Search Results - "AGADJANYAN, M. G"

DNA prime-protein boost increased the titer, avidity and persistence of anti-Aβ antibodies in wild-type mice by Davtyan, H, Mkrtichyan, M, Movsesyan, N, Petrushina, I, Mamikonyan, G, Cribbs, D H, Agadjanyan, M G, Ghochikyan, A

“…Recently, we reported that a DNA vaccine, composed of three copies of a self B cell epitope of amyloid-β (Aβ 42 ) and the foreign T-cell epitope, Pan DR…”
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DNA, but not protein vaccine based on mutated BORIS antigen significantly inhibits tumor growth and prolongs the survival of mice by Mkrtichyan, M, Ghochikyan, A, Loukinov, D, Davtyan, H, Ichim, T E, Cribbs, D H, Lobanenkov, V V, Agadjanyan, M G

“…The ideal immunological target for cancer vaccine development would meet the criteria of tumor specificity, immunogenicity and vital dependency of the tumor on…”
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Active immunization with tau epitope in a mouse model of tauopathy induced strong antibody response together with improvement in short memory and pSer396-tau pathology by Joly-Amado, A., Davtyan, H., Serraneau, K., Jules, P., Zitnyar, A., Pressman, E., Zagorski, K., Antonyan, T., Hovakimyan, A., Paek, H.J., Gordon, M.N., Cribbs, D.H., Petrovsky, N., Agadjanyan, M.G., Ghochikyan, A., Morgan, D.

“…Abnormal tau hyperphosphorylation and its aggregation into neurofibrillary tangles are a hallmark of tauopathies, neurodegenerative disorders that include…”
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Inflammatory changes parallel the early stages of Alzheimer disease by Parachikova, A, Agadjanyan, M.G, Cribbs, D.H, Blurton-Jones, M, Perreau, V, Rogers, J, Beach, T.G, Cotman, C.W

“…Abstract Alzheimer disease (AD) is the most prominent cause of dementia in the elderly. To determine changes in the AD brain that may mediate the transition…”
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Gene Inoculation Generates Immune Responses Against Human Immunodeficiency Virus Type 1 by Wang, Bin, Ugen, Kenneth E., Srikantan, Vasantha, Agadjanyan, Michael G., Dang, Kesen, Refaeli, Yosef, Sato, Alice I., Boyer, Jean, Williams, William V., Weiner, David B.

“…Recently, immunization techniques in which DNA constructs are introduced directly into mammalian tissue in vivo have been developed. In theory, gene…”
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Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes by Kim, Jong J., Nottingham, Liesl K., Wilson, Darren M., Bagarazzi, Mark L., Tsai, Anthony, Morrison, Lake D., Javadian, Ali, Chalian, Ara A., Agadjanyan, Michael G., Weiner, David B.

“…DNA immunization has been investigated as a potential immunization strategy against infectious diseases and cancer. To enhance a DNA vaccine's ability to…”
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Mucosal immunization with a DNA vaccine induces immune responses against HIV-1 at a mucosal site by Wang, Bin, Dang, Kesen, Agadjanyan, Michael G., Srikantans, Vasantha, Li, Feng, Ugen, Kenneth E., Boyer, Jean, Merva, Michael, Williams, William V., Weiner, David B.

“…Mucosal immunity is the first defense system in protection against mucosal infection by sexually transmitted diseases and subsequent systemic dissemination of…”
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Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes by Kirn, Jong J, Bagarazzi, Mark L, Trivedi, Neil, Hu, Yin, Kazahaya, Ken, Wilson, Darren M, Ciccarelli, Richard, Chattergoon, Michael A, Dang, Kesan, Mahalingam, Sundarasamy, Chalian, Ara A, Agadjanyan, Michael G, Boyer, Jean D, Wang, Bin, Weiner, David B

“…Nucleic acid immunization is a novel vaccination technique to induce antigen-specific immune responses. We have developed expression cassettes for cell surface…”
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Macrophage colony-stimulating factor can modulate immune responses and attract dendritic cells in vivo by Kim, J J, Yang, J S, Lee, D J, Wilson, D M, Nottingham, L K, Morrison, L, Tsai, A, Oh, J, Dang, K, Dentchev, T, Agadjanyan, M G, Sin, J I, Chalian, A A, Weiner, D B

“…Studies have indicated that professional APCs in the periphery, such as dendritic cells and macrophages, play an important role in initiating DNA…”
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CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines by Kim, J J, Nottingham, L K, Sin, J I, Tsai, A, Morrison, L, Oh, J, Dang, K, Hu, Y, Kazahaya, K, Bennett, M, Dentchev, T, Wilson, D M, Chalian, A A, Boyer, J D, Agadjanyan, M G, Weiner, D B

“…The potential roles of CD8(+) T-cell-induced chemokines in the expansion of immune responses were examined using DNA immunogen constructs as model antigens. We…”
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An HIV type 2 DNA vaccine induces cross-reactive immune responses against HIV type 2 and SIV by Agadjanyan, M G, Trivedi, N N, Kudchodkar, S, Bennett, M, Levine, W, Lin, A, Boyer, J, Levy, D, Ugen, K E, Kim, J J, Weiner, D B

