Search Results - "AFIONE, S"

AAV2-mediated transfer of the human aquaporin-1 cDNA restores fluid secretion from irradiated miniature pig parotid glands by Gao, R, Yan, X, Zheng, C, Goldsmith, C M, Afione, S, Hai, B, Xu, J, Zhou, J, Zhang, C, Chiorini, J A, Baum, B J, Wang, S

“…Previously (Shan et al , 2005), we reported that adenoviral vector-mediated transfer of the human aquaporin-1 (hAQP1) cDNA to minipig parotid glands following…”
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Effect of human vasoactive intestinal peptide gene transfer in a murine model of Sjögren’s syndrome by Lodde, B M, Mineshiba, F, Wang, J, Cotrim, A P, Afione, S, Tak, P P, Baum, B J

“…Background: Sjögren’s syndrome (SS), an autoimmune exocrinopathy mainly affecting lachrymal and salivary glands, results in ocular and oral dryness…”
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Stable in vivo Expression of the Cystic Fibrosis Transmembrane Conductance Regulator with an Adeno-Associated Virus Vector by Flotte, Terence R., Afione, Sandra A., Conrad, Carol, McGarth, Sharon A., Solow, Rikki, Oka, Hidemi, Zeitlin, Pamela L., Guggino, William B., Carter, Barrie J.

“…Adeno-associated virus (AAV) vectors expressing the normal cystic fibrosis transmembrane conductance regulator (CFTR) cDNA complement the cystic fibrosis (CF)…”
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Safety of single-dose administration of an adeno-associated virus (AAV)-CFTR vector in the primate lung by Conrad, C K, Allen, S S, Afione, S A, Reynolds, T C, Beck, S E, Fee-Maki, M, Barrazza-Ortiz, X, Adams, R, Askin, F B, Carter, B J, Guggino, W B, Flotte, T R

“…Gene therapy for cystic fibrosis (CF) would ideally be accomplished with a vector capable of long-term expression of the cystic fibrosis transmembrane…”
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Adeno-Associated Virus Type 2 Rep78 Induces Apoptosis through Caspase Activation Independently of p53 by Schmidt, M, Afione, S, Kotin, R M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Adeno-associated virus vector gene expression occurs in nondividing cells in the absence of vector DNA integration by Flotte, T R, Afione, S A, Zeitlin, P L

“…Adeno-associated virus type 2 (AAV2)-based vectors are capable of stable expression in the airway epithelium and may be useful for gene therapy for human…”
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Recombinant adeno-associated virus (AAV-CFTR) vectors do not integrate in a site-specific fashion in an immortalized epithelial cell line by Kearns, W G, Afione, S A, Fulmer, S B, Pang, M C, Erikson, D, Egan, M, Landrum, M J, Flotte, T R, Cutting, G R

“…Adeno-associated virus-2 (AAV) can integrate in a site-specific manner to human chromosome 19 and is currently in phase I clinical trials for cystic fibrosis…”
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AAV5-mediated gene transfer to the parotid glands of non-human primates by Voutetakis, A, Zheng, C, Cotrim, A P, Mineshiba, F, Afione, S, Roescher, N, Swaim, W D, Metzger, M, Eckhaus, M A, Donahue, R E, Dunbar, C E, Chiorini, J A, Baum, B J

“…Salivary glands are potentially useful target sites for multiple clinical applications of gene transfer. Previously, we have shown that serotype 2…”
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Enhanced transduction of mouse salivary glands with AAV5-based vectors by KATANO, H, KOK, M. R, COTRIM, A. P, YAMANO, S, SCHMIDT, M, AFIONE, S, BAU M, B. J, CHIORINI, J. A

“…We previously demonstrated that recombinant adeno-associated virus vectors based on serotype 2 (rAAV2) can direct transgene expression in salivary gland cells…”
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Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter by FLOTTE, T. R, AFIONE, S. A, SOLOW, R, DRUMM, M. L, MARKAKIS, D, GUGGINO, W. B, ZEITLIN, P. L, CARTER, B. J

