Search Results - "ADUSUMILLI, Prasad S"

Cisplatin-induced antitumor immunomodulation: a review of preclinical and clinical evidence by de Biasi, Andreas R, Villena-Vargas, Jonathan, Adusumilli, Prasad S

“…Contrary to the long held belief that chemotherapy is immunosuppressive, emerging evidence indicates that the anticancer activity of cisplatin is not limited…”
Get full text

Tumor Spread through Air Spaces is an Important Pattern of Invasion and Impacts the Frequency and Location of Recurrences after Limited Resection for Small Stage I Lung Adenocarcinomas by Kadota, Kyuichi, Nitadori, Jun-Ichi, Sima, Camelia S, Ujiie, Hideki, Rizk, Nabil P, Jones, David R, Adusumilli, Prasad S, Travis, William D

“…Tumor invasion in lung adenocarcinoma is defined as infiltration of stroma, blood vessels, or pleura. Based on observation of tumor spread through air spaces…”
Get more information

Mesothelioma: Scientific clues for prevention, diagnosis, and therapy by Carbone, Michele, Adusumilli, Prasad S., Alexander, H. Richard, Baas, Paul, Bardelli, Fabrizio, Bononi, Angela, Bueno, Raphael, Felley‐Bosco, Emanuela, Galateau‐Salle, Francoise, Jablons, David, Mansfield, Aaron S., Minaai, Michael, Perrot, Marc, Pesavento, Patricia, Rusch, Valerie, Severson, David T., Taioli, Emanuela, Tsao, Anne, Woodard, Gavitt, Yang, Haining, Zauderer, Marjorie G., Pass, Harvey I.

“…Mesothelioma affects mostly older individuals who have been occupationally exposed to asbestos. The global mesothelioma incidence and mortality rates are…”
Get full text

Shape-Sensing Robotic-Assisted Bronchoscopy in the Diagnosis of Pulmonary Parenchymal Lesions by Kalchiem-Dekel, Or, Connolly, James G., Lin, I-Hsin, Husta, Bryan C., Adusumilli, Prasad S., Beattie, Jason A., Buonocore, Darren J., Dycoco, Joseph, Fuentes, Paige, Jones, David R., Lee, Robert P., Park, Bernard J., Rocco, Gaetano, Chawla, Mohit, Bott, Matthew J.

“…The landscape of guided bronchoscopy for the sampling of pulmonary parenchymal lesions is evolving rapidly. Shape-sensing robotic-assisted bronchoscopy (ssRAB)…”
Get full text

Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors by Valero, Cristina, Lee, Mark, Hoen, Douglas, Weiss, Kate, Kelly, Daniel W., Adusumilli, Prasad S., Paik, Paul K., Plitas, George, Ladanyi, Marc, Postow, Michael A., Ariyan, Charlotte E., Shoushtari, Alexander N., Balachandran, Vinod P., Hakimi, A. Ari, Crago, Aimee M., Long Roche, Kara C., Smith, J. Joshua, Ganly, Ian, Wong, Richard J., Patel, Snehal G., Shah, Jatin P., Lee, Nancy Y., Riaz, Nadeem, Wang, Jingming, Zehir, Ahmet, Berger, Michael F., Chan, Timothy A., Seshan, Venkatraman E., Morris, Luc G. T.

“…Treatment with immune checkpoint inhibitors (ICI) has demonstrated clinical benefit for a wide range of cancer types. Because only a subset of patients…”
Get full text

Improved prediction of immune checkpoint blockade efficacy across multiple cancer types by Chowell, Diego, Yoo, Seong-Keun, Valero, Cristina, Pastore, Alessandro, Krishna, Chirag, Lee, Mark, Hoen, Douglas, Shi, Hongyu, Kelly, Daniel W., Patel, Neal, Makarov, Vladimir, Ma, Xiaoxiao, Vuong, Lynda, Sabio, Erich Y., Weiss, Kate, Kuo, Fengshen, Lenz, Tobias L., Samstein, Robert M., Riaz, Nadeem, Adusumilli, Prasad S., Balachandran, Vinod P., Plitas, George, Ari Hakimi, A., Abdel-Wahab, Omar, Shoushtari, Alexander N., Postow, Michael A., Motzer, Robert J., Ladanyi, Marc, Zehir, Ahmet, Berger, Michael F., Gönen, Mithat, Morris, Luc G. T., Weinhold, Nils, Chan, Timothy A.

