Search Results - "AGARWAL, Roshan"

Ovarian cancer: strategies for overcoming resistance to chemotherapy by Agarwal, Roshan, Kaye, Stan B

“…Ovarian cancer is responsible for 4% of deaths from cancer in women. Treatment comprises a combination of surgery and chemotherapy, but patients typically…”
Get full text

EMA/CO for High-Risk Gestational Trophoblastic Neoplasia: Good Outcomes With Induction Low-Dose Etoposide-Cisplatin and Genetic Analysis by ALIFRANGIS, Constantine, AGARWAL, Roshan, SHORT, Delia, FISHER, Rosemary A, SEBIRE, Neil J, HARVEY, Richard, SAVAGE, Philip M, SECKL, Michael J

“…Patients with high-risk (International Federation of Gynecology and Obstetrics score ≥ 7) gestational trophoblastic neoplasia (GTN) frequently receive…”
Get full text

Mechanisms of transcoelomic metastasis in ovarian cancer by Tan, David S P, Agarwal, Roshan, Kaye, Stanley B

“…Metastasis from epithelial ovarian cancer can occur via the transcoelomic, haematogeneous, or lymphatic route. Of these, transcoelomic metastasis is the most…”
Get more information

Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics by HENNESSY, Bryan T, GONZALEZ-ANGULO, Ana-Maria, WENBIN LIU, STIVERS, David, BAGGERLY, Keith, CAREY, Mark, LLUCH, Ana, MONTEAGUDO, Carlos, XIAPING HE, WEIGMAN, Victor, CHENG FAN, PALAZZO, Juan, STEMKE-HALE, Katherine, HORTOBAGYI, Gabriel N, NOLDEN, Laura K, WANG, Nicholas J, VALERO, Vicente, GRAY, Joe W, PEROU, Charles M, MILLS, Gordon B, GILCREASE, Michael Z, KRISHNAMURTHY, Savitri, LEE, Ju-Seog, FRIDLYAND, Jane, SAHIN, Aysegul, AGARWAL, Roshan, JOY, Corwin

“…Metaplastic breast cancers (MBC) are aggressive, chemoresistant tumors characterized by lineage plasticity. To advance understanding of their pathogenesis and…”
Get full text

Venous access devices for the delivery of long-term chemotherapy: the CAVA three-arm RCT by Wu, Olivia, McCartney, Elaine, Heggie, Robert, Germeni, Evi, Paul, James, Soulis, Eileen, Dillon, Susan, Ryan, Caoimhe, Sim, Moira, Dixon-Hughes, Judith, Agarwal, Roshan, Bodenham, Andrew, Menne, Tobias, Jones, Brian, Moss, Jonathan

“…Venous access devices are used for patients receiving long-term chemotherapy. These include centrally inserted tunnelled catheters or Hickman-type devices…”
Get full text

DNA-PK Mediates AKT Activation and Apoptosis Inhibition in Clinically Acquired Platinum Resistance by Stronach, Euan A, Chen, Michelle, Maginn, Elaina N, Agarwal, Roshan, Mills, Gordon B, Wasan, Harpreet, Gabra, Hani

“…Abstract Clinical resistance to chemotherapy is a frequent event in cancer treatment and is closely linked to poor outcome. High-grade serous (HGS) ovarian…”
Get full text

Chemotherapy and human chorionic gonadotropin concentrations 6 months after uterine evacuation of molar pregnancy: a retrospective cohort study by Agarwal, Roshan, MRCP, Teoh, Suliana, MRCP, Short, Delia, BSc, Harvey, Richard, PhD, Savage, Philip M, FRCP, Seckl, Michael J, Prof

“…Summary Background Indications for chemotherapy in gestational trophoblastic disease include raised human chorionic gonadotropin (hCG) concentrations 6 months…”
Get full text

Androgen Receptor Levels and Association with PIK3CA Mutations and Prognosis in Breast Cancer by GONZALEZ-ANGULO, Ana M, STEMKE-HALE, Katherine, MILLS, Gordon B, HENNESSY, Bryan T, PALLA, Shana L, CAREY, Mark, AGARWAL, Roshan, MERIC-BERSTAM, Funda, TRAINA, TiffanyA, HUDIS, Clifford, HORTOBAGYI, Gabriel N, GERALD, William L

