Search Results - "ABRAHMSÉN, Lars"

Synthetic affibody molecules : A novel class of affinity ligands for molecular imaging of HER2-expressing malignant tumors by ORLOVA, Anna, TOLMACHEV, Vladimir, PEHRSON, Rikard, LINDBORG, Malin, TRAN, Thuy, SANDSTRÖM, Mattias, NILSSON, Fredrik Y, WENNBORG, Anders, ABRAHMSEN, Lars, FELDWISCH, Joachim

“…The Affibody molecule Z(HER2:342-pep2), site-specifically and homogeneously conjugated with a 1,4,7,10-tetra-azacylododecane-N,N',N'',N'''-tetraacetic acid…”
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Tumor targeting using affibody molecules: interplay of affinity, target expression level, and binding site composition by Tolmachev, Vladimir, Tran, Thuy A, Rosik, Daniel, Sjöberg, Anna, Abrahmsén, Lars, Orlova, Anna

“…Radionuclide imaging of cancer-associated molecular alterations may contribute to patient stratification for targeting therapy. Scaffold high-affinity…”
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engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein by Seijsing, Johan, Lindborg, Malin, Höidén-Guthenberg, Ingmarie, Bönisch, Heiko, Guneriusson, Elin, Frejd, Fredrik Y., Abrahmsén, Lars, Ekblad, Caroline, Löfblom, John, Uhlén, Mathias, Gräslund, Torbjörn

“…Proteins endocytosed from serum are degraded in the lysosomes. However, serum albumin (SA) and IgG, through its Fc part, bind to the neonatal Fc receptor…”
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Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Improves Hepatic Insulin Sensitivity in Hyperglycemic Mice Strains by Alberts, Pēteris, Nilsson, Cecilia, Selén, Göran, Engblom, Lars O. M, Edling, Naimie H. M, Norling, Solveig, Klingström, Gunnel, Larsson, Catarina, Forsgren, Margareta, Ashkzari, Mandana, Nilsson, Catrine E, Fiedler, Maj, Bergqvist, Elisabet, Öhman, Birgitta, Björkstrand, Eva, Abrahmsén, Lars B

“…11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been proposed as a new target for type 2 diabetes drugs. The aim of the present study was to assess the…”
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Targeting MDM4 as a Novel Therapeutic Approach in Prostate Cancer Independent of p53 Status by Mejía-Hernández, Javier Octavio, Raghu, Dinesh, Caramia, Franco, Clemons, Nicholas, Fujihara, Kenji, Riseborough, Thomas, Teunisse, Amina, Jochemsen, Aart G, Abrahmsén, Lars, Blandino, Giovanni, Russo, Andrea, Gamell, Cristina, Fox, Stephen B, Mitchell, Catherine, Takano, Elena A, Byrne, David, Miranda, Panimaya Jeffreena, Saleh, Reem, Thorne, Heather, Sandhu, Shahneen, Williams, Scott G, Keam, Simon P, Haupt, Ygal, Haupt, Sue

“…Metastatic prostate cancer is a lethal disease in patients incapable of responding to therapeutic interventions. Invasive prostate cancer spread is caused by…”
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Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ) by Degtjarik, Oksana, Golovenko, Dmitrij, Diskin-Posner, Yael, Abrahmsén, Lars, Rozenberg, Haim, Shakked, Zippora

“…In response to genotoxic stress, the tumor suppressor p53 acts as a transcription factor by regulating the expression of genes critical for cancer prevention…”
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Arylsulfonamidothiazoles as a New Class of Potential Antidiabetic Drugs. Discovery of Potent and Selective Inhibitors of the 11β-Hydroxysteroid Dehydrogenase Type 1 by Barf, Tjeerd, Vallgårda, Jerk, Emond, Rikard, Häggström, Charlotta, Kurz, Guido, Nygren, Alf, Larwood, Vivienne, Mosialou, Erifili, Axelsson, Kent, Olsson, Rolf, Engblom, Lars, Edling, Naimie, Rönquist-Nii, Yuko, Öhman, Birgitta, Alberts, Peteris, Abrahmsén, Lars

“…Novel antidiabetic arylsulfonamidothiazoles are presented that exert action through selective inhibition of the 11β-hydroxysteroid dehydrogenase type 1…”
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Design, synthesis and biological evaluation of a multifunctional HER2-specific Affibody molecule for molecular imaging by Tran, Thuy A., Rosik, Daniel, Abrahmsén, Lars, Sandström, Mattias, Sjöberg, Anna, Wållberg, Helena, Ahlgren, Sara, Orlova, Anna, Tolmachev, Vladimir

“…Purpose The purpose of this study was to design and evaluate a novel platform for labelling of Affibody molecules, enabling both recombinant and synthetic…”
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N‐terminal engineering of amyloid‐β‐binding Affibody molecules yields improved chemical synthesis and higher binding affinity by Lindgren, Joel, Wahlström, Anna, Danielsson, Jens, Markova, Natalia, Ekblad, Caroline, Gräslund, Astrid, Abrahmsén, Lars, Karlström, Amelie Eriksson, Wärmländer, Sebastian K.T.S.