“…Only a fraction of patients with cancer respond to immune checkpoint blockade (ICB) treatment, but current decision-making procedures have limited accuracy. In…”
Get full text

CAR T-cell intrinsic PD-1 checkpoint blockade: A two-in-one approach for solid tumor immunotherapy by Chen, Nan, Morello, Aurore, Tano, Zachary, Adusumilli, Prasad S.

“…PD-L1/2 expression in solid tumors inhibits chimeric antigen receptor (CAR) T-cell efficacy. A PD-1 dominant negative receptor expressed in CAR T cells…”
Get full text

Spread through Air Spaces (STAS) Is an Independent Predictor of Recurrence and Lung Cancer-Specific Death in Squamous Cell Carcinoma by Lu, Shaohua, Tan, Kay See, Kadota, Kyuichi, Eguchi, Takashi, Bains, Sarina, Rekhtman, Natasha, Adusumilli, Prasad S, Travis, William D

“…Spread through air spaces (STAS) is a recently recognized pattern of invasion in lung adenocarcinoma; however, it has not yet been characterized in squamous…”
Get more information

Tumor Spread Through Air Spaces Is a Predictor of Occult Lymph Node Metastasis in Clinical Stage IA Lung Adenocarcinoma by Vaghjiani, Raj G, Takahashi, Yusuke, Eguchi, Takashi, Lu, Shaohua, Kameda, Koji, Tano, Zachary, Dozier, Jordan, Tan, Kay See, Jones, David R, Travis, William D, Adusumilli, Prasad S

“…In patients with stage IA lung adenocarcinoma (ADC), sublobar resection and tumor spread through air spaces (STAS) are associated with high rates of…”
Get more information

Solid Predominant Histologic Subtype in Resected Stage I Lung Adenocarcinoma Is an Independent Predictor of Early, Extrathoracic, Multisite Recurrence and of Poor Postrecurrence Survival by Ujiie, Hideki, Kadota, Kyuichi, Chaft, Jamie E, Buitrago, Daniel, Sima, Camelia S, Lee, Ming-Ching, Huang, James, Travis, William D, Rizk, Nabil P, Rudin, Charles M, Jones, David R, Adusumilli, Prasad S

“…To examine the significance of the proposed International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society…”
Get full text

Impact of micropapillary histologic subtype in selecting limited resection vs lobectomy for lung adenocarcinoma of 2cm or smaller by Nitadori, Jun-ichi, Bograd, Adam J, Kadota, Kyuichi, Sima, Camelia S, Rizk, Nabil P, Morales, Eduardo A, Rusch, Valerie W, Travis, William D, Adusumilli, Prasad S

“…We sought to analyze the prognostic significance of the new International Association for the Study of Lung Cancer (IASLC), American Thoracic Society (ATS),…”
Get full text

Pathologic Assessment After Neoadjuvant Chemotherapy for NSCLC: Importance and Implications of Distinguishing Adenocarcinoma From Squamous Cell Carcinoma by Qu, Yang, Emoto, Katsura, Eguchi, Takashi, Aly, Rania G, Zheng, Hua, Chaft, Jamie E, Tan, Kay See, Jones, David R, Kris, Mark G, Adusumilli, Prasad S, Travis, William D

“…Major pathologic response after neoadjuvant chemotherapy (NAC) for NSCLC has been defined as 10% or less residual viable tumor without distinguishing between…”
Get more information

The Underlying Tumor Genomics of Predominant Histologic Subtypes in Lung Adenocarcinoma by Caso, Raul, Sanchez-Vega, Francisco, Tan, Kay See, Mastrogiacomo, Brooke, Zhou, Jian, Jones, Gregory D, Nguyen, Bastien, Schultz, Nikolaus, Connolly, James G, Brandt, Whitney S, Bott, Matthew J, Rocco, Gaetano, Molena, Daniela, Isbell, James M, Liu, Yuan, Mayo, Marty W, Adusumilli, Prasad S, Travis, William D, Jones, David R

“…The purpose of the study is to genomically characterize the biology and related therapeutic opportunities of prognostically important predominant histologic…”
Get more information

