Search Results - "ADAMS, Andrew B"

Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway by Adams, Andrew B, Ford, Mandy L, Larsen, Christian P

“…T cell activation is a complex process that requires multiple cell signaling pathways, including a primary recognition signal and additional costimulatory…”
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Xenoantigen Deletion and Chemical Immunosuppression Can Prolong Renal Xenograft Survival by Adams, Andrew B, Kim, Steven C, Martens, Gregory R, Ladowski, Joseph M, Estrada, Jose L, Reyes, Luz M, Breeden, Cindy, Stephenson, Allison, Eckhoff, Devin E, Tector, Matt, Tector, Alfred Joseph

“…OBJECTIVE:Xenotransplantation using pig organs could end the donor organ shortage for transplantation, but humans have xenoreactive antibodies that cause early…”
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Targeting co-stimulatory pathways: transplantation and autoimmunity by Ford, Mandy L., Adams, Andrew B., Pearson, Thomas C.

“…Key Points T-cell co-stimulatory signals, expressed either constitutively or upon activation, critically affect the magnitude and character of autoreactive or…”
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Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model by Higginbotham, Laura, Mathews, Dave, Breeden, Cynthia A., Song, Mingqing, Farris III, Alton Brad, Larsen, Christian P., Ford, Mandy L., Lutz, Andrew J., Tector, Matthew, Newell, Kenneth A., Tector, A. Joseph, Adams, Andrew B.

“…Xenotransplantation has the potential to alleviate the organ shortage that prevents many patients with end‐stage renal disease from enjoying the benefits of…”
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Blockade of BAFF Reshapes the Hepatic B Cell Receptor Repertoire and Attenuates Autoantibody Production in Cholestatic Liver Disease by Thapa, Manoj, Tedesco, Dana, Gumber, Sanjeev, Elrod, Elizabeth J, Han, Jin-Hwan, Kitchens, William H, Magliocca, Joseph F, Adams, Andrew B, Grakoui, Arash

“…Defects in biliary transport proteins, MDR3 in humans and Mdr2 in mice, can lead to a spectrum of cholestatic liver disorders. Although B cell disorders and…”
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Current Status of Renal Xenotransplantation and Next Steps by Tector, Alfred J, Adams, Andrew B, Tector, Matt

“…Renal transplantation is the preferred treatment of ESKD, but the shortage of suitable donor kidneys from the cadaver pool means that many patients with ESKD…”
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Secondary intervention after endovascular abdominal aortic aneurysm repair by Conrad, Mark F, Adams, Andrew B, Guest, Julie M, Paruchuri, Vikram, Brewster, David C, LaMuraglia, Glenn M, Cambria, Richard P

“…Endovascular Abdominal Aortic Aneurysm Repair (EVAR) has been criticized because of the need for frequent secondary interventions (2ndINT) to maintain…”
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Targeted mapping and utilization of the perihepatic surface for therapeutic beta cell replacement and retrieval in diabetic non-human primates by Leishman, David J, Oppler, Scott H, Stone, Laura L Hocum, O'Brien, Timothy D, Ramachandran, Sabarinathan, Willenberg, Bradley J, Adams, Andrew B, Hering, Bernhard J, Graham, Melanie L

“…Successful diabetes reversal using pancreatic islet transplantation by various groups illustrates the significant achievements made in cell-based diabetes…”
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A Survey of Current Procurement Travel Practices, Accident Frequency, and Perceptions of Safety by Schenk, Austin D., Washburn, William K., Adams, Andrew B., Lynch, Raymond J.

“…In 2018, 81% of the 36, 529 solid organs transplanted in the United States came from deceased donors. These organs were recovered through widespread use of…”
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Cutting Edge: Administration of Anti-CD40 Ligand and Donor Bone Marrow Leads to Hemopoietic Chimerism and Donor-Specific Tolerance Without Cytoreductive Conditioning by Durham, Megan M, Bingaman, Adam W, Adams, Andrew B, Ha, Jongwon, Waitze, Seung-Yeun, Pearson, Thomas C, Larsen, Christian P

“…Transplantation tolerance, defined as allograft acceptance by an immunocompetent recipient in the absence of long-term immunosuppression, has remained an…”
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Anti-C5 Antibody Tesidolumab Reduces Early Antibody-mediated Rejection and Prolongs Survival in Renal Xenotransplantation by Adams, Andrew B., Lovasik, Brendan P., Faber, David A., Burlak, Christopher, Breeden, Cynthia, Estrada, Jose L., Reyes, Luz M., Vianna, Rodrigo M., Tector, Matthew F., Tector, Alfred J.

