Search Results - "AGARAM, Narasimhan P"

MYOD1-mutant spindle cell and sclerosing rhabdomyosarcoma: an aggressive subtype irrespective of age. A reappraisal for molecular classification and risk stratification by Agaram, Narasimhan P., LaQuaglia, Michael P., Alaggio, Rita, Zhang, Lei, Fujisawa, Yumi, Ladanyi, Marc, Wexler, Leonard H., Antonescu, Cristina R.

“…Sclerosing and spindle cell rhabdomyosarcoma is a rare histologic subtype, designated in the latest WHO classification as a stand-alone pathologic entity…”
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Recurrent NTRK1 Gene Fusions Define a Novel Subset of Locally Aggressive Lipofibromatosis-like Neural Tumors by Agaram, Narasimhan P, Zhang, Lei, Sung, Yun-Shao, Chen, Chun-Liang, Chung, Catherine T, Antonescu, Cristina R, Fletcher, Christopher DM

“…The family of pediatric fibroblastic and myofibroblastic proliferations encompasses a wide spectrum of pathologic entities with overlapping morphologies and…”
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Histology-based Classification Predicts Pattern of Recurrence and Improves Risk Stratification in Primary Retroperitoneal Sarcoma by Tan, Marcus C B, Brennan, Murray F, Kuk, Deborah, Agaram, Narasimhan P, Antonescu, Cristina R, Qin, Li-Xuan, Moraco, Nicole, Crago, Aimee M, Singer, Samuel

“…OBJECTIVE:To determine the prognostic significance of histologic type/subtype in a large series of patients with primary resected retroperitoneal sarcoma…”
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Prognostic stratification of clinical and molecular epithelioid hemangioendothelioma subsets by Rosenbaum, Evan, Jadeja, Bhumika, Xu, Bin, Zhang, Lei, Agaram, Narasimhan P., Travis, William, Singer, Samuel, Tap, William D., Antonescu, Cristina R.

“…Epithelioid hemangioendothelioma is a low-grade malignant vascular tumor with an intermediate clinical behavior between benign hemangiomas and high-grade…”
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Prevalence of tumor-infiltrating lymphocytes and PD-L1 expression in the soft tissue sarcoma microenvironment by D’Angelo, Sandra P., MD, Shoushtari, Alexander N., MD, Agaram, Narasimhan P., MD, Kuk, Deborah, Qin, Li-Xuan, PhD, Carvajal, Richard D., MD, Dickson, Mark A., MD, Gounder, Mrinal, MD, Keohan, Mary Louise, MD, Schwartz, Gary K., MD, Tap, William D., MD

“…Summary The prognostic and predictive implications of programmed death-ligand 1 (PD-L1) is unknown in sarcoma. We sought to examine the immune milieu in…”
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Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets by Nacev, Benjamin A., Sanchez-Vega, Francisco, Smith, Shaleigh A., Antonescu, Cristina R., Rosenbaum, Evan, Shi, Hongyu, Tang, Cerise, Socci, Nicholas D., Rana, Satshil, Gularte-Mérida, Rodrigo, Zehir, Ahmet, Gounder, Mrinal M., Bowler, Timothy G., Luthra, Anisha, Jadeja, Bhumika, Okada, Azusa, Strong, Jonathan A., Stoller, Jake, Chan, Jason E., Chi, Ping, D’Angelo, Sandra P., Dickson, Mark A., Kelly, Ciara M., Keohan, Mary Louise, Movva, Sujana, Thornton, Katherine, Meyers, Paul A., Wexler, Leonard H., Slotkin, Emily K., Glade Bender, Julia L., Shukla, Neerav N., Hensley, Martee L., Healey, John H., La Quaglia, Michael P., Alektiar, Kaled M., Crago, Aimee M., Yoon, Sam S., Untch, Brian R., Chiang, Sarah, Agaram, Narasimhan P., Hameed, Meera R., Berger, Michael F., Solit, David B., Schultz, Nikolaus, Ladanyi, Marc, Singer, Samuel, Tap, William D.

“…The genetic, biologic, and clinical heterogeneity of sarcomas poses a challenge for the identification of therapeutic targets, clinical research, and advancing…”
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Head and Neck Mesenchymal Tumors with Kinase Fusions: A Report of 15 Cases With Emphasis on Wide Anatomic Distribution and Diverse Histologic Appearance by Xu, Bin, Suurmeijer, Albert J.H., Agaram, Narasimhan P., Antonescu, Cristina R.

