Search Results - "ABDULKARIM, Baroj"

Translation is required for miRNA‐dependent decay of endogenous transcripts by Biasini, Adriano, Abdulkarim, Baroj, de Pretis, Stefano, Tan, Jennifer Y, Arora, Rajika, Wischnewski, Harry, Dreos, Rene, Pelizzola, Mattia, Ciaudo, Constance, Marques, Ana Claudia

“…Post‐transcriptional repression of gene expression by miRNAs occurs through transcript destabilization or translation inhibition. mRNA decay is known to…”
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RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate by CNOP, Miriam, ABDULKARIM, Baroj, BUGLIANI, Marco, LADRIERE, Laurence, MARSELLI, Lorella, MCCARTHY, Mark I, MARCHETTI, Piero, SAMMETH, Michael, EIZIRIK, Décio L, BOTTU, Guy, CUNHA, Daniel A, IGOILLO-ESTEVE, Mariana, MASINI, Matilde, TURATSINZE, Jean-Valery, GRIEBEL, Thasso, VILLATE, Olatz, SANTIN, Izortze

“…Pancreatic β-cell dysfunction and death are central in the pathogenesis of type 2 diabetes (T2D). Saturated fatty acids cause β-cell failure and contribute to…”
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Guanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis by Abdulkarim, Baroj, Hernangomez, Miriam, Igoillo-Esteve, Mariana, Cunha, Daniel A, Marselli, Lorella, Marchetti, Piero, Ladriere, Laurence, Cnop, Miriam

“…Deficient as well as excessive/prolonged endoplasmic reticulum (ER) stress signaling can lead to pancreatic β cell failure and the development of diabetes…”
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A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly by Abdulkarim, Baroj, Nicolino, Marc, Igoillo-Esteve, Mariana, Daures, Mathilde, Romero, Sophie, Philippi, Anne, Senée, Valérie, Lopes, Miguel, Cunha, Daniel A, Harding, Heather P, Derbois, Céline, Bendelac, Nathalie, Hattersley, Andrew T, Eizirik, Décio L, Ron, David, Cnop, Miriam, Julier, Cécile

“…Dysregulated endoplasmic reticulum stress and phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) are associated with pancreatic β-cell…”
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tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans by Igoillo-Esteve, Mariana, Genin, Anne, Lambert, Nelle, Désir, Julie, Pirson, Isabelle, Abdulkarim, Baroj, Simonis, Nicolas, Drielsma, Anais, Marselli, Lorella, Marchetti, Piero, Vanderhaeghen, Pierre, Eizirik, Décio L, Wuyts, Wim, Julier, Cécile, Chakera, Ali J, Ellard, Sian, Hattersley, Andrew T, Abramowicz, Marc, Cnop, Miriam

“…We describe a new syndrome of young onset diabetes, short stature and microcephaly with intellectual disability in a large consanguineous family with three…”
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Publisher Correction: Loss-of-function of the long non-coding RNA A830019P07Rik in mice does not affect insulin expression and secretion by Guay, Claudiane, Abdulkarim, Baroj, Tan, Jennifer Y., Dubuis, Gilles, Rütti, Sabine, Laybutt, David Ross, Widmann, Christian, Regazzi, Romano, Marques, Ana Claudia

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Loss-of-function of the long non-coding RNA A830019P07Rik in mice does not affect insulin expression and secretion by Guay, Claudiane, Abdulkarim, Baroj, Tan, Jennifer Y., Dubuis, Gilles, Rütti, Sabine, Laybutt, David Ross, Widmann, Christian, Regazzi, Romano, Marques, Ana Claudia

“…Long non-coding RNAs (lncRNAs) contribute to diverse cellular functions and the dysregulation of their expression or function can contribute to diseases,…”
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The Contribution of lincRNAs at the Interface between Cell Cycle Regulation and Cell State Maintenance by Biasini, Adriano, Smith, Adam Alexander Thil, Abdulkarim, Baroj, Ferreira da Silva, Maria, Tan, Jennifer Yihong, Marques, Ana Claudia

“…Cell cycle progression is controlled by the interplay of established cell cycle regulators. Changes in these regulators' activity underpin differences in cell…”
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tRNA-derived fragments in T lymphocyte–beta cell crosstalk and in type 1 diabetes pathogenesis in NOD mice by Brozzi, Flora, Jacovetti, Cécile, Cosentino, Cristina, Menoud, Véronique, Wu, Kejing, Bayazit, Mustafa Bilal, Abdulkarim, Baroj, Iseli, Christian, Guex, Nicolas, Guay, Claudiane, Regazzi, Romano

