Search Results - "ACHIM, A."

PRAME Expression in Melanocytic Tumors by Lezcano, Cecilia, Jungbluth, Achim A, Nehal, Kishwer S, Hollmann, Travis J, Busam, Klaus J

“…PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen that was isolated by autologous T cells in a melanoma patient. While…”
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Comparison of Immunohistochemistry for PRAME With Cytogenetic Test Results in the Evaluation of Challenging Melanocytic Tumors by Lezcano, Cecilia, Jungbluth, Achim A., Busam, Klaus J.

“…PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen. Although diffuse immunoreactivity for PRAME is found in most primary…”
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NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls by Solomon, James P., Linkov, Irina, Rosado, Andrea, Mullaney, Kerry, Rosen, Ezra Y., Frosina, Denise, Jungbluth, Achim A., Zehir, Ahmet, Benayed, Ryma, Drilon, Alexander, Hyman, David M., Ladanyi, Marc, Sireci, Anthony N., Hechtman, Jaclyn F.

“…With the FDA approval of larotrectinib, NTRK fusion assessment has recently become a standard part of management for patients with locally advanced or…”
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Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions by Hechtman, Jaclyn F, Benayed, Ryma, Hyman, David M, Drilon, Alexander, Zehir, Ahmet, Frosina, Denise, Arcila, Maria E, Dogan, Snjezana, Klimstra, David S, Ladanyi, Marc, Jungbluth, Achim A

“…Activating neurotrophic tyrosine receptor kinase (NTRK) fusions, typically detected using nucleic-acid based assays, are highly targetable and define certain…”
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Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNST by Prieto-Granada, Carlos N, Wiesner, Thomas, Messina, Jane L, Jungbluth, Achim A, Chi, Ping, Antonescu, Cristina R

“…Most malignant peripheral nerve sheath tumors (MPNSTs) exhibit combined inactivation of NF1, CDKN2A, and polycomb repressive complex 2 component genes…”
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Immunohistochemistry for PRAME in the Distinction of Nodal Nevi From Metastatic Melanoma by Lezcano, Cecilia, Pulitzer, Melissa, Moy, Andrea P., Hollmann, Travis J., Jungbluth, Achim A., Busam, Klaus J.

“…The distinction of metastatic melanoma from melanocytic nevi in lymph nodes can on occasion be difficult. As diffuse immunohistochemical (IHC) PRAME…”
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A Performance Comparison of Commonly Used Assays to Detect RET Fusions by Yang, Soo-Ryum, Aypar, Umut, Rosen, Ezra Y, Mata, Douglas A, Benayed, Ryma, Mullaney, Kerry, Jayakumaran, Gowtham, Zhang, Yanming, Frosina, Denise, Drilon, Alexander, Ladanyi, Marc, Jungbluth, Achim A, Rekhtman, Natasha, Hechtman, Jaclyn F

“…Selpercatinib and pralsetinib induce deep and durable responses in patients with advanced fusion-positive lung and thyroid cancer. fusion testing strategies…”
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Pan‐Trk immunohistochemistry is a sensitive and specific ancillary tool for diagnosing secretory carcinoma of the salivary gland and detecting ETV6–NTRK3 fusion by Xu, Bin, Haroon Al Rasheed, Mohamed R, Antonescu, Cristina R, Alex, Deepu, Frosina, Denise, Ghossein, Ronald, Jungbluth, Achim A, Katabi, Nora

“…Aims Secretory carcinoma (SC) of the salivary gland typically harbours ETV6–NTRK3 fusion, which can be utilised clinically to assist with diagnosis. Pan‐Trk…”
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Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing by Hensley, Martee L, Chavan, Shweta S, Solit, David B, Murali, Rajmohan, Soslow, Robert, Chiang, Sarah, Jungbluth, Achim A, Bandlamudi, Chaitanya, Srinivasan, Preethi, Tap, William D, Rosenbaum, Evan, Taylor, Barry S, Donoghue, Mark T A, Hyman, David M

