Search Results - "ADER, Isabelle"

FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model by Gstalder, Cécile, Ader, Isabelle, Cuvillier, Olivier

“…Clear cell renal cell carcinoma (ccRCC) is characterized by intratumoral hypoxia and chemoresistance. The hypoxia-inducible factors HIF1α and HIF2α play a…”
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Human adipose stromal-vascular fraction self-organizes to form vascularized adipose tissue in 3D cultures by Muller, Sandra, Ader, Isabelle, Creff, Justine, Leménager, Hélène, Achard, Pauline, Casteilla, Louis, Sensebé, Luc, Carrière, Audrey, Deschaseaux, Frédéric

“…Native human subcutaneous adipose tissue (AT) is well organized into unilocular adipocytes interspersed within dense vascularization. This structure is…”
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Lactate Fluxes and Plasticity of Adipose Tissues: A Redox Perspective by Lagarde, Damien, Jeanson, Yannick, Portais, Jean-Charles, Galinier, Anne, Ader, Isabelle, Casteilla, Louis, Carrière, Audrey

“…Lactate, a metabolite produced when the glycolytic flux exceeds mitochondrial oxidative capacities, is now viewed as a critical regulator of metabolism by…”
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When the Sphingosine Kinase 1/Sphingosine 1-Phosphate Pathway Meets Hypoxia Signaling: New Targets for Cancer Therapy by ADER, Isabelle, MALAVAUD, Bernard, CUVILLIER, Olivier

“…The reduction in the normal level of tissue oxygen tension or hypoxia is a characteristic of solid tumors that triggers the activation of signaling pathways…”
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First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer by Brizuela, Leyre, Ader, Isabelle, Mazerolles, Catherine, Bocquet, Magalie, Malavaud, Bernard, Cuvillier, Olivier

“…This is the first report of sphingosine 1-phosphate lyase (SPL) protein expression and enzymatic activity in human neoplasm. This enzyme drives irreversible…”
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The emerging roles of lactate as a redox substrate and signaling molecule in adipose tissues by Carrière, Audrey, Lagarde, Damien, Jeanson, Yannick, Portais, Jean-Charles, Galinier, Anne, Ader, Isabelle, Casteilla, Louis

“…Thermogenic (brown and beige) adipose tissues improve glucose and lipid homeostasis and therefore represent putative targets to cure obesity and related…”
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Long non-coding RNA Neat1 and paraspeckle components are translational regulators in hypoxia by Godet, Anne-Claire, Roussel, Emilie, David, Florian, Hantelys, Fransky, Morfoisse, Florent, Alves, Joffrey, Pujol, Françoise, Ader, Isabelle, Bertrand, Edouard, Burlet-Schiltz, Odile, Froment, Carine, Henras, Anthony K, Vitali, Patrice, Lacazette, Eric, Tatin, Florence, Garmy-Susini, Barbara, Prats, Anne-Catherine

“…Internal ribosome entry sites (IRESs) drive translation initiation during stress. In response to hypoxia, (lymph)angiogenic factors responsible for tissue…”
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Mass Spectrometry-based Absolute Quantification of 20S Proteasome Status for Controlled Ex-vivo Expansion of Human Adipose-derived Mesenchymal Stromal/Stem Cells[S] by Menneteau, Thomas, Fabre, Bertrand, Garrigues, Luc, Stella, Alexandre, Zivkovic, Dusan, Roux-Dalvai, Florence, Mouton-Barbosa, Emmanuelle, Beau, Mathilde, Renoud, Marie-Laure, Amalric, François, Sensébé, Luc, Gonzalez-de-Peredo, Anne, Ader, Isabelle, Burlet-Schiltz, Odile, Bousquet, Marie-Pierre

“…20S proteasomes are very heterogeneous protein complexes involved in many cellular processes. In the present study, we combined an MRM-based assay with the…”
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Hypoxia-inducible factors and sphingosine 1-phosphate signaling by Cuvillier, Olivier, Ader, Isabelle

“…Hypoxia, defined as reduced tissue oxygen concentration, is a characteristic of solid tumors and is an indicator of unfavorable diagnosis in patients. At the…”
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Hypoxia, Therapeutic Resistance, and Sphingosine 1-Phosphate by Cuvillier, Olivier, Ader, Isabelle, Bouquerel, Pierre, Brizuela, Leyre, Gstalder, Cécile, Malavaud, Bernard

“…Hypoxia, defined as a poor oxygenation, has been long recognized as a hallmark of solid tumors and a negative prognostic factor for response to therapeutics…”
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Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia by Hantelys, Fransky, Godet, Anne-Claire, David, Florian, Tatin, Florence, Renaud-Gabardos, Edith, Pujol, Françoise, Diallo, Leila H, Ader, Isabelle, Ligat, Laetitia, Henras, Anthony K, Sato, Yasufumi, Parini, Angelo, Lacazette, Eric, Garmy-Susini, Barbara, Prats, Anne-Catherine

