Search Results - "AGUAYO, A. J."

Effects of Ocular Injury and Administration of Brain-Derived Neurotrophic Factor on Survival and Regrowth of Axotomized Retinal Ganglion Cells by Mansour-Robaey, S., Clarke, D. B., Y.-C. Wang, Bray, G. M., Aguayo, A. J.

“…Optic nerve transection in adult rats results in the death of ≈50% of the axotomized retinal ganglion cells (RGCs) by 1 week and nearly 90% by 2 weeks after…”
Get full text

Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats by Berkelaar, M, Clarke, DB, Wang, YC, Bray, GM, Aguayo, AJ

“…Using quantitative anatomical techniques, we show that after intraorbital optic nerve transection in adult rats, virtually all retinal ganglion cells (RGCs)…”
Get full text

Influences of peripheral nerve grafts on the survival and regrowth of axotomized retinal ganglion cells in adult rats by Villegas-Perez, MP, Vidal-Sanz, M, Bray, GM, Aguayo, AJ

“…To investigate the role of extrinsic influences on the survival and growth of axotomized retinal ganglion cells (RGCs) in the mature mammalian CNS, both optic…”
Get full text

Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat by Vidal-Sanz, M, Bray, GM, Villegas-Perez, MP, Thanos, S, Aguayo, AJ

“…In adult rats, one optic nerve was transected and replaced by a 4 cm segment of autologous peripheral nerve (PN) that linked one eye and the superior…”
Get full text

Degenerative and Regenerative Responses of Injured Neurons in the Central Nervous System of Adult Mammals by Aguayo, A. J., Rasminsky, M., Bray, G. M., Carbonetto, S., McKerracher, L., Villegas-Perez, M. P., Vidal-Sanz, M., Carter, D. A.

“…In adult mammals, the severing of the optic nerve near the eye is followed by a loss of retinal ganglion cells (RGCs) and a failure of axons to regrow into the…”
Get full text

Colocalization of TrkB and Brain-Derived Neurotrophic Factor Proteins in Green-Red-Sensitive Cone Outer Segments by Di Polo, Adriana, Cheng, Li, Bray, Garth M, Aguayo, Albert J

“…To examine the distribution of neurotrophins (NTs) and their catalytic receptors in adult rat photoreceptors. Immunocytochemistry and Western blot analyses…”
Get full text

Regenerated retinal ganglion cell axons can form well-differentiated synapses in the superior colliculus of adult hamsters by Carter, DA, Bray, GM, Aguayo, AJ

“…To investigate in adult animals the distribution and differentiation of the synapses made by axotomized CNS neurons whose regenerating axons are guided back to…”
Get full text

Expression of the growth-associated protein GAP-43 in adult rat retinal ganglion cells following axon injury by Doster, S K, Lozano, A M, Aguayo, A J, Willard, M B

“…We have studied the expression of the growth-associated protein GAP-43 after injury to the axons of adult rat retinal ganglion cells (CNS neurons that do not…”
Get more information

Electrophysiologic Responses in Hamster Superior Colliculus Evoked by Regenerating Retinal Axons by Keirstead, S. A., Rasminsky, M., Fukuda, Y., Carter, D. A., Aguayo, A. J., Vidal-Sanz, M.

“…Autologous peripheral nerve grafts were used to permit and direct the regrowth of retinal ganglion cell axons from the eye to the ipsilateral superior…”
Get full text

Prolonged administration of NT-4/5 fails to rescue most axotomized retinal ganglion cells in adult rats by Clarke, David B, Bray, Garth M, Aguayo, Albert J

“…The survival of axotomized RGCs was increased by intravitreal NT-4/5 given by repeated injections or osmotic minipumps, but the effects were less complete than…”
Get full text

Temporal changes in beta-tubulin and neurofilament mRNA levels after transection of adult rat retinal ganglion cell axons in the optic nerve by McKerracher, L, Essagian, C, Aguayo, AJ

“…Axons of adult mammalian retinal ganglion cells (RGCs) do not regenerate spontaneously after injury in the optic nerve and show a persistent decrease in the…”
Get full text

Long-term growth and remodeling of regenerated retino-collicular connections in adult hamsters by Carter, DA, Bray, GM, Aguayo, AJ

“…The capacity of regenerating axons for long-term growth and synaptic plasticity was investigated in the visual system of adult hamsters. Four to six and 8-10…”
Get full text

Lengthy regrowth of cut axons from ganglion cells after peripheral nerve transplantation into the retina of adult rats by So, K F, Aguayo, A J

“…Ganglion cell axons regrew to approximately their normal length (2 cm) when autologous peripheral nerve segments were inserted into the retina of adult rats…”
Get more information

Synapse formation and preferential distribution in the granule cell layer by regenerating retinal ganglion cell axons guided to the cerebellum of adult hamsters by Zwimpfer, TJ, Aguayo, AJ, Bray, GM

“…To investigate constraints and preferences for synaptogenesis in the injured mammalian CNS, regenerating retinal ganglion cell (RGC) axons of adult hamsters…”
Get full text

Selective impairment of slow axonal transport after optic nerve injury in adult rats by McKerracher, L, Vidal-Sanz, M, Essagian, C, Aguayo, AJ

“…To investigate cellular responses of injured mammalian CNS neurons, we examined the slow transport of cytoskeletal proteins in rat retinal ganglion cell (RGC)…”
Get full text

Marked increase in beta-tubulin mRNA expression during regeneration of axotomized retinal ganglion cells in adult mammals by McKerracher, L, Essagian, C, Aguayo, AJ

“…Changes in gene expression were investigated in axotomized CNS neurons under conditions that inhibit or permit regrowth of their damaged axons. Levels of mRNA…”
Get full text

Synaptic connections made by axons regenerating in the central nervous system of adult mammals by AGUAYO, A. J, BRAY, G. M, RASMINSKY, M, ZWIMPFER, T, CARTER, D, VIDAL-SANZ, M

“…The restoration of connections in the injured central nervous system (CNS) of adult mammals is hindered by the failure of axons to grow back to their natural…”
Get full text

Prolonged Delivery of Brain-Derived Neurotrophic Factor by Adenovirus-Infected Muller Cells Temporarily Rescues Injured Retinal Ganglion Cells by Di Polo, Adriana, Aigner, Ludwig J., Dunn, Robert J., Bray, Garth M., Aguayo, Albert J.

“…In this study, we demonstrate that: (i) injection of an adenovirus (Ad) vector containing the brain-derived neurotrophic factor (BDNF) gene (Ad.BDNF) into the…”
Get full text

The use of peripheral nerve grafts to enhance neuronal survival, promote growth and permit terminal reconnections in the central nervous system of adult rats by BRAY, G. M, VILLEGAS-PEREZ, M. P, VIDAL-SANZ, M, AGUAYO, A. J

“…During both development and regeneration, the survival of neurones and the growth of axons are controlled by inherent neuronal properties, conditions in the…”
Get full text

Injured neurons in the olfactory bulb of the adult rat grow axons along grafts of peripheral nerve by Friedman, B, Aguayo, AJ

“…Certain neurons in the central nervous system (CNS) of adult mammals extend axons for several cm along peripheral nerve grafts inserted into the brain or…”
Get full text