“…The aggregation of amyloid‐β (Aβ) peptides is believed to be a major factor in the onset and progression of Alzheimer's disease. Molecules binding with high…”
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Structural basis for high-affinity HER2 receptor binding by an engineered protein by Eigenbrot, Charles, Ultsch, Mark, Dubnovitsky, Anatoly, Abrahmsén, Lars, Härd, Torleif, Bax, Adriaan

“…The human epidermal growth factor receptor 2 (HER2) is specifically overexpressed in tumors of several cancers, including an aggressive form of breast cancer…”
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Extending Half-life by Indirect Targeting of the Neonatal Fc Receptor (FcRn) Using a Minimal Albumin Binding Domain by Andersen, Jan Terje, Pehrson, Rikard, Tolmachev, Vladimir, Daba, Muluneh Bekele, Abrahmsén, Lars, Ekblad, Caroline

“…The therapeutic and diagnostic efficiency of engineered small proteins, peptides, and chemical drug candidates is hampered by short in vivo serum half-life…”
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Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation by Liu, David S., Duong, Cuong P., Haupt, Sue, Montgomery, Karen G., House, Colin M., Azar, Walid J., Pearson, Helen B., Fisher, Oliver M., Read, Matthew, Guerra, Glen R., Haupt, Ygal, Cullinane, Carleen, Wiman, Klas G., Abrahmsen, Lars, Phillips, Wayne A., Clemons, Nicholas J.

“…TP53 , a critical tumour suppressor gene, is mutated in over half of all cancers resulting in mutant-p53 protein accumulation and poor patient survival…”
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HEHEHE-Tagged Affibody Molecule May Be Purified by IMAC, Is Conveniently Labeled with [99mTc(CO)3]+, and Shows Improved Biodistribution with Reduced Hepatic Radioactivity Accumulation by Tolmachev, Vladimir, Hofström, Camilla, Malmberg, Jennie, Ahlgren, Sara, Hosseinimehr, Seyed Jalal, Sandström, Mattias, Abrahmsén, Lars, Orlova, Anna, Gräslund, Torbjörn

“…Affibody molecules are a class of small (ca. 7 kDa) robust scaffold proteins suitable for radionuclide molecular imaging of therapeutic targets in vivo. A…”
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Design of an Optimized Scaffold for Affibody Molecules by Feldwisch, Joachim, Tolmachev, Vladimir, Lendel, Christofer, Herne, Nina, Sjöberg, Anna, Larsson, Barbro, Rosik, Daniel, Lindqvist, Eva, Fant, Gunilla, Höidén-Guthenberg, Ingmarie, Galli, Joakim, Jonasson, Per, Abrahmsén, Lars

“…Affibody molecules are non-immunoglobulin-derived affinity proteins based on a three-helical bundle protein domain. Here, we describe the design process of an…”
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Regulation of 11β-hydroxysteroid dehydrogenase type 1 and glucose-stimulated insulin secretion in pancreatic islets of Langerhans by Ortsäter, Henrik, Alberts, Peteris, Warpman, Ulrika, Engblom, Lars O. M., Abrahmsén, Lars, Bergsten, Peter

“…Background In rodents, the enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) converts inactive 11‐dehydrocorticosterone (DHC) into active…”
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Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy by Bykov, Vladimir J N, Zhang, Qiang, Zhang, Meiqiongzi, Ceder, Sophia, Abrahmsen, Lars, Wiman, Klas G

“…TP53 is the most frequently mutated gene in cancer. The p53 protein activates transcription of genes that promote cell cycle arrest or apoptosis, or regulate…”
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Targeting of HER2-Expressing Tumors with a Site-Specifically 99mTc-Labeled Recombinant Affibody Molecule, ZHER2:2395, with C-Terminally Engineered Cysteine by Ahlgren, Sara, Wallberg, Helena, Tran, Thuy A, Widstrom, Charles, Hjertman, Magnus, Abrahmsen, Lars, Berndorff, Dietmar, Dinkelborg, Ludger M, Cyr, John E, Feldwisch, Joachim, Orlova, Anna, Tolmachev, Vladimir

“…The detection of human epidermal growth factor receptor type 2 (HER2) expression in malignant tumors provides important information influencing patient…”
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Targeting of HER2 -Expressing Tumors Using 111 In-ABY-025, a Second-Generation Affibody Molecule with a Fundamentally Reengineered Scaffold by Ahlgren, Sara, Orlova, Anna, Wållberg, Helena, Hansson, Monika, Sandström, Mattias, Lewsley, Richard, Wennborg, Anders, Abrahmsén, Lars, Tolmachev, Vladimir, Feldwisch, Joachim

“…Overexpression of HER2 in breast carcinomas predicts response to trastuzumab therapy. Affibody molecules based on a non-immunoglobulin scaffold have…”
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Effects of Lysine-Containing Mercaptoacetyl-Based Chelators on the Biodistribution of 99mTc-Labeled Anti-HER2 Affibody Molecules by Tran, Thuy A, Ekblad, Torun, Orlova, Anna, Sandström, Mattias, Feldwisch, Joachim, Wennborg, Anders, Abrahmsén, Lars, Tolmachev, Vladimir, Karlström, Amelie Eriksson

“…The effects of polar (mercaptoacetyl-triseryl) and negatively charged (mercaptoacetyl-triglumatyl) chelators on the biodistribution of 99mTc-labeled anti-HER2…”
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99mTc-maEEE-ZHER2:342, an Affibody Molecule-Based Tracer for the Detection of HER2 Expression in Malignant Tumors by Tran, Thuy, Engfeldt, Torun, Orlova, Anna, Sandström, Mattias, Feldwisch, Joachim, Abrahmsén, Lars, Wennborg, Anders, Tolmachev, Vladimir, Karlström, Amelie Eriksson

“…Detection of HER2-overexpression in tumors and metastases is important for the selection of patients who will benefit from trastuzumab treatment. Earlier…”
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