Search Results - "A. A. Tykhomyrov"

Peculiarities of the antioxidant and radioprotective effects of hydrated C60 fullerene nanostuctures in vitro and in vivo by Andrievsky, Grigory V, Bruskov, Vadim I, Tykhomyrov, Artem A, Gudkov, Sergey V

“…Aqueous solutions of highly stable supramolecular donor-acceptor complexes of chemically nonmodified pristine C(60) fullerene molecules with H(2)O molecules…”
Get full text

Levels of angiogenic regulators and MMP-2, -9 activities in Martorell ulcer: a case report by Petrenko, O. M., Tykhomyrov, A. A.

“…Martorell hypertensive ischemic leg ulcers (HYTILU) represent a unique form of lower extremity non-healing ulcers that develop in association with poorly…”
Get full text

Plasminogen modulates formation and release of platelet angiogenic regulators by Tykhomyrov, A. A., Zhernosekov, D. D., Grinenko, T. V.

“…Platelets store, produce and release a variety of angiogenesis regulators, which can contribute to both normal tissue repair and angiopathy-associated…”
Get full text

Dynamics of thrombin-induced exposition of actin on the platelet surface by Tykhomyrov, A A

“…Platelets play the key role in thrombosis and are also involved in angiogenesis as well as immune and reparative responses. In the function cascade, platelets…”
Get full text

Glial Fibrillary Acidic Protein (GFAP): on the 45th Anniversary of Its Discovery by Tykhomyrov, А. A., Pavlova, A. S., Nedzvetsky, V. S.

“…Glial fibrillary acidic protein (GFAP) is the main component of intermediate filaments of the cytoskeleton of astrocytes. Over more than four decades of…”
Get full text

L-ARGININE AND L-GLUTAMIC ACID INCREASE THE CONTENT OF PROTEIN C IN THE EARLY STAGES OF ISOLATION FROM DONOR PLASMA by Patalakh, I. I.

“…Current large-scale production of blood-derived pharmacological preparations is aimed at expanding the list of products and deeper extraction of target…”
Get full text

Identification of the binding site for plasminogen kringle 5 in the α-chain of fibrin(ogen) D-fragment by L. G. Kapustianenko, T. V. Grinenko, A. V. Rebriev, O. I. Yusova, A. A. Tykhomyrov

“…The interaction of the fifth kringle of Glu-plasminogen with fibrin triggers activation and initiation of fibrinolysis, yet the site on fibrin that binds…”
Get full text

Citicoline affects serum angiostatin and neurospecific protein levels in patients with atrial fibrillation and ischemic stroke by Tykhomyrov, A. A., Kushnir, Yu. S., Nedzvetsky, V. S., Grinenko, T. V., Kuryata, O. V.

“…Ischemic stroke is considered as one of the most frequent and severe complications of atrial fibrillation. The present study was undertaken to examine whether…”
Get full text

PRODUCTION AND CHARACTERIZATION OF ANTIBODIES TO TISSUE PLASMINOGEN ACTIVATOR: APPLICATION FOR THE PLATELET FLOW CYTOMETRY ASSAY by Yusova, E. I.

“…Tissue plasminogen activator (tPA) is one of the key protein of plasminogen/plasmin system that converts plasminogen in the active proteinase plasmin…”
Get full text

High thiamine dose restores levels of specific astroglial proteins in rat brain astrocytes affected by chronic ethanol consumption by Pavlova, O. S., Tykhomyrov, A. A., Mejenskaya, O. A.

“…Long-term ethyl alcohol consumption induces a deficiency of essential nutrient thiamine (vitamin B1 ) and profoundly impairs metabolic processes in nervous…”
Get full text

Plasminogen modulates formation of reactive oxygen species in human platelets by Tykhomyrov, A. A., Zhernosekov, D. D., Guzyk, M. M., Korsa, V. V., Grinenko, T. V.

“…Reactive oxygen species (ROS) are considered to be important signalling molecules controlling many platelet functions. ROS production has been shown to be…”
Get full text

PLASMINOGEN AND ANGIOSTATIN LEVELS IN FEMALE BENIGN BREAST LESIONS by Tykhomyrov, A A, Vovchuk, I L, Grinenko, T V

“…It is known that benign breast tissue exhibit relatively low angiogenic capacity. Activation of angiogenesis in mammary pre-malignant lesions could be…”
Get full text

Multiple effects of angiostatins in injured cornea by Bilous, V. L., Tykhomyrov, A. O.

“…Prolonged inflammation and excessive neovascularization of the cornea due to severe injury can impair optical clarity and lead to vision impairment…”
Get full text

Effects of a Propolis Extract on the Viability of and Levels of Cytoskeletal and Regulatory Proteins in Rat Brain Astrocytes: an In Vitro Study by Agca, C. A., Tykhomyrov, A. A., Baydas, G., Nedzvetsky, V. S.

“…A potential for the use of propolis in preventive and therapeutic purposes has been acknowledged, but little attention has been paid to estimation of possible…”
Get full text

Changes in the Levels of Neurospecific Proteins and Indices of Apoptosis in the Rat Cornea at Chronic Ethanol Consumption: Protective Effects of Thiamine Administration by Pavlova, O. S., Bilous, V. L., Korsa, V. V., Stepanenko, S. P., Parkhomenko, Yu. M., Tykhomyrov, A. O.

“…Long-term ethanol (EtOH) consumption may induce damage to corneal nerves leading to the development of ocular diseases, vision impairments, and possible…”
Get full text

Plasminogen and its fragments in rat brain: a plausible role for astrocytes in angiostatin generation by Tykhomyrov, A. A., Nedzvetsky, V. S., Agca, C. A., Korsa, V. V., Grinenko, T. V.

“…The purpose of the present study was to examine the plasminogen localization and to detect levels of its fragments (angiostatins) in various regions of rat…”
Get full text

Serum Levels of the Biomarkers Associated with Astrocytosis, Neurodegeneration, and Demyelination: Neurological Benefits of Citicoline Treatment of Patients with Ischemic Stroke and Atrial Fibrillation by Kuryata, O. V., Kushnir, Yu. S., Nedzvetsky, V. S., Korsa, V. V., Tykhomyrov, A. A.

“…Ischemic stroke is a main complication of atrial fibrillation (cardiac arrhythmia). The aim of our study was to estimate the effects of citicoline…”
Get full text

ULTRASOUND-ASSISTED AND ENZYMATIC-BASED METHOD FOR ISOLATION OF β-GLUCANS FROM OAT BRAN by Korsa, V. V.

“…β-Glucans are a group of non-starchy polysaccharides, or (1,3),(1,4)-β-D-glucans, that can be found in the cell walls of several species of bacteria, algae,…”
Get full text

Functional properties of individual sub-domains of the fibrin(ogen) αC-domains by Stohnii, Y.M., Yatsenko, T.A., Nikulina, V.V., Kucheriavyi, Y.P., Hrabovskyi, O.O., Slominskyi, O.Yu, Savchenko, K.S., Garmanchuk, L.V., Varbanets, L.D., Tykhomyrov, A.O., Chernyshenko, V.O.

“…•The use of specific proteases allowed us to obtain truncated forms of fibrin(ogen) lacking its C-terminal sub-domains or both N- and C-terminal sub-domains of…”
Get full text

Interaction of actin with plasminogen/plasmin system: mechanisms and physiological role by Tykhomyrov, A. A.

“…In the present review, we have summarized and analyzed the literature data concerning cooperation between multifunctional proteins, the components of…”
Get full text