Search Results - "ADLER, Adam J"

High glucose promotes regulatory T cell differentiation by Pitmon, Elise, Meehan, Eileen Victoria, Ahmadi, Elham, Adler, Adam J, Wang, Kepeng

“…The consumption of processed foods and sugary sodas in Western diets correlates with an increased incidence of obesity, metabolic syndromes such as type 2…”
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IL-17 inhibits CXCL9/10-mediated recruitment of CD8+ cytotoxic T cells and regulatory T cells to colorectal tumors by Chen, Ju, Ye, Xiaoyang, Pitmon, Elise, Lu, Mengqian, Wan, Jun, Jellison, Evan R., Adler, Adam J., Vella, Anthony T., Wang, Kepeng

“…BackgroundThe IL-17 family cytokines are potent drivers of colorectal cancer (CRC) development. We and others have shown that IL-17 mainly signals to tumor…”
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Costimulation Induces CD4 T Cell Antitumor Immunity via an Innate-like Mechanism by Morales Del Valle, Crystal, Maxwell, Joseph R., Xu, Maria M., Menoret, Antoine, Mittal, Payal, Tsurutani, Naomi, Adler, Adam J., Vella, Anthony T.

“…Chronic exposure to tumor-associated antigens inactivates cognate T cells, restricting the repertoire of tumor-specific effector T cells. This problem was…”
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Presensitizing with a Toll-like receptor 3 ligand impairs CD8 T-cell effector differentiation and IL-33 responsiveness by Ngoi, Soo Mun, St. Rose, Marie-Clare, Menoret, Antoine M, Smith, Dirk E, Tovey, Michael G, Adler, Adam J, Vella, Anthony T

“…The synthetic double-stranded RNA poly(I:C) is commonly used as an adjuvant to boost CD8 T-cell function; however, polyinosinic:polycytidylic acid [poly(I:C)]…”
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Macrophage polarization and meta-inflammation by Li, Chuan, Xu, Maria M., Wang, Kepeng, Adler, Adam J., Vella, Anthony T., Zhou, Beiyan

“…Chronic overnutrition and obesity induces low-grade inflammation throughout the body. Termed “meta-inflammation,” this chronic state of inflammation is…”
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Letter from the Editor and Introduction to the 2023 Thematic Issue by Adler, Adam J

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Cancer Immunology and Immunotherapy: From Defining Basic Immunology to Leading the Fight Against Cancer by Adler, Adam J.

“…The past decade has seen the advent and widespread use of several immunotherapeutic modalities that have markedly improved treatment outcomes for patients with…”
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Letter from the Editor: 2022 by Adler, Adam J.

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Letter from the Editor: 2021 by Adler, Adam J.

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Addressing current challenges in cancer immunotherapy with mathematical and computational modelling by Konstorum, Anna, Vella, Anthony T., Adler, Adam J., Laubenbacher, Reinhard C.

“…The goal of cancer immunotherapy is to boost a patient's immune response to a tumour. Yet, the design of an effective immunotherapy is complicated by various…”
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Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function by Garcia Cruz, Dunia, Giri, Raghavendra R., Gamiotea Turro, Daylin, Balsbaugh, Jeremy L., Adler, Adam J., Rodriguez, Annabelle

“…Deficiency of lymphocyte activation gene-3 (LAG3) is significantly associated with increased cardiovascular disease risk with in vitro results demonstrating…”
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A mathematical model of combined CD8 T cell costimulation by 4-1BB (CD137) and OX40 (CD134) receptors by Konstorum, Anna, Vella, Anthony T., Adler, Adam J., Laubenbacher, Reinhard C.

“…Combined agonist stimulation of the TNFR costimulatory receptors 4-1BB (CD137) and OX40(CD134) has been shown to generate supereffector CD8 T cells that…”
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Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells by Tewalt, Eric F., Cohen, Jarish N., Rouhani, Sherin J., Guidi, Cynthia J., Qiao, Hui, Fahl, Shawn P., Conaway, Mark R., Bender, Timothy P., Tung, Kenneth S., Vella, Anthony T., Adler, Adam J., Chen, Lieping, Engelhard, Victor H.

