Search Results - "ADAMZIK, Michael"

Aquaporins in sepsis- an update by Rump, Katharina, Adamzik, Michael

“…Aquaporins (AQPs), a family of membrane proteins that facilitate the transport of water and small solutes, have garnered increasing attention for their role in…”
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Function of aquaporins in sepsis: a systematic review by Rump, Katharina, Adamzik, Michael

“…Sepsis is a common cause of death in intensive care units worldwide. Due to the high complexity of this immunological syndrome development of novel therapeutic…”
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Epigenetic Mechanisms of Postoperative Cognitive Impairment Induced by Anesthesia and Neuroinflammation by Rump, Katharina, Adamzik, Michael

“…Cognitive impairment after surgery is a common problem, affects mainly the elderly, and can be divided into postoperative delirium and postoperative cognitive…”
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Efficacy, safety, and side effects of oliceridine in acute postoperative pain, a protocol for a systematic review and meta-analysis by Wolf, Anne, Unterberg, Matthias, Witowski, Andrea, Adamzik, Michael, Wolf, Alexander

“…This will be the first meta-analysis on the efficacy, safety, and side effects of oliceridine on postoperative pain. Our aim with this work is to evaluate the…”
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Long-term mortality and outcome in hospital survivors of septic shock, sepsis, and severe infections: The importance of aftercare by Rahmel, Tim, Schmitz, Stefanie, Nowak, Hartmuth, Schepanek, Kaspar, Bergmann, Lars, Halberstadt, Peter, Hörter, Stefan, Peters, Jürgen, Adamzik, Michael

“…Patients with severe infections and especially sepsis have a high in-hospital mortality, but even hospital survivors face long-term sequelae, decreased…”
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Comparison of mortality prediction models in acute respiratory distress syndrome undergoing extracorporeal membrane oxygenation and development of a novel prediction score: the PREdiction of Survival on ECMO Therapy-Score (PRESET-Score) by Hilder, Michael, Herbstreit, Frank, Adamzik, Michael, Beiderlinden, Martin, Bürschen, Markus, Peters, Jürgen, Frey, Ulrich H

“…Extracorporeal membrane oxygenation (ECMO) is a life-saving therapy in acute respiratory distress syndrome (ARDS) patients but is associated with complications…”
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Midazolam impacts acetyl—And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium? by Rump, Katharina, Holtkamp, Caroline, Bergmann, Lars, Nowak, Hartmuth, Unterberg, Matthias, Orlowski, Jennifer, Thon, Patrick, Bazzi, Zainab, Bazzi, Maha, Adamzik, Michael, Koos, Björn, Rahmel, Tim

“…Midazolam is a widely used short-acting benzodiazepine. However, midazolam is also criticized for its deliriogenic potential. Since delirium is associated with…”
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Increased circulating microRNA-122 is a biomarker for discrimination and risk stratification in patients defined by sepsis-3 criteria by Rahmel, Tim, Schäfer, Simon T, Frey, Ulrich H, Adamzik, Michael, Peters, Jürgen

“…Sepsis is now operationally defined as life-threatening organ dysfunction caused by an infection, identified by an acute change in SOFA-Score of at least two…”
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The aquaporin 5 -1364A/C promoter polymorphism impacts on resolution of acute kidney injury in pneumonia evoked ARDS by Rahmel, Tim, Nowak, Hartmuth, Rump, Katharina, Siffert, Winfried, Peters, Jürgen, Adamzik, Michael

“…Aquaporin 5 (AQP5) expression impacts on cellular water transport, renal function but also on key mechanisms of inflammation and immune cell migration that…”
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The Impact of Pathogens on Sepsis Prevalence and Outcome by Dyck, Birte, Unterberg, Matthias, Adamzik, Michael, Koos, Björn

“…Sepsis, a severe global healthcare challenge, is characterized by significant morbidity and mortality. The 2016 redefinition by the Third International…”
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Methazolamide Reduces the AQP5 mRNA Expression and Immune Cell Migration-A New Potential Drug in Sepsis Therapy? by Rump, Katharina, Koos, Björn, Ziehe, Dominik, Thon, Patrick, Rahmel, Tim, Palmowski, Lars, Marko, Britta, Wolf, Alexander, Witowski, Andrea, Bazzi, Zainab, Bazzi, Maha, Orlowski, Jennifer, Adamzik, Michael, Bergmann, Lars, Unterberg, Matthias

“…Sepsis is a life-threatening condition caused by the dysregulated host response to infection. Novel therapeutic options are urgently needed and aquaporin…”
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AQP5-1364A/C Polymorphism Affects AQP5 Promoter Methylation by Rump, Katharina, Spellenberg, Theresa, von Busch, Alexander, Wolf, Alexander, Ziehe, Dominik, Thon, Patrick, Rahmel, Tim, Adamzik, Michael, Koos, Björn, Unterberg, Matthias

“…The quantity of aquaporin 5 protein in neutrophil granulocytes is associated with human sepsis-survival. The C-allele of the aquaporin (AQP5)-1364A/C…”
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Assessing SOFA score trajectories in sepsis using machine learning: A pragmatic approach to improve the accuracy of mortality prediction by Palmowski, Lars, Nowak, Hartmuth, Witowski, Andrea, Koos, Björn, Wolf, Alexander, Weber, Maike, Kleefisch, Daniel, Unterberg, Matthias, Haberl, Helge, von Busch, Alexander, Ertmer, Christian, Zarbock, Alexander, Bode, Christian, Putensen, Christian, Limper, Ulrich, Wappler, Frank, Köhler, Thomas, Henzler, Dietrich, Oswald, Daniel, Ellger, Björn, Ehrentraut, Stefan F, Bergmann, Lars, Rump, Katharina, Ziehe, Dominik, Babel, Nina, Sitek, Barbara, Marcus, Katrin, Frey, Ulrich H, Thoral, Patrick J, Adamzik, Michael, Eisenacher, Martin, Rahmel, Tim

