Search Results - "A. Chalyk, Bohdan"

Synthesis of Spirocyclic Pyrrolidines: Advanced Building Blocks for Drug Discovery by Chalyk, Bohdan A., Butko, Maryna V., Yanshyna, Oksana O., Gavrilenko, Konstantin S., Druzhenko, Tetiana V., Mykhailiuk, Pavel K.

“…In the context of drug discovery, novel spirocyclic pyrrolidines have been synthesized in two steps from common three‐ to seven‐membered‐ring (hetero)alicyclic…”
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Synthesis of Spirocyclic and Fused Isoxazoline Building Blocks by Chalyk, Bohdan A., Izhyk, Vitalii V., Danyleiko, Kyrylo, Sosunovych, Bohdan, Vashchenko, Bohdan V., Zginnyk, Oleksandr, Olshanska, Violetta, Teodorovic, Peter, Biitseva, Angelina V., Volochnyuk, Dmitriy M., Grygorenko, Oleksandr O.

“…A highly efficient multigram synthesis of spirocyclic and fused isoxazoline building blocks is described. Isoxazoline‐3‐carboxylates were synthesized via a…”
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Functionalization of Alkenes with Difluoromethyl Nitrile Oxide to Access the Difluoromethylated Derivatives by Chalyk, Bohdan A., Zginnyk, Oleksandr, Khutorianskyi, Andrii V., Mykhailiuk, Pavel K.

“…Electron-rich, electron-deficient, and non-activated alkenes can be rapidly functionalized by in situ-generated difluoromethyl nitrile oxide. The (3+2)…”
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Synthesis of 5‑(Fluoroalkyl)isoxazole Building Blocks by Regioselective Reactions of Functionalized Halogenoximes by Chalyk, Bohdan A, Hrebeniuk, Kateryna V, Fil, Yulia V, Gavrilenko, Konstantin S, Rozhenko, Alexander B, Vashchenko, Bohdan V, Borysov, Oleksandr V, Biitseva, Angelina V, Lebed, Pavlo S, Bakanovych, Iulia, Moroz, Yurii S, Grygorenko, Oleksandr O

“…A comprehensive study on the synthesis of 5-fluoroalkyl-substituted isoxazoles starting from functionalized halogenoximes is reported. One-pot metal-free [3 +…”
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Regioselective Synthesis of Functionalized 3- or 5‑Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles by Chalyk, Bohdan A, Khutorianskyi, Andrii, Lysenko, Andrii, Fil, Yulia, Kuchkovska, Yuliya O, Gavrilenko, Konstantin S, Bakanovych, Iulia, Moroz, Yurii S, Gorlova, Alina O, Grygorenko, Oleksandr O

“…A facile synthetic route toward either 3- or 5-fluoroalkyl-substituted isoxazoles or pyrazoles containing an additional functionalization site was developed…”
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Bicyclic Pyrrolidines for Medicinal Chemistry via [3 + 2]-Cycloaddition by Savych, Vladimir I, Mykhalchuk, Vladimir L, Melnychuk, Pavlo V, Isakov, Andrii O, Savchuk, Taras, Timoshenko, Vadim M, Siry, Sergiy A, Pavlenko, Sergiy O, Kovalenko, Dmytro V, Hryshchuk, Oleksandr V, Reznik, Vitalii A, Chalyk, Bohdan A, Yarmolchuk, Vladimir S, Rusanov, Eduard B, Mykhailiuk, Pavel K

“…A general approach to bicyclic fused pyrrolidines via [3 + 2]-cycloaddition between nonstabilized azomethyne ylide and endocyclic electron-deficient alkenes…”
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Synthesis of functionalized 4,5-dihydroisoxazoles decorated with the dimethylphosphinoyl group by Fedyk, Andrii V., Chalyk, Bohdan A.