“…Lymphatic endothelial cells (LECs) induce peripheral tolerance by direct presentation to CD8 T cells (TCD8). We demonstrate that LECs mediate deletion only via…”
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Autoregulated splicing of TRA2 β programs T cell fate in response to antigen-receptor stimulation by Karginov, Timofey A, Ménoret, Antoine, Leclair, Nathan K, Harrison, Andrew G, Chandiran, Karthik, Suarez-Ramirez, Jenny E, Yurieva, Marina, Karlinsey, Keaton, Wang, Penghua, O'Neill, Rachel J, Murphy, Patrick A, Adler, Adam J, Cauley, Linda S, Anczuków, Olga, Zhou, Beiyan, Vella, Anthony T

“…T cell receptor (TCR) sensitivity to peptide-major histocompatibility complex (MHC) dictates T cell fate. Canonical models of TCR sensitivity cannot be fully…”
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The IKK-neutralizing compound Bay11 kills supereffector CD8 T cells by altering caspase-dependent activation-induced cell death by Lee, Seung‐Joo, Long, Meixiao, Adler, Adam J., Mittler, Robert S., Vella, Anthony T.

“…Antigen with dual costimulation through CD137 and CD134 induces powerful CD8 T cell responses. These effector T cells are endowed with an intrinsic survival…”
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CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation by Qui, Harry Z, Hagymasi, Adam T, Bandyopadhyay, Suman, St Rose, Marie-Clare, Ramanarasimhaiah, Raghunath, Ménoret, Antoine, Mittler, Robert S, Gordon, Scott M, Reiner, Steven L, Vella, Anthony T, Adler, Adam J

“…Cytotoxic CD4 Th1 cells are emerging as a therapeutically useful T cell lineage that can effectively target tumors, but until now the pathways that govern…”
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Dual Sovereignty, Due Process, and Duplicative Punishment: A New Solution to an Old Problem by ADLER, ADAM J.

“…The Double Jeopardy Clause prohibits the government from prosecuting or punishing a defendant multiple times for the same offense. Double jeopardy protections,…”
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Tc17 CD8 T Cells: Functional Plasticity and Subset Diversity by Yen, Hung-Rong, Harris, Timothy J, Wada, Satoshi, Grosso, Joseph F, Getnet, Derese, Goldberg, Monica V, Liang, Kai-Li, Bruno, Tullia C, Pyle, Kristin J, Chan, Siaw-Li, Anders, Robert A, Trimble, Cornelia L, Adler, Adam J, Lin, Tzou-Yien, Pardoll, Drew M, Huang, Ching-Tai, Drake, Charles G

“…IL-17-secreting CD8 T cells (Tc17) have been described in several settings, but little is known regarding their functional characteristics. While Tc1 cells…”
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GRK2 enforces androgen receptor dependence in the prostate and prostate tumors by Adler, Adam J., Mittal, Payal, Hagymasi, Adam T., Menoret, Antoine, Shen, Chen, Agliano, Federica, Wright, Kyle T., Grady, James J., Kuo, Chia-Ling, Ballesteros, Enrique, Claffey, Kevin P., Vella, Anthony T.

“…Metastatic tumors that have become resistant to androgen deprivation therapy represent the major challenge in treating prostate cancer. Although these…”
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Costimulation Endows Immunotherapeutic CD8 T Cells with IL-36 Responsiveness during Aerobic Glycolysis by Tsurutani, Naomi, Mittal, Payal, St Rose, Marie-Clare, Ngoi, Soo Mun, Svedova, Julia, Menoret, Antoine, Treadway, Forrest B, Laubenbacher, Reinhard, Suárez-Ramírez, Jenny E, Cauley, Linda S, Adler, Adam J, Vella, Anthony T

“…CD134- and CD137-primed CD8 T cells mount powerful effector responses upon recall, but even without recall these dual-costimulated T cells respond to signal 3…”
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