“…An increasing amount of longitudinal health data is available on critically ill septic patients in the age of digital medicine, including daily sequential…”
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Intravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study by Rahmel, Tim, Kraft, Felix, Haberl, Helge, Achtzehn, Ute, Brandenburger, Timo, Neb, Holger, Jarczak, Dominik, Dietrich, Maximilian, Magunia, Harry, Zimmer, Frieda, Basten, Jale, Landgraf, Claudia, Koch, Thea, Zacharowski, Kai, Weigand, Markus A, Rosenberger, Peter, Ullrich, Roman, Meybohm, Patrick, Nierhaus, Axel, Kindgen-Milles, Detlef, Timmesfeld, Nina, Adamzik, Michael

“…Abstract Background A profound inflammation-mediated lung injury with long-term acute respiratory distress and high mortality is one of the major complications…”
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The Association between the rs3747406 Polymorphism in the Glucocorticoid-Induced Leucine Zipper Gene and Sepsis Survivals Depends on the SOFA Score by Rusev, Stefan, Thon, Patrick, Rahmel, Tim, Ziehe, Dominik, Marko, Britta, Nowak, Hartmuth, Ellger, Björn, Limper, Ulrich, Schwier, Elke, Henzler, Dietrich, Ehrentraut, Stefan Felix, Bergmann, Lars, Unterberg, Matthias, Adamzik, Michael, Koos, Björn, Rump, Katharina, SepsisDataNet Nrw Research Group

“…The variability in mortality in sepsis could be a consequence of genetic variability. The glucocorticoid system and the intermediate TSC22D3 gene…”
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AQP3 and AQP9-Contrary Players in Sepsis? by Thon, Patrick, Rahmel, Tim, Ziehe, Dominik, Palmowski, Lars, Marko, Britta, Nowak, Hartmuth, Wolf, Alexander, Witowski, Andrea, Orlowski, Jennifer, Ellger, Björn, Wappler, Frank, Schwier, Elke, Henzler, Dietrich, Köhler, Thomas, Zarbock, Alexander, Ehrentraut, Stefan Felix, Putensen, Christian, Frey, Ulrich Hermann, Anft, Moritz, Babel, Nina, Sitek, Barbara, Adamzik, Michael, Bergmann, Lars, Unterberg, Matthias, Koos, Björn, Rump, Katharina

“…Sepsis involves an immunological systemic response to a microbial pathogenic insult, leading to a cascade of interconnected biochemical, cellular, and…”
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The Aquaporin 3 Polymorphism (rs17553719) Is Associated with Sepsis Survival and Correlated with IL-33 Secretion by Ziehe, Dominik, Marko, Britta, Thon, Patrick, Rahmel, Tim, Palmowski, Lars, Nowak, Hartmuth, von Busch, Alexander, Wolf, Alexander, Witowski, Andrea, Vonheder, Jolene, Ellger, Björn, Wappler, Frank, Schwier, Elke, Henzler, Dietrich, Köhler, Thomas, Zarbock, Alexander, Ehrentraut, Stefan Felix, Putensen, Christian, Frey, Ulrich Hermann, Anft, Moritz, Babel, Nina, Adamzik, Michael, Koos, Björn, Bergmann, Lars, Unterberg, Matthias, Rump, Katharina

“…Sepsis is a common life-threatening disease caused by dysregulated immune response and metabolic acidosis which lead to organ failure. An abnormal expression…”
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Therapeutic Suggestions During General Anesthesia Reduce Postoperative Nausea and Vomiting in High-Risk Patients – A Post hoc Analysis of a Randomized Controlled Trial by Nowak, Hartmuth, Wolf, Alexander, Rahmel, Tim, Oprea, Guenther, Grause, Lisa, Moeller, Manuela, Gyarmati, Katharina, Mittler, Corinna, Zagler, Alexandra, Lutz, Katrin, Loeser, Johannes, Saller, Thomas, Tryba, Michael, Adamzik, Michael, Hansen, Ernil, Zech, Nina

“…Postoperative nausea and vomiting (PONV) are one of the most adverse events after general anesthesia, a distressing experience, and pose a risk to the patient…”
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The Pro-Inflammatory Deletion Allele of the NF-κB1 Polymorphism Is Characterized by a Depletion of Subunit p50 in Sepsis by Marko, Britta, Heurich, Paulina, Thon, Patrick, Zimmer, Frieda, Bergmann, Lars, Nowak, Hartmuth, Rump, Katharina, Koos, Björn, Adamzik, Michael, Unterberg, Matthias, Rahmel, Tim

“…The functionally important NF-κB1 promoter polymorphism (−94ins/delATTG) significantly shapes inflammation and impacts the outcome of sepsis. However,…”
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Mortality rates of severe COVID-19-related respiratory failure with and without extracorporeal membrane oxygenation in the Middle Ruhr Region of Germany by Aweimer, Assem, Petschulat, Lea, Jettkant, Birger, Köditz, Roland, Finkeldei, Johannes, Dietrich, Johannes W., Breuer, Thomas, Draese, Christian, Frey, Ulrich H., Rahmel, Tim, Adamzik, Michael, Buchwald, Dirk, Useini, Dritan, Brechmann, Thorsten, Hosbach, Ingolf, Bünger, Jürgen, Ewers, Aydan, El-Battrawy, Ibrahim, Mügge, Andreas

“…The use of extracorporeal membrane oxygenation (ECMO) is discussed to improve patients’ outcome in severe COVID-19 with respiratory failure, but data on ECMO…”
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