Search Results - "AGNIHOTHRAM, Sudhakar"

Rapid generation of a mouse model for Middle East respiratory syndrome by Zhao, Jincun, Li, Kun, Wohlford-Lenane, Christine, Agnihothram, Sudhakar S., Fett, Craig, Zhao, Jingxian, Gale, Michael J., Baric, Ralph S., Enjuanes, Luis, Gallagher, Tom, McCray, Paul B., Perlman, Stanley

“…In this era of continued emergence of zoonotic virus infections, the rapid development of rodent models represents a critical barrier to public health…”
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SARS-like WIV1-CoV poised for human emergence by Menachery, Vineet D., Yount, Boyd L., Sims, Amy C., Debbink, Kari, Agnihothram, Sudhakar S., Gralinski, Lisa E., Graham, Rachel L., Scobey, Trevor, Plante, Jessica A., Royal, Scott R., Swanstrom, Jesica, Sheahan, Timothy P., Pickles, Raymond J., Corti, Davide, Randell, Scott H., Lanzavecchia, Antonio, Marasco, Wayne A., Baric, Ralph S.

“…Outbreaks from zoonotic sources represent a threat to both human disease as well as the global economy. Despite a wealth of metagenomics studies,methods to…”
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Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution by Tang, Xian-Chun, Agnihothram, Sudhakar S., Jiao, Yongjun, Stanhope, Jeremy, Graham, Rachel L., Peterson, Eric C., Avnir, Yuval, Tallarico, Aimee St. Clair, Sheehan, Jared, Zhu, Quan, Baric, Ralph S., Marasco, Wayne A.

“…The newly emerging Middle East Respiratory Syndrome coronavirus (MERS-CoV) causes a Severe Acute Respiratory Syndrome-like disease with ∼43% mortality. Given…”
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A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence by Menachery, Vineet D, Yount, Boyd L, Debbink, Kari, Agnihothram, Sudhakar, Gralinski, Lisa E, Plante, Jessica A, Graham, Rachel L, Scobey, Trevor, Ge, Xing-Yi, Donaldson, Eric F, Randell, Scott H, Lanzavecchia, Antonio, Marasco, Wayne A, Shi, Zhengli-Li, Baric, Ralph S

“…Ralph Baric, Vineet Menachery and colleagues characterize a SARS-like coronavirus circulating in Chinese horseshoe bats to determine its potential to infect…”
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Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus by Scobey, Trevor, Yount, Boyd L., Sims, Amy C., Donaldson, Eric F., Agnihothram, Sudhakar S., Menachery, Vineet D., Graham, Rachel L., Swanstrom, Jesica, Bove, Peter F., Kim, Jeeho D., Grego, Sonia, Randell, Scott H., Baric, Ralph S.

“…Severe acute respiratory syndrome with high mortality rates (∼50%) is associated with a novel group 2c betacoronavirus designated Middle East respiratory…”
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Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection by Totura, Allison L, Whitmore, Alan, Agnihothram, Sudhakar, Schäfer, Alexandra, Katze, Michael G, Heise, Mark T, Baric, Ralph S

“…Toll-like receptors (TLRs) are sensors that recognize molecular patterns from viruses, bacteria, and fungi to initiate innate immune responses to invading…”
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A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge by BOLLES, Meagan, DEMING, Damon, BARIC, Ralph S, LONG, Kristin, AGNIHOTHRAM, Sudhakar, WHITMORE, Alan, FERRIS, Martin, FUNKHOUSER, William, GRALINSKI, Lisa, TOTURA, Allison, HEISE, Mark

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Crystal Structure of the Receptor-Binding Domain from Newly Emerged Middle East Respiratory Syndrome Coronavirus by Chen, Yaoqing, Rajashankar, Kanagalaghatta R, Yang, Yang, Agnihothram, Sudhakar S, Liu, Chang, Lin, Yi-Lun, Baric, Ralph S, Li, Fang

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Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity by Menachery, Vineet D, Yount, Jr, Boyd L, Josset, Laurence, Gralinski, Lisa E, Scobey, Trevor, Agnihothram, Sudhakar, Katze, Michael G, Baric, Ralph S

“…The sudden emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and, more recently, Middle Eastern respiratory syndrome CoV (MERS-CoV)…”
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Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus by Corti, Davide, Zhao, Jincun, Pedotti, Mattia, Simonelli, Luca, Agnihothram, Sudhakar, Fett, Craig, Fernandez-Rodriguez, Blanca, Foglierini, Mathilde, Agatic, Gloria, Vanzetta, Fabrizia, Gopal, Robin, Langrish, Christopher J., Barrett, Nicholas A, Sallusto, Federica, Baric, Ralph S., Varani, Luca, Zambon, Maria, Perlman, Stanley, Lanzavecchia, Antonio

