Familial pyoderma gangrenosum presenting in infancy

Pyoderma gangrenosum (PG) is a rare, poorly understood skin disease that occurs in all age groups. Less than 0.4% of patients are infants and represent a diagnostic challenge as early lesions may resemble other skin disorders. Here we report for the first time three siblings affected with PG all pre...

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Bibliographic Details
Published in:	European journal of pediatrics Vol. 155; no. 9; pp. 759 - 762
Main Authors:	AL-RIMAWI, H. S, ABUEKTEISH, F. M, DAOUD, A. S, OBOOSI, M. M
Format:	Journal Article
Language:	English
Published:	Heidelberg Springer 01-09-1996 Berlin Springer Nature B.V
Subjects:	Abdomen Abscesses Adolescent Age groups Age of Onset Autosomal recessive inheritance Biological and medical sciences Biopsy Child Child, Preschool Dehydrogenases Dermatology Disease Female Glucose Heredity Humans Immunoglobulins Infants Inflammatory bowel disease Inflammatory Bowel Diseases - complications Laboratories Liver Lupus Male Medical sciences Neutrophils Proteins Pyoderma Pyoderma gangrenosum Pyoderma Gangrenosum - complications Pyoderma Gangrenosum - diagnosis Pyoderma Gangrenosum - drug therapy Pyoderma Gangrenosum - genetics Recurrence Siblings Skin diseases Skin involvement in other diseases. Miscellaneous. General aspects Stomatitis - complications Ulcers Human Case study Skin disease Sibling Child Pyoderma gangrenosum
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Summary:	Pyoderma gangrenosum (PG) is a rare, poorly understood skin disease that occurs in all age groups. Less than 0.4% of patients are infants and represent a diagnostic challenge as early lesions may resemble other skin disorders. Here we report for the first time three siblings affected with PG all presenting during infancy. Unlike the older age group, the ulcers spared the legs but involved the buttocks, thighs and perianal area in all the infants. This is the first reported family with PG affecting three siblings suggesting autosomal recessive inheritance. The diagnosis may be more difficult in infants due to absence of underlying associated disorders and the tendency of the lesions to appear in areas where infants frequently have other dermatoses. PG characteristically involves the buttocks, thighs and perianal area and spares the legs.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0340-6199 1432-1076
DOI:	10.1007/BF02002902