“…Adeno-associated virus type 2 (AAV) vectors have been used for gene expression in respiratory epithelial cells and may be useful in gene therapy for diseases…”
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In vivo model of adeno-associated virus vector persistence and rescue by Afione, S A, Conrad, C K, Kearns, W G, Chunduru, S, Adams, R, Reynolds, T C, Guggino, W B, Cutting, G R, Carter, B J, Flotte, T R

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Gender differences in serotype 2 adeno-associated virus biodistribution after administration to rodent salivary glands by Voutetakis, A, Zheng, C, Wang, J, Goldsmith, C M, Afione, S, Chiorini, J A, Wenk, M L, Vallant, M, Irwin, R D, Baum, B J

“…Salivary glands (SGs) have proven useful targets for clinical applications of gene therapeutics. In this toxicology and biodistribution study, which conforms…”
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Evaluation of a rapamycin-regulated serotype 2 adeno-associated viral vector in macaque parotid glands by Zheng, C, Voutetakis, A, Metzger, M, Afione, S, Cotrim, AP, Eckhaus, MA, Rivera, VM, Clackson, T, Chiorini, JA, Donahue, RE, Dunbar, CE, Baum, BJ

“…Oral Diseases (2010) 16, 269–277 Objectives:  Salivary glands are useful target organs for local and systemic gene therapeutics. For such applications, the…”
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674. Administration of rAAV2 and rAAV5 to the Parotid Gland of Non-Human Primates by Voutetakis, A., Zheng, C., Chiorini, J.A., Schmidt, M., Afione, S., Metzger, M., Dunbar, C., Donahue, R.E., Baum, B.J.

“…Previous studies from our laboratory showed that therapeutic levels of transgene expression were obtained from mouse submandibular glands after retro-ductal…”
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Gene expression from adeno-associated virus vectors in airway epithelial cells by Flotte, T R, Solow, R, Owens, R A, Afione, S, Zeitlin, P L, Carter, B J

“…Lung diseases such as cystic fibrosis (CF) might be treated by gene therapy using viral vectors delivered to the airway. One potential vector is the defective…”
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Gene therapy vectors as drug delivery systems by AFIONE, S. A, CONRAD, C. K, FLOTTE, T. R

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Gene Therapy of Salivary Diseases by Baum, Bruce J, Afione, Sandra, Chiorini, John A, Cotrim, Ana P, Goldsmith, Corinne M, Zheng, Changyu

“…For many years, our research group worked to develop gene transfer approaches for salivary gland disorders that lacked effective conventional therapy. The…”
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Delayed expression of adeno-associated virus vector DNA by Afione, S A, Wang, J, Walsh, S, Guggino, W B, Flotte, T R

“…Two previous reports indicated that recombinant adeno-associated virus (rAAV) vectors were dependent on helper adenovirus (Ad) for efficient conversion of…”
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A Shortened Adeno-Associated virus Expression Cassette for CFTR Gene Transfer to Cystic Fibrosis Airway Epithelia by Ostedgaard, Lynda S., Rokhlina, Tatiana, Karp, Philip H., Lashmit, Philip, Afione, Sandra, Schmidt, Michael, Zabner, Joseph, Stinski, Mark F., Chiorini, Jay A., Welsh, Michael J.

“…Adeno-associated viruses (AAVs) such as AAV5 that transduce airway epithelia from the apical surface are attractive vectors for gene transfer in cystic…”
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Effects of passive immunization against vasoactive intestinal peptide on serum prolactin and LH levels by Lasaga, M, Debeljuk, L, Afione, S, Aleman, I T, Duvilanski, B

“…Recent findings suggest that vasoactive intestinal peptide (VIP) may be a physiological regulator of prolactin secretion and may also be involved in the…”
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