Search Results - "ADRIAN, THOMAS E."

SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions by Uddin, Mohammed, Mustafa, Farah, Rizvi, Tahir A, Loney, Tom, Suwaidi, Hanan Al, Al-Marzouqi, Ahmed H Hassan, Eldin, Afaf Kamal, Alsabeeha, Nabeel, Adrian, Thomas E, Stefanini, Cesare, Nowotny, Norbert, Alsheikh-Ali, Alawi, Senok, Abiola C

“…The COVID-19 pandemic is due to infection caused by the novel SARS-CoV-2 virus that impacts the lower respiratory tract. The spectrum of symptoms ranges from…”
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Anti-Inflammatory Effects of Bioactive Compounds from Seaweeds, Bryozoans, Jellyfish, Shellfish and Peanut Worms by Khursheed, Md, Ghelani, Hardik, Jan, Reem K, Adrian, Thomas E

“…Inflammation is a defense mechanism of the body in response to harmful stimuli such as pathogens, damaged cells, toxic compounds or radiation. However, chronic…”
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The Anti-Cancer Effects of Frondoside A by Adrian, Thomas E, Collin, Peter

“…Frondoside A is a triterpenoid glycoside from the Atlantic Sea Cucumber, . Frondoside A has a broad spectrum of anti-cancer effects, including induction of…”
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Inhibitory Effects of Salinomycin on Cell Survival, Colony Growth, Migration, and Invasion of Human Non-Small Cell Lung Cancer A549 and LNM35: Involvement of NAG-1 by Arafat, Kholoud, Iratni, Rabah, Takahashi, Takashi, Parekh, Khatija, Al Dhaheri, Yusra, Adrian, Thomas E, Attoub, Samir

“…A major challenge for oncologists and pharmacologists is to develop more potent and less toxic drugs that will decrease the tumor growth and improve the…”
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Molecular Docking Identifies 1,8-Cineole (Eucalyptol) as A Novel PPARγ Agonist That Alleviates Colon Inflammation by Venkataraman, Balaji, Almarzooqi, Saeeda, Raj, Vishnu, Bhongade, Bhoomendra A, Patil, Rajesh B, Subramanian, Veedamali S, Attoub, Samir, Rizvi, Tahir A, Adrian, Thomas E, Subramanya, Sandeep B

“…Inflammatory bowel disease, comprising Crohn's disease (CD) and ulcerative colitis (UC), is often debilitating. The disease etiology is multifactorial,…”
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The Effects of Different Repetitive Transcranial Magnetic Stimulation (rTMS) Protocols on Cortical Gene Expression in a Rat Model of Cerebral Ischemic-Reperfusion Injury by Ljubisavljevic, Milos R, Javid, Asma, Oommen, Joji, Parekh, Khatija, Nagelkerke, Nico, Shehab, Safa, Adrian, Thomas E

“…Although repetitive Transcranial Magnetic Stimulation (rTMS) in treatment of stroke in humans has been explored over the past decade the data remain…”
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β-Myrcene Mitigates Colon Inflammation by Inhibiting MAP Kinase and NF-κB Signaling Pathways by Almarzooqi, Saeeda, Venkataraman, Balaji, Raj, Vishnu, Alkuwaiti, Sultan Ali Abdulla, Das, Karuna M, Collin, Peter D, Adrian, Thomas E, Subramanya, Sandeep B

“…Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders that include Crohn's disease (CD) and ulcerative colitis (UC). The incidence of IBD is…”
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Cis-Nerolidol Inhibits MAP Kinase and NF-κB Signaling Pathways and Prevents Epithelial Tight Junction Dysfunction in Colon Inflammation: In Vivo and In Vitro Studies by Raj, Vishnu, Venkataraman, Balaji, Ojha, Shreesh K, Almarzooqi, Saeeda, Subramanian, Veedamali S, Al-Ramadi, Basel K, Adrian, Thomas E, Subramanya, Sandeep B

“…Inflammation of the GI tract leads to compromised epithelial barrier integrity, which increases intestine permeability. A compromised intestinal barrier is a…”
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Frondoside a suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis by Attoub, Samir, Arafat, Kholoud, Gélaude, An, Al Sultan, Mahmood Ahmed, Bracke, Marc, Collin, Peter, Takahashi, Takashi, Adrian, Thomas E, De Wever, Olivier

“…A major challenge for oncologists and pharmacologists is to develop less toxic drugs that will improve the survival of lung cancer patients. Frondoside A is a…”
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Saffron-Based Crocin Prevents Early Lesions of Liver Cancer: In vivo, In vitro and Network Analyses by Amin, Amr, Hamza, Alaaeldin A, Daoud, Sayel, Khazanehdari, Kamal, Hrout, Ala'a Al, Baig, Badriya, Chaiboonchoe, Amphun, Adrian, Thomas E, Zaki, Nazar, Salehi-Ashtiani, Kourosh

“…The angiogenesis inhibitor, sorafenib, remains the only available therapy of hepatocellular carcinoma (HCC). Only recently patents of VEGF receptors-3…”
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Using publicly available datasets to identify population-based transcriptomic landscape contributing to the aggressiveness of breast cancer in young women by Tabbal, Marah, Hachim, Mahmood Y, Jan, Reem Kais, Adrian, Thomas E

