Search Results - "ACEñA, José Luis"

Recent advances in the trifluoromethylation methodology and new CF3-containing drugs by Zhu, Wei, Wang, Jiang, Wang, Shuni, Gu, Zhanni, Aceña, José Luis, Izawa, Kunisuke, Liu, Hong, Soloshonok, Vadim A.

“…•Assessment of current methods for the synthesis of CF3-containing molecules.•Description of five trifluoromethylated new drug candidates.•Evaluation of the…”
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Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases. Part 3: Michael addition reactions and miscellaneous transformations by Aceña, José Luis, Sorochinsky, Alexander E., Soloshonok, Vadim

“…The major goal of this review is a critical discussion of the literature data on asymmetric synthesis of α-amino acids via Michael addition reactions involving…”
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1,2,3-Benzotriazine Synthesis by Heterocyclization of p‑Tosylmethyl Isocyanide Derivatives by Maqueda-Zelaya, Francisco, Aceña, José Luis, Merino, Estíbaliz, Vaquero, Juan J., Sucunza, David

“…An efficient methodology to form 4-alkoxy- and 4-aryloxybenzo­[d]­[1,2,3]­triazines via an intramolecular heterocyclization of…”
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Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases; Part 1: alkyl halide alkylations by Sorochinsky, Alexander E, Aceña, José Luis, Moriwaki, Hiroki, Sato, Tatsunori, Soloshonok, Vadim A

“…Alkylations of chiral or achiral Ni(II) complexes of glycine Schiff bases constitute a landmark in the development of practical methodology for asymmetric…”
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Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases. Part 2: Aldol, Mannich addition reactions, deracemization and (S) to (R) interconversion of α-amino acids by Sorochinsky, Alexander E, Aceña, José Luis, Moriwaki, Hiroki, Sato, Tatsunori, Soloshonok, Vadim

“…This review provides a comprehensive treatment of literature data dealing with asymmetric synthesis of α-amino-β-hydroxy and α,β-diamino acids via homologation…”
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Asymmetric synthesis of α-(1-oxoisoindolin-3-yl)glycine: synthetic and mechanistic challenges by Li, Tingting, Zhou, Shengbin, Wang, Jiang, Aceña, José Luis, Soloshonok, Vadim A, Liu, Hong

“…We report herein that the NaOMe-catalyzed reactions between the chiral glycine Schiff base (S)-4 with 2-cyanobenzaldehyde 3a provide for a convenient…”
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Asymmetric Carbon-Carbon Bond Formation under Solventless Conditions in Ball Mills by Jörres, Manuel, Aceña, José Luis, Soloshonok, Vadim A., Bolm, Carsten

“…Solventless asymmetric alkylation of a nickel complex in a ball mill led to α‐amino acid precursors with essentially complete stereochemical control; this…”
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Sustainable Synthesis of Oximes, Hydrazones, and Thiosemicarbazones under Mild Organocatalyzed Reaction Conditions by Morales, Sara, Aceña, José Luis, García Ruano, José Luis, Cid, M. Belén

“…Pyrrolidine catalyzes very efficiently, presumably via iminium activation, the formation of acyloximes, acylhydrazones, and thiosemicarbazones derived from…”
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Asymmetric Synthesis of (2S,3S)‑α-(1-Oxoisoindolin-3-yl)glycines under Low-Basicity “Kinetic” Control by Li, Tingting, Zhou, Shengbin, Wang, Jiang, Aceña, José Luis, Soloshonok, Vadim A, Liu, Hong

“…The previously illusive (2S,3S)-configured α-(1-oxoisoindolin-3-yl)­glycines can be prepared under mild DBU-catalyzed, low-basicity conditions. The overall…”
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NH-type of chiral Ni(II) complexes of glycine Schiff base: design, structural evaluation, reactivity and synthetic applications by Bergagnini, Mackenzie, Fukushi, Kazunobu, Han, Jianlin, Shibata, Norio, Roussel, Christian, Ellis, Trevor K, Aceña, José Luis, Soloshonok, Vadim A

