Search Results - "AGRELO, Rubén"
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Detection of Lymph Node Micrometastases by Gene Promoter Hypermethylation in Samples Obtained by Endosonography- Guided Fine-Needle Aspiration Biopsy
Published in Clinical cancer research (01-07-2004)“…Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has become a fundamental procedure for gastrointestinal and lung cancer staging. However, there…”
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Cyclooxygenase 2 Expression in Colorectal Cancer with DNA Mismatch Repair Deficiency
Published in Clinical cancer research (15-03-2006)“…Background: Cyclooxygenase 2 (COX-2) overexpression is a frequent but not universal event in colorectal cancer. It has been suggested that COX-2 protein…”
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SATB1 Defines the Developmental Context for Gene Silencing by Xist in Lymphoma and Embryonic Cells
Published in Developmental cell (01-04-2009)“…The noncoding Xist RNA triggers silencing of one of the two female X chromosomes during X inactivation in mammals. Gene silencing by Xist is restricted to a…”
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Promoter hypermethylation as a mechanism for Lamin A/C silencing in a subset of neuroblastoma cells
Published in PloS one (19-04-2017)“…Nuclear lamins support the nuclear envelope and provide anchorage sites for chromatin. They are involved in DNA synthesis, transcription, and replication. It…”
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Epigenetic Inactivation of the Premature Aging Werner Syndrome Gene in Human Cancer
Published in Proceedings of the National Academy of Sciences - PNAS (06-06-2006)“…Werner syndrome (WS) is an inherited disorder characterized by premature onset of aging, genomic instability, and increased cancer incidence. The disease is…”
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A novel Werner Syndrome mutation: pharmacological treatment by read-through of nonsense mutations and epigenetic therapies
Published in Epigenetics (01-04-2015)“…Werner Syndrome (WS) is a rare inherited disease characterized by premature aging and increased propensity for cancer. Mutations in the WRN gene can be of…”
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Cancer progenitors and epigenetic contexts: An Xisting connection
Published in Epigenetics (16-11-2009)“…In mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The non coding RNA Xist triggers X inactivation. Gene…”
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Inactivation of the Lamin A/C Gene by CpG Island Promoter Hypermethylation in Hematologic Malignancies, and Its Association With Poor Survival in Nodal Diffuse Large B-Cell Lymphoma
Published in Journal of clinical oncology (10-06-2005)“…Lamins support the nuclear envelope and provide anchorage sites for chromatin, but they are also involved in DNA synthesis, transcription, and apoptosis…”
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Cross-Talk between Aging and Cancer
Published in Annals of the New York Academy of Sciences (01-04-2007)“…: The risk of having cancer increases with age probably because progenitor cells from mature organisms accumulate enough molecular lesions to evade the…”
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Cross-talk between aging and cancer: the epigenetic language
Published in Annals of the New York Academy of Sciences (01-04-2007)“…The risk of having cancer increases with age probably because progenitor cells from mature organisms accumulate enough molecular lesions to evade the…”
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Response: The Diversity of Proteins Linking Xist to Gene Silencing
Published in Developmental cell (16-10-2012)“…In this issue, Nechanitzky et al. question the role of SATB proteins in conferring cellular competence to respond to Xist. Here, Wutz and Agrelo respond,…”
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X inactivation and disease
Published in Seminars in cell & developmental biology (01-04-2010)“…X inactivation is the mechanism by which mammals adjust the X-linked gene dosage between the sexes. The dosage difference between XX females and XY males is…”
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ConteXt of change—X inactivation and disease
Published in EMBO molecular medicine (01-01-2010)“…Epigenetic regulation is important for stable maintenance of cell identity. For continued function of organs and tissues, illegitimate changes in cell identity…”
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X inactivation and progenitor cancer cells
Published in Cancers (26-04-2011)“…In mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The 17 kb non-coding RNA called Xist triggers X…”
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A new molecular model of cellular aging based on Werner syndrome
Published in Medical hypotheses (01-01-2007)“…Summary In the Hayflick model, a decrease in the number of cells capable of undergoing proliferation constitutes the main criterion of cellular aging and is…”
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Cancer progenitors and epigenetic contexts: An Xist ing connection
Published in Epigenetics (16-11-2009)Get full text
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The impact of MECP2 mutations in the expression patterns of Rett syndrome patients
Published in Human genetics (2005)“…Rett syndrome (RTT), the second most common cause of mental retardation in females, has been associated with mutations in MeCP2, the archetypical member of the…”
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