Search Results - "ABRAMS, S. I"

How tumours escape mass destruction by Stewart, T J, Abrams, S I

“…It is now well established that the immune system can control neoplastic development and growth in a process termed immunosurveillance. A link between host…”
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Regression of Extensive Pulmonary Metastases in Mice by Adoptive Transfer of Antigen-Specific CD8+ CTL Reactive Against Tumor Cells Expressing a Naturally Occurring Rejection Epitope by Ryan, Mary Hilburger, Bristol, J. Andrew, McDuffie, Elwood, Abrams, Scott I

“…In this study, we developed a mouse model of adoptive immunotherapy reflecting immune recognition of syngeneic tumor cells naturally expressing an endogenous…”
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A phase I vaccine trial with peptides reflecting ras oncogene mutations of solid tumors by Khleif, S N, Abrams, S I, Hamilton, J M, Bergmann-Leitner, E, Chen, A, Bastian, A, Bernstein, S, Chung, Y, Allegra, C J, Schlom, J

“…Mutations in the ras genes occur in 20% of all human cancers. These genes, in turn, produce mutated proteins that are unique to cancer cells, rendering them…”
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Characterization of CD8+ cytotoxic T lymphocyte/tumor cell interactions reflecting recognition of an endogenously expressed murine wild-type p53 determinant by RYAN, Mary Hilburger, ABRAMS, Scott I

“…p53 mutations are frequently found in human cancers and are often associated with the overexpression of wild-type (WT) protein or peptide sequences, supporting…”
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Mutant ras epitopes as targets for cancer vaccines by Abrams, S I, Hand, P H, Tsang, K Y, Schlom, J

“…The ras p21 proto-oncogenes (ie, K-ras, H-ras, N-ras) encode a family of proteins vital to cellular signaling and function. Point mutations in these genes have…”
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Influence of interferon γ on modulation of Fas expression by human colon carcinoma cells and their subsequent sensitivity to antigen-specific CD8+ cytotoxic T lymphocyte attack by BERGMANN-LEITNER, E. S, ABRAMS, S. I

“…The inability of certain neoplastic populations to undergo Fas-mediated death by immune effector mechanisms may confer a selective survival advantage, which…”
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Admixture of a recombinant vaccinia virus containing the gene for the costimulatory molecule B7 and a recombinant vaccinia virus containing a tumor-associated antigen gene results in enhanced specific T-cell responses and antitumor immunity by HODGE, J. W, MCLAUGHLIN, J. P, ABRAMS, S. I, SHUPERT, W. L, SCHLOM, J, KANTOR, J. A

“…At least two signals are required for the activation of naive T cells by antigen-bearing target cells: an antigen-specific signal, delivered through the T-cell…”
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Strategies in the development of recombinant vaccines for colon cancer by Schlom, J, Tsang, K Y, Kantor, J A, Abrams, S I, Zaremba, S, Greiner, J, Hodge, J W

“…A new era involving the evaluation of recombinant vaccines for colon cancer has begun with the concurrent emergence of insights and technologies in the fields…”
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Sensitivity of T cells to anti-CD3-stimulated suicide is independent of functional phenotype by Russell, J H, Rush, B J, Abrams, S I, Wang, R

“…We have examined mixed populations and cloned murine CD4+ T cell lines for their sensitivity to anti-CD3-stimulated suicide. The sensitivity of CD4+ clones to…”
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Treatment of human colon carcinoma cell lines with anti-neoplastic agents enhances their lytic sensitivity to antigen-specific CD8+ cytotoxic T lymphocytes by BERGMANN-LEITNER, Elke S, ABRAMS, Scott I

“…Certain anti-neoplastic agents at subtoxic doses may exert immunomodulatory effects, which alter the expression of specific tumor cell surface molecules. We…”
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Evidence for an early calcium-independent event in the activation of the human natural killer cell cytolytic mechanism by Brahmi, Z, Bray, RA, Abrams, SI

“…In this study, we examined the functional status of human natural killer (NK) cells after their direct interaction with the NK-sensitive tumor target cell…”
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CD4+ T lymphocyte-induced target cell detachment. A model for T cell- mediated lytic and nonlytic inflammatory processes by Abrams, SI, Russell, JH

“…We have been exploring the hypothesis that T lymphocytes have the potential to mediate immune damage through nonlytic disruption of tissue organization. In…”
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Compared mechanisms of tumor cytolysis by human natural killer cells and activated polymorphonuclear leukocytes by Abrams, SI, Brahmi, Z

“…The mechanism(s) of natural killer (NK) cell-mediated cytotoxicity (CMC) remains largely unknown. In this study, we investigated the possibility of human NK…”
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Differential Role of Fas/Fas Ligand Interactions in Cytolysis of Primary and Metastatic Colon Carcinoma Cell Lines by Human Antigen-Specific CD8+ CTL by Bergmann-Leitner, Elke S, Abrams, Scott I

“…We have previously identified mutated ras peptides reflecting the glycine to valine substitution at position 12 as HLA-A2-restricted, CD8+ CTL neo-epitopes…”
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The functional loss of human natural killer cell activity induced by K562 is reversible via an interleukin-2-dependent mechanism by Abrams, S I, Brahmi, Z

“…In a recent study, we evaluated the functional status of human natural killer (NK) cells after their interaction with the NK-sensitive tumor target cell (TC),…”
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Target cell directed NK inactivation. Concomitant loss of NK and antibody-dependent cellular cytotoxicity activities by Abrams, SI, Brahmi, Z

“…We investigated the inactivation of human NK cells, a population of large granular lymphocytes (LGL), with K562, an NK-sensitive target cell (TC) and KLCL, an…”
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Mechanism of action of phorbol myristate acetate on human natural killer cell activity by Abrams, S I, Bray, R A, Brahmi, Z

“…We have investigated the kinetics of inhibition and regeneration of human natural killer (NK) cell-mediated lysis of K562, a human erythroleukemia cell line,…”
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Rational antigen modification as a strategy to upregulate or downregulate antigen recognition by Abrams, S I, Schlom, J

“…Recent and rapid advances in our understanding of the cellular and molecular mechanisms of antigen recognition by CD8(+) and CD4(+) T lymphocytes have led to…”
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Cytotoxic T lymphocyte-induced loss of target cell adhesion and lysis involve common and separate signaling pathways by Abrams, SI, McCulley, DE, Meleedy-Rey, P, Russell, JH

“…Recently, we demonstrated that an early event in the CTL-target cell (TC) interaction is loss of TC adherence to substrate. This loss of adhesion is…”
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Development of a Murine Mutant Ras CD8+ CTL Peptide Epitope Variant That Possesses Enhanced MHC Class I Binding and Immunogenic Properties by Bristol, J. Andrew, Schlom, Jeffrey, Abrams, Scott I

“…We recently identified a murine mutant Ras p21 CD8+ CTL epitope reflecting residues 4 to 12, containing the mutation of Gly to Val at codon 12, that bound…”
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