Search Results - "A M Nadzan"

Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists by Mukherjee, Ranjan, Davies, Peter J. A, Crombie, Diane L, Bischoff, Eric D, Cesario, Rosemary M, Jow, Lily, Hamann, Lawrence G, Boehm, Marcus F, Mondon, Carl E, Nadzan, Alex M, Paterniti, James R, Heyman, Richard A

“…Retinoic acid receptors (RAR), thyroid hormone receptors (TR), peroxisome proliferator activated receptors (PPARs) and the orphan receptor, LXR, bind…”
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Activation of specific RXR heterodimers by an antagonist of RXR homodimers by Lala, Deepak S, Mukherjee, Ranjan, Schulman, Ira G, Koch, Stacie S. Canan, Dardashti, Laura J, Nadzan, Alex M, Croston, Glenn E, Evans, Ronald M, Heyman, Richard A

“…Retinoid X receptor (RXR) plays a central role in the regulation of many intracellular receptor signalling pathways and can mediate ligand-dependent…”
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Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells by Boehm, Marcus F, Zhang, Lin, Zhi, Lin, McClurg, Michael R, Berger, Elain, Wagoner, Murriel, Mais, Dale E, Suto, Carla M, Davies, Peter J. A, Heyman, Richard A, Nadzan, Alex M

“…Structural modifications of the retinoid X receptor (RXR) selective compound 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2- naphthyl)ethenyl]benzoic acid…”
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Identification of the First Retinoid X Receptor Homodimer Antagonist by Canan Koch, Stacie S, Dardashti, Laura J, Hebert, Jonathan J, White, Steven K, Croston, Glenn E, Flatten, Karen S, Heyman, Richard A, Nadzan, Alex M

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Synthesis of Retinoid X Receptor-Specific Ligands That Are Potent Inducers of Adipogenesis in 3T3-L1 Cells by Canan Koch, Stacie S, Dardashti, Laura J, Cesario, Rosemary M, Croston, Glenn E, Boehm, Marcus F, Heyman, Richard A, Nadzan, Alex M

“…A novel series of oxime ligands has been synthesized that displays potent, specific activation of the retinoid X receptors (RXRs). The oximes of 3-substituted…”
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Intracellular receptors and signal transducers and activators of transcription superfamilies : novel targets for small-molecule drug discovery by ROSEN, J, DAY, A, JONES, T. K, JONES, E. T. T, NADZAN, A. M, STEIN, R. B

“…The proliferation and differentiation of mammalian cells is modulated by a number of specific signal molecules that regulate gene expression. Among these…”
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A novel retinoic acid receptor-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice by SHALINSKY, D. R, BISCHOFF, E. D, LAMPH, W. W, ZHANG, L, BOEHM, M. F, DAVIES, P. J. A, NADZAN, A. M, HEYMAN, R. A

“…We have identified a novel retinoid, ALRT1550, that potently and selectively activates retinoic acid receptors (RARs). ALRT1550 binds RARs with Kd values of…”
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Effects of selective CCK receptor agonists on food intake after central or peripheral administration in rats by Asin, K E, Gore, Jr, P A, Bednarz, L, Holladay, M, Nadzan, A M

“…In this paper report the effects of peripheral (intraperitoneal, i.p.) and central (intracerebroventricular, i.c.v.) injection of selective cholecystokinin…”
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A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey by Asin, K E, Bednarz, L, Nikkel, A L, Gore, Jr, P A, Nadzan, A M

“…The anorectic actions of cholecystokinin (CCK)-8 and of a selective CCK-A agonist, A-71623, were examined in CD1 mice, beagle dogs, and cynomolgus monkeys…”
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Discovery of Novel Retinoic Acid Receptor Agonists Having Potent Antiproliferative Activity in Cervical Cancer Cells by Zhang, Lin, Nadzan, Alex M, Heyman, Richard A, Love, Deborah L, Mais, Dale E, Croston, Glenn, Lamph, William W, Boehm, Marcus F

