Search Results - "ABRAMS, Scott I"

Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell-dependent mechanism by Waight, Jeremy D, Hu, Qiang, Miller, Austin, Liu, Song, Abrams, Scott I

“…Myeloid-derived suppressor cells (MDSC) are induced under diverse pathologic conditions, including neoplasia, and suppress innate and adaptive immunity. While…”
Get full text

Overcoming primary and acquired resistance to anti-PD-L1 therapy by induction and activation of tumor-residing cDC1s by Oba, Takaaki, Long, Mark D., Keler, Tibor, Marsh, Henry C., Minderman, Hans, Abrams, Scott I., Liu, Song, Ito, Fumito

“…The ability of cancer cells to ensure T-cell exclusion from the tumor microenvironment is a significant mechanism of resistance to anti-PD-1/PD-L1 therapy…”
Get full text

Granulocytic Myeloid-Derived Suppressor Cells as Negative Regulators of Anticancer Immunity by Kramer, Elliot D, Abrams, Scott I

“…The immune system plays a critical role in cancer progression and response to therapy. However, the immune system can be compromised during the neoplastic…”
Get full text

Targeting CXCL12/CXCR4 signaling with oncolytic virotherapy disrupts tumor vasculature and inhibits breast cancer metastases by Gil, Margaret, Seshadri, Mukund, Komorowski, Marcin P, Abrams, Scott I, Kozbor, Danuta

“…Oncolytic viruses hold promise for the treatment of cancer, but their interaction with the tumor microenvironment needs to be elucidated for optimal tumor cell…”
Get full text

Cancer in primary immunodeficiency diseases: Cancer incidence in the United States Immune Deficiency Network Registry by Mayor, Paul C., MD, Eng, Kevin H., PhD, Singel, Kelly L., BS, Abrams, Scott I., PhD, Odunsi, Kunle, MD PhD, Moysich, Kirsten B., PhD, Fuleihan, Ramsay, MD, Garabedian, Elizabeth, RN, Lugar, Patricia, MD, Ochs, Hans D., MD, Bonilla, Francisco A., MD PhD, Buckley, Rebecca H., MD, Sullivan, Kathleen E., MD PhD, Ballas, Zuhair K., MD, Cunningham-Rundles, Charlotte, MD PhD, Segal, Brahm H., MD

“…Abstract Background We evaluated the overall and site-specific incidence of cancer in subjects with primary immunodeficiency diseases (PIDD) enrolled in the…”
Get full text

Tristetraprolin regulates the skeletal phenotype and osteoclastogenic potential through monocytic myeloid‐derived suppressor cells by Zhang, Lixia, Kwack, Kyu Hwan, Thiyagarajan, Ramkumar, Mullaney, Kylie K., Lamb, Natalie A., Bard, Jonathan E., Sohn, Jiho, Seldeen, Kenneth L., Arao, Yukitomo, Blackshear, Perry J., Abrams, Scott I., Troen, Bruce R., Kirkwood, Keith L.

“…Tristetraprolin (TTP; also known as NUP475, GOS24, or TIS11), encoded by Zfp36, is an RNA‐binding protein that regulates target gene expression by promoting…”
Get full text

Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature by Kokolus, Kathleen M., Capitano, Maegan L., Lee, Chen-Ting, Eng, Jason W.-L., Waight, Jeremy D., Hylander, Bonnie L., Sexton, Sandra, Hong, Chi-Chen, Gordon, Christopher J., Abrams, Scott I., Repasky, Elizabeth A.

“…We show here that fundamental aspects of antitumor immunity in mice are significantly influenced by ambient housing temperature. Standard housing temperature…”
Get full text

Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs by Mastio, Jérôme, Condamine, Thomas, Dominguez, George, Kossenkov, Andrew V, Donthireddy, Laxminarasimha, Veglia, Filippo, Lin, Cindy, Wang, Fang, Fu, Shuyu, Zhou, Jie, Viatour, Patrick, Lavilla-Alonso, Sergio, Polo, Alexander T, Tcyganov, Evgenii N, Mulligan, Jr, Charles, Nam, Brian, Bennett, Joseph, Masters, Gregory, Guarino, Michael, Kumar, Amit, Nefedova, Yulia, Vonderheide, Robert H, Languino, Lucia R, Abrams, Scott I, Gabrilovich, Dmitry I

“…We have identified a precursor that differentiates into granulocytes in vitro and in vivo yet belongs to the monocytic lineage. We have termed these cells…”
Get full text

Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8⁺ T-cell axis by Brackett, Craig M., Kojouharov, Bojidar, Veith, Jean, Greene, Kellee F., Burdelya, Lyudmila G., Gollnick, Sandra O., Abrams, Scott I., Gudkov, Andrei V.

“…Activation of an anticancer innate immune response is highly desirable because of its inherent ability to generate an adaptive antitumor T-cell response…”
Get full text

Tumor-induced myeloid dysfunction and its implications for cancer immunotherapy by Messmer, Michelle N., Netherby, Colleen S., Banik, Debarati, Abrams, Scott I.

