Search Results - "ACS chemical neuroscience"

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms by Baig, Abdul Mannan, Khaleeq, Areeba, Ali, Usman, Syeda, Hira

“…The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion…”
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Expression of the SARS-CoV‑2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age by Bilinska, Katarzyna, Jakubowska, Patrycja, Von Bartheld, Christopher S, Butowt, Rafal

“…The COVID-19 pandemic revealed that there is a loss of smell in many patients, including in infected but otherwise asymptomatic individuals. The underlying…”
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SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection by Butowt, Rafal, Bilinska, Katarzyna

“…The novel SARS-CoV-2 virus has very high infectivity, which allows it to spread rapidly around the world. Attempts at slowing the pandemic at this stage depend…”
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Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences by von Bartheld, Christopher S, Hagen, Molly M, Butowt, Rafal

“…A significant proportion of people who test positive for COVID-19 have chemosensory deficits. However, the reported prevalence of these deficits in smell and…”
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The Rodent Forced Swim Test Measures Stress-Coping Strategy, Not Depression-like Behavior by Commons, Kathryn G, Cholanians, Aram B, Babb, Jessica A, Ehlinger, Daniel G

“…The forced swim test (FST) measures coping strategy to an acute inescapable stress and thus provides unique insight into the neural limb of the stress…”
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What Contributes to Serotonin–Norepinephrine Reuptake Inhibitors’ Dual-Targeting Mechanism? The Key Role of Transmembrane Domain 6 in Human Serotonin and Norepinephrine Transporters Revealed by Molecular Dynamics Simulation by Xue, Weiwei, Yang, Fengyuan, Wang, Panpan, Zheng, Guoxun, Chen, Yuzong, Yao, Xiaojun, Zhu, Feng

“…Dual inhibition of serotonin and norepinephrine transporters (hSERT and hNET) gives greatly improved efficacy and tolerability for treating major depressive…”
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Taste and Smell Disorders in COVID-19 Patients: Role of Interleukin‑6 by Cazzolla, Angela P, Lovero, Roberto, Lo Muzio, Lorenzo, Testa, Nunzio F, Schirinzi, Annalisa, Palmieri, Giuseppe, Pozzessere, Pietro, Procacci, Vito, Di Comite, Mariasevera, Ciavarella, Domenico, Pepe, Maria, De Ruvo, Caterina, Crincoli, Vito, Di Serio, Francesca, Santacroce, Luigi

“…The rapid recovery of smell and taste functions in COVID-19 patients could be attributed to a decrease in interleukin-6 levels rather than central nervous…”
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Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis by Yong, Shin Jie

“…Long-COVID is a postviral illness that can affect survivors of COVID-19, regardless of initial disease severity or age. Symptoms of long-COVID include fatigue,…”
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Proinflammatory Cytokines in the Olfactory Mucosa Result in COVID-19 Induced Anosmia by Torabi, Abolfazl, Mohammadbagheri, Esmaeil, Akbari Dilmaghani, Nader, Bayat, Amir-Hossein, Fathi, Mobina, Vakili, Kimia, Alizadeh, Rafieh, Rezaeimirghaed, Omidvar, Hajiesmaeili, Mohammadreza, Ramezani, Mahtab, Simani, Leila, Aliaghaei, Abbas

“…Studies have found increased rates of dysosmia in patients with Novel Coronavirus disease 2019 (COVID-19). However, the mechanism that causes olfactory loss is…”
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Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins by Sciacca, Michele F, Lolicato, Fabio, Tempra, Carmelo, Scollo, Federica, Sahoo, Bikash R, Watson, Matthew D, García-Viñuales, Sara, Milardi, Danilo, Raudino, Antonio, Lee, Jennifer C, Ramamoorthy, Ayyalusamy, La Rosa, Carmelo

“…An increasing number of human diseases has been shown to be linked to aggregation and amyloid formation by intrinsically disordered proteins (IDPs). Amylin,…”
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Brain Tissue Responses to Neural Implants Impact Signal Sensitivity and Intervention Strategies by Kozai, Takashi D. Y, Jaquins-Gerstl, Andrea S, Vazquez, Alberto L, Michael, Adrian C, Cui, X. Tracy

“…Implantable biosensors are valuable scientific tools for basic neuroscience research and clinical applications. Neurotechnologies provide direct readouts of…”
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Understanding the Role of Systemic Inflammation in Alzheimer’s Disease by Walker, Keenan A, Ficek, Bronte N, Westbrook, Reyhan

“…Human and animal studies suggest that inflammation occurring outside the central nervous system (systemic inflammation) may play a key role in promoting…”
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Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death by Chen, Xuechai, Yu, Chunyu, Guo, Minjun, Zheng, Xiaotong, Ali, Sakhawat, Huang, Hua, Zhang, Lihua, Wang, Shensen, Huang, Yinghui, Qie, Shuyan, Wang, Juan

“…N 6-Methyladenosine (m6A) is the most prevalent internal modification that occurs in the mRNA of eukaryotes and plays a vital role in the post-transcriptional…”
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Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression by Hibicke, Meghan, Landry, Alexus N, Kramer, Hannah M, Talman, Zoe K, Nichols, Charles D

“…Psilocybin shows efficacy to alleviate depression in human clinical trials for six or more months after only one or two treatments. Another hallucinogenic…”
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Interactions between SARS-CoV‑2 N‑Protein and α‑Synuclein Accelerate Amyloid Formation by Semerdzhiev, Slav A, Fakhree, Mohammad A. A, Segers-Nolten, Ine, Blum, Christian, Claessens, Mireille M. A. E

“…First cases that point at a correlation between SARS-CoV-2 infections and the development of Parkinson’s disease (PD) have been reported. Currently, it is…”
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Drug–Target Kinetics in Drug Discovery by Tonge, Peter J

“…The development of therapies for the treatment of neurological cancer faces a number of major challenges including the synthesis of small molecule agents that…”
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Neurological Insights of COVID-19 Pandemic by Das, Gaurav, Mukherjee, Nabanita, Ghosh, Surajit

“…The novel coronavirus SARS-CoV-2, which was identified after a recent outbreak in Wuhan, China, in December 2019, has kept the whole world in tenterhooks due…”
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Molecular Mechanism for the Allosteric Inhibition of the Human Serotonin Transporter by Antidepressant Escitalopram by Xue, Weiwei, Fu, Tingting, Deng, Shengzhe, Yang, Fengyuan, Yang, Jingyi, Zhu, Feng

“…Human serotine transporter (hSERT) is one of the most influential drug targets, and its allosteric modulators (e.g., escitalopram) have emerged to be the…”
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Deleterious Outcomes in Long-Hauler COVID-19: The Effects of SARS-CoV‑2 on the CNS in Chronic COVID Syndrome by Baig, Abdul Mannan

“…Amid our understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the mechanisms involved in the causation of acute-phase coronavirus…”
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Peripheral Nerve Conduit: Materials and Structures by Houshyar, Shadi, Bhattacharyya, Amitava, Shanks, Robert

“…Peripheral nerve injuries (PNIs) are the most common injury types to affect the nervous system. Restoration of nerve function after PNI is a challenging…”
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