“…The work being reported here deals with the design of a new type of "N-H" Ni(II) complexes of glycine Schiff bases and study general aspects of their…”
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Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas by Zhou, Yu, Wang, Jiang, Gu, Zhanni, Wang, Shuni, Zhu, Wei, Aceña, José Luis, Soloshonok, Vadim A, Izawa, Kunisuke, Liu, Hong

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Straightforward Stereoselective Access to Cyclic Peptidomimetics by Fustero, Santos, Mateu, Natalia, Albert, Laia, Aceña, José Luis

“…The preparation of cyclic dipeptide mimetics from chiral imino lactones derived from (R)-phenylglycinol is described. Key steps of the synthetic route included…”
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Alkylations of Chiral Nickel(II) Complexes of Glycine under Phase-Transfer Conditions by Houck, Daniel, Luis Aceña, José, Soloshonok, Vadim A.

“…Alkylation reactions of nickel(II) complex 6 derived from glycine and 2‐[(1‐benzyl‐L‐prolyl)amino]benzophenone (BPBP) were studied under…”
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Cross-Metathesis Reactions as an Efficient Tool in the Synthesis of Fluorinated Cyclic β-Amino Acids by Fustero, Santos, Sánchez-Roselló, María, Aceña, José Luis, Fernández, Begoña, Asensio, Amparo, Sanz-Cervera, Juan F, Pozo, Carlos del

“…The synthesis of enantiomerically pure, cyclic, γ,γ-difluorinated β-amino acids with various ring sizes has been carried out with a cross-metathesis (CM)…”
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Diastereoselective Intramolecular Additions of Allyl- and Propargylsilanes to Iminium Ions: Synthesis of Cyclic and Bicyclic Quaternary Amino Acids by Fustero, Santos, Mateu, Natalia, Simón-Fuentes, Antonio, Aceña, José Luis

“…Chiral imino lactones derived from (R)-phenylglycinol containing an allyl- or propargyltrimethylsilyl group in the side chain readily cyclized in the presence…”
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Tailor-Made α-Amino Acids in the Pharmaceutical Industry: Synthetic Approaches to (1R,2S)-1-Amino-2-vinylcyclopropane-1-carboxylic Acid (Vinyl-ACCA) by Sato, Tatsunori, Izawa, Kunisuke, Aceña, José Luis, Liu, Hong, Soloshonok, Vadim A.

“…(1R,2S)‐1‐Amino‐2‐vinylcyclopropane‐1‐carboxylic acid (vinyl‐ACCA) is the essential pharmacophoric unit in a new generation of highly potent hepatitis C virus…”
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Synthetic and biological applications of fluorous reagents as phase tags by Fustero, Santos, Aceña, José Luis, Catalán, Silvia

“…The search for new and better techniques for the purification of organic compounds has made the recent emergence of fluorous chemistry in the field of organic…”
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Synthesis of fluorine-containing α-amino acids in enantiomerically pure form via homologation of Ni(II) complexes of glycine and alanine Schiff bases by Aceña, José Luis, Sorochinsky, Alexander E., Moriwaki, Hiroki, Sato, Tatsunori, Soloshonok, Vadim A.

“…•Comprehensive review of asymmetric synthesis of fluorine-containing amino acids via Ni(II) complex chemistry.•Methodologically flexible approaches including:…”
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Fluorous TBAF: A Convenient and Selective Reagent for Fluoride-Mediated Deprotections by Fustero, Santos, García Sancho, Amador, Aceña, José Luis, Sanz-Cervera, Juan F

“…A fluorous analogue of TBAF has been developed for its use in the clean removal of silicon-derived protecting groups. Purification of the crude mixtures by…”
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Chemical Kinetic Resolution of Unprotected β-Substituted β-Amino Acids Using Recyclable Chiral Ligands by Zhou, Shengbin, Wang, Jiang, Chen, Xia, Aceña, José Luis, Soloshonok, Vadim A., Liu, Hong

“…The first chemical method for resolution of N,C‐unprotected β‐amino acids was developed through enantioselective formation and disassembly of nickel(II)…”
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