Outcome of older patients receiving mechanical ventilation

To determine the threshold of age that best discriminates the survival of mechanically ventilated patients and to estimate the outcome of mechanically ventilated older patients. International prospective cohort study. Three hundred sixty-one intensive care units from 20 countries. PATIENTS AND PARTI...

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Bibliographic Details
Published in:	Intensive care medicine Vol. 30; no. 4; pp. 639 - 646
Main Authors:	ESTEBAN, Andrés, ANZUETO, Antonio, MATAMIS, Dimitrios, PIMENTEL, Jorge, ABROUG, Freki, FRUTOS-VIVAR, Fernando, ALIA, Inmaculada, ELY, E. Wesley, BROCHARD, Laurent, STEWART, Thomas E, APEZTEGUIA, Carlos, TOBIN, Martin J, NIGHTINGALE, Peter
Format:	Journal Article
Language:	English
Published:	Heidelberg Springer 01-04-2004 Berlin Springer Nature B.V
Subjects:	Acute Kidney Injury - mortality Acute Kidney Injury - therapy Adult Age Factors Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Cohort Studies Critical Care Female Humans Intensive care medicine Intensive Care Units Logistic Models Male Medical sciences Prognosis Prospective Studies Respiration, Artificial - adverse effects Respiratory Distress Syndrome, Adult - mortality Respiratory Distress Syndrome, Adult - therapy Risk Factors Shock - mortality Shock - therapy Survival Rate Time Factors Human Intensive care Prognosis Respiratory failure Outcome Intensive care unit Epidemiology Survival rate Mechanical ventilation Elderly Resuscitation
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Summary:	To determine the threshold of age that best discriminates the survival of mechanically ventilated patients and to estimate the outcome of mechanically ventilated older patients. International prospective cohort study. Three hundred sixty-one intensive care units from 20 countries. PATIENTS AND PARTICIPANTS. Five thousand one hundred eighty-three patients mechanically ventilated for more than 12 h. None. Recursive partitioning and logistic regression were used and an outcome model was derived and validated using independent subgroups of the cohort. Two age thresholds (43 and 70 years) were found, by partitioning recursive analysis, to be associated with outcome. This study focuses on the analysis of patients older than 43 years of age, divided in two subgroups: between 43 and 70 years (middle age group) and older than 70 years (elderly group). Survival in hospital was 45% (95% C.I.: 43-48) for the elderly group and 55% (53-57) for the middle age group ( p<0.001). Advanced age was not associated with prolongation of mechanical ventilation, weaning or length of stay in the ICU and in hospital ( p>0.05). Variables associated with mortality in the elderly were: acute renal failure, shock, Simplified Acute Physiology Score II and a ratio of PaO(2) to FIO(2) more than 150. Older mechanically ventilated patients (age >70 years) had a lower ICU and hospital survival, but the duration of mechanical ventilation, ICU and hospital stay were similar to younger patients. Factors associated with the highest risk of mortality in patients older than 70 were the development of complications during the course of mechanical ventilation, such as acute renal failure and shock.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0342-4642 1432-1238
DOI:	10.1007/s00134-004-2160-5