Search Results - "A. Link"

Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides by Schröder, Hendrik V., Zhang, Yi, Link, A. James

“…Mechanically interlocked molecules (MIMs), such as rotaxanes and catenanes, have captured the attention of chemists both from a synthetic perspective and…”
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Mechanisms of action of ribosomally synthesized and posttranslationally modified peptides (RiPPs) by Cao, Li, Do, Truc, Link, A James

“…Natural products remain a critical source of medicines and drug leads. One of the most rapidly growing superclasses of natural products is RiPPs: ribosomally…”
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Protein Engineering in Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs) by Do, Truc, Link, A. James

“…Ribosomally synthesized and post-translationally modified peptides (RiPPs) make up a rapidly growing superfamily of natural products. RiPPs exhibit an…”
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Heterologous and in Vitro Reconstitution of Fuscanodin, a Lasso Peptide from Thermobifida fusca by Koos, Joseph D, Link, A. James

“…Lasso peptides are a class of ribosomally derived natural products typified by their threaded rotaxane structure. The conversion of a linear precursor peptide…”
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Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin by Braffman, Nathaniel R., Piscotta, Frank J., Hauver, Jesse, Campbell, Elizabeth A., Link, A. James, Darst, Seth A.

“…We report crystal structures of the antibacterial lasso peptides microcin J25 (MccJ25) and capistruin (Cap) bound to their natural enzymatic target, the…”
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Genome mining for lasso peptides: past, present, and future by Cheung-Lee, Wai Ling, Link, A. James

“…Over the course of roughly a decade, the lasso peptide field has been transformed. Whereas new compounds were discovered infrequently via activity-driven…”
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On the Reliability of N-Mixture Models for Count Data by Barker, Richard J., Schofield, Matthew R., Link, William A., Sauer, John R.

“…N-mixture models describe count data replicated in time and across sites in terms of abundance N and detectability p. They are popular because they allow…”
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Lasso peptides: structure, function, biosynthesis, and engineering by Maksimov, Mikhail O, Pan, Si Jia, James Link, A

“…Lasso peptides are a class of ribosomally-synthesized and posttranslationally-modified natural products with diverse bioactivities. This review describes the…”
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Discovery and structure of the antimicrobial lasso peptide citrocin by Cheung-Lee, Wai Ling, Parry, Madison E., Jaramillo Cartagena, Alexis, Darst, Seth A., Link, A. James

“…We report the identification of citrocin, a 19-amino acid-long antimicrobial lasso peptide from the bacteria Citrobacter pasteurii and Citrobacter braakii. We…”
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New developments in RiPP discovery, enzymology and engineering by Montalbán-López, Manuel, Scott, Thomas A, Ramesh, Sangeetha, Rahman, Imran R, van Heel, Auke J, Viel, Jakob H, Bandarian, Vahe, Dittmann, Elke, Genilloud, Olga, Goto, Yuki, Grande Burgos, María José, Hill, Colin, Kim, Seokhee, Koehnke, Jesko, Latham, John A, Link, A James, Martínez, Beatriz, Nair, Satish K, Nicolet, Yvain, Rebuffat, Sylvie, Sahl, Hans-Georg, Sareen, Dipti, Schmidt, Eric W, Schmitt, Lutz, Severinov, Konstantin, Süssmuth, Roderich D, Truman, Andrew W, Wang, Huan, Weng, Jing-Ke, van Wezel, Gilles P, Zhang, Qi, Zhong, Jin, Piel, Jörn, Mitchell, Douglas A, Kuipers, Oscar P, van der Donk, Wilfred A

“…Covering: up to June 2020Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large group of natural products. A community-driven…”
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On the robustness of N-mixture models by Link, William A., Schofield, Matthew R., Barker, Richard J., Sauer, John R.

“…N-mixture models provide an appealing alternative to mark–recapture models, in that they allow for estimation of detection probability and population size from…”
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Cyclic Peptides from Graspetide Biosynthesis and Native Chemical Ligation by Choi, Brian, Acuña, Arthur, Link, A. James

“…The ribosomally synthesized and post-translationally modified peptide (RiPP) superfamily of natural products includes many examples of cyclic peptides with…”
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Genome Mining and Discovery of Imiditides, a Family of RiPPs with a Class-Defining Aspartimide Modification by Cao, Li, Do, Truc, Zhu, Angela, Duan, Jianshu, Alam, Nathan, Link, A. James

“…Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large and diverse class of natural products of ribosomal origin. In the past…”
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Mechanistic Analysis of the Biosynthesis of the Aspartimidylated Graspetide Amycolimiditide by Choi, Brian, Elashal, Hader E., Cao, Li, Link, A. James

“…Several classes of ribosomally synthesized and post-translationally modified peptides (RiPPs) are composed of multiple macrocycles. The enzymes that assemble…”
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Self-Assembly of Catenanes from Lasso Peptides by Allen, Caitlin D, Link, A. James

“…Lasso peptides exist naturally in a threaded state as [1]­rotaxanes, and we reasoned that lasso peptides cleaved in their loop region could serve as building…”
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Kinetics of Aspartimide Formation and Hydrolysis in Lasso Peptide Lihuanodin by Cao, Li, Elashal, Hader E., Link, A. James

“…Aspartimides are notorious as undesired side products in solid-phase peptide synthesis and in pharmaceutical formulations. However, we have discovered several…”
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Sequence Diversity in the Lasso Peptide Framework: Discovery of Functional Microcin J25 Variants with Multiple Amino Acid Substitutions by Pan, Si Jia, Link, A. James

“…Microcin J25 (MccJ25) is a ribosomally synthesized antimicrobial peptide that has an unusual threaded lasso structure in which the C-terminal “tail” of the…”
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On thinning of chains in MCMC by Link, William A., Eaton, Mitchell J.

“…Summary 1. Markov chain Monte Carlo (MCMC) is a simulation technique that has revolutionised the analysis of ecological data, allowing the fitting of complex…”
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Electrical detection of pathogenic bacteria via immobilized antimicrobial peptides by Mannoor, Manu S., Zhang, Siyan, Link, A. James, McAlpine, Michael C., Lieber, Charles

“…The development of a robust and portable biosensor for the detection of pathogenic bacteria could impact areas ranging from waterquality monitoring to testing…”
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Phenotype-Guided Comparative Genomics Identifies the Complete Transport Pathway of the Antimicrobial Lasso Peptide Ubonodin in Burkholderia by Do, Truc, Thokkadam, Alina, Leach, Robert, Link, A. James

“…New antibiotics are needed as bacterial infections continue to be a leading cause of death, but efforts to develop compounds with promising antibacterial…”
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