Search Results - "AERTS, M."

A novel feature for monitoring the enzymatic harvesting process of adherent cell cultures based on lens-free imaging by Deckers, T., Aerts, J.-M., Bloemen, V.

“…Adherent cell cultures are often dissociated from their culture vessel (and each other) through enzymatic harvesting, where the detachment response is…”
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Comparison of estimates of global flood models for flood hazard and exposed gross domestic product: a China case study by Aerts, Jerom P. M, Uhlemann-Elmer, Steffi, Eilander, Dirk, Ward, Philip J

“…Over the past decade global flood hazard models have been developed and continuously improved. There is now a significant demand for testing global hazard maps…”
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Is precision livestock farming an engineer's daydream or nightmare, an animal's friend or foe, and a farmer's panacea or pitfall? by Wathes, C.M., Kristensen, H.H., Aerts, J.-M., Berckmans, D.

“…This paper reviews the development of precision livestock farming (PLF), from the view point of the engineer, the farm animal and the farmer; PLF is the…”
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Severity in polycystic liver disease is associated with aetiology and female gender: Results of the International PLD Registry by Aerts, René M. M., Kievit, Wietske, Jong, Michiel E., Ahn, Curie, Bañales, Jesús M., Reiterová, Jana, Nevens, Frederik, Drenth, Joost P. H.

“…Background & Aims Polycystic liver disease (PLD) occurs in two genetic disorders, autosomal‐dominant polycystic kidney disease (ADPKD) and autosomal‐dominant…”
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Temporal and Spatial Distribution of the Acetic Acid Bacterium Communities throughout the Wooden Casks Used for the Fermentation and Maturation of Lambic Beer Underlines Their Functional Role by De Roos, J, Verce, M, Aerts, M, Vandamme, P, De Vuyst, L

“…Few data have been published on the occurrence and functional role of acetic acid bacteria (AAB) in lambic beer production processes, mainly due to their…”
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Tracking the sources of psychrotrophic bacteria contaminating chicken cuts during processing by Samapundo, S., de Baenst, I., Aerts, M., Cnockaert, M., Devlieghere, F., Van Damme, P.

“…The major aim of the study was to establish the routes via which spoilage associated psychrotrophic bacteria contaminate poultry products at a large processing…”
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Evolution of Mammalian Chitinase(-Like) Members of Family 18 Glycosyl Hydrolases by Bussink, Anton P, Speijer, Dave, Aerts, Johannes M. F. G, Boot, Rolf G

“…Family 18 of glycosyl hydrolases encompasses chitinases and so-called chi-lectins lacking enzymatic activity due to amino acid substitutions in their active…”
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Lysosomal glycosphingolipid catabolism by acid ceramidase: formation of glycosphingoid bases during deficiency of glycosidases by Ferraz, Maria J., Marques, André R. A., Appelman, Monique D., Verhoek, Marri, Strijland, Anneke, Mirzaian, Mina, Scheij, Saskia, Ouairy, Cécile M., Lahav, Daniel, Wisse, Patrick, Overkleeft, Herman S., Boot, Rolf G., Aerts, Johannes M.

“…Glycosphingoid bases are elevated in inherited lysosomal storage disorders with deficient activity of glycosphingolipid catabolizing glycosidases. We…”
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Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish by Artola, Marta, Kuo, Chi-Lin, Lelieveld, Lindsey T, Rowland, Rhianna J, van der Marel, Gijsbert A, Codée, Jeroen D. C, Boot, Rolf G, Davies, Gideon J, Aerts, Johannes M. F. G, Overkleeft, Herman S

“…Gaucher disease is caused by inherited deficiency in glucocerebrosidase (GBA, a retaining β-glucosidase), and deficiency in GBA constitutes the largest known…”
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LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance by Rothaug, Michelle, Zunke, Friederike, Mazzulli, Joseph R., Schweizer, Michaela, Altmeppen, Hermann, Lüllmann-Rauch, Renate, Kallemeijn, Wouter W., Gaspar, Paulo, Aerts, Johannes M., Glatzel, Markus, Saftig, Paul, Krainc, Dimitri, Schwake, Michael, Blanz, Judith

“…Significance Our report highlights, for the first time to our knowledge, a distinct relationship between lysosomal integral membrane protein type-2 (LIMP-2)…”
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a-Synuclein and lipids in erythrocytes of Gaucher disease carriers and patients before and after enzyme replacement therapy by Moraitou, Marina, Sotiroudis, Georgios, Papagiannakis, Nikolaos, Ferraz, Maria M J, Xenakis, Aristotelis, Aerts, Johannes M F G, Stefanis, Leonidas, Michelakakis, Helen

“…It is well established that patients with Gaucher disease, as well as carriers of the disease have an increased risk for developing Parkinson's disease. A…”
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Glycosphingolipids-Nature, Function, and Pharmacological Modulation by Wennekes, Tom, van den Berg, Richard J. B. H. N., Boot, Rolf G., van der Marel, Gijsbert A., Overkleeft, Herman S., Aerts, Johannes M. F. G.

