Search Results - "AGARWAL, Sandeep K"

STAT‐3 contributes to pulmonary fibrosis through epithelial injury and fibroblast‐myofibroblast differentiation by Pedroza, Mesias, Le, Thuy T., Lewis, Katherine, Karmouty‐Quintana, Harry, To, Sarah, George, Anuh T., Blackburn, Michael R., Tweardy, David J., Agarwal, Sandeep K.

“…ABSTRACT Lung fibrosis is the hallmark of the interstitial lung diseases. Alveolar epithelial cell (AEC) injury is akey step that contributes to a profibrotic…”
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Targeting type I interferons in systemic lupus erythematous by Bruera, Sebastian, Chavula, Thandiwe, Madan, Riya, Agarwal, Sandeep K

“…Systemic lupus erythematosus (SLE) is a complex autoimmune disease with systemic clinical manifestations including, but not limited to, rash, inflammatory…”
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Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride by Pedroza, Mesias, To, Sarah, Smith, Jennifer, Agarwal, Sandeep K

“…Liver fibrosis is characterized by the excessive deposition of extracellular matrix (ECM) leading to impaired function and cirrhosis. Previous reports support…”
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Cadherin-11 is a novel regulator of extracellular matrix synthesis and tissue mechanics by Row, Sindhu, Liu, Yayu, Alimperti, Stella, Agarwal, Sandeep K, Andreadis, Stelios T

“…We discovered that Cadherin-11 (CDH11) regulates collagen and elastin synthesis, both affecting the mechanical properties and contractile function of animal…”
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Targeting of cadherin-11 decreases skin fibrosis in the tight skin-1 mouse model by Pedroza, Mesias, Welschhans, Robert L, Agarwal, Sandeep K

“…Systemic sclerosis (SSc) is an autoimmune disease clinically manifesting as progressive fibrosis of the skin and internal organs. Cadherin-11 (CDH11)…”
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Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis by Le, Thanh-Thuy T, Karmouty-Quintana, Harry, Melicoff, Ernestina, Le, Thanh-Truc T, Weng, Tingting, Chen, Ning-Yuan, Pedroza, Mesias, Zhou, Yang, Davies, Jonathan, Philip, Kemly, Molina, Jose, Luo, Fayong, George, Anuh T, Garcia-Morales, Luis J, Bunge, Raquel R, Bruckner, Brian A, Loebe, Matthias, Seethamraju, Harish, Agarwal, Sandeep K, Blackburn, Michael R

“…Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease with progressive fibrosis and death within 2-3 y of diagnosis. IPF incidence and prevalence rates…”
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Cadherin-11 Regulates Macrophage Development and Function by To, Sarah, Chavula, Thandiwe, Pedroza, Mesias, Smith, Jennifer, Agarwal, Sandeep K

“…Cadherin-11 (CDH11) is a cell-cell adhesion protein that has previously been reported to play an important role in the pathogenesis of pulmonary fibrosis. It…”
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Cadherin-11 in Synovial Lining Formation and Pathology in Arthritis by Lee, David M, Kiener, Hans P, Agarwal, Sandeep K, Noss, Erika H, Watts, Gerald F.M, Chisaka, Osamu, Takeichi, Masatoshi, Brenner, Michael B

“…The normal synovium forms a membrane at the edges of joints and provides lubrication and nutrients for the cartilage. In rheumatoid arthritis, the synovium is…”
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Osteopontin in Systemic Sclerosis and Its Role in Dermal Fibrosis by Wu, Minghua, Schneider, Daniel J., Mayes, Maureen D., Assassi, Shervin, Arnett, Frank C., Tan, Filemon K., Blackburn, Michael R., Agarwal, Sandeep K.

“…Osteopontin (OPN) is a matricellular protein with proinflammatory and profibrotic properties. Previous reports demonstrate a role for OPN in wound healing and…”
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Factors influencing prescribing the first add-on disease-modifying antirheumatic drugs in patients initiating methotrexate for rheumatoid arthritis by Huang, Yinan, Chatterjee, Satabdi, Agarwal, Sandeep K., Chen, Hua, Johnson, Michael L., Aparasu, Rajender R.