“…Although the risk of breast cancer increases with advancing age, some regions have larger number of young breast cancer patients (≤45 years-old), such as the…”
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Diabetic Neuropathy: Update on Pathophysiological Mechanism and the Possible Involvement of Glutamate Pathways by Hussain, Nadia, Adrian, Thomas E

“…Diabetic neuropathy is a common complication of diabetes. It adversely affects the lives of most diabetics. It is the leading cause of non-traumatic limb…”
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Nerolidol Mitigates Colonic Inflammation: An Experimental Study Using both In Vivo and In Vitro Models by Raj, Vishnu, Venkataraman, Balaji, Almarzooqi, Saeeda, Chandran, Sanjana, Ojha, Shreesh K, Attoub, Samir, Adrian, Thomas E, Subramanya, Sandeep B

“…Nerolidol (NED) is a naturally occurring sesquiterpene alcohol present in various plants with potent anti-inflammatory effects. In the current study, we…”
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Thymoquinone, a Dietary Bioactive Compound, Exerts Anti-Inflammatory Effects in Colitis by Stimulating Expression of the Colonic Epithelial PPAR-γ Transcription Factor by Venkataraman, Balaji, Almarzooqi, Saeeda, Raj, Vishnu, Alhassani, Abdullah T, Alhassani, Ahmad S, Ahmed, Khadijah J, Subramanian, Veedamali S, Ojha, Shreesh K, Attoub, Samir, Adrian, Thomas E, Subramanya, Sandeep B

“…Inflammatory bowel diseases (IBD) are chronic inflammatory disorders with increasing incidence and prevalence worldwide. Here, we investigated thymoquinone…”
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Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest by Ujiki, Michael B, Ding, Xian-Zhong, Salabat, M Reza, Bentrem, David J, Golkar, Laleh, Milam, Ben, Talamonti, Mark S, Bell, Jr, Richard H, Iwamura, Takeshi, Adrian, Thomas E

“…Many chemotherapeutic agents have been used to treat pancreatic cancer without success. Apigenin, a naturally occurring flavonoid, has been shown to inhibit…”
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Frondoside A inhibits human breast cancer cell survival, migration, invasion and the growth of breast tumor xenografts by Al Marzouqi, Nadia, Iratni, Rabah, Nemmar, Abderrahim, Arafat, Kholoud, Ahmed Al Sultan, Mahmood, Yasin, Javed, Collin, Peter, Mester, Jan, Adrian, Thomas E., Attoub, Samir

“…Breast cancer is a major challenge for pharmacologists to develop new drugs to improve the survival of cancer patients. Frondoside A is a triterpenoid…”
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α-Bisabolol Mitigates Colon Inflammation by Stimulating Colon PPAR-γ Transcription Factor: In Vivo and In Vitro Study by Venkataraman, Balaji, Almarzooqi, Saeeda, Raj, Vishnu, Dudeja, Pradeep K., Bhongade, Bhoomendra A., Patil, Rajesh B., Ojha, Shreesh K., Attoub, Samir, Adrian, Thomas E., Subramanya, Sandeep B.

“…The incidence and prevalence of inflammatory bowel disease (IBD, Crohn’s disease, and ulcerative colitis) are increasing worldwide. The etiology of IBD is…”
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Frondanol, a Nutraceutical Extract from Cucumaria frondosa , Attenuates Colonic Inflammation in a DSS-Induced Colitis Model in Mice by Subramanya, Sandeep B, Chandran, Sanjana, Almarzooqi, Saeeda, Raj, Vishnu, Al Zahmi, Aisha Salem, Al Katheeri, Radeya Ahmed, Al Zadjali, Samira Ali, Collin, Peter D, Adrian, Thomas E

“…Frondanol is a nutraceutical lipid extract of the intestine of the edible Atlantic sea cucumber, with potent anti-inflammatory effects. In the current study,…”
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Pharmacokinetics in Mouse and Comparative Effects of Frondosides in Pancreatic Cancer by Al Shemaili, Jasem, Parekh, Khatija A, Newman, Robert A, Hellman, Björn, Woodward, Carl, Adem, Abdu, Collin, Peter, Adrian, Thomas E

“…The frondosides are triterpenoid glycosides from the Atlantic sea cucumber Cucumaria frondosa. Frondoside A inhibits growth, invasion, metastases and…”
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1,2,3-Triazolyl ester of ketorolac (15K), a potent PAK1 blocker, inhibits both growth and metastasis of orthotopic human pancreatic cancer xenografts in mice by Hennig, Rene, Albawardi, Alia, Almarzooqi, Saeeda, Haneefa, Shoja, Imbaraj, Edward, Zaaba, Nur Elena, Nemmar, Abderrahim, Subramanya, Sandeep, Maruta, Hiroshi, Adrian, Thomas E.

“…More than 90% of human pancreatic cancers carry the oncogenic mutant of Ki-RAS and their growth depends on its downstream kinase PAK1, mainly because PAK1…”
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