“…Immune function relies on an appropriate balance of the lymphoid and myeloid responses. In the case of neoplasia, this balance is readily perturbed by the…”
Get full text

The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production by Netherby, Colleen S, Messmer, Michelle N, Burkard-Mandel, Lauren, Colligan, Sean, Miller, Austin, Cortes Gomez, Eduardo, Wang, Jianmin, Nemeth, Michael J, Abrams, Scott I

“…Alterations in myelopoiesis are common across various tumor types, resulting in immature populations termed myeloid-derived suppressor cells (MDSCs). MDSC…”
Get full text

Inhibiting the biogenesis of myeloid-derived suppressor cells enhances immunotherapy efficacy against mammary tumor progression by Colligan, Sean H, Amitrano, Andrea M, Zollo, Robert A, Peresie, Jennifer, Kramer, Elliot D, Morreale, Brian, Barbi, Joseph, Singh, Prashant K, Yu, Han, Wang, Jianmin, Opyrchal, Mateusz, Sykes, David B, Nemeth, Michael J, Abrams, Scott I

“…While immune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape in oncology, they are effective in select subsets of patients. Efficacy…”
Get full text

Local, multimodal intralesional therapy renders distant brain metastases susceptible to PD-L1 blockade in a preclinical model of triple-negative breast cancer by Yokoi, Toshihiro, Oba, Takaaki, Kajihara, Ryutaro, Abrams, Scott I., Ito, Fumito

“…Despite recent progress in therapeutic strategies, prognosis of metastatic triple-negative breast cancer (TNBC) remains dismal. Evidence suggests that the…”
Get full text

Aryl hydrocarbon receptor suppresses STING-mediated type I IFN expression in triple-negative breast cancer by Martin, Jeffrey C., da Silva Fernandes, Tatiane, Chaudhry, Kanita A., Oshi, Masanori, Abrams, Scott I., Takabe, Kazuaki, Rosario, Spencer R., Bianchi-Smiraglia, Anna

“…Triple-negative breast cancer (TNBC) is one of the most aggressive types of cancer. Despite decades of intense investigation, treatment options remain limited,…”
Get full text

CD163 + macrophages in the triple-negative breast tumor microenvironment are associated with improved survival in the Women's Circle of Health Study and the Women's Circle of Health Follow-Up Study by Omilian, Angela R, Cannioto, Rikki, Mendicino, Lucas, Stein, Leighton, Bshara, Wiam, Qin, Bo, Bandera, Elisa V, Zeinomar, Nur, Abrams, Scott I, Hong, Chi-Chen, Yao, Song, Khoury, Thaer, Ambrosone, Christine B

“…Tumor-associated macrophages (TAMs) are a prominent immune subpopulation in the tumor microenvironment that could potentially serve as therapeutic targets for…”
Get full text

A Call for Epidemiological Research on Myeloid-Derived Suppressor Cells in Ovarian Cancer: A Review of the Existing Immunological Evidence and Suggestions for Moving Forward by Stenzel, Ashley E, Abrams, Scott I, Moysich, Kirsten B

“…Recently, there have been encouraging findings suggesting that myeloid-derived suppressor cells (MDSCs) may be a good target for studying immune suppression in…”
Get full text

Discovering Myeloid Cell Heterogeneity in Mandibular Bone - Cell by Cell Analysis by Kwack, Kyu Hwan, Lamb, Natalie A, Bard, Jonathan E, Kramer, Elliot D, Zhang, Lixia, Abrams, Scott I, Kirkwood, Keith L

“…The myeloid-derived bone marrow progenitor populations from different anatomical locations are known to have diverse osteoclastogenesis potential…”
Get full text

Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes by Ku, Amy W, Muhitch, Jason B, Powers, Colin A, Diehl, Michael, Kim, Minhyung, Fisher, Daniel T, Sharda, Anand P, Clements, Virginia K, O'Loughlin, Kieran, Minderman, Hans, Messmer, Michelle N, Ma, Jing, Skitzki, Joseph J, Steeber, Douglas A, Walcheck, Bruce, Ostrand-Rosenberg, Suzanne, Abrams, Scott I, Evans, Sharon S

“…Myeloid-derived suppressor cells (MDSC) contribute to an immunosuppressive network that drives cancer escape by disabling T cell adaptive immunity. The…”
Get full text

Tumor-derived thymic stromal lymphopoietin enhances lung metastasis through an alveolar macrophage-dependent mechanism by Burkard-Mandel, Lauren, O'Neill, Rachel, Colligan, Sean, Seshadri, Mukund, Abrams, Scott I.

“…It is well-recognized that macrophages, which arise from circulating precursors, enhance tumor progression in patients and animal models. However, less is…”
Get full text

Platelet integrin α6β1 controls lung metastasis through direct binding to cancer cell–derived ADAM9 by Mammadova-Bach, Elmina, Zigrino, Paola, Brucker, Camille, Bourdon, Catherine, Freund, Monique, De Arcangelis, Adèle, Abrams, Scott I., Orend, Gertaud, Gachet, Christian, Mangin, Pierre Henri

“…Metastatic dissemination of cancer cells, which accounts for 90% of cancer mortality, is the ultimate hallmark of malignancy. Growing evidence suggests that…”
Get full text