Search Results - "AGUINALDO, Juan Gilberto S"

Evaluation of neovessels in atherosclerotic plaques of rabbits using an albumin-binding intravascular contrast agent and MRI by Cornily, Jean-Christophe, Hyafil, Fabien, Calcagno, Claudia, Briley-Saebo, Karen C., Tunstead, James, Aguinaldo, Juan-Gilberto S., Mani, Venkatesh, Lorusso, Vito, Cavagna, Friedrich M., Fayad, Zahi A.

“…Purpose To test whether B‐22956/1, a novel intravascular contrast agent with a high affinity to serum albumin (Bracco Imaging SpA.), allowed quantifying…”
Get full text

Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI by Amirbekian, Vardan, Lipinski, Michael J, Briley-Saebo, Karen C, Amirbekian, Smbat, Aguinaldo, Juan Gilberto S, Weinreb, David B, Vucic, Esad, Frias, Juan C, Hyafil, Fabien, Mani, Venkatesh, Fisher, Edward A, Fayad, Zahi A

“…We investigated the ability of targeted immunomicelles to detect and assess macrophages in atherosclerotic plaque using MRI in vivo. There is a large clinical…”
Get full text

An ApoA-I Mimetic Peptide High-Density-Lipoprotein-Based MRI Contrast Agent for Atherosclerotic Plaque Composition Detection by Cormode, David P., Briley-Saebo, Karen C., Mulder, Willem J. M., Aguinaldo, Juan Gilberto S., Barazza, Alessandra, Ma, Yanqing, Fisher, Edward A., Fayad, Zahi A.

“…Cardiovascular disease is one of the prime causes of mortality throughout the world and there is a need for targeted and effective contrast agents to allow…”
Get full text

Molecular imaging of macrophages in atherosclerotic plaques using bimodal PEG-micelles by Mulder, Willem J. M., Strijkers, Gustav J., Briley-Saboe, Karen C., Frias, Juan C., Aguinaldo, Juan Gilberto S., Vucic, Esad, Amirbekian, Vardan, Tang, Cheuk, Chin, Patrick T. K., Nicolay, Klaas, Fayad, Zahi A.

“…Pegylated, fluorescent, and paramagnetic micelles were developed. The micelles were conjugated with macrophage scavenger receptor (MSR)‐specific antibodies…”
Get full text

Evaluation of Matrix Metalloproteinases in Atherosclerosis Using a Novel Noninvasive Imaging Approach by Lancelot, Eric, Amirbekian, Vardan, Brigger, Irène, Raynaud, Jean-Sébastien, Ballet, Sébastien, David, Christelle, Rousseaux, Olivier, Le Greneur, Soizic, Port, Marc, Lijnen, Henri R, Bruneval, Patrick, Michel, Jean-Baptiste, Ouimet, Tanja, Roques, Bernard, Amirbekian, Smbat, Hyafil, Fabien, Vucic, Esad, Aguinaldo, Juan Gilberto S, Corot, Claire, Fayad, Zahi A

“…OBJECTIVE—Despite great advances in our knowledge, atherosclerosis continues to kill more people than any other disease in the Western world. This is because…”
Get full text

Atherosclerosis and Matrix Metalloproteinases : Experimental Molecular MR Imaging in Vivo by AMIRBEKIAN, Vardan, AGUINALDO, Juan Gilberto S, FISHER, Edward A, GALIS, Zorina S, FAYAD, Zahi A, AMIRBEKIAN, Smbat, HYAFIL, Fabien, VUCIC, Esad, SIROL, Marc, WEINREB, David B, LE GRENEUR, Soizic, LANCELOT, Eric, COROT, Claire

“…To evaluate the capability of P947, a magnetic resonance (MR) imaging contrast agent that molecularly targets matrix metalloproteinases (MMPs), to aid…”
Get full text

Lipid-rich atherosclerotic plaques detected by gadofluorine-enhanced in vivo magnetic resonance imaging by SIROL, Marc, ITSKOVICH, Vitalii V, MANI, Venkatesh, AGUINALDO, Juan Gilberto S, FALLON, John T, MISSELWITZ, Bernd, WEINMANN, Hanns-Joachim, FUSTER, Valentin, TOUSSAINT, Jean-Francois, FAYAD, Zahi A

“…MRI of specific components in atherosclerotic plaque may provide information on plaque stability and its potential to rupture. We evaluated gadofluorine in…”
Get full text

Macrophage-Specific Lipid-Based Nanoparticles Improve Cardiac Magnetic Resonance Detection and Characterization of Human Atherosclerosis by Lipinski, Michael J., MD, Frias, Juan C., PhD, Amirbekian, Vardan, MD, Briley-Saebo, Karen C., PhD, Mani, Venkatesh, PhD, Samber, Daniel, PE, Abbate, Antonio, MD, Aguinaldo, Juan Gilberto S., MD, Massey, Davis, DDS, MD, PhD, Fuster, Valentin, MD, PhD, Vetrovec, George W., MD, Fayad, Zahi A., PhD

“…Objectives We sought to determine whether gadolinium (Gd)-containing lipid-based nanoparticles (NPs) targeting the macrophage scavenger receptor-B (CD36)…”
Get full text

Serial Studies of Mouse Atherosclerosis by In Vivo Magnetic Resonance Imaging Detect Lesion Regression After Correction of Dyslipidemia by Trogan, Eugene, Fayad, Zahi A, Itskovich, Vitalii V, Aguinaldo, Juan-Gilberto S, Mani, Venkatesh, Fallon, John T, Chereshnev, Igor, Fisher, Edward A

“…OBJECTIVE—We determined the effects of sustained normocholesterolemia on advanced mouse atherosclerosis and whether changes in plaque size and composition can…”
Get full text

