Search Results - "A. Scarff"

Structure of the shutdown state of myosin-2 by Scarff, Charlotte A., Carrington, Glenn, Casas-Mao, David, Chalovich, Joseph M., Knight, Peter J., Ranson, Neil A., Peckham, Michelle

“…Myosin-2 is essential for processes as diverse as cell division and muscle contraction. Dephosphorylation of its regulatory light chain promotes an inactive,…”
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Using a SMALP platform to determine a sub-nm single particle cryo-EM membrane protein structure by Parmar, Mayuriben, Rawson, Shaun, Scarff, Charlotte A., Goldman, Adrian, Dafforn, Timothy R., Muench, Stephen P., Postis, Vincent L.G.

“…The field of membrane protein structural biology has been revolutionized over the last few years with a number of high profile structures being solved using…”
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Approaches to altering particle distributions in cryo‐electron microscopy sample preparation by Drulyte, Ieva, Johnson, Rachel M., Hesketh, Emma L., Hurdiss, Daniel L., Scarff, Charlotte A., Porav, Sebastian A., Ranson, Neil A., Muench, Stephen P., Thompson, Rebecca F.

“…Cryo‐electron microscopy (cryo‐EM) can now be used to determine high‐resolution structural information on a diverse range of biological specimens. Recent…”
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Initial performance of the COSINE-100 experiment by Adhikari, G., Adhikari, P., de Souza, E. Barbosa, Carlin, N., Choi, S., Choi, W. Q., Djamal, M., Ezeribe, A. C., Ha, C., Hahn, I. S., Hubbard, A. J. F., Jeon, E. J., Jo, J. H., Joo, H. W., Kang, W. G., Kang, W., Kauer, M., Kim, B. H., Kim, H., Kim, H. J., Kim, K. W., Kim, M. C., Kim, N. Y., Kim, S. K., Kim, Y. D., Kim, Y. H., Kudryavtsev, V. A., Lee, H. S., Lee, J., Lee, J. Y., Lee, M. H., Leonard, D. S., Lim, K. E., Lynch, W. A., Maruyama, R. H., Mouton, F., Olsen, S. L., Park, H. K., Park, H. S., Park, J. S., Park, K. S., Pettus, W., Pierpoint, Z. P., Prihtiadi, H., Ra, S., Rogers, F. R., Rott, C., Scarff, A., Spooner, N. J. C., Thompson, W. G., Yang, L., Yong, S. H.

“…COSINE is a dark matter search experiment based on an array of low background NaI(Tl) crystals located at the Yangyang underground laboratory. The assembly of…”
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Estimating Collision Cross Sections of Negatively Charged N-Glycans using Traveling Wave Ion Mobility-Mass Spectrometry by Hofmann, Johanna, Struwe, Weston B, Scarff, Charlotte A, Scrivens, James H, Harvey, David J, Pagel, Kevin

“…Glycosylation is one of the most common post-translational modifications occurring in proteins. A detailed structural characterization of the involved…”
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Background model for the NaI(Tl) crystals in COSINE-100 by Adhikari, P., Adhikari, G., Souza, E. Barbosa de, Carlin, N., Choi, S., Choi, W. Q., Djamal, M., Ezeribe, A. C., Ha, C., Hahn, I. S., Hubbard, A. J. F., Jeon, E. J., Jo, J. H., Joo, H. W., Kang, W. G., Kauer, M., Kang, W. S., Kim, B. H., Kim, H., Kim, H. J., Kim, K. W., Kim, M. C., Kim, N. Y., Kim, S. K., Kim, Y. D., Kim, Y. H., Kudryavtsev, V. A., Lee, H. S., Lee, J., Lee, J. Y., Lee, M. H., Leonard, D. S., Lynch, W. A., Maruyama, R. H., Mouton, F., Olsen, S. L., Park, H. K., Park, H. S., Park, J. S., Park, K. S., Pettus, W., Prihtiadi, H., Ra, S., Rott, C., Scarff, A., Spooner, N. J. C., Thompson, W. G., Yang, L., Yong, S. H.