Loss of BAP1 function leads to EZH2-dependent transformation by LaFave, Lindsay M, Béguelin, Wendy, Koche, Richard, Teater, Matt, Spitzer, Barbara, Chramiec, Alan, Papalexi, Efthymia, Keller, Matthew D, Hricik, Todd, Konstantinoff, Katerina, Micol, Jean-Baptiste, Durham, Benjamin, Knutson, Sarah K, Campbell, John E, Blum, Gil, Shi, Xinxu, Doud, Emma H, Krivtsov, Andrei V, Chung, Young Rock, Khodos, Inna, de Stanchina, Elisa, Ouerfelli, Ouathek, Adusumilli, Prasad S, Thomas, Paul M, Kelleher, Neil L, Luo, Minkui, Keilhack, Heike, Abdel-Wahab, Omar, Melnick, Ari, Armstrong, Scott A, Levine, Ross L

“…BAP1 regulation of EZH2 provides therapeutic opportunities in cancer. The tumor suppressors BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex…”
Get full text

Safety and Feasibility of Lung Resection After Immunotherapy for Metastatic or Unresectable Tumors by Bott, Matthew J., Cools-Lartigue, Jonathan, Tan, Kay See, Dycoco, Joseph, Bains, Manjit S., Downey, Robert J., Huang, James, Isbell, James M., Molena, Daniela, Park, Bernard J., Rusch, Valerie W., Sihag, Smita, Jones, David R., Adusumilli, Prasad S.

“…Surgeons are increasingly asked to operate on patients with residual disease after immunotherapy. The safety and utility of lung resection in this setting are…”
Get full text

Clinical Impact of Immune Microenvironment in Stage I Lung Adenocarcinoma: Tumor Interleukin-12 Receptor β2 (IL-12Rβ2), IL-7R, and Stromal FoxP3/CD3 Ratio Are Independent Predictors of Recurrence by SUZUKI, Kei, KADOTA, Kyuichi, SIMA, Camelia S, NITADORI, Jun-Ichi, RUSCH, Valerie W, TRAVIS, William D, SADELAIN, Michel, ADUSUMILLI, Prasad S

“…Mounting evidence suggests that tumor-infiltrating immune cells have prognostic value for patients with solid organ malignancies. Our aim was to investigate…”
Get full text

Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes by Chang, Jason C, Offin, Michael, Falcon, Christina, Brown, David, Houck-Loomis, Brian R, Meng, Fanli, Rudneva, Vasilisa A, Won, Helen H, Amir, Sharon, Montecalvo, Joseph, Desmeules, Patrice, Kadota, Kyuichi, Adusumilli, Prasad S, Rusch, Valerie W, Teed, Sarah, Sabari, Joshua K, Benayed, Ryma, Nafa, Khedoudja, Borsu, Laetitia, Li, Bob T, Schram, Alison M, Arcila, Maria E, Travis, William D, Ladanyi, Marc, Drilon, Alexander, Rekhtman, Natasha

“…Invasive mucinous adenocarcinoma (IMA) is a unique subtype of lung adenocarcinoma, characterized genomically by frequent mutations or specific gene fusions,…”
Get full text

Expansion of the Concept of Micropapillary Adenocarcinoma to Include a Newly Recognized Filigree Pattern as Well as the Classical Pattern Based on 1468 Stage I Lung Adenocarcinomas by Emoto, Katsura, Eguchi, Takashi, Tan, Kay See, Takahashi, Yusuke, Aly, Rania G, Rekhtman, Natasha, Travis, William D, Adusumilli, Prasad S

“…The classical micropapillary (MIP) pattern is defined in the 2015 WHO classification as tumor cells growing in papillary tufts forming florets that lack…”
Get more information

CAR T-cell Therapy for Lung Cancer and Malignant Pleural Mesothelioma by Zeltsman, Masha, DO, Dozier, Jordan, MD, McGee, Erin, BS, Ngai, Daniel, BS, Adusumilli, Prasad S., MD, FACS, FCCP

“…Abstract Immunotherapy is a promising field that harnesses the power of the immune system as a therapeutic agent for cancer treatment. Beneficial outcomes…”
Get full text

Early Quality of Life Outcomes After Robotic-Assisted Minimally Invasive and Open Esophagectomy by Sarkaria, Inderpal S., Rizk, Nabil P., Goldman, Debra A., Sima, Camelia, Tan, Kay See, Bains, Manjit S., Adusumilli, Prasad S., Molena, Daniela, Bott, Matthew, Atkinson, Thomas, Jones, David R., Rusch, Valerie W.

“…Minimally invasive esophagectomy may improve some perioperative outcomes over open approaches; effects on quality of life are less clear. A prospective trial…”
Get full text