“…Mesenchymal tumors harboring various kinase fusions were recently recognized as emerging entities mainly in the soft tissues. We herein investigate the…”
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Validation of a digital pathology system including remote review during the COVID-19 pandemic by Hanna, Matthew G., Reuter, Victor E., Ardon, Orly, Kim, David, Sirintrapun, Sahussapont Joseph, Schüffler, Peter J., Busam, Klaus J., Sauter, Jennifer L., Brogi, Edi, Tan, Lee K., Xu, Bin, Bale, Tejus, Agaram, Narasimhan P., Tang, Laura H., Ellenson, Lora H., Philip, John, Corsale, Lorraine, Stamelos, Evangelos, Friedlander, Maria A., Ntiamoah, Peter, Labasin, Marc, England, Christine, Klimstra, David S., Hameed, Meera

“…Remote digital pathology allows healthcare systems to maintain pathology operations during public health emergencies. Existing Clinical Laboratory Improvement…”
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Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma by Gounder, Mrinal M., Agaram, Narasimhan P., Trabucco, Sally E., Robinson, Victoria, Ferraro, Richard A., Millis, Sherri Z., Krishnan, Anita, Lee, Jessica, Attia, Steven, Abida, Wassim, Drilon, Alexander, Chi, Ping, Angelo, Sandra P. D’, Dickson, Mark A., Keohan, Mary Lou, Kelly, Ciara M., Agulnik, Mark, Chawla, Sant P., Choy, Edwin, Chugh, Rashmi, Meyer, Christian F., Myer, Parvathi A., Moore, Jessica L., Okimoto, Ross A., Pollock, Raphael E., Ravi, Vinod, Singh, Arun S., Somaiah, Neeta, Wagner, Andrew J., Healey, John H., Frampton, Garrett M., Venstrom, Jeffrey M., Ross, Jeffrey S., Ladanyi, Marc, Singer, Samuel, Brennan, Murray F., Schwartz, Gary K., Lazar, Alexander J., Thomas, David M., Maki, Robert G., Tap, William D., Ali, Siraj M., Jin, Dexter X.

“…There are more than 70 distinct sarcomas, and this diversity complicates the development of precision-based therapeutics for these cancers. Prospective…”
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Soft tissue tumors characterized by a wide spectrum of kinase fusions share a lipofibromatosis‐like neural tumor pattern by Kao, Yu‐Chien, Suurmeijer, Albert J. H., Argani, Pedram, Dickson, Brendan C., Zhang, Lei, Sung, Yun‐Shao, Agaram, Narasimhan P, Fletcher, Christopher D. M., Antonescu, Cristina R.

“…Gene fusions resulting in oncogenic activation of various receptor tyrosine kinases, including NTRK1‐3, ALK, and RET, have been increasingly recognized in soft…”
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Recurrent YAP1 and KMT2A Gene Rearrangements in a Subset of MUC4-negative Sclerosing Epithelioid Fibrosarcoma by Kao, Yu-Chien, Lee, Jen-Chieh, Zhang, Lei, Sung, Yun-Shao, Swanson, David, Hsieh, Tsung-Han, Liu, Yun-Ru, Agaram, Narasimhan P., Huang, Hsuan-Ying, Dickson, Brendan C., Antonescu, Cristina R.

“…Sclerosing epithelioid fibrosarcoma (SEF) is an aggressive soft tissue sarcoma, characterized by a distinctive epithelioid phenotype in a densely sclerotic…”
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Recurrent MYOD1 mutations in pediatric and adult sclerosing and spindle cell rhabdomyosarcomas: Evidence for a common pathogenesis by Agaram, Narasimhan P., Chen, Chun-Liang, Zhang, Lei, LaQuaglia, Michael P., Wexler, Leonard, Antonescu, Cristina R.

“…Sclerosing and spindle cell rhabdomyosarcoma (RMS) are rare types of RMS recently reclassified as a stand‐alone pathologic entity, separate from embryonal RMS…”
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Malignant peripheral nerve sheath tumor in children: A clinicopathologic and molecular study with parallels to the adult counterpart by Agaram, Narasimhan P., Wexler, Leonard H., Chi, Ping, Antonescu, Cristina R.