“…The COSINE-100 dark matter search experiment is an array of NaI(Tl) crystal detectors located in the Yangyang Underground Laboratory (Y2L). To understand…”
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Low threshold results and limits from the DRIFT directional dark matter detector by Battat, J.B.R., Ezeribe, A.C., Gauvreau, J.-L., Harton, J.L., Lafler, R., Law, E., Lee, E.R., Loomba, D., Lumnah, A., Miller, E.H., Monte, A., Mouton, F., Paling, S.M., Phan, N.S., Robinson, M., Sadler, S.W., Scarff, A., Schuckman II, F.G., Snowden-Ifft, D.P., Spooner, N.J.C., Waldram, N.

“…We present results from a 54.7 live-day shielded run of the DRIFT-IId detector, the world's most sensitive, directional, dark matter detector. Several…”
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A cryo-EM grid preparation device for time-resolved structural studies by Kontziampasis, Dimitrios, Klebl, David P, Iadanza, Matthew G, Scarff, Charlotte A, Kopf, Florian, Sobott, Frank, Monteiro, Diana C F, Trebbin, Martin, Muench, Stephen P, White, Howard D

“…Structural biology generally provides static snapshots of protein conformations that can provide information on the functional mechanisms of biological…”
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Background modeling for dark matter search with 1.7 years of COSINE-100 data by Adhikari, G., de Souza, E. Barbosa, Carlin, N., Choi, J. J., Choi, S., Djamal, M., Ezeribe, A. C., França, L. E., Ha, C., Hahn, I. S., Jeon, E. J., Jo, J. H., Joo, H. W., Kang, W. G., Kauer, M., Kim, H., Kim, H. J., Kim, K. W., Kim, S. H., Kim, S. K., Kim, W. K., Kim, Y. D., Kim, Y. H., Ko, Y. J., Lee, E. K., Lee, H., Lee, H. S., Lee, H. Y., Lee, I. S., Lee, J., Lee, J. Y., Lee, M. H., Lee, S. H., Lee, S. M., Leonard, D. S., Lynch, W. A., Manzato, B. B., Maruyama, R. H., Neal, R. J., Olsen, S. L., Park, B. J., Park, H. K., Park, H. S., Park, K. S., Pitta, R. L. C., Prihtiadi, H., Ra, S. J., Rott, C., Shin, K. A., Scarff, A., Spooner, N. J. C., Thompson, W. G., Yang, L., Yu, G. H.

“…We present a background model for dark matter searches using an array of NaI(Tl) crystals in the COSINE-100 experiment that is located in the Yangyang…”
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Examination of Ataxin-3 (atx-3) Aggregation by Structural Mass Spectrometry Techniques: A Rationale for Expedited Aggregation upon Polyglutamine (polyQ) Expansion by Scarff, Charlotte A., Almeida, Bruno, Fraga, Joana, Macedo-Ribeiro, Sandra, Radford, Sheena E., Ashcroft, Alison E.

“…Expansion of polyglutamine stretches leads to the formation of polyglutamine-containing neuronal aggregates and neuronal death in nine diseases for which there…”
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Demonstration of ThGEM-multiwire hybrid charge readout for directional dark matter searches by Ezeribe, A.C., Eldridge, C., Lynch, W., Marcelo Gregorio, R.R., Scarff, A., Spooner, N.J.C.

“…Sensitivities of current directional dark matter search detectors using gas time projection chambers are now constrained by target mass. A ton-scale gas TPC…”
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Structure of the protective nematode protease complex H-gal-GP and its conservation across roundworm parasites by Scarff, Charlotte A, Thompson, Rebecca F, Newlands, George F J, Jamson, Alexander H, Kennaway, Christopher, da Silva, Vivian J, Rabelo, Elida M, Song, Chun-Feng, Trinick, John, Smith, W David, Muench, Stephen P

