Search Results - "A. D. van der Meer"

Primary Human Lung Alveolus‐on‐a‐chip Model of Intravascular Thrombosis for Assessment of Therapeutics by Jain, A, Barrile, R, van der Meer, AD, Mammoto, A, Mammoto, T, Ceunynck, K, Aisiku, O, Otieno, MA, Louden, CS, Hamilton, GA, Flaumenhaft, R, Ingber, DE

“…Pulmonary thrombosis is a significant cause of patient mortality; however, there are no effective in vitro models of thrombi formation in human lung…”
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Microfluidic Technology in Vascular Research by van der Meer, A. D., Poot, A. A., Duits, M. H. G., Feijen, J., Vermes, I.

“…Vascular cell biology is an area of research with great biomedical relevance. Vascular dysfunction is involved in major diseases such as atherosclerosis,…”
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Cell type-specific changes in transcriptomic profiles of endothelial cells, iPSC-derived neurons and astrocytes cultured on microfluidic chips by Middelkamp, H. H. T., Verboven, A. H. A., De Sá Vivas, A. G., Schoenmaker, C., Klein Gunnewiek, T. M., Passier, R., Albers, C. A., ‘t Hoen, P. A. C., Nadif Kasri, N., van der Meer, A. D.

“…In vitro neuronal models are essential for studying neurological physiology, disease mechanisms and potential treatments. Most in vitro models lack controlled…”
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BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function by Griep, L. M., Wolbers, F., de Wagenaar, B., ter Braak, P. M., Weksler, B. B., Romero, I. A., Couraud, P. O., Vermes, I., van der Meer, A. D., van den Berg, A.

“…The blood-brain barrier (BBB) is a unique feature of the human body, preserving brain homeostasis and preventing toxic substances to enter the brain. However,…”
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Modular operation of microfluidic chips for highly parallelized cell culture and liquid dosing via a fluidic circuit board by Vollertsen, A. R., de Boer, D., Dekker, S., Wesselink, B. A. M., Haverkate, R., Rho, H. S., Boom, R. J., Skolimowski, M., Blom, M., Passier, R., van den Berg, A., van der Meer, A. D., Odijk, M.

“…Microfluidic systems enable automated and highly parallelized cell culture with low volumes and defined liquid dosing. To achieve this, systems typically…”
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Embedded macrophages induce intravascular coagulation in 3D blood vessel-on-chip by Middelkamp, H.H.T., Weener, H.J., Gensheimer, T., Vermeul, K., de Heus, L.E., Albers, H.J., van den Berg, A., van der Meer, A.D.

“…Macrophages are innate immune cells that prevent infections and help in wound healing and vascular inflammation. While these cells are natural helper cells,…”
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Shear‐sensitive nanocapsule drug release for site‐specific inhibition of occlusive thrombus formation by Molloy, C. P., Yao, Y., Kammoun, H., Bonnard, T., Hoefer, T., Alt, K., Tovar‐Lopez, F., Rosengarten, G., Ramsland, P. A., Meer, A. D., Berg, A., Murphy, A. J., Hagemeyer, C. E., Peter, K., Westein, E.

“…Essentials Vessel stenosis due to large thrombus formation increases local shear 1‐2 orders of magnitude. High shear at stenotic sites was exploited to trigger…”
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Guiding organs-on-chips towards applications: a balancing act between integration of advanced technologies and standardization by J. Meneses, F. Conceição, A. D. van der Meer, A. D. van der Meer, S. de Wit, L. Moreira Teixeira, L. Moreira Teixeira

“…Organs-on-chips (OoC) are in vitro models that emulate key functionalities of tissues or organs in a miniaturized and highly controlled manner. Due to their…”
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Analyzing shear stress-induced alignment of actin filaments in endothelial cells with a microfluidic assay by van der Meer, A. D., Poot, A. A., Feijen, J., Vermes, I.

