Effect of reserved line’s anti-tuberculosis medicines to antiinflammatory cytokine production for patients with pulmonary tuberculosis

The results of research show the impact of ofloxacin, para-aminosalicylic acid (PASA) and capreomycin in conjunction with the BCG vaccine strain to the cytokine-production ability of mononuclear peripheral blood leukocytes for patients with infiltrative pulmonary tuberculosis prior to specific antit...

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Bibliographic Details
Published in:	Bi͡u︡lletenʹ Sibirskoĭ medit͡s︡iny Vol. 9; no. 5; pp. 64 - 71
Main Authors:	T. Ye. Kononova, O. I. Urazova, V. A. Serebryakova, V. V. Novitsky, O. A. Vasiliyeva, I. O. Naslednikova, O. V. Voronkova, R. R. Khasanova, A. Ye. Kolosova
Format:	Journal Article
Language:	English
Published:	Siberian State Medical University (Tomsk) 28-10-2010
Subjects:	продукция цитокинов противотуберкулезные препараты резервного ряда туберкулез легких
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Summary:	The results of research show the impact of ofloxacin, para-aminosalicylic acid (PASA) and capreomycin in conjunction with the BCG vaccine strain to the cytokine-production ability of mononuclear peripheral blood leukocytes for patients with infiltrative pulmonary tuberculosis prior to specific antituberculosis therapy. The results show that ofloxacin has inducing effect on the secretion of interleukin (IL) 4 and transforming growth factor (TGF) β; PASA and capreomycin have such effect for the products of IL10 and TGFβ. This influence has a negative effect during the active development of the pathological process and during specific treatment.
ISSN:	1682-0363 1819-3684
DOI:	10.20538/1682-0363-2010-5-64-71