Search Results - "ACKROFF, Karen"

Role of gut nutrient sensing in stimulating appetite and conditioning food preferences by Sclafani, Anthony, Ackroff, Karen

“…The discovery of taste and nutrient receptors (chemosensors) in the gut has led to intensive research on their functions. Whereas oral sugar, fat, and umami…”
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Greater reductions in fat preferences in CALHM1 than CD36 knockout mice by Sclafani, Anthony, Ackroff, Karen

“…Several studies indicate an important role of gustation in intake and preference for dietary fat. The present study compared fat preference deficits produced…”
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SGLT1 sugar transporter/sensor is required for post-oral glucose appetition by Sclafani, Anthony, Koepsell, Hermann, Ackroff, Karen

“…Recent findings suggest that the intestinal sodium-glucose transporter 1 (SGLT1) glucose transporter and sensor mediates, in part, the appetite-stimulation…”
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Learning of food preferences: mechanisms and implications for obesity & metabolic diseases by Berthoud, Hans-Rudolf, Morrison, Christopher D., Ackroff, Karen, Sclafani, Anthony

“…Omnivores, including rodents and humans, compose their diets from a wide variety of potential foods. Beyond the guidance of a few basic orosensory biases such…”
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Post-oral appetite stimulation by sugars and nonmetabolizable sugar analogs by Zukerman, Steven, Ackroff, Karen, Sclafani, Anthony

“…Post-oral sugar actions enhance the intake of and preference for sugar-rich foods, a process referred to as appetition. Here, we investigated the role of…”
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Flavor preference conditioning by different sugars in sweet ageusic Trpm5 knockout mice by Sclafani, Anthony, Ackroff, Karen

“…Abstract Knockout (KO) mice missing the taste signaling protein Trpm5 have greatly attenuated sweetener preferences but develop strong preferences for glucose…”
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Commentary: Sugar Metabolism Regulates Flavor Preferences and Portal Glucose Sensing by Sclafani, Anthony, Ackroff, Karen

“…(2010) reported that IG glucose infusions increased striatal dopamine release. [...]the enhanced flavor conditioning produced by glucose may result because the…”
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Post-oral glucose stimulation of intake and conditioned flavor preference in C57BL/6J mice: A concentration–response study by Zukerman, Steven, Ackroff, Karen, Sclafani, Anthony

“…Abstract In a recent study, intragastric (IG) self-infusion of 16% glucose stimulated 1-h intake and conditioned a preference for a flavored saccharin solution…”
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Learned flavor preferences. The variable potency of post-oral nutrient reinforcers by Ackroff, Karen

“…The notion that preferences for flavors paired with various nutrients can be attributed simply to their energy content (“flavor-calorie learning”) is belied by…”
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MSG intake and preference in mice are influenced by prior testing experience by Ackroff, Karen, Weintraub, Rachel, Sclafani, Anthony

“…Abstract Monosodium glutamate (MSG), the prototypical umami substance, is used as a flavor enhancer in many foods, but when presented alone is often only…”
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Selective effects of vagal deafferentation and celiac–superior mesenteric ganglionectomy on the reinforcing and satiating action of intestinal nutrients by Sclafani, Anthony, Ackroff, Karen, Schwartz, Gary J

“…The role of vagal afferents and splanchnic fibers in nutrient-induced flavor conditioning and feeding suppression was determined. Male rats were fitted with…”
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Glucose appetition in C57BL/6J mice: Influence of nonnutritive sweetener experience, food deprivation state and sex differences by Sclafani, Anthony, Ackroff, Karen

“…•Glucose has potent postoral actions (appetition) that enhance its reward value in C57BL/6 mice.•Glucose appetition is revealed in tests with initially…”
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Fat preference deficits and experience-induced recovery in global taste-deficient Trpm5 and Calhm1 knockout mice by Sclafani, Anthony, Ackroff, Karen

“…•Taste receptors mediate the preference for dietary fat via TRPM5 and CALHM1 ion channels.•Trpm5 knockout (KO) mice had greatly reduced preferences for 0.5 -…”
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Nutrient-conditioned intake stimulation does not require a distinctive flavor cue in rats by Sclafani, Anthony, Ackroff, Karen

“…The postoral actions of nutrients in rodents can stimulate intake and condition flavor preferences through an appetition process. Appetition is revealed in…”
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Role of lipolysis in postoral and oral fat preferences in mice by Sclafani, Anthony, Ackroff, Karen

“…Fatty acid receptors in the mouth and gut are implicated in the appetite for fat-rich foods. The role of lipolysis in oral- and postoral-based fat preferences…”
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Capsaicin-induced visceral deafferentation does not attenuate flavor conditioning by intragastric fat infusions in mice by Sclafani, Anthony, Ackroff, Karen

“…The postoral actions of sugar and fat can rapidly stimulate the intake of and preference for flavors associated with these nutrients via a process known as…”
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Operant licking for intragastric sugar infusions: Differential reinforcing actions of glucose, sucrose and fructose in mice by Sclafani, Anthony, Ackroff, Karen

“…Abstract Intragastric (IG) flavor conditioning studies in rodents indicate that isocaloric sugar infusions differ in their reinforcing actions, with glucose…”
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Flavor preferences conditioned by nutritive and non-nutritive sweeteners in mice by Sclafani, Anthony, Ackroff, Karen

“…Abstract Recent studies suggest that preferences are conditioned by nutritive (sucrose) but not by non-nutritive (sucralose) sweeteners in mice. Here we…”
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Flavor preferences conditioned by intragastric glucose but not fructose or galactose in C57BL/6J mice by Sclafani, Anthony, Ackroff, Karen

“…Abstract The present study determined if mice, like rats, differ in their flavor conditioning responses to intragastric (IG) infusions of three common…”
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Residual Glucose Taste in T1R3 Knockout but not TRPM5 Knockout Mice by Sclafani, Anthony, Zukerman, Steven, Ackroff, Karen

“…•T1R2+T1R3 taste receptor primarily mediates sweetener preference in mammals•T1R3 Knockout (KO) mice were indifferent to glucose and fructose in 1-min choice…”
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