“…Hypoxia, a major inducer of angiogenesis, triggers major changes in gene expression at the transcriptional level. Furthermore, under hypoxia, global protein…”
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sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer by Brizuela, Leyre, Dayon, Audrey, Doumerc, Nicolas, Ader, Isabelle, Golzio, Muriel, Izard, Jean-Claude, Hara, Yukihiko, Malavaud, Bernard, Cuvillier, Olivier

“…The sphingosine kinase-1/sphingosine 1-phosphate (SphK1/S1P) pathway has been associated with cancer promotion and progression and resistance to treatments in…”
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Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells by Brizuela, Leyre, Martin, Claire, Jeannot, Pauline, Ader, Isabelle, Gstalder, Cécile, Andrieu, Guillaume, Bocquet, Magalie, Laffosse, Jean-Michel, Gomez-Brouchet, Anne, Malavaud, Bernard, Sabbadini, Roger A., Cuvillier, Olivier

“…Sphingosine 1-phosphate (S1P) plays important roles in cell proliferation, differentiation or survival mainly through its surface G-protein-coupled receptors…”
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A locally optimised machine learning approach to early prognostication of long-term neurological outcomes after out-of-hospital cardiac arrest by Pey, Vincent, Doumard, Emmanuel, Komorowski, Matthieu, Rouget, Antoine, Delmas, Clément, Vardon-Bounes, Fanny, Poette, Michaël, Ratineau, Valentin, Dray, Cédric, Ader, Isabelle, Minville, Vincent

“…Out-of-hospital cardiac arrest (OHCA) represents a major burden for society and health care, with an average incidence in adults of 67 to 170 cases per 100,000…”
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RhoB controls the 24 kDa FGF-2-induced radioresistance in HeLa cells by preventing post-mitotic cell death by ADER, Isabelle, TOULAS, Christine, DALENC, Florence, DELMAS, Caroline, BONNET, Jacques, COHEN-JONATHAN, Elizabeth, FAVRE, Gilles

“…Farnesylated Ras oncoprotein induces a cellular resistance to ionizing radiation that can be reversed by farnesyltransferase inhibitors (FTI). We previously…”
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Sphingosine Kinase 1: A New Modulator of Hypoxia Inducible Factor 1α during Hypoxia in Human Cancer Cells by Ader, Isabelle, Brizuela, Leyre, Bouquerel, Pierre, Malavaud, Bernard, Cuvillier, Olivier

“…Abstract Here, we provide the first evidence that sphingosine kinase 1 (SphK1), an oncogenic lipid kinase balancing the intracellular level of key signaling…”
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Periostin Plasma Levels and Changes on Physical and Cognitive Capacities in Community-Dwelling Older Adults by Sánchez-Sánchez, Juan Luis, Ader, Isabelle, Jeanson, Yannick, Planat-Benard, Valérie, Vellas, Bruno, Casteilla, Louis, de Souto-Barreto, Philipe

“…Abstract Periostin, involved in extracellular matrix development and support, has been shown to be elevated in senescent tissues and fibrotic states,…”
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Periostin Plasma Levels and Changes on Physical and Cognitive Capacities in Community-Dwelling Older Adults by Sánchez-Sánchez, Juan Luis, Ader, Isabelle, Jeanson, Yannick, Planat-Benard, Valérie, Vellas, Bruno, Casteilla, Louis, de Souto-Barreto, Philipe

“…Abstract Periostin, involved in extracellular matrix development and support, has been shown to be elevated in senescent tissues and fibrotic states,…”
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Synthesis, structures, and selective toxicity to cancer cells of gold(I) complexes involving N-heterocyclic carbene ligands by Boselli, Luca, Ader, Isabelle, Carraz, Maëlle, Hemmert, Catherine, Cuvillier, Olivier, Gornitzka, Heinz

“…New gold(I) complexes containing two 1-[2-(diethylamino)ethyl]imidazolydene ligands have been synthesized and characterized. The X-ray structures of two key…”
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Lactate fluxes mediated by the monocarboxylate transporter-1 are key determinants of the metabolic activity of beige adipocytes by Lagarde, Damien, Jeanson, Yannick, Barreau, Corinne, Moro, Cedric, Peyriga, Lindsay, Cahoreau, Edern, Guissard, Christophe, Arnaud, Emmanuelle, Galinier, Anne, Bouzier-Sore, Anne-Karine, Pellerin, Luc, Chouchani, Edward T., Pénicaud, Luc, Ader, Isabelle, Portais, Jean-Charles, Casteilla, Louis, Carrière, Audrey

“…Activation of energy-dissipating brown/beige adipocytes represents an attractive therapeutic strategy against metabolic disorders. While lactate is known to…”
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