“…We examined whether prospective molecular characterization of advanced metastatic disease can reveal grade and/or histology-specific differences to inform…”
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ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity by Lewis, Natasha, Soslow, Robert A, Delair, Deborah F, Park, Kay J, Murali, Rajmohan, Hollmann, Travis J, Davidson, Ben, Micci, Francesca, Panagopoulos, Ioannis, Hoang, Lien N, Arias-Stella, Javier A, Oliva, Esther, Young, Robert H, Hensley, Martee L, Leitao, Mario M, Hameed, Meera, Benayed, Ryma, Ladanyi, Marc, Frosina, Denise, Jungbluth, Achim A, Antonescu, Cristina R, Chiang, Sarah

“…High-grade endometrial stromal sarcoma likely encompasses underrecognized tumors harboring genetic abnormalities besides YWHAE–NUTM2 fusion. Triggered by three…”
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Sediment sources, spatiotemporal variability and rates of fluvial bedload transport in glacier-connected steep mountain valleys in western Norway (Erdalen and Bødalen drainage basins) by Beylich, Achim A., Laute, Katja

“…Contemporary fluvial bedload transport rates are still very difficult to measure and, as a result of this, in many sites only quantitative data on suspended…”
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Immunohistochemistry for PRAME in Dermatopathology by Lezcano, Cecilia, Jungbluth, Achim A, Busam, Klaus J

“…Preferentially expressed antigen in melanoma (PRAME) is a tumor-associated antigen first identified in a melanoma patient and found to be expressed in most…”
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NTRK Fusions Define a Novel Uterine Sarcoma Subtype With Features of Fibrosarcoma by Chiang, Sarah, Cotzia, Paolo, Hyman, David M, Drilon, Alexander, Tap, William D, Zhang, Lei, Hechtman, Jaclyn F, Frosina, Denise, Jungbluth, Achim A, Murali, Rajmohan, Park, Kay J, Soslow, Robert A, Oliva, Esther, Iafrate, A John, Benayed, Ryma, Ladanyi, Marc, Antonescu, Cristina R

“…Tropomyosin receptor kinase (Trk) inhibitors have shown high response rates in patients with tumors harboring NTRK fusions. We identified 4 NTRK…”
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Inter‐ and intraobserver agreement of programmed death ligand 1 scoring in head and neck squamous cell carcinoma, urothelial carcinoma and breast carcinoma by Downes, Michelle R, Slodkowska, Elzbieta, Katabi, Nora, Jungbluth, Achim A, Xu, Bin

“…Aims Programmed death‐ligand 1 (PD‐L1) expression by tumour cells (TC) is a mechanism for tumour immune escape through down‐regulation of antitumour T cell…”
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Molecular Characterization of Inflammatory Myofibroblastic Tumors With Frequent ALK and ROS1 Gene Fusions and Rare Novel RET Rearrangement by Antonescu, Cristina R, Suurmeijer, Albert J.H, Zhang, Lei, Sung, Yun-Shao, Jungbluth, Achim A, Travis, William D, Al-Ahmadie, Hikmat, Fletcher, Christopher D.M, Alaggio, Rita

“…Approximately 50% of conventional inflammatory myofibroblastic tumors (IMTs) harbor ALK gene rearrangement and overexpress ALK. Recently, gene fusions…”
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Combining impact sensor field and laboratory flume measurements with other techniques for studying fluvial bedload transport in steep mountain streams by Beylich, Achim A., Laute, Katja