“…Retinoic acid receptor (RAR) active retinoids have proven therapeutically useful for treating certain cancers and dermatological diseases. Herein, we describe…”
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Behavioral effects of A71623, a highly selective CCK-A agonist tetrapeptide by Asin, K E, Bednarz, L, Nikkel, A L, Gore, Jr, P A, Montana, W E, Cullen, M J, Shiosaki, K, Craig, R, Nadzan, A M

“…We studied the behavioral effects of a novel cholecystokinin tetrapeptide (CCK-4) analogue, A71623, with full agonist activity and high affinity and…”
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Intraventricular CCK-8 reduces single meal size in the baboon by interaction with type-A CCK receptors by Figlewicz, D P, Nadzan, A M, Sipols, A J, Green, P K, Liddle, R A, Porte, Jr, D, Woods, S C

“…Intraventricular cholecystokinin COOH-terminal octapeptide (CCK-8) decreases meal size in the meal-trained baboon. In the present study, we tested whether this…”
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Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors by Lin, C W, Shiosaki, K, Miller, T R, Witte, D G, Bianchi, B R, Wolfram, C A, Kopecka, H, Craig, R, Wagenaar, F, Nadzan, A M

“…Based on their relative affinities for cholecystokinin octapeptide (26-33) (CCK-8), cholecystokinin tetrapeptide (30-33) (CCK-4), desulfated CCK-8, and…”
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Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro by J M Essigmann, R G Croy, A M Nadzan, W F Busby, Jr, V N Reinhold, G Büchi, G N Wogan

“…The covalent binding of the hepatocarcinogen aflatoxin B1 by rat liver microsomes to calf thymus DNA resulted in a binding level equal to one aflatoxin residue…”
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Distinct requirements for activation at CCK-A and CCK-B/gastrin receptors: studies with a C-terminal hydrazide analogue of cholecystokinin tetrapeptide (30-33) by Lin, C W, Holladay, M W, Barrett, R W, Wolfram, C A, Miller, T R, Witte, D, Kerwin, Jr, J F, Wagenaar, F, Nadzan, A M

“…We describe here the properties of tert-butyloxycarbonyl-Trp-Leu-Asp-Phe-NHNH2 (A-57696), a C-terminal hydrazide analogue of tert-butyloxycarbonyl-CCK4…”
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Cholecystokinin receptors: relationships among phosphoinositide breakdown, amylase release and receptor affinity in pancreas by Lin, C W, Bianchi, B R, Grant, D, Miller, T, Danaher, E A, Tufano, M D, Kopecka, H, Nadzan, A M

“…The gut hormone cholecystokinin (CCK) octapeptide stimulates the release of amylase from exocrine pancreas, a process believed to be the result of the…”
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Boc-CCK-4 derivatives containing side-chain ureas as potent and selective CCK-A receptor agonists by Shiosaki, Kazumi, Lin, Chun Wel, Kopecka, Hana, Tufano, Michael D, Bianchi, Bruce R, Miller, Thomas R, Witte, David G, Nadzan, Alex M

“…Novel Boc-CCK-4 derivatives were communicated recently as having high potency and selectivity for the CCK-A receptor (Shiosaki et al. J. Med. Chem. 1990, 33,…”
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A71378: a CCK agonist with high potency and selectivity for CCK-A receptors by Lin, C W, Holladay, M W, Witte, D G, Miller, T R, Wolfram, C A, Bianchi, B R, Bennett, M J, Nadzan, A M

“…Receptors for the brain and gut peptide cholecystokinin (CCK) have been classified into two classes, CCK-A and CCK-B. To date, peptide analogues with…”
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Development of CCK-tetrapeptide analogs as potent and selective CCK-A receptor agonists by Shiosaki, Kazumi, Lin, Chun Wel, Kopecka, Hana, Craig, Richard, Wagenaar, Frank L, Bianchi, Bruce, Miller, Thomas, Witte, David, Nadzan, Alex M

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Centrally administered CCK-8 suppresses activity in mice by a "peripheral-type" CCK receptor by Britton, D R, Yahiro, L, Cullen, M J, Kerwin, Jr, J F, Kopecka, H, Nadzan, A M

“…Cholecystokinin octapeptide (CCK-8) administered either systemically (IP) or centrally (ICV) suppresses several types of behavior in mice including exploratory…”
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