“…The physiology of vascular endothelial cells is strongly affected by fluid shear stress on their surface. In this study, a microfluidic assay was employed to…”
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Lowering Caveolin-1 Expression in Human Vascular Endothelial Cells Inhibits Signal Transduction in Response to Shear Stress by van der Meer, A. D., Kamphuis, M. M. J., Poot, A. A., Feijen, J., Vermes, I.

“…Vascular endothelial cells have an extensive response to physiological levels of shear stress. There is evidence that the protein caveolin-1 is involved in the…”
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Fast-track practice in cardiac surgery: results and predictors of outcome by Haanschoten, Marco C., van Straten, Albert H.M., ter Woorst, Joost F., Stepaniak, Pieter S., van der Meer, Auke-Dick, van Zundert, André A.J., Soliman Hamad, Mohamed A.

“…OBJECTIVES Various studies have shown different parameters as independent risk factors in predicting the success of fast-track postoperative management in…”
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Flow cytometric analysis of the uptake of low‐density lipoprotein by endothelial cells in microfluidic channels by van der Meer, A. D., Vermeul, K., Poot, A. A., Feijen, J., Vermes, I.

“…Acceptance of microfluidic technology in everyday laboratory practice by biologists is still low. One of the reasons for this is that the technology combines…”
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Pharmacokinetics of the enantiomers of bupivacaine following intravenous administration of the racemate by Burm, AG, Meer, AD, Kleef, JW, Zeijlmans, PW, Groen, K

“…1. The pharmacokinetics of R(+)‐bupivacaine and S(‐)‐bupivacaine were investigated following a 10 min intravenous infusion of the racemate (dose 30 mg) in 10…”
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Pharmacokinetics of prilocaine after intravenous administration in volunteers : Enantioselectivity by VAN DER MEER, A. D, BURM, A. G. L, STIENSTRA, R, VAN KLEEF, J. W, VLETTER, A. A, OLIEMAN, W

“…Prilocaine exists in two stereoisomeric configurations, the enantiomers S(+)- and R(-)-prilocaine. The drug is clinically used as the racemate. This study…”
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Shear stress induces a transient and VEGFR-2-dependent decrease in the motion of injected particles in endothelial cells by van der Meer, A D, Li, Y, Duits, M H G, Poot, A A, Feijen, J, Vermes, I

“…Vascular endothelial cells form the inner lining of all blood vessels and play a central role in vessel physiology and disease. Endothelial cells are highly…”
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New Approach Methodologies for Human-Relevant Biokinetics Predictions: Meeting the Paradigm Shift in Toxicology Towards an Animal-Free Chemical Risk Assessment by Punt, Ans, Bouwmeester, Hans, Blaauboer, Bas J, Coecke, Sandra, Hakkert, Betty, Hendriks, Delilah F.G, Jennings, Paul, Kramer, Nynke I, Neuhoff, Sibylle, Masereeuw, Rosalinde, Paini, Alicia, Peijnenburg, Ad A.C.M, Rooseboom, Ma, Shuler, Michael L, Sorrell, Ian, Spee, Bart, Strikwold, Marije, van der Meer, Andries D, van der Zande, Meike, Vinken, Mathieu, Yang, Huan, Bos, Peter M.J, Heringa, Minne B

“…For almost fifteen years, the availability and regulatory acceptance of new approach methodologies (NAMs) to assess the absorption, distribution, metabolism…”
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Periampullary and pancreatic head carcinoma: facts and factors influencing mortality, survival, and quality of postoperative life by Lygidakis, N J, Brummelkamp, W H, Tytgat, G H, Huïbtegtse, K H, Lubbers, M J, van der Meer, A D, Schenk, K E, van Gulik, T M, Roesing, H

“…From September 1983 to December 1985 40 patients from a total of 55 with periampullary and pancreatic head carcinoma underwent resectional surgery in our…”
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A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly by Quiros-Solano, W.F., Gaio, N., Silvestri, C., Arik, Y.B., Stassen, O.M.J.A., van der Meer, A.D., Bouten, C.V.C., van den Berg, A., Dekker, R., Sarro, P.M.

“…We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on…”
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