“…Aim. To synthesize a hybrid molecular platform incorporating dimethylphosphinoyl and 4,5-dihydroisoxazole moieties suitable for the creation of focused…”
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Reductive Recyclization of sp 3 -Enriched Functionalized Isoxazolines into α-Hydroxy Lactams by Chalyk, Bohdan A, Khutorianskyi, Andrii V, Vashchenko, Bohdan V, Danyleiko, Kyrylo, Grynyova, Anastasiia, Osipova, Anastasiia O, Kozytskiy, Andriy, Syniuchenko, Darya, Tsymbaliuk, Anton, Gavrilenko, Konstantin S, Biitseva, Angelina V, Volochnyuk, Dmitriy M, Komarov, Igor V, Grygorenko, Oleksandr O

“…An efficient synthesis (up to a 200 g scale) of 3-hydroxypyrrolidin-2-ones bearing alkyl substituents or functional groups at the C-5 position is described…”
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Synthesis of 6‐Azaspiro[4.3]alkanes: Innovative Scaffolds for Drug Discovery by Chalyk, Bohdan A., Isakov, Andrei A., Butko, Maryna V., Hrebeniuk, Kateryna V., Savych, Olena V., Kucher, Olexandr V., Gavrilenko, Konstantin S., Druzhenko, Tetiana V., Yarmolchuk, Vladimir S., Zozulya, Sergey, Mykhailiuk, Pavel K.

“…New scaffolds for drug discovery, 6‐azaspiro[4.3]alkanes, have been synthesized in two steps from four‐membered‐ring ketones: cyclobutanone, thienone,…”
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Synthesis of Bi‐ and Polyfunctional Isoxazoles from Amino Acid Derived Halogenoximes and Active Methylene Nitriles by Chalyk, Bohdan A., Hrebeniuk, Kateryna V., Gavrilenko, Konstantin S., Shablykin, Oleh V., Yanshyna, Oksana O., Bash, Daniil, Mykhailiuk, Pavel K., Liashuk, Oleksandr S., Grygorenko, Oleksandr O.

“…The reaction of chloroximes that have a protected amino group and active methylene nitriles under basic conditions has been shown to give functionalized…”
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Synthesis of Spirocyclic Pyrrolidines: Advanced Building Blocks for Drug Discovery by Chalyk, Bohdan A., Butko, Maryna V., Yanshyna, Oksana O., Gavrilenko, Konstantin S., Druzhenko, Tetiana V., Mykhailiuk, Pavel K.

“…Invited for the cover of this issue is the group of Pavel K. Mykhailiuk at the Taras Shevchenko National University of Kyiv and Enamine Ltd. The image depicts…”
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Synthesis of 4‐Hetarylisoxazoles from Amino Acid‐Derived Halogenoximes and Push‐Pull Enamines by Chalyk, Bohdan A., Hrebeniuk, Kateryna V., Gavrilenko, Konstantin S., Kulik, Irene B., Rozhenko, Alexander B., Volochnyuk, Dmitriy M., Liashuk, Oleksandr S., Grygorenko, Oleksandr O.

“…An approach to 4‐hetarylisoxazole‐derived amines and other related 3,4‐disubstituted isoxazoles which relies on [3+2] cycloaddition of amino acid‐derived…”
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Preparation of 5-Amino-1,2-dihydro-4-(1-methyl-4-piperidinyl)pyrrol-3-ones by V. Tverdokhlebov, Anton, A. Chalyk, Bohdan, T. Iminov, Rustam, A. Tolmachev, Andrey

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Front Cover: Synthesis of Spirocyclic Pyrrolidines: Advanced Building Blocks for Drug Discovery (Chem. Eur. J. 66/2017) by Chalyk, Bohdan A., Butko, Maryna V., Yanshyna, Oksana O., Gavrilenko, Konstantin S., Druzhenko, Tetiana V., Mykhailiuk, Pavel K.

“…The cover picture shows novel building blocks for drug discovery—spirocyclic pyrrolidine. The synthesis starts from common four‐, five‐, six‐ and…”
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Polymorphic transition due to grinding: the case of 3‐[1‐(tert‐butoxycarbonyl)azetidin‐3‐yl]‐1,2‐oxazole‐4‐carboxylic acid by Konovalova, Irina S., Shaposhnyk, Anna M., Baumer, Vyacheslav N., Chalyk, Bohdan A., Shishkina, Svitlana V.