“…Pig-to-primate renal xenotransplantation is plagued by early antibody-mediated graft loss which precludes clinical application of renal xenotransplantation. We…”
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Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor–Positive Cells and Pathogenesis of Cholestatic Liver Disease by Tedesco, Dana, Thapa, Manoj, Chin, Chui Yoke, Ge, Yong, Gong, Minghao, Li, Jing, Gumber, Sanjeev, Speck, Patrick, Elrod, Elizabeth J., Burd, Eileen M., Kitchens, William H., Magliocca, Joseph F., Adams, Andrew B., Weiss, David S., Mohamadzadeh, Mansour, Grakoui, Arash

“…Variants at the ABCB4 or MDR2 locus, which encodes a biliary transport protein, are associated with a spectrum of cholestatic liver diseases. Exacerbation of…”
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Long‐term survival of pig‐to‐rhesus macaque renal xenografts is dependent on CD4 T cell depletion by Kim, Steven C., Mathews, David V., Breeden, Cynthia P., Higginbotham, Laura B., Ladowski, Joseph, Martens, Gregory, Stephenson, Allison, Farris, Alton B., Strobert, Elizabeth A., Jenkins, Joe, Walters, Eric M., Larsen, Christian P., Tector, Matthew, Tector, Alfred J., Adams, Andrew B.

“…The shortage of available organs remains the greatest barrier to expanding access to transplant. Despite advances in genetic editing and immunosuppression,…”
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Transplantation Versus Resection for Hilar Cholangiocarcinoma: An Argument for Shifting Treatment Paradigms for Resectable Disease by Ethun, Cecilia G, Lopez-Aguiar, Alexandra G, Anderson, Douglas J, Adams, Andrew B, Fields, Ryan C, Doyle, Maria B, Chapman, William C, Krasnick, Bradley A, Weber, Sharon M, Mezrich, Joshua D, Salem, Ahmed, Pawlik, Timothy M, Poultsides, George, Tran, Thuy B, Idrees, Kamran, Isom, Chelsea A, Martin, Robert C G, Scoggins, Charles R, Shen, Perry, Mogal, Harveshp D, Schmidt, Carl, Beal, Eliza, Hatzaras, Ioannis, Shenoy, Rivfka, Cardona, Kenneth, Maithel, Shishir K

“…OBJECTIVE:To investigate the influence of type of surgery (transplant vs resection) on overall survival (OS) in patients with hilar cholangiocarcinoma (H-CCA)…”
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Calcineurin Inhibitor–Free CD28 Blockade-Based Protocol Protects Allogeneic Islets in Nonhuman Primates by ADAMS, Andrew B, SHIRASUGI, Nozomu, HOLLENHAUGH, Dianne, KENYON, Norma S, PEARSON, Thomas C, LARSEN, Christian P, DURHAM, Megan M, STROBERT, Elizabeth, ANDERSON, Dan, REES, Phyllis, COWAN, Shannon, HUAYING XU, BLINDER, Yelena, CHEUNG, Michael

“…Calcineurin Inhibitor–Free CD28 Blockade-Based Protocol Protects Allogeneic Islets in Nonhuman Primates Andrew B. Adams 1 , Nozomu Shirasugi 1 , Megan M…”
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Enhancing Kidney Transplantation and the Role of Xenografts: Report of a Scientific Workshop Sponsored by the National Kidney Foundation by Adams, Andrew B., Blumberg, Emily A., Gill, John S., Katz, Eliezer, Kawai, Tatsuo, Schold, Jesse D., Sykes, Megan, Tector, Alfred, Sachs, David H.

“…Chronic kidney disease affects an estimated 37 million people in the United States; of these,>800,000 have end-stage renal disease requiring chronic dialysis…”
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Biomarkers of operational tolerance following kidney transplantation – The immune tolerance network studies of spontaneously tolerant kidney transplant recipients by Newell, Kenneth A., Adams, Andrew B., Turka, Laurence A.

“…Studies of kidney transplant recipients who have developed spontaneous and sustained tolerance have revealed an association with B cells. Unexpectedly tolerant…”
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The landscape of liver transplantation for patients with alcohol-associated liver disease in the United States by Vock, David M, Humphreville, Vanessa, Ramanathan, Karthik V, Adams, Andrew B, Lim, Nicholas, Nguyen, Vinh H, Wothe, Jillian K, Chinnakotla, Srinath

“…Indications for liver transplants have expanded to include patients with alcohol-associated liver disease (ALD) over the last decade. Concurrently, the liver…”
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CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection by Mathews, David V, Dong, Ying, Higginbotham, Laura B, Kim, Steven C, Breeden, Cynthia P, Stobert, Elizabeth A, Jenkins, Joseph, Tso, J Yun, Larsen, Christian P, Adams, Andrew B

“…Interrupting T cell costimulatory signals as a strategy to control undesired immune responses, such as occur in autoimmunity or transplantation, has the…”
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Optimization of de novo belatacept‐based immunosuppression administered to renal transplant recipients by Kirk, Allan D., Adams, Andrew B., Durrbach, Antoine, Ford, Mandy L., Hildeman, David A., Larsen, Christian P., Vincenti, Flavio, Wojciechowski, David, Woodle, E. Steve

“…Kidney transplant recipients administered belatacept‐based maintenance immunosuppression present with a more favorable metabolic profile, reduced incidence of…”
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