Rapid extended coverage simultaneous multisection black-blood vessel wall MR imaging by Mani, Venkatesh, Itskovich, Vitalii V, Szimtenings, Michael, Aguinaldo, Juan Gilberto S, Samber, Daniel D, Mizsei, Gabor, Fayad, Zahi A

“…A two-dimensional rapid extended coverage (REX) rapid acquisition with relaxation enhancement (RARE) pulse sequence for simultaneous multisection double…”
Get more information

Long-term Air Pollution Exposure and Acceleration of Atherosclerosis and Vascular Inflammation in an Animal Model by Sun, Qinghua, Wang, Aixia, Jin, Ximei, Natanzon, Alex, Duquaine, Damon, Brook, Robert D, Aguinaldo, Juan-Gilberto S, Fayad, Zahi A, Fuster, Valentin, Lippmann, Morton, Chen, Lung Chi, Rajagopalan, Sanjay

“…CONTEXT Recent studies have suggested a link between inhaled particulate matter exposure in urban areas and susceptibility to cardiovascular events; however,…”
Get full text

Comparison of gated and nongated fast multislice black-blood carotid imaging using rapid extended coverage and inflow/outflow saturation techniques by Mani, Venkatesh, Itskovich, Vitalii V., Aguiar, Silvia H., Mizsei, Gabor, Aguinaldo, Juan Gilberto S., Samber PE, Daniel D., Macaluso, Frank M., Fayad, Zahi A.

“…Purpose To comparatively analyze two fast in vivo multislice black‐blood carotid artery vessel wall imaging techniques with and without cardiac gating…”
Get full text

Targeted Molecular Probes for Imaging Atherosclerotic Lesions With Magnetic Resonance Using Antibodies That Recognize Oxidation-Specific Epitopes by BRILEY-SAEBO, Karen C, SHAW, Peter X, MULDER, Willem J. M, CHOI, Seung-Hyuk, VUCIC, Esad, AGUINALDO, Juan Gilberto S, WITZTUM, Joseph L, FUSTER, Valentin, TSIMIKAS, Sotirios, FAYAD, Zahi A

“…Oxidized low-density lipoprotein plays a key role in the initiation, progression, and destabilization of atherosclerotic plaques and is present in macrophages…”
Get full text

MRI to detect atherosclerosis with gadolinium-containing immunomicelles targeting the macrophage scavenger receptor by Lipinski, Michael J., Amirbekian, Vardan, Frias, Juan C., Aguinaldo, Juan Gilberto S., Mani, Venkatesh, Briley-Saebo, Karen C., Fuster, Valentin, Fallon, John T., Fisher, Edward A., Fayad, Zahi A.

“…The ability to specifically image macrophages may enable improved detection and characterization of atherosclerosis. In this study we evaluated the in vitro…”
Get full text

Magnetic resonance imaging of vulnerable atherosclerotic plaques: Current imaging strategies and molecular imaging probes by Briley-Saebo, Karen C., Mulder, Willem J.M., Mani, Venkatesh, Hyafil, Fabien, Amirbekian, Vardan, Aguinaldo, Juan Gilberto S., Fisher, Edward A., Fayad, Zahi A.

“…The vulnerability or destabilization of atherosclerotic plaques has been directly linked to plaque composition. Imaging modalities, such as magnetic resonance…”
Get full text

Quantification of human atherosclerotic plaques using spatially enhanced cluster analysis of multicontrast-weighted magnetic resonance images by Itskovich, Vitalii V., Samber, Daniel D., Mani, Venkatesh, Aguinaldo, Juan Gilberto S., Fallon, John T., Tang, Cheuk Y., Fuster, Valentin, Fayad, Zahi A.

“…One of the current limitations of magnetic resonance imaging (MRI) is the lack of an objective method to classify plaque components. Here we present a cluster…”
Get full text

Gadolinium mixed-micelles: Effect of the amphiphile on in vitro and in vivo efficacy in apolipoprotein E knockout mouse models of atherosclerosis by Briley-Saebo, Karen C., Amirbekian, Vardan, Mani, Venkatesh, Aguinaldo, Juan Gilberto S., Vucic, Esad, Carpenter, David, Amirbekian, Smbat, Fayad, Zahi A.

“…Gadolinium (Gd) micelles are nanoparticles that incorporate phospholipids, surfactants, and lipophilic Gd complexes. Preliminary studies have shown that…”
Get full text

Non-invasive MRI of mouse models of atherosclerosis by Weinreb, David B., Aguinaldo, Juan Gilberto S., Feig, Jonathan E., Fisher, Edward A., Fayad, Zahi A.

“…Early detection and characterization of atherosclerotic lesions susceptible to sudden rupture and thrombosis may decrease morbidity and mortality. Plaque…”
Get full text

Parallel and nonparallel simultaneous multislice black-blood double inversion recovery techniques for vessel wall imaging by Itskovich, Vitalii V., Mani, Venkatesh, Mizsei, Gabor, Aguinaldo, Juan Gilberto S., Samber, Daniel D., Macaluso, Frank, Wisdom, Paul, Fayad, Zahi A.

“…Purpose To reduce long examination times of black‐blood vessel wall imaging by acquiring multiple slices simultaneously and by using parallel acquisition…”
Get full text

Carotid black blood MRI burden of atherosclerotic disease assessment correlates with ultrasound intima-media thickness by Mani, Venkatesh, Aguiar, Silvia H, Itskovich, Vitalii V, Weinshelbaum, Karen B, Postley, John E, Wasenda, Erika J, Aguinaldo, Juan Gilberto S, Samber, Daniel D, Fayad, Zahi A

“…The aim of this study was to correlate carotid black blood MRI based measurements with those obtained by ultrasound intima-media thickness (IMT). Seventeen…”
Get more information