“…The timing and rate of fluvial bedload transport are of central importance within sediment budget studies and in many applications in river science and…”
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Phase I trial of overlapping long peptides from a tumor self-antigen and poly-ICLC shows rapid induction of integrated immune response in ovarian cancer patients by Sabbatini, Paul, Tsuji, Takemasa, Ferran, Luis, Ritter, Erika, Sedrak, Christine, Tuballes, Kevin, Jungbluth, Achim A, Ritter, Gerd, Aghajanian, Carol, Bell-McGuinn, Katherine, Hensley, Martee L, Konner, Jason, Tew, William, Spriggs, David R, Hoffman, Eric W, Venhaus, Ralph, Pan, Linda, Salazar, Andres M, Diefenbach, Catherine Magid, Old, Lloyd J, Gnjatic, Sacha

“…Long peptides are efficiently presented to both CD4(+) and CD8(+) T cells after intracellular processing by antigen-presenting cells. To investigate the safety…”
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Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas by Geyer, Felipe C., Li, Anqi, Papanastasiou, Anastasios D., Smith, Alison, Selenica, Pier, Burke, Kathleen A., Edelweiss, Marcia, Wen, Huei-Chi, Piscuoglio, Salvatore, Schultheis, Anne M., Martelotto, Luciano G., Pareja, Fresia, Kumar, Rahul, Brandes, Alissa, Fan, Dan, Basili, Thais, Da Cruz Paula, Arnaud, Lozada, John R., Blecua, Pedro, Muenst, Simone, Jungbluth, Achim A., Foschini, Maria P., Wen, Hannah Y., Brogi, Edi, Palazzo, Juan, Rubin, Brian P., Ng, Charlotte K. Y., Norton, Larry, Varga, Zsuzsanna, Ellis, Ian O., Rakha, Emad A., Chandarlapaty, Sarat, Weigelt, Britta, Reis-Filho, Jorge S.

“…Adenomyoepithelioma of the breast is a rare tumor characterized by epithelial−myoepithelial differentiation, whose genetic underpinning is largely unknown…”
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BCOR Overexpression Is a Highly Sensitive Marker in Round Cell Sarcomas With BCOR Genetic Abnormalities by Kao, Yu-Chien, Sung, Yun-Shao, Zhang, Lei, Jungbluth, Achim A, Huang, Shih-Chiang, Argani, Pedram, Agaram, Narasimhan P, Zin, Angelica, Alaggio, Rita, Antonescu, Cristina R

“…With the advent of next-generation sequencing, an increasing number of novel gene fusions and other abnormalities have emerged recently in the spectrum of…”
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Integrative Molecular Characterization of Malignant Pleural Mesothelioma by Hmeljak, Julija, Sanchez-Vega, Francisco, Hoadley, Katherine A, Shih, Juliann, Stewart, Chip, Heiman, David, Tarpey, Patrick, Danilova, Ludmila, Drill, Esther, Gibb, Ewan A, Bowlby, Reanne, Kanchi, Rupa, Osmanbeyoglu, Hatice U, Sekido, Yoshitaka, Takeshita, Jumpei, Newton, Yulia, Graim, Kiley, Gupta, Manaswi, Gay, Carl M, Diao, Lixia, Gibbs, David L, Thorsson, Vesteinn, Iype, Lisa, Kantheti, Havish, Severson, David T, Ravegnini, Gloria, Desmeules, Patrice, Jungbluth, Achim A, Travis, William D, Dacic, Sanja, Chirieac, Lucian R, Galateau-Sallé, Françoise, Fujimoto, Junya, Husain, Aliya N, Silveira, Henrique C, Rusch, Valerie W, Rintoul, Robert C, Pass, Harvey, Kindler, Hedy, Zauderer, Marjorie G, Kwiatkowski, David J, Bueno, Raphael, Tsao, Anne S, Creaney, Jenette, Lichtenberg, Tara, Leraas, Kristen, Bowen, Jay, Felau, Ina, Zenklusen, Jean Claude, Akbani, Rehan, Cherniack, Andrew D, Byers, Lauren A, Noble, Michael S, Fletcher, Jonathan A, Robertson, A Gordon, Shen, Ronglai, Aburatani, Hiroyuki, Robinson, Bruce W, Campbell, Peter, Ladanyi, Marc

“…Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a…”
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