“…Advances in Disease-Modifying Antirheumatic Drugs (DMARDs) have expanded the treatment landscape for Rheumatoid Arthritis (RA). Guidelines recommend adding…”
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The genetics of scleroderma (systemic sclerosis) by Agarwal, Sandeep K, Reveille, John D

“…PURPOSE OF REVIEWTo determine the advances made in the genetics of scleroderma in candidate gene association studies. RECENT FINDINGSOver the past 18 months, a…”
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Association of Interleukin 23 Receptor Polymorphisms with Anti-Topoisomerase-I Positivity and Pulmonary Hypertension in Systemic Sclerosis by AGARWAL, Sandeep K, GOURH, Pravitt, SHETE, Sanjay, PAZ, Gene, DIVECHA, Dipal, REVEILLE, John D, ASSASSI, Shervin, TAN, Filemon K, MAYES, Maureen D, ARNETT, Frank C

“…Objective. IL23R has been identified as a susceptibility gene for development of multiple autoimmune diseases. We investigated the possible association of…”
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Insights into the genetic landscape of systemic sclerosis by El-Halwagi, Ali, Agarwal, Sandeep K.

“…Systemic sclerosis (SSc) is a complex autoimmune disease that clinically manifests as progressive fibrosis of the skin and internal organs. Autoimmunity and…”
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Genetics and Genomic Studies in Scleroderma (Systemic Sclerosis) by Agarwal, Sandeep K., MD, PhD, Tan, Filemon K., MD, PhD, Arnett, Frank C., MD

“…It currently is believed that scleroderma is a complex polygenic disease that occurs in genetically predisposed individuals who have encountered specific…”
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Cadherin-11 Induces Rheumatoid Arthritis Fibroblast-Like Synoviocytes to Form Lining Layers in Vitro by Kiener, Hans P., Lee, David M., Agarwal, Sandeep K., Brenner, Michael B.

“…The synovial lining of diarthrodial joints is composed of a condensed network of synoviocytes that form an intact layer via cell-to-cell contacts with…”
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Macrophages and cadherins in fibrosis and systemic sclerosis by To, Sarah, Agarwal, Sandeep K

“…PURPOSE OF REVIEWMacrophages are key players in systemic sclerosis (SSc) and fibrosis. The mechanism by which macrophages regulate fibrogenesis is unclear and…”
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Role of STAT3 in skin fibrosis and transforming growth factor beta signalling by Pedroza, Mesias, To, Sarah, Assassi, Shervin, Wu, Minghua, Tweardy, David, Agarwal, Sandeep K

“…Abstract Objective SSc is an autoimmune disease characterized by progressive fibrosis of the skin and internal organs. IL-6 and related cytokines that signal…”
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Oral delivery of RNAi for cancer therapy by Afrin, Humayra, Geetha Bai, Renu, Kumar, Raj, Ahmad, Sheikh Shafin, Agarwal, Sandeep K., Nurunnabi, Md

“…Cancer is a major health concern worldwide and is still in a continuous surge of seeking for effective treatments. Since the discovery of RNAi and their…”
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Stress and Autoimmunity by McCray, Courtney J., MD, Agarwal, Sandeep K., MD, PhD

“…Stress reduction interventions can have a positive therapeutic effect in autoimmune disease patients. Physicians and patients must recognize the potential for…”
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Association Study of ITGAM, ITGAX, and CD58 Autoimmune Risk Loci in Systemic Sclerosis: Results from 2 Large European Caucasian Cohorts by COUSTET, Baptiste, AGARWAL, Sandeep K, LUC CRACOWSKI, Jean, TIEV, Kiet, SIBILIA, Jean, MOUTHON, Luc, FRANCES, Camille, AMOURA, Zahir, CARPENTIER, Patrick, MEYER, Olivier, KAHAN, Andre, BOILEAU, Catherine, GOURH, Pravitt, ARNETT, Frank C, ALLANORE, Yannick, GUEDJ, Mickael, MAYES, Maureen D, DIEUDE, Philippe, WIPFF, Julien, AVOUAC, Jerome, HACHULLA, Eric, DIOT, Elisabeth

“…Accumulating evidence shows that shared autoimmunity is critical for the pathogenesis of many autoimmune diseases. Systemic sclerosis (SSc) belongs to the…”
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