Search Results - "ABE, Hiromi"

Highly multiplexed CRISPR‐Cas9‐nuclease and Cas9‐nickase vectors for inactivation of hepatitis B virus by Sakuma, Tetsushi, Masaki, Keiichi, Abe‐Chayama, Hiromi, Mochida, Keiji, Yamamoto, Takashi, Chayama, Kazuaki

“…CRISPR‐Cas9‐mediated genome‐editing technology contributes not only to basic genomic studies but also to clinical studies such as genetic correction and virus…”
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The glycosylation stoichiometry of EWS species in neuronal cells by Kamemura, Kazuo, Abe, Hiromi

“…Although Ewing sarcoma protein (EWS) is known to be glycosylated by O-linked β-N-acetylglucosamine (O-GlcNAc), the dynamics and stoichiometry of its…”
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A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population by Mbarek, Hamdi, Ochi, Hidenori, Urabe, Yuji, Kumar, Vinod, Kubo, Michiaki, Hosono, Naoya, Takahashi, Atsushi, Kamatani, Yoichiro, Miki, Daiki, Abe, Hiromi, Tsunoda, Tatsuhiko, Kamatani, Naoyuki, Chayama, Kazuaki, Nakamura, Yusuke, Matsuda, Koichi

“…Hepatitis B virus (HBV) infection is a major health issue worldwide which may lead to hepatic dysfunction, liver cirrhosis and hepatocellular carcinoma. To…”
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Novel Robust in Vitro Hepatitis B Virus Infection Model Using Fresh Human Hepatocytes Isolated from Humanized Mice by Ishida, Yuji, Yamasaki, Chihiro, Yanagi, Ami, Yoshizane, Yasumi, Fujikawa, Kazuyuki, Watashi, Koichi, Abe, Hiromi, Wakita, Takaji, Hayes, C. Nelson, Chayama, Kazuaki, Tateno, Chise

“…The molecular mechanisms underlying the hepatitis B virus (HBV) life cycle are poorly understood because of the lack of appropriate in vitro infection models…”
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Neuropathic pain in rats with a partial sciatic nerve ligation is alleviated by intravenous injection of monoclonal antibody to high mobility group box-1 by Nakamura, Yoki, Morioka, Norimitsu, Abe, Hiromi, Zhang, Fang Fang, Hisaoka-Nakashima, Kazue, Liu, Keyue, Nishibori, Masahiro, Nakata, Yoshihiro

“…High mobility group box-1 (HMGB1) is associated with the pathogenesis of inflammatory diseases. A previous study reported that intravenous injection of…”
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Aryl hydrocarbon receptor protects against bacterial infection by promoting macrophage survival and reactive oxygen species production by Kimura, Akihiro, Abe, Hiromi, Tsuruta, Sanae, Chiba, Sayuri, Fujii-Kuriyama, Yoshiaki, Sekiya, Takashi, Morita, Rimpei, Yoshimura, Akihiko

“…The AhR protects against Listeria infection by enhancing macrophage survival and ROS production Aryl hydrocarbon receptor (AhR) is crucial for various immune…”
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Long term persistence of NS5A inhibitor-resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy by Yoshimi, Satoshi, Imamura, Michio, Murakami, Eisuke, Hiraga, Nobuhiko, Tsuge, Masataka, Kawakami, Yoshiiku, Aikata, Hiroshi, Abe, Hiromi, Hayes, C. Nelson, Sasaki, Tamito, Ochi, Hidenori, Chayama, Kazuaki

“…Although interferon‐free antiviral treatment is expected to improve treatment of hepatitis C, it is unclear to what extent pre‐existing drug‐resistant amino…”
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ITPA Polymorphism Affects Ribavirin-Induced Anemia and Outcomes of Therapy—A Genome-Wide Study of Japanese HCV Virus Patients by Ochi, Hidenori, Maekawa, Toshiro, Abe, Hiromi, Hayashida, Yasufumi, Nakano, Rikita, Kubo, Michaki, Tsunoda, Tatsuhiko, Hayes, C. Nelson, Kumada, Hiromitsu, Nakamura, Yusuke, Chayama, Kazuaki

“…Background & Aims Ribavirin-induced anemia is one of the major causes of discontinuation and dose reduction during anti-hepatitis C virus therapy. Factors…”
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A novel cDNA‐uPA/SCID/Rag2−/−/Jak3−/− mouse model for hepatitis virus infection and reconstruction of human immune system by Uchida, Takuro, Teraoka, Yuji, Imamura, Michio, Abe‐Chayama, Hiromi, Makokha, Grace Naswa, Hayes, Clair Nelson, Aikata, Hiroshi, Hamamura, Satoko, Ishida, Yuji, Tateno, Chise, Shirouzu, Takayuki, Kawai, Shintaro, Tanaka, Yuka, Ohdan, Hideki, Okada, Seiji, Chayama, Kazuaki

“…Although human hepatocyte‐transplanted immunodeficient mice support infection with hepatitis viruses, these mice fail to develop viral hepatitis due to the…”
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Possible Association between Serum Matrix Metalloproteinase-9 (MMP-9) Levels and Relapse in Depressed Patients following Electroconvulsive Therapy (ECT) by Shibasaki, Chiyo, Itagaki, Kei, Abe, Hiromi, Kajitani, Naoto, Okada-Tsuchioka, Mami, Takebayashi, Minoru

“…Matrix metalloproteinases are involved in neuroinflammatory processes, which could underlie depression. Serum levels of MMP-9 and MMP-2 in depressed patients…”
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Identification of Lysophosphatidic Acid Receptor 1 in Astroglial Cells as a Target for Glial Cell Line-derived Neurotrophic Factor Expression Induced by Antidepressants by Kajitani, Naoto, Miyano, Kanako, Okada-Tsuchioka, Mami, Abe, Hiromi, Itagaki, Kei, Hisaoka-Nakashima, Kazue, Morioka, Norimitsu, Uezono, Yasuhito, Takebayashi, Minoru