“…Malignant peripheral nerve sheath tumors (MPNST) are aggressive neoplasms, arising either sporadically, in the setting of neurofibromatosis type I (NF1) or…”
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Predictors of Survival and Recurrence in Primary Leiomyosarcoma by Gladdy, Rebecca A., Qin, Li-Xuan, Moraco, Nicole, Agaram, Narasimhan P., Brennan, Murray F., Singer, Samuel

“…Background Leiomyosarcoma is a soft tissue sarcoma whose outcome has historically been confounded by the inclusion of gastrointestinal stromal tumors. Thus, we…”
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Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma by D’Angelo, Sandra P., Richards, Allison L., Conley, Anthony P., Woo, Hyung Jun, Dickson, Mark A., Gounder, Mrinal, Kelly, Ciara, Keohan, Mary Louise, Movva, Sujana, Thornton, Katherine, Rosenbaum, Evan, Chi, Ping, Nacev, Benjamin, Chan, Jason E., Slotkin, Emily K., Kiesler, Hannah, Adamson, Travis, Ling, Lilan, Rao, Pavitra, Patel, Shreyaskumar, Livingston, Jonathan A., Singer, Samuel, Agaram, Narasimhan P., Antonescu, Cristina R., Koff, Andrew, Erinjeri, Joseph P., Hwang, Sinchun, Qin, Li-Xuan, Donoghue, Mark T. A., Tap, William D.

“…PD-1 blockade (nivolumab) efficacy remains modest for metastatic sarcoma. In this paper, we present an open-label, non-randomized, non-comparative pilot study…”
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Extraskeletal myxoid chondrosarcoma with non– EWSR1 - NR4A3 variant fusions correlate with rhabdoid phenotype and high-grade morphology by Agaram, Narasimhan P., MBBS, Zhang, Lei, Sung, Yun-Shao, Singer, Samuel, MD, Antonescu, Cristina R., MD

“…Summary Extraskeletal myxoid chondrosarcomas (EMC) are rare soft tissue sarcomas with distinctive histology and uncertain histogenesis, characterized by Ewing…”
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A genetic dichotomy between pure sclerosing epithelioid fibrosarcoma (SEF) and hybrid SEF/low-grade fibromyxoid sarcoma: A pathologic and molecular study of 18 cases by Prieto-Granada, Carlos, Zhang, Lei, Chen, Hsiao-Wei, Sung, Yun-Shao, Agaram, Narasimhan P, Jungbluth, Achim A, Antonescu, Cristina R

“…Sclerosing epithelioid fibrosarcoma (SEF) is a rare soft tissue tumor exhibiting considerable morphologic overlap with low‐grade fibromyxoid sarcoma (LGFMS)…”
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Rb and p53-Deficient Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma Require Skp2 for Survival by Li, George Z, Okada, Tomoyo, Kim, Young-Mi, Agaram, Narasimhan P, Sanchez-Vega, Francisco, Shen, Yawei, Tsubokawa, Norifumi, Rios, Jordan, Martin, Axel S, Dickson, Mark A, Qin, Li-Xuan, Socci, Nicholas D, Singer, Samuel

“…Myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) are highly genetically complex soft tissue sarcomas. Up to 50% of patients develop…”
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KDR Activating Mutations in Human Angiosarcomas Are Sensitive to Specific Kinase Inhibitors by ANTONESCU, Cristina R, YOSHIDA, Akihiko, TIANHUO GUO, CHANG, Ning-En, LEI ZHANG, AGARAM, Narasimhan P, QIN, Li-Xuan, BRENNAN, Murray F, SINGER, Samuel, MAKI, Robert G

“…Angiosarcomas (AS) represent a heterogeneous group of malignant vascular tumors occurring not only in different anatomic locations but also in distinct…”
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Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors by Agaram, Narasimhan P., Wong, Grace C., Guo, Tianhua, Maki, Robert G., Singer, Samuel, DeMatteo, Ronald P., Besmer, Peter, Antonescu, Cristina R.

“…BRAF and NRAS are commonly mutated in cancer and represent the most frequent genetic events in malignant melanoma. More recently, a subset of melanomas was…”
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