“…Middle East Respiratory Syndrome (MERS) is a highly lethal pulmonary infection caused by a previously unidentified coronavirus (CoV), likely transmitted to…”
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Evidence Supporting a Zoonotic Origin of Human Coronavirus Strain NL63 by HUYNH, Jeremy, SHIMENA LI, FRIEMAN, Matthew B, BARIC, Ralph S, DONALDSON, Eric F, YOUNT, Boyd, SMITH, Alexander, STURGES, Leslie, OLSEN, John C, NAGEL, Juliet, JOHNSON, Joshua B, AGNIHOTHRAM, Sudhakar, GATES, J. Edward

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Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus by Josset, Laurence, Menachery, Vineet D, Gralinski, Lisa E, Agnihothram, Sudhakar, Sova, Pavel, Carter, Victoria S, Yount, Boyd L, Graham, Rachel L, Baric, Ralph S, Katze, Michael G

“…A novel human coronavirus (HCoV-EMC) was recently identified in the Middle East as the causative agent of a severe acute respiratory syndrome (SARS) resembling…”
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Mouse dipeptidyl peptidase 4 is not a functional receptor for Middle East respiratory syndrome coronavirus infection by Cockrell, Adam S, Peck, Kayla M, Yount, Boyd L, Agnihothram, Sudhakar S, Scobey, Trevor, Curnes, Nicole R, Baric, Ralph S, Heise, Mark T

“…Human dipeptidyl peptidase 4 (hDPP4) was recently identified as the receptor for Middle East respiratory syndrome coronavirus (MERS-CoV) infection, suggesting…”
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Tropism of and Innate Immune Responses to the Novel Human Betacoronavirus Lineage C Virus in Human Ex Vivo Respiratory Organ Cultures by Chan, Renee W Y, Chan, Michael C W, Agnihothram, Sudhakar, Chan, Louisa L Y, Kuok, Denise I T, Fong, Joanne H M, Guan, Y, Poon, Leo L M, Baric, Ralph S, Nicholls, John M, Peiris, J S Malik

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Molecular Determinants of Severe Acute Respiratory Syndrome Coronavirus Pathogenesis and Virulence in Young and Aged Mouse Models of Human Disease by FRIEMAN, Matthew, YOUNT, Boyd, BARIC, Ralph S, AGNIHOTHRAM, Sudhakar, PAGE, Carly, DONALDSON, Eric, ROBERTS, Anjeanette, VOGEL, Leatrice, WOODRUFF, Becky, SCORPIO, Diana, SUBBARAO, Kanta

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Evaluation of Serologic and Antigenic Relationships Between Middle Eastern Respiratory Syndrome Coronavirus and Other Coronaviruses to Develop Vaccine Platforms for the Rapid Response to Emerging Coronaviruses by Agnihothram, Sudhakar, Gopal, Robin, Yount, Boyd L., Donaldson, Eric F., Menachery, Vineet D., Graham, Rachel L., Scobey, Trevor D., Gralinski, Lisa E., Denison, Mark R., Zambon, Maria, Baric, Ralph S.

“…Background. Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012, causing severe acute respiratory disease and pneumonia, with 44% mortality…”
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Infection of Murine Macrophages by Salmonella enterica Serovar Heidelberg Blocks Murine Norovirus Infectivity and Virus-induced Apoptosis by Agnihothram, Sudhakar S, Basco, Maria D S, Mullis, Lisa, Foley, Steven L, Hart, Mark E, Sung, Kidon, Azevedo, Marli P

“…Gastroenteritis caused by bacterial and viral pathogens constitutes a major public health threat in the United States accounting for 35% of hospitalizations…”
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Author Correction: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence by Menachery, Vineet D., Yount, Boyd L., Debbink, Kari, Agnihothram, Sudhakar, Gralinski, Lisa E., Plante, Jessica A., Graham, Rachel L., Scobey, Trevor, Ge, Xing-Yi, Donaldson, Eric F., Randell, Scott H., Lanzavecchia, Antonio, Marasco, Wayne A., Shi, Zhengli-Li, Baric, Ralph S.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Role of the Stable Signal Peptide and Cytoplasmic Domain of G2 in Regulating Intracellular Transport of the Junín Virus Envelope Glycoprotein Complex by AGNIHOTHRAM, Sudhakar S, YORK, Joanne, NUNBERG, Jack H

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Bitopic Membrane Topology of the Stable Signal Peptide in the Tripartite Junín Virus GP-C Envelope Glycoprotein Complex by AGNIHOTHRAM, Sudhakar S, YORK, Joanne, TRAHEY, Meg, NUNBERG, Jack H

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