I S, D'Alonzo, J S, Ahern, J D, Marshall, M S, Smith, G M, Scolnick, E M, Gibbs, J B

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Inhibition of yeast adenylate cyclase by antibodies to ras p21 by Gibbs, J B, Marsico-Ahern, J D, Scolnick, E M, Sigal, I S

“…Monoclonal antibody Y13-259 to ras p21 was shown to bind to the highly conserved residues in the region 63-73 and to neutralize ras action in the Saccharomyces…”
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Activity of a recombinant transforming growth factor-alpha-Pseudomonas exotoxin hybrid protein against primary human tumor colony-forming units by Von Hoff, D D, Marshall, M H, Heimbrook, D C, Stirdivant, S M, Ahern, J D, Herbert, W K, Maigetter, R Z, Oliff, A

“…Transforming growth factor-alpha-Pseudomonas exotoxin-40 (TP40) is a recombinant fusion protein. TP40 consists of the entire human transforming growth…”
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Molecular approaches towards an anti-ras drug by Sigal, I S, Smith, G M, Jurnak, F, Marsico-Ahern, J D, D'Alonzo, J S, Scolnick, E M, Gibbs, J B

“…The ras proteins have intrinsic biochemical properties that are similar to those of the guanine nucleotide binding regulatory proteins (G-proteins). Increased…”
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Biological activity of a transforming growth factor-alpha--Pseudomonas exotoxin fusion protein in vitro and in vivo by Heimbrook, D C, Stirdivant, S M, Ahern, J D, Balishin, N L, Patrick, D R, Edwards, G M, Defeo-Jones, D, FitzGerald, D J, Pastan, I, Oliff, A

“…Transforming growth factor-alpha (TGF alpha)-pseudomonas exotoxin-40 (PE40) is a chimeric protein consisting of an N-terminal TGF alpha domain fused to a…”
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Regulatory T cells as a target for induction of immune tolerance in allergy by Ahern, David J, Robinson, Douglas S

“…PURPOSE OF REVIEWReduced activity of regulatory T cells has recently been described in several diseases, including allergy. This concept of an alteration in…”
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Retinoblastoma protein binding properties are dependent on 4 cysteine redisues in the protein binding pocket by STIRDIVANT, S. M, AHERN, J. D, OLIFF, A, HEIMBROOK, D. C

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Activity of a recombinant tranforming growth factor-α-pseudomonas exotoxin hybrid protein against primary human tumor colony-forming units by VON HOFF, D. D, MARSHALL, M. H, HEIMBROOK, D. C, STIRDIVANT, S. M, AHERN, J. D, HERBERT, W. K, MAIGETTER, R. Z, OLIFF, A

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Initial Experience with the Milton Keynes Optical Fiber Cable TV Trial by Fox, J., Fordham, D., Wood, R., Ahern, D.

“…This paper describes a small trial of an advanced cable TV network with evolutionary potential for the wideband local network of the future. Major features of…”
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