“…Roundworm parasite infections are a major cause of human and livestock disease worldwide and a threat to global food security. Disease control currently relies…”
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Nonproportionality of NaI(Tl) scintillation detector for dark matter search experiments by Lee, S. M., Adhikari, G., Carlin, N., Cho, J. Y., Choi, J. J., Choi, S., Ezeribe, A. C., França, L. E., Ha, C., Hahn, I. S., Hollick, S. J., Jeon, E. J., Joo, H. W., Kang, W. G., Kauer, M., Kim, B. H., Kim, H. J., Kim, J., Kim, K. W., Kim, S. H., Kim, S. K., Kim, S. W., Kim, W. K., Kim, Y. D., Kim, Y. H., Ko, Y. J., Lee, D. H., Lee, E. K., Lee, H., Lee, H. S., Lee, H. Y., Lee, I. S., Lee, J., Lee, J. Y., Lee, M. H., Lee, S. H., Lee, Y. J., Leonard, D. S., Luan, N. T., Manzato, B. B., Maruyama, R. H., Neal, R. J., Nikkel, J. A., Olsen, S. L., Park, B. J., Park, H. K., Park, H. S., Park, J. C., Park, K. S., Park, S. D., Pitta, R. L. C., Prihtiadi, H., Ra, S. J., Rott, C., Shin, K. A., Cavalcante, D. F. F. S., Scarff, A., Son, M. K., Spooner, N. J. C., Truc, L. T., Yang, L., Yu, G. H.

“…We present a comprehensive study of the nonproportionality of NaI(Tl) scintillation detectors within the context of dark matter search experiments. Our…”
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Probing Hemoglobin Structure by Means of Traveling-Wave Ion Mobility Mass Spectrometry by Scarff, Charlotte A., Patel, Vibhuti J., Thalassinos, Konstantinos, Scrivens, James H.

“…Hemoglobin (Hb) is a tetrameric noncovalent complex consisting of two α- and two β-globin chains each associated with a heme group. Its exact assembly pathway…”
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First background-free limit from a directional dark matter experiment: Results from a fully fiducialised DRIFT detector by Battat, J.B.R., Brack, J., Daw, E., Dorofeev, A., Ezeribe, A.C., Gauvreau, J.-L., Gold, M., Harton, J.L., Landers, J.M., Law, E., Lee, E.R., Loomba, D., Lumnah, A., Matthews, J.A.J., Miller, E.H., Monte, A., Mouton, F., Murphy, A.StJ, Paling, S.M., Phan, N., Robinson, M., Sadler, S.W., Scarff, A., Schuckman II, F.G., Snowden-Ifft, D.P., Spooner, N.J.C., Telfer, S., Vahsen, S.E., Walker, D., Warner, D., Yuriev, L.

“…The addition of O2 to gas mixtures in time projection chambers containing CS2 has recently been shown to produce multiple negative ions that travel at slightly…”
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Plant-expressed virus-like particles reveal the intricate maturation process of a eukaryotic virus by Castells-Graells, Roger, Ribeiro, Jonas R. S., Domitrovic, Tatiana, Hesketh, Emma L., Scarff, Charlotte A., Johnson, John E., Ranson, Neil A., Lawson, David M., Lomonossoff, George P.

“…Many virus capsids undergo exquisitely choreographed maturation processes in their host cells to produce infectious virions, and these remain poorly…”
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Cryo-electron microscopy analysis of myosin at work and at rest by McMillan, Sean N., Scarff, Charlotte A.

“…Myosins are a superfamily of ATP-driven actin-dependent molecular motors that are responsible for diverse functions from muscle contraction to cell division…”
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Travelling wave ion mobility mass spectrometry studies of protein structure: biological significance and comparison with X-ray crystallography and nuclear magnetic resonance spectroscopy measurements by Scarff, Charlotte A., Thalassinos, Konstantinos, Hilton, Gillian R., Scrivens, James H.

“…The three‐dimensional conformation of a protein is central to its biological function. The characterisation of aspects of three‐dimensional protein structure…”
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Variations on Negative Stain Electron Microscopy Methods: Tools for Tackling Challenging Systems by Scarff, Charlotte A, Fuller, Martin J G, Thompson, Rebecca F, Iadanza, Matthew G

“…Negative stain electron microscopy (EM) allows relatively simple and quick observation of macromolecules and macromolecular complexes through the use of…”
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Meticillin-resistant Staphylococcus aureus (MRSA) in hospitals and the community: model predictions based on the UK situation by Robotham, J.V, Scarff, C.A, Jenkins, D.R, Medley, G.F

“…Summary Theoretical modelling has shown that patient movements in and out of hospitals are likely to affect nosocomial transmission dynamics considerably. The…”
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