“…Preclinical and clinical evidence suggests that glial cell line-derived neurotrophic factor (GDNF) is important in the therapeutic effect of antidepressants. A…”
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Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients by Abe, Hiromi, Ochi, Hidenori, Maekawa, Toshiro, Hayes, C. Nelson, Tsuge, Masataka, Miki, Daiki, Mitsui, Fukiko, Hiraga, Nobuhiko, Imamura, Michio, Takahashi, Shoichi, Ohishi, Waka, Arihiro, Koji, Kubo, Michiaki, Nakamura, Yusuke, Chayama, Kazuaki

“…Background & Aims A common genetic variation at the IL28 locus has been found to affect the response of peg-interferon and ribavirin combination therapy…”
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Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP by Makokha, Grace Naswa, Abe-Chayama, Hiromi, Chowdhury, Sajeda, Hayes, C. Nelson, Tsuge, Masataka, Yoshima, Tadahiko, Ishida, Yuji, Zhang, Yizhou, Uchida, Takuro, Tateno, Chise, Akiyama, Rie, Chayama, Kazuaki

“…Hepatitis B virus (HBV) infects the liver and is a key risk factor for hepatocellular carcinoma. Identification of host factors that support viral replication…”
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Altered Serum Levels of Matrix Metalloproteinase-2, -9 in Response to Electroconvulsive Therapy for Mood Disorders by Shibasaki, Chiyo, Takebayashi, Minoru, Itagaki, Kei, Abe, Hiromi, Kajitani, Naoto, Okada-Tsuchioka, Mami, Yamawaki, Shigeto

“…Background: Inflammatory processes could underlie mood disorders. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMP) are…”
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Abatacept treatment for patients with severe acute hepatitis caused by hepatitis B virus infection—Pilot study by Teraoka, Yuji, Imamura, Michio, Uchida, Takuro, Ohya, Kazuki, Morio, Kei, Fujino, Hatsue, Ono, Atsushi, Nakahara, Takashi, Murakami, Eisuke, Yamauchi, Masami, Kawaoka, Tomokazu, Miki, Daiki, Tsuge, Masataka, Hiramatsu, Akira, Abe‐Chayama, Hiromi, Nelson Hayes, C., Aikata, Hiroshi, Chayama, Kazuaki

“…Although glucocorticoids have been used for immunosuppression of patients with primary hepatitis B virus (HBV) infection‐induced severe hepatitis, the…”
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Serum PreS1 and HBsAg ratio reflects liver fibrosis and predicts the development of hepatocellular carcinoma in chronic hepatitis B patients by Nishida, Yuno, Imamura, Michio, Teraoka, Yuji, Morio, Kei, Fujino, Hatsue, Ono, Atsushi, Nakahara, Takashi, Murakami, Eisuke, Yamauchi, Masami, Kawaoka, Tomokazu, Miki, Daiki, Tsuge, Masataka, Hiramatsu, Akira, Abe‐Chayama, Hiromi, Hayes, C. Nelson, Aikata, Hiroshi, Sasaki, Noriko, Sekiguchi, Tomomi, Kinukawa, Hideki, Yoshimura, Toru, Chayama, Kazuaki

“…While the preS1 region of the large hepatitis B surface protein plays an essential role in hepatitis B virus (HBV) infection, the effect of preS1 on liver…”
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Shared preventive factors associated with relapse after a response to electroconvulsive therapy in four major psychiatric disorders by Omori, Wataru, Itagaki, Kei, Kajitani, Naoto, Abe, Hiromi, Okada‐Tsuchioka, Mami, Okamoto, Yasumasa, Takebayashi, Minoru

“…Aim The efficacy of electroconvulsive therapy (ECT) has been established in psychiatric disorders but the high rate of relapse is a critical problem. The…”
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A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections by Kosaka, Keiichi, Hiraga, Nobuhiko, Imamura, Michio, Yoshimi, Satoshi, Murakami, Eisuke, Nakahara, Takashi, Honda, Yoji, Ono, Atsushi, Kawaoka, Tomokazu, Tsuge, Masataka, Abe, Hiromi, Hayes, C. Nelson, Miki, Daiki, Aikata, Hiroshi, Ochi, Hidenori, Ishida, Yuji, Tateno, Chise, Yoshizato, Katsutoshi, Sasaki, Tamito, Chayama, Kazuaki

“…•TK-NOG mice with humanized livers are available for hepatitis viruses infection.•The infectiveness with hepatitis viruses is as well or better than uPA/SCID…”
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Comparative study on the replication of HCV1b genome between wild‐type and cell culture‐adaptive mutant in regard to sensitivities against anti‐HCV drugs by Miyayama, Yohei, Lee, Heini, Song, HoJoong, Abe‐Chayama, Hiromi, Miki, Daiki, Imamura, Michio, Chayama, Kazuaki, Hijikata, Makoto

“…The replicon system, which mimics viral genome replication in culture cells, has been widely used to analyze the genome replication of the hepatitis C virus…”
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Stimulation of spinal dorsal horn β2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase by Zhang, Fang Fang, Morioka, Norimitsu, Abe, Hiromi, Fujii, Shiori, Miyauchi, Kazuki, Nakamura, Yoki, Hisaoka-Nakashima, Kazue, Nakata, Yoshihiro

“…The noradrenaline-adrenergic system has a crucial role in controlling nociceptive transduction at the spinal level. While α-adrenergic receptors are known to…”
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