“…Purpose: To examine the androgen receptor (AR) levels in breast cancer and to assess the impact of AR expression on patient outcomes. Experimental Design:…”
Get full text

Prognostic markers and long-term outcome of placental-site trophoblastic tumours: a retrospective observational study by Schmid, Peter, Dr, Nagai, Yutaka, MD, Agarwal, Roshan, MRCP, Hancock, Barry, Prof, Savage, Philip M, FRCP, Sebire, Neil J, FRCPath, Lindsay, Iain, FRCPath, Wells, Michael, Prof, Fisher, Rosemary A, PhD, Short, Delia, Newlands, Edward S, Prof, Wischnewsky, Manfred B, Prof, Seckl, Michael J, Prof

“…Summary Background Placental-site trophoblastic tumours are a rare form of gestational trophoblastic disease and consequently information about optimum…”
Get full text

Emerging Role of the RAB25 Small GTPase in Cancer by Agarwal, Roshan, Jurisica, Igor, Mills, Gordon B, Cheng, Kwai Wa

“…RAB25, a member of the rat sarcoma (RAS) family of small GTPase, has been implicated in the pathophysiology of ovarian, breast and other cancers. Its role in…”
Get full text

Central Giant Cell Granuloma of the Mandible: A Case Report by Desai, Ojas V, Kshirsagar, Rajesh, Singh, Vikram, Nair, Vivek S, Sane, Vikrant, Jain, Saurabh, Agarwal, Roshan

“…This article presents a clinical case of a central giant cell granuloma (CGCG) resembling a periapical lesion of endodontic origin. A 39-year-old, otherwise…”
Get full text

Integrative Analysis of Cyclin Protein Levels Identifies Cyclin B1 as a Classifier and Predictor of Outcomes in Breast Cancer by AGARWAL, Roshan, GONZALEZ-ANGULO, Ana-Maria, WEN LIN KUO, SORLIE, Therese, SAHIN, Aysegul, VALERO, Vicente, KEYOMARSI, Khandan, GRAY, Joe W, BORRESEN-DALE, Anne-Lise, MILLS, Gordon B, HENNESSY, Bryan T, MYHRE, Simen, CAREY, Mark, LEE, Ju-Seog, OVERGAARD, Jens, ALSNER, Jan, STEMKE-HALE, Katherine, LLUCH, Ana, NEVE, Richard M

“…Purpose: We studied the expression levels of cyclins B1, D1, and E1 and the implications of cyclin overexpression for patient outcomes in distinct breast…”
Get full text

Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers by Hennessy, Bryan T, Lu, Yiling, Gonzalez-Angulo, Ana Maria, Carey, Mark S, Myhre, Simen, Ju, Zhenlin, Davies, Michael A, Liu, Wenbin, Coombes, Kevin, Meric-Bernstam, Funda, Bedrosian, Isabelle, McGahren, Mollianne, Agarwal, Roshan, Zhang, Fan, Overgaard, Jens, Alsner, Jan, Neve, Richard M, Kuo, Wen-Lin, Gray, Joe W, Borresen-Dale, Anne-Lise, Mills, Gordon B

“…Introduction The lack of large panels of validated antibodies, tissue handling variability, and intratumoral heterogeneity potentially hamper comprehensive…”
Get full text

Autotaxin delays apoptosis induced by carboplatin in ovarian cancer cells by Vidot, Susanne, Witham, James, Agarwal, Roshan, Greenhough, Sebastian, Bamrah, Harnoor S., Tigyi, Gabor J., Kaye, Stanley B., Richardson, Alan

“…Drug resistance remains a barrier to the effective long term treatment of ovarian cancer. We have established an RNAi-based screen to identify genes which…”
Get full text

Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set by Park, Eun Sung, Rabinovsky, Rosalia, Carey, Mark, Hennessy, Bryan T, Agarwal, Roshan, Liu, Wenbin, Ju, Zhenlin, Deng, Wanleng, Lu, Yiling, Woo, Hyun Goo, Kim, Sang-Bae, Cheong, Jae-Ho, Garraway, Levi A, Weinstein, John N, Mills, Gordon B, Lee, Ju-Seog, Davies, Michael A

“…Aberrations in oncogenes and tumor suppressors frequently affect the activity of critical signal transduction pathways. To analyze systematically the…”
Get full text

Malignant Ovarian Germ Cell Tumors: Identification of Novel Prognostic Markers and Long-Term Outcome After Multimodality Treatment by MURUGAESU, Nirupa, SCHMID, Peter, DANCEY, Gairin, AGARWAL, Roshan, HOLDEN, Lydia, MCNEISH, Lain, SAVAGE, Philip M, NEWLANDS, Edward S, RUSTIN, Gordon J. S, SECKL, Michael J

“…Malignant ovarian germ cell tumors are rare and knowledge about prognostic parameters currently is limited. This study was undertaken to evaluate long-term…”
Get full text

The OPCML tumor suppressor functions as a cell surface repressor-adaptor, negatively regulating receptor tyrosine kinases in epithelial ovarian cancer by McKie, Arthur B, Vaughan, Sebastian, Zanini, Elisa, Okon, Imoh S, Louis, Louay, de Sousa, Camila, Greene, Mark I, Wang, Qiang, Agarwal, Roshan, Shaposhnikov, Dmitry, Wong, Joshua L C, Gungor, Hatice, Janczar, Szymon, El-Bahrawy, Mona, Lam, Eric W-F, Chayen, Naomi E, Gabra, Hani

“…Epithelial ovarian cancer is the leading cause of death from gynecologic malignancy, and its molecular basis is poorly understood. We previously demonstrated…”
Get more information

Eligibility of patients with brain metastases for phase I trials: time for a rethink? by Carden, Craig P, FRACP, Agarwal, Roshan, MRCP, Saran, Frank, Prof, Judson, Ian R, Prof

“…Summary Since the inception of phase I clinical trials in cancer, patients with symptomatic brain metastases have commonly been excluded from participation…”
Get full text

Transient ectopic expression as a method to detect genes conferring drug resistance by Witham, James, Vidot, Susanne, Agarwal, Roshan, Kaye, Stanley B., Richardson, Alan

“…Ectopic expression provides an alternative to RNAi to conduct functional genomic screens. We have determined whether transient expression can be used to…”
Get full text

An Association of Cancer Physicians' strategy for improving services and outcomes for cancer patients by Baird, Richard, Banks, Ian, Cameron, David, Chester, John, Earl, Helena, Flannagan, Mark, Januszewski, Adam, Kennedy, Richard, Payne, Sarah, Samuel, Emlyn, Taylor, Hannah, Agarwal, Roshan, Ahmed, Samreen, Archer, Caroline, Board, Ruth, Carser, Judith, Copson, Ellen, Cunningham, David, Coleman, Rob, Dangoor, Adam, Dark, Graham, Eccles, Diana, Gallagher, Chris, Glaser, Adam, Griffiths, Richard, Hall, Geoff, Hall, Marcia, Harari, Danielle, Hawkins, Michael, Hill, Mark, Johnson, Peter, Jones, Alison, Kalsi, Tania, Karapanagiotou, Eleni, Kemp, Zoe, Mansi, Janine, Marshall, Ernie, Mitchell, Alex, Moe, Maung, Michie, Caroline, Neal, Richard, Newsom-Davis, Tom, Norton, Alison, Osborne, Richard, Patel, Gargi, Radford, John, Ring, Alistair, Shaw, Emily, Skinner, Rod, Stark, Dan, Turnbull, Sam, Velikova, Galina, White, Jeff, Young, Alison, Joffe, Johnathan, Selby, Peter

“…The Association of Cancer Physicians in the United Kingdom has developed a strategy to improve outcomes for cancer patients and identified the goals and…”
Get full text