“…The discovery of the glycosphingolipids is generally attributed to Johan L. W. Thudichum, who in 1884 published on the chemical composition of the brain. In…”
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Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases by van der Gracht, Daniël, Rowland, Rhianna J, Roig-Zamboni, Véronique, Ferraz, Maria J, Louwerse, Max, Geurink, Paul P, Aerts, Johannes M. F. G, Sulzenbacher, Gerlind, Davies, Gideon J, Overkleeft, Herman S, Artola, Marta

“…Lysosomal exoglycosidases are responsible for processing endocytosed glycans from the non-reducing end to produce the corresponding monosaccharides. Genetic…”
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mode of antifungal action of plant, insect and human defensins by Aerts, A. M, François, I. E. J. A, Cammue, B. P. A, Thevissen, K

“…Defensins are small (~ 5 kDa), basic, cysteine-rich antimicrobial peptides that fulfill an important role in the innate immunity of their host by combating…”
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Large-sample assessment of varying spatial resolution on the streamflow estimates of the wflow_sbm hydrological model by Aerts, Jerom P. M, Hut, Rolf W, van de Giesen, Nick C, Drost, Niels, van Verseveld, Willem J, Weerts, Albrecht H, Hazenberg, Pieter

“…Distributed hydrological modelling moves into the realm of hyper-resolution modelling. This results in a plethora of scaling-related challenges that remain…”
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Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics by Kytidou, Kassiani, Artola, Marta, Overkleeft, Herman S, Aerts, Johannes M F G

“…Plants contain numerous glycoconjugates that are metabolized by specific glucosyltransferases and hydrolyzed by specific glycosidases, some also catalyzing…”
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Long-term effect of antibodies against infused alpha-galactosidase A in Fabry disease on plasma and urinary (lyso)Gb3 reduction and treatment outcome by Rombach, Saskia M, Aerts, Johannes M F G, Poorthuis, Ben J H M, Groener, Johanna E M, Donker-Koopman, Wilma, Hendriks, Erik, Mirzaian, Mina, Kuiper, Sijmen, Wijburg, Frits A, Hollak, Carla E M, Linthorst, Gabor E

“…Enzyme replacement therapy (ERT) with alpha-Galactosidase A (aGal A) may cause antibody (AB) formation against aGal A in males with Fabry disease (FD). Anti…”
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Elevated globotriaosylsphingosine is a hallmark of Fabry disease by Aerts, Johannes M, Groener, Johanna E, Kuiper, Sijmen, Donker-Koopman, Wilma E, Strijland, Anneke, Ottenhoff, Roelof, van Roomen, Cindy, Mirzaian, Mina, Wijburg, Frits A, Linthorst, Gabor E, Vedder, Anouk C, Rombach, Saskia M, Cox-Brinkman, Josanne, Somerharju, Pentti, Boot, Rolf G, Hollak, Carla E, Brady, Roscoe O, Poorthuis, Ben J

“…Fabry disease is an X-linked lysosomal storage disease caused by deficiency of α-galactosidase A that affects males and shows disease expression in…”
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Animal Models for the Study of Gaucher Disease by Cabasso, Or, Kuppuramalingam, Aparna, Lelieveld, Lindsey, Van der Lienden, Martijn, Boot, Rolf, Aerts, Johannes M., Horowitz, Mia

“…In Gaucher disease (GD), a relatively common sphingolipidosis, the mutant lysosomal enzyme acid β-glucocerebrosidase (GCase), encoded by the GBA1 gene, fails…”
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Clinical management of polycystic liver disease by van Aerts, René M.M., van de Laarschot, Liyanne F.M., Banales, Jesus M., Drenth, Joost P.H.

“…A 41-year old female underwent a computed tomography (CT) scan in 2010 because of symptoms suggestive of appendicitis. Incidentally, multiple liver lesions…”
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