“…Aims/hypothesis tRNAs play a central role in protein synthesis. Besides this canonical function, they were recently found to generate non-coding RNA fragments…”
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DNAJC3 deficiency induces β-cell mitochondrial apoptosis and causes syndromic young-onset diabetes by Lytrivi, Maria, Senée, Valérie, Salpea, Paraskevi, Fantuzzi, Federica, Philippi, Anne, Abdulkarim, Baroj, Sawatani, Toshiaki, Marín-Cañas, Sandra, Pachera, Nathalie, Degavre, Anne, Singh, Pratibha, Derbois, Céline, Lechner, Doris, Ladrière, Laurence, Igoillo-Esteve, Mariana, Cosentino, Cristina, Marselli, Lorella, Deleuze, Jean-François, Marchetti, Piero, Eizirik, Décio L, Nicolino, Marc, Chaussenot, Annabelle, Julier, Cécile, Cnop, Miriam

“…Objective DNAJC3, also known as P58IPK, is an Hsp40 family member that interacts with and inhibits PKR-like ER-localized eIF2α kinase (PERK). Dnajc3 deficiency…”
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Unveiling a common mechanism of apoptosis in β-cells and neurons in Friedreich's ataxia by Igoillo-Esteve, Mariana, Gurgul-Convey, Ewa, Hu, Amélie, Romagueira Bichara Dos Santos, Laila, Abdulkarim, Baroj, Chintawar, Satyan, Marselli, Lorella, Marchetti, Piero, Jonas, Jean-Christophe, Eizirik, Décio L, Pandolfo, Massimo, Cnop, Miriam

“…Friedreich's ataxia (FRDA) is a neurodegenerative disorder associated with cardiomyopathy and diabetes. Effective therapies for FRDA are an urgent unmet need;…”
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Guanabenz Sensitizes Pancreatic [beta] Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis by Baroj Abdulkarim, Hernangomez, Miriam, Igoillo-Esteve, Mariana, Cunha, Daniel A, Marselli, Lorella, Marchetti, Piero, Ladriere, Laurence, Cnop, Miriam

“…Abstract Deficient as well as excessive/prolonged endoplasmic reticulum (ER) stress signaling can lead to pancreatic β cell failure and the development of…”
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Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia by Igoillo-Esteve, Mariana, Oliveira, Ana F, Cosentino, Cristina, Fantuzzi, Federica, Demarez, Céline, Toivonen, Sanna, Hu, Amélie, Chintawar, Satyan, Lopes, Miguel, Pachera, Nathalie, Cai, Ying, Abdulkarim, Baroj, Rai, Myriam, Marselli, Lorella, Marchetti, Piero, Tariq, Mohammad, Jonas, Jean-Christophe, Boscolo, Marina, Pandolfo, Massimo, Eizirik, Décio L, Cnop, Miriam

“…Friedreich ataxia is an autosomal recessive neurodegenerative disease associated with a high diabetes prevalence. No treatment is available to prevent or delay…”
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Loss-of-function mutations in DNAJC3 cause young-onset diabetes due to oxidative stress and mitochondrial [Beta]-cell apoptosis by Abdulkarim, Baroj, Senée, Valérie, Philippi, Anne, Singh, Pratibha, Daures, Mathilde, Igoillo-Esteve, Mariana, Chaussenot, Annabelle, Nicolino, Marc, Eizirik, Décio L, Julier, Cecile, Cnop, Miriam

“…Pancreatic β-cells synthesize and secrete large amounts of insulin. Translation and folding of insulin and other secretory proteins takes place in the…”
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tRNA Methyltransferase Homolog Gene TRMT10A Mutation in Young Onset Diabetes and Primary Microcephaly in Humans: e1003888 by Igoillo-Esteve, Mariana, Genin, Anne, Lambert, Nelle, Désir, Julie, Pirson, Isabelle, Abdulkarim, Baroj, Simonis, Nicolas, Drielsma, Anais, Marselli, Lorella, Marchetti, Piero, Vanderhaeghen, Pierre, Eizirik, Décio L, Wuyts, Wim, Julier, Cécile, Chakera, Ali J, Ellard, Sian, Hattersley, Andrew T, Abramowicz, Marc, Cnop, Miriam

“…We describe a new syndrome of young onset diabetes, short stature and microcephaly with intellectual disability in a large consanguineous family with three…”
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