“…We have previously reported on the generation of specific functional immune responses after inoculation of animals with expression vectors encoding HIV-1…”
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Nucleic acid immunization of chimpanzees as a prophylactic/immunotherapeutic vaccination model for HIV-1: prelude to a clinical trial by Ugen, Kenneth E., Boyer, Jean D., Wang, Bin, Bagarazzi, Mark, Javadian, Ali, Frost, Pat, Merva, Michael M., Agadjanyan, Michael G., Nyland, Susan, Williams, William V., Coney, Leslie, Ciccarelli, Richard, Weiner, David B.

“…Vaccine development strategies have often utilized recombinant envelope glycoproteins which usually generate strong humoral immune responses but which do not…”
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Modulation of amplitude and direction of in vivo immune responses by co‐administration of cytokine gene expression cassettes with DNA immunogens by Kim, Jong J., Trivedi, Neil N., Nottingham, Liesl K., Morrison, Lake, Tsai, Anthony, Hu, Yin, Mahalingam, Sundarasamy, Dang, Kesen, Ahn, Lois, Doyle, Nicole K., Wilson, Darren M., Chattergoon, Michael A., Chalian, Ara A., Boyer, Jean D., Agadjanyan, Michael G., Weiner, David B.

“…Immunization with nucleic acids has been shown to induce both antigen‐specific cellular and humoral immune responses in vivo. We hypothesize that immunization…”
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Generation and characterization of the humoral immune response to DNA immunization with a chimeric β‐amyloid‐interleukin‐4 minigene by Ghochikyan, Anahit, Vasilevko, Vitaly, Petrushina, Irina, Movsesyan, Nina, Babikyan, Davit, Tian, Wenqiang, Sadzikava, Nadya, Ross, Ted M., Head, Elizabeth, Cribbs, David H., Agadjanyan, Michael G.

“…Active immunization with fibrillar β–amyloid peptide (Aβ42) as well as passive transfer of anti‐Aβ antibodies significantly reduces Aβ plaque deposition,…”
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Identification of an 80-kilodalton membrane glycoprotein important for human T-cell leukemia virus type I and type II syncytium formation and infection by Agadjanyan, M G, Ugen, K E, Wang, B, Williams, W V, Weiner, D B

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Importance of IgG2c isotype in the immune response to β-amyloid in amyloid precursor protein/transgenic mice by Petrushina, Irina, Tran, Mike, Sadzikava, Nadya, Ghochikyan, Anahit, Vasilevko, Vitaly, Agadjanyan, Michael G., Cribbs, David H.

“…A careful analysis of the immune response to immunization of amyloid precursor protein/transgenic (APP/Tg) mice with β-amyloid (Aβ) may provide insights into…”
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Molecular cloning, expression, and biological characterization of an HTLV-II envelope glycoprotein: HIV-1 expression is permissive for HTLV-II-induced cell fusion by Wang, B, Agadjanyan, M G, Srikantan, V, Ugen, K E, Hall, W, Kaplan, M H, Dang, K, Williams, W V, Weiner, D B

“…The human T cell leukemia virus II (HTLV-II) is a type C retrovirus closely related to the human transforming retrovirus HTLV-I. In contrast to HTLV-I, the…”
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Cytokine molecular adjuvants modulate immune responses induced by DNA vaccine constructs for HIV-1 and SIV by Kim, J J, Simbiri, K A, Sin, J I, Dang, K, Oh, J, Dentchev, T, Lee, D, Nottingham, L K, Chalian, A A, McCallus, D, Ciccarelli, R, Agadjanyan, M G, Weiner, D B

“…DNA or nucleic acid immunization has been shown to induce both antigen-specific cellular and humoral immune responses in vivo. Moreover, immune responses…”
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CD86 (B7-2) Can Function to Drive MHC-Restricted Antigen-Specific CTL Responses In Vivo by Agadjanyan, Michael G, Kim, Jong J, Trivedi, Neil, Wilson, Darren M, Monzavi-Karbassi, Behjatolah, Morrison, Lake D, Nottingham, Liesl K, Dentchev, Tzvete, Tsai, Anthony, Dang, Kesen, Chalian, Ara A, Maldonado, Michael A, Williams, William V, Weiner, David B

“…Activation of T cells requires both TCR-specific ligation by direct contact with peptide Ag-MHC complexes and coligation of the B7 family of ligands through…”
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Mimotopes of conformational epitopes in fibrillar β-amyloid by Gevorkian, Goar, Petrushina, Irina, Manoutcharian, Karen, Ghochikyan, Anahit, Acero, Gonzalo, Vasilevko, Vitaly, Cribbs, David H., Agadjanyan, Michael G.

“…In Alzheimer's disease (AD) β-amyloid peptide accumulates in the brain in different forms including fibrils. Amyloid fibrils could be recognized as foreign by…”
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