“…A polymorphic transition as a result of grinding was found for 3‐[1‐(tert‐butoxycarbonyl)azetidin‐3‐yl]‐1,2‐oxazole‐4‐carboxylic acid. The thorough study of…”
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Multigram Synthesis of Fluoroalkyl-Substituted Pyrazole-4-carboxylic Acids by Iminov, Rustam T., Mashkov, Alexander V., Vyzir, Ivan I., Chalyk, Bohdan A., Tverdokhlebov, Anton V., Mykhailiuk, Pavel K., Babichenko, Ludmila N., Tolmachev, Andrey A., Volovenko, Yulian M., Biitseva, Angelina, Shishkin, Oleg V., Shishkina, Svetlana V.

“…Acylation of tert‐butyl 3‐(methylamino)but‐2‐enoate with fluorinated acetic acid anhydrides occurred at the enamine carbon atom. The reaction of the resulting…”
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Front Cover: Synthesis of 6‐Azaspiro[4.3]alkanes: Innovative Scaffolds for Drug Discovery (Eur. J. Org. Chem. 31/2017) by Chalyk, Bohdan A., Isakov, Andrei A., Butko, Maryna V., Hrebeniuk, Kateryna V., Savych, Olena V., Kucher, Olexandr V., Gavrilenko, Konstantin S., Druzhenko, Tetiana V., Yarmolchuk, Vladimir S., Zozulya, Sergey, Mykhailiuk, Pavel K.

“…The cover picture shows novel scaffolds for drug discovery, 6 azaspiro[4.3]alkanes, which have been synthesized by Enamine chemists (Ukraine, Kyiv). The…”
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A Convenient Route to 1-Alkyl-5-trifluoromethyl-1,2,3-triazole-4-carboxylic Acids Employing a Diazo Transfer Reaction by Iminov, Rustam T., Mashkov, Alexander V., Chalyk, Bohdan A., Mykhailiuk, Pavel K., Tverdokhlebov, Anton V., Tolmachev, Andrey A., Volovenko, Yulian M., Shishkin, Oleg V., Shishkina, Svetlana V.

“…The reaction of ethyl 3‐(alkylamino)‐4,4,4‐trifluoro‐but‐2‐enoates with mesyl azide in the presence of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) gave ethyl…”
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Reductive Recyclization of sp3‑Enriched Functionalized Isoxazolines into α‑Hydroxy Lactams by Chalyk, Bohdan A, Khutorianskyi, Andrii V, Vashchenko, Bohdan V, Danyleiko, Kyrylo, Grynyova, Anastasiia, Osipova, Anastasiia O, Kozytskiy, Andriy, Syniuchenko, Darya, Tsymbaliuk, Anton, Gavrilenko, Konstantin S, Biitseva, Angelina V, Volochnyuk, Dmitriy M, Komarov, Igor V, Grygorenko, Oleksandr O

“…An efficient synthesis (up to a 200 g scale) of 3-hydroxypyrrolidin-2-ones bearing alkyl substituents or functional groups at the C-5 position is described…”
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Cover Feature: Synthesis of Bi‐ and Polyfunctional Isoxazoles from Amino Acid Derived Halogenoximes and Active Methylene Nitriles (Eur. J. Org. Chem. 22/2018) by Chalyk, Bohdan A., Hrebeniuk, Kateryna V., Gavrilenko, Konstantin S., Shablykin, Oleh V., Yanshyna, Oksana O., Bash, Daniil, Mykhailiuk, Pavel K., Liashuk, Oleksandr S., Grygorenko, Oleksandr O.

“…The Cover Feature shows the retrosynthetic disconnection of 5‐amino‐3‐(piperidin‐4‐yl)isoxazole‐4‐carbonitrile, a representative of functionalized…”
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