Search Results - "ADRA, Chaker"

Immunomodulation by Mesenchymal Stem Cells : A Potential Therapeutic Strategy for Type 1 Diabetes by ABDI, Reza, FIORINA, Paolo, ADRA, Chaker N, ATKINSON, Mark, SAYEGH, Mohamed H

“…Mesenchymal stem cells (MSCs) are pluripotent stromal cells that have the potential to give rise to cells of diverse lineages. Interestingly, MSCs can be found…”
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Immunomodulatory Function of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Autoimmune Type 1 Diabetes by Fiorina, Paolo, Jurewicz, Mollie, Augello, Andrea, Vergani, Andrea, Dada, Shirine, La Rosa, Stefano, Selig, Martin, Godwin, Jonathan, Law, Kenneth, Placidi, Claudia, Smith, R. Neal, Capella, Carlo, Rodig, Scott, Adra, Chaker N, Atkinson, Mark, Sayegh, Mohamed H, Abdi, Reza

“…Human clinical trials in type 1 diabetes (T1D) patients using mesenchymal stem cells (MSC) are presently underway without prior validation in a mouse model for…”
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Profiling of normal and malignant breast tissue show CD44high/CD24low phenotype as a predominant stem/progenitor marker when used in combination with Ep-CAM/CD49f markers by Ghebeh, Hazem, Sleiman, Ghida Majed, Manogaran, Pulicat S, Al-Mazrou, Amer, Barhoush, Eman, Al-Mohanna, Falah H, Tulbah, Asma, Al-Faqeeh, Khalid, Adra, Chaker N

“…Accumulating evidence supports cancer to initiate and develop from a small population of stem-like cells termed as cancer stem cells (CSC). The exact phenotype…”
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Fascin is a key regulator of breast cancer invasion that acts via the modification of metastasis-associated molecules by Al-Alwan, Monther, Olabi, Safiah, Ghebeh, Hazem, Barhoush, Eman, Tulbah, Asma, Al-Tweigeri, Taher, Ajarim, Dahish, Adra, Chaker

“…The actin-bundling protein, fascin, is a member of the cytoskeletal protein family that has restricted expression in specialized normal cells. However, many…”
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TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD by Stokes, Alexander, Wakano, Clay, Koblan-Huberson, Murielle, Adra, Chaker N., Fleig, Andrea, Turner, Helen

“…Certain TRP cation channels confer the ability to sense environmental stimuli (heat, cold, pressure, osmolarity) across physiological and pathophysiological…”
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Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues by Kutok, Jeffery L., Yang, Xing, Folkerth, Rebecca, Adra, Chaker N.

“…HTm4 (MS4A3) is a member of a family of four‐transmembrane proteins designated MS4A. MS4A proteins fulfil diverse functions, acting as cell surface signalling…”
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A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells by Stokes, Alexander J, Shimoda, Lori M N, Koblan-Huberson, Murielle, Adra, Chaker N, Turner, Helen

“…Cutaneous mast cell responses to physical (thermal, mechanical, or osmotic) stimuli underlie the pathology of physical urticarias. In vitro experiments suggest…”
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Assessment by miRNA microarray of an autologous cancer antigen‐pulsed adoptive immune ensemble cell therapy (AC‐ACT) approach; demonstrated induction of anti‐oncogenic and anti‐PD‐L1 miRNAs by Chinami, Masanobu, Iwabuchi, Kaoru, Muto, Yoshiteru, Uchida, Yasuhiko, Arita, Ryu, Shuraim, Rana A., Adra, Chaker N.

“…A 60‐year‐old woman with stage IV rectal cancer received adoptive cell therapy with autologous cancer antigen (AC‐ACT) causing induction of anti‐oncogenic and…”
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Genetic Diagnosis in Consanguineous Families With Kidney Disease by Homozygosity Mapping Coupled With Whole-Exome Sequencing by Al-Romaih, Khaldoun I., PhD, Genovese, Giulio, PhD, Al-Mojalli, Hamad, MD, Al-Othman, Saleh, MD, PhD, Al-Manea, Hadeel, MD, Al-Suleiman, Mohammed, MD, Al-Jondubi, Mohammed, MD, Atallah, Nourah, BSc, Al-Rodayyan, Maha, BSc, Weins, Astrid, MD, PhD, Pollak, Martin R., MD, Adra, Chaker N., PhD

“…Background Accurate diagnosis of the primary cause of an individual's kidney disease can be essential for proper management. Some kidney diseases have…”
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Anti-inflammatory potential of CB1-mediated cAMP elevation in mast cells by Small-Howard, Andrea L, Shimoda, Lori M N, Adra, Chaker N, Turner, Helen

“…Cannabinoids are broadly immunosuppressive, and anti-inflammatory properties have been reported for certain marijuana constituents and endogenously produced…”
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Cell cycle disruption and apoptotic activity of 3-aminothiazolo[3,2- a]benzimidazole-2-carbonitrile and its homologues by Sarhan, Abdelwareth A.O., Al-Dhfyan, Abdullah, Al-Mozaini, Maha A., Adra, Chaker N., Aboul-Fadl, Tarek

“…3-Aminothiazolo[3,2- a]benzimidazole-2-carbonitrile ( 2) was prepared and upon hydrolysis using concentrated sulfuric acid or phosphoric acid resulted in the…”
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Transplant Tourism Outcome: A Single Center Experience by ALGHAMDI, Saad A, NABI, Zahid G, ALKHAFAJI, Dania M, ASKANDRANI, Sumaya A, ABDELSALAM, Mohamed S, SHUKRI, Mohamed M, ELDALI, Abdelmoneim M, ADRA, Chaker N, ALKURBI, Lutfi A, ALBAQUMI, Mamdouh N

“…Transplant tourism is the term used for patients who travel abroad for transplantation. Transplant tourism has always been surrounded with controversy…”
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Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma by Arima, Kazuhiko, Umeshita-Suyama, Ritsuko, Sakata, Yasuhisa, Akaiwa, Mina, Mao, Xiao-Quan, Enomoto, Tadao, Dake, Yoshio, Shimazu, Shin-ichiro, Yamashita, Tetsuji, Sugawara, Naoto, Brodeur, Scott, Geha, Raif, Puri, Raj K., Sayegh, Mohamad H., Adra, Chaker N., Hamasaki, Naotaka, Hopkin, Julian M., Shirakawa, Taro, Izuhara, Kenji

“…Background: A substantial body of evidence exists to support the pivotal role of IL-13 in the pathogenesis of bronchial asthma. We recently found that a…”
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Identification of granulocyte subtype–selective receptors and ion channels by using a high-density oligonucleotide probe array by Nakajima, Toshiharu, Iikura, Motoyasu, Okayama, Yoshimichi, Matsumoto, Kenji, Uchiyama, Chitose, Shirakawa, Taro, Yang, Xing, Adra, Chaker N., Hirai, Koichi, Saito, Hirohisa

“…During inflammation, neutrophils, basophils, and eosinophils release cell type–specific mediators and proteases through signaling molecules, such as G…”
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Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma by AKAHOSHI, Mitsuteru, OBARA, Kazuhiko, FUJIWARA, Hiroshi, MIYATAKE, Akihiko, FUJITA, Kimie, HIGASHI, Noritaka, TANIGUCHI, Masami, ENOMOTO, Tadao, MAO, Xiao-Quan, NAKASHIMA, Hitoshi, ADRA, Chaker N, NAKAMURA, Yusuke, HIROTA, Tomomitsu, TAMARI, Mayumi, SHIRAKAWA, Taro, MATSUDA, Akira, HASEGAWA, Koichi, TAKAHASHI, Naomi, SHIMIZU, Makiko, NAKASHIMA, Kazuko, LEI CHENG, DOI, Satoru

“…Asthma is a phenotypically heterogeneous disorder with many etiologic factors and clinical characteristics. T-bet, a Th1-specific transcription factor of T-box…”
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Human HTm4 is a hematopoietic cell cycle regulator by Donato, José L, Ko, Jon, Kutok, Jeffery L, Cheng, Tao, Shirakawa, Taro, Mao, Xiao-Quan, Beach, David, Scadden, David T, Sayegh, Mohamed H, Adra, Chaker N

“…Proper control of cell cycle progression is critical for the constant self-renewal, differentiation, and homeostasis of the hematopoietic system. Cells of all…”
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RGA protein associates with a TRPV ion channel during biosynthesis and trafficking by Barnhill, Jason C., Stokes, Alexander J., Koblan-Huberson, Murielle, Shimoda, Lori M.N., Muraguchi, Atsushi, Adra, Chaker N., Turner, Helen

“…TRPV ion channels transduce a range of temperature stimuli. We proposed that analysis of the protein–protein interactions made by TRPV2 might give insight into…”
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Binding of HTm4 to Cyclin-dependent Kinase (Cdk)-associated Phosphatase (KAP)·Cdk2·Cyclin A Complex Enhances the Phosphatase Activity of KAP, Dissociates Cyclin A, and Facilitates KAP Dephosphorylation of Cdk2 by Chinami, Masanobu, Yano, Yoshihiko, Yang, Xing, Salahuddin, Saira, Moriyama, Kosei, Shiroishi, Mitsunori, Turner, Helen, Shirakawa, Taro, Adra, Chaker N.

“…Cyclin-dependent kinase 2 (cdk2) activation requires phosphorylation of Thr160 and dissociation from cyclin A. The T-loop of cdk2 contains a regulatory…”
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Immunomodulation by Mesenchymal Stem Cells by Abdi, Reza, Fiorina, Paolo, Adra, Chaker N., Atkinson, Mark, Sayegh, Mohamed H.

“…Immunomodulation by Mesenchymal Stem Cells A Potential Therapeutic Strategy for Type 1 Diabetes Reza Abdi 1 , Paolo Fiorina 1 2 , Chaker N. Adra 1 3 , Mark…”
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Differential marker expression by cultures rich in mesenchymal stem cells by Wetzig, Andrew, Alaiya, Ayodele, Al-Alwan, Monther, Pradez, Christian Benedict, Pulicat, Manogaran S, Al-Mazrou, Amer, Shinwari, Zakia, Sleiman, Ghida Majed, Ghebeh, Hazem, Al-Humaidan, Hind, Gaafar, Ameera, Kanaan, Imaduddin, Adra, Chaker

“…Mesenchymal stem cells have properties that make them amenable to therapeutic use. However, the acceptance